The mechanism of AKT activation in cancer
December 2025
The serine/threonine kinase AKT is a central signaling node frequently dysregulated in cancer, integrating inputs from both canonical PI3K-dependent and alternative activation pathways to drive tumorigenesis....
DNA mutation rates in evolution, longevity, and disease: An evolutionary and biological trade-off
March 2026
For millions of years, life has adapted to shifting environments, with mutation as the engine of this change. The same mutations that fuel evolution also drive genetic diseases, cancer and age-related...
Targeting ferroptosis in cancer therapy: Mechanisms, strategies, and clinical applications
December 2025
Programmed cell death (PCD) is a fundamental biological process that plays a critical role in maintaining cellular homeostasis and modulating the effectiveness of cancer therapies. Among the various...
Endogenous double-stranded RNA: Bridging immune activation and cancer therapeutics
June 2025
Although it was previously believed that double-stranded RNAs (dsRNAs) were exclusively associated with viral infections, accumulating evidence indicates that dsRNAs can also arise from endogenous sources....
Dual immune checkpoint blockade strategies for cancer therapy
March 2026
The application of immune checkpoint inhibitors (ICIs) has transformed the treatment paradigm for advanced malignancies and has significantly improved the clinical outcomes of patients with various...
Natural killer cell immunotherapies beyond cancer
December 2025
Natural killer (NK) cells are innate lymphocytes that play central roles in immune surveillance, tissue homeostasis, and the regulation of adaptive immunity. While traditionally studied in the context...
Advances in bioactive polysaccharides: Structural characterization, signaling mechanisms, and therapeutic applications
March 2026
Polysaccharides represent a structurally diverse class of natural macromolecules with broad biomedical potential. Recent advances in extraction technologies, structural characterization, chemical modification...
CRISPR libraries: A powerful screening tool for function and mechanism study of cancer
December 2025
CRISPR libraries enable high-throughput screening of the whole genome or specific gene sets by integrating tens of thousands of single-guide RNAs, encompassing various types such as gene knockout, transcriptional...
Calcium entry channels and their role in the pathogenesis of acute pancreatitis
March 2026
Acute pancreatitis (AP) is a common gastrointestinal emergency, and dysregulated calcium (Ca2+) homeostasis within pancreatic acinar cells plays a key role in its development via intracellular Ca2+...
Lactylation in concert with other post-translational modifications: Regulatory networks and disease implications
June 2026
Lactate and lysine lactylation (Kla) have evolved from being viewed as metabolic end products to key molecular mediators linking cellular metabolism to chromatin dynamics and signaling outputs. Emerging...
RNA modification-mediated aberrant alternative splicing: An underlying driver of disease pathogenesis
December 2025
RNA modification and alternative splicing are central mechanisms in the regulation of eukaryotic gene expression. RNA modifications, which occur in a variety of chemical forms, exert widespread influences...
Topical VEGF-A mRNA therapy promotes angiogenesis and accelerates wound healing
December 2025
Promoting angiogenesis through supplementation of pro-angiogenic cytokines accelerates wound healing, yet clinical application has been hindered by high costs, short half-life, and adverse effects....
Multi-omics advances for molecular characterization, precision medicine, and prognostic implications in leukemia
March 2025
Leukemia encompasses a heterogeneous group of hematologic malignancies driven by complex molecular alterations. Recent advancements in genomics, transcriptomics and proteomics have uncovered pivotal...
RNA m6A modification: a key regulator in normal and malignant processes
June 2025
The dedicated control of gene abundance is essential for both biological and pathological processes in mammals. Multiple layers of gene expression regulation, including transcriptional, post-transcriptional,...
From fork protection to chromatin compaction: Replication-associated determinants of PARP inhibitor response
June 2026
PARP inhibitors (PARPi) exploit synthetic lethality to achieve durable responses in tumors with homologous recombination (HR) defects, most prominently BRCA1/2 deficiency. Yet resistance is common,...
Ribonucleotide reductases in cancer: Mechanisms, clinical progress, and prospects
September 2025
Ribonucleotide reductase (RNR) catalyzes the rate limiting conversion of ribonucleotides to deoxyribonucleotides (dNTPs), essential for DNA synthesis and repair. Aberrant RNR activity in cancer drives...
Navigating glucocorticoid resistance: From GR isoforms to nuclear condensates
March 2026
Glucocorticoids (GCs) are widely prescribed for their anti-inflammatory and pro-apoptotic effects, mediated primarily through the glucocorticoid receptor (GR). However, acquired GC resistance remains...
AI-enhanced 3D bioprinting innovations and challenges in bone marrow organoid engineering
June 2026
Bone marrow (BM) organoids represent a vital frontier for probing hematopoietic mechanisms, pathological niche remodeling, and regenerative therapeutics. Despite their potential, faithfully simulating...
Expert consensus on adjunctive therapy and dietary intervention of medicinal and food homologous substances for colorectal cancer (2026 Edition)
September 2026
Colorectal cancer (CRC) is a common malignant gastrointestinal neoplasm that poses a serious threat to human health, with its incidence and mortality steadily increasing worldwide. Under the dual insults...
S-palmitoylation: A novel player in cancer and its emerging therapeutic implications
September 2025
S-palmitoylation is a reversible post-translational lipid modification involving the covalent attachment of palmitic acid to cysteine residues, thereby regulating protein localization, stability, trafficking,...
Beyond ADCs: Antibody-encapsulated drug for targeted cancer therapy
September 2026
Antibody-drug conjugates (ADCs) have transformed cancer treatment by covalently linking the monoclonal antibody with cytotoxic payload, yet their clinical potential remains constrained by intrinsic...
Synthetic cell model reveals the coupling of ecDNA maintenance and genomic instability
June 2026
Tumor cells commonly harbor highly amplified extrachromosomal DNA (ecDNA), which encompasses oncogenes along with large noncoding regulatory regions. However, it remains ambiguous whether ecDNA maintenance...
The emerging role of aging in tumorigenesis
September 2026
Aging is the predominant risk factor for cancer, with over 90% of cancers arising in individuals older than 50 years. It is associated with increased cancer incidence, poorer prognosis, and decreased...
Development and validation of a prognostic nomogram based on clinicopathological characteristics for renal cell carcinoma in patients aged 30 years or younger: A 12-year single-centre study
September 2026
To develop and validate a risk model assessment associated with the survival prognosis of patients with renal cell carcinoma (RCC) aged 30 years or younger to guide clinical decisions....
Integrating genomic landscape and patient-derived organoids to uncover therapeutic vulnerabilities in breast cancer brain metastases
March 2026
Breast cancer brain metastases (BCBrMs) remain a major clinical challenge, affecting up to 30 % of patients with metastatic breast cancer and associated with a poor prognosis. While genomic studies...