#AI reads Urine#Urinary polyphenol signature of the Mediterranean diet is associated with lower cardiovascular disease risk

This study conducted a case-cohort analysis based on the PREDIMED trial, measuring 62 phenolic metabolites in the urine of 1,180 individuals at high risk of cardiovascular disease. It identified a combination of 8 metabolites that reflect adherence to the Mediterranean diet, which are derived from typical foods of this diet such as olive oil, nuts, fruits, vegetables, and red wine. The results showed a dose-dependent negative correlation between this metabolite signature and the risk of cardiovascular disease—individuals in the highest quartile of metabolite levels had a 52% lower risk compared to those in the lowest quartile. Additionally, the signature exhibited a protective effect against specific conditions including heart failure and myocardial infarction. These findings confirm that polyphenols from the Mediterranean diet may be the key factor in reducing the risk of cardiovascular disease, while also providing an objective urinary metabolite biomarker for assessing dietary adherence and cardiovascular disease risk.

BMC Med. 2025 Dec 18. doi: 10.1186/s12916-025-04587-w.

Youhe Gao

Statement: During the preparation of this work the author(s) used Doubao / AI reading for summarizing the content. After using this tool/service, the author(s) reviewed and edited the content as needed and take(s) full responsibility for the content of the published article.

For earlier AI Reads Urine articles：https://www.keaipublishing.com/en/journals/advances-in-biomarker-sciences-and-technology/ai-reads-urine/