#AI reads Urine#Urinary Metabolomic Changes and Potential Exercise-Induced Muscle Damage Biomarkers Identification in Trained Young Males Following Acute Intermittent Rowing Training

This study recruited 22 young males with athletic training backgrounds to undergo acute intermittent rowing training. By analyzing blood and urine samples, as well as assessing muscle function and pain levels before and after training, it was found that after training, four key blood biochemical indicators reflecting muscle damage were significantly elevated, the immune system showed an obvious response, jumping ability decreased, and delayed-onset muscle soreness occurred, confirming that the training induced exercise-induced muscle damage. Meanwhile, 45 urinary metabolites were detected to have significant changes (33 upregulated and 12 downregulated), involving multiple metabolic pathways such as phenylacetate metabolism and ammonia recycling. These changes were related to the body's metabolic adaptation to oxidative stress, inflammatory responses, and ammonia metabolism imbalance. Finally, four potential urinary biomarkers (2'-Deoxycytidine, Cytosine, Phenylacetaldehyde, and Pyridoxamine) were screened out, providing important evidence for the further development of a non-invasive and real-time assessment method for exercise-induced muscle damage based on urine.

Biosensors 2025, 15, 803. https:// doi.org/10.3390/bios15120803

Youhe Gao

Statement: During the preparation of this work the author(s) used Doubao / AI reading for summarizing the content. After using this tool/service, the author(s) reviewed and edited the content as needed and take(s) full responsibility for the content of the published article.

For earlier AI Reads Urine articles：

https://www.keaipublishing.com/en/journals/advances-in-biomarker-sciences-and-technology/ai-reads-urine/