CRISPR libraries: A powerful screening tool for function and mechanism study of cancer
December 2025
CRISPR libraries enable high-throughput screening of the whole genome or specific gene sets by integrating tens of thousands of single-guide RNAs, encompassing various types such as gene knockout, transcriptional...
The mechanism of AKT activation in cancer
December 2025
The serine/threonine kinase AKT is a central signaling node frequently dysregulated in cancer, integrating inputs from both canonical PI3K-dependent and alternative activation pathways to drive tumorigenesis....
Endogenous double-stranded RNA: Bridging immune activation and cancer therapeutics
June 2025
Although it was previously believed that double-stranded RNAs (dsRNAs) were exclusively associated with viral infections, accumulating evidence indicates that dsRNAs can also arise from endogenous sources....
RNA m6A modification: a key regulator in normal and malignant processes
June 2025
The dedicated control of gene abundance is essential for both biological and pathological processes in mammals. Multiple layers of gene expression regulation, including transcriptional, post-transcriptional,...
RNA modification-mediated aberrant alternative splicing: An underlying driver of disease pathogenesis
December 2025
RNA modification and alternative splicing are central mechanisms in the regulation of eukaryotic gene expression. RNA modifications, which occur in a variety of chemical forms, exert widespread influences...
Targeting ferroptosis in cancer therapy: Mechanisms, strategies, and clinical applications
December 2025
Programmed cell death (PCD) is a fundamental biological process that plays a critical role in maintaining cellular homeostasis and modulating the effectiveness of cancer therapies. Among the various...
S-palmitoylation: A novel player in cancer and its emerging therapeutic implications
September 2025
S-palmitoylation is a reversible post-translational lipid modification involving the covalent attachment of palmitic acid to cysteine residues, thereby regulating protein localization, stability, trafficking,...
Multi-omics advances for molecular characterization, precision medicine, and prognostic implications in leukemia
March 2025
Leukemia encompasses a heterogeneous group of hematologic malignancies driven by complex molecular alterations. Recent advancements in genomics, transcriptomics and proteomics have uncovered pivotal...
Natural killer cell immunotherapies beyond cancer
December 2025
Natural killer (NK) cells are innate lymphocytes that play central roles in immune surveillance, tissue homeostasis, and the regulation of adaptive immunity. While traditionally studied in the context...
Topical VEGF-A mRNA therapy promotes angiogenesis and accelerates wound healing
December 2025
Promoting angiogenesis through supplementation of pro-angiogenic cytokines accelerates wound healing, yet clinical application has been hindered by high costs, short half-life, and adverse effects....
Oncolytic virotherapy offers hope for high-grade glioma treatment
June 2025
High-grade glioma continues to rank among the most lethal human cancers. Due to their high invasiveness, pronounced heterogeneity and complex carcinogenic mechanism, therapeutic options remain limited....
T cell-macrophage crosstalk in GVHD and cancer immunotherapy
December 2025
The immune microenvironment is pivotal in regulating two complementary adverse outcomes of allogeneic hematopoietic stem cell transplantation (allo-HSCT): graft-versus-host disease (GVHD) and tumor...
Calcium entry channels and their role in the pathogenesis of acute pancreatitis
March 2026
Acute pancreatitis (AP) is a common gastrointestinal emergency, and dysregulated calcium (Ca2+) homeostasis within pancreatic acinar cells plays a key role in its development via intracellular Ca2+...
Ribonucleotide reductases in cancer: Mechanisms, clinical progress, and prospects
September 2025
Ribonucleotide reductase (RNR) catalyzes the rate limiting conversion of ribonucleotides to deoxyribonucleotides (dNTPs), essential for DNA synthesis and repair. Aberrant RNR activity in cancer drives...
Dual roles of LMO2 in promoting tumor angiogenesis and progression
September 2025
LIM domain only 2 (LMO2) is a critical transcription factor involved in developmental and adult angiogenesis; however, the specific mechanisms through which LMO2 regulates tumor angiogenesis remain...
Deciphering the role of liver metabolic enzymes in dementia pathogenesis
September 2025
The relationship between liver metabolic enzymes and the risk of dementia, as well as whether genetic factors can explain these potential associations, remains unclear. Based on data from 347,605 dementia-free...
The molecular and immune microenvironmental landscape of brain metastases: Implications for novel treatment options
March 2025
Brain metastases (BM), in which cells from a primary malignant tumor spread through the circulatory system into the microvasculature of the brain, eventually progress despite multiple therapeutic programmes...
TRIM24 drives colorectal cancer progression via CAVIN2 degradation and ERK/RhoA pathway activation
September 2025
Microsatellite‐stable (MSS) colorectal cancer (CRC), which constitutes the majority of advanced cases, has a dismal prognosis and is largely refractory to immune checkpoint inhibitors, while rapidly...
The role of YTHDF2 in anti-tumor immunity
March 2025
RNA N6-methyladenosine (m6A) modification has been identified as the most abundant RNA modification and plays crucial roles in both physiological and pathological processes. YTHDF2 was the first identified...
Activation of the NRF2 signaling pathway mitigates arthrofibrosis by suppressing myofibroblast ferroptosis through oxidative stress regulation
September 2025
Arthrofibrosis, a debilitating chronic disorder marked by restricted joint mobility and functional impairment, is driven by pathological fibroblast activation involving dysregulated proliferation and...
Paternal exercise as an epigenetic legacy: Sperm microRNAs bridge intergenerational metabolic health
December 2025
Lycium barbarum polysaccharide suppresses uridine induced malignant progression of lung adenocarcinoma via UPP1 regulation
March 2026
Lycium barbarum polysaccharide (LBP), derived from the fruit of Lycium chinense Mill., has been extensively studied for their potential health benefits in both dietary and medicinal contexts. Specifically,...
Antioxidant dipeptide, cyclo (Phe-Phe), protects against bone dysplasia by suppression of phospholipid peroxidation
June 2025
Prenatal exposure to dexamethasone (Dex) has been identified as a significant factor that impairs longitudinal skeletal growth in fetuses, resulting in notable deficiencies in bone development. However,...
Increased co-expression of CTLA4/LAG3 predicted adverse clinical outcomes in patients with T-cell malignancies
March 2025
The application of immune checkpoint blockers (ICBs) in immunotherapy has markedly improved the prognosis for patients with solid tumors and B-cell lymphomas, and it holds promise as a novel therapeutic...
Identification of WDR62 variants as a genetic contributor for human infertility
September 2025
WDR62 is crucial for the initiation of germ cell meiosis in mice. In Wdr62-deficient male mice, germ cells are arrested at the metaphase I stage of meiosis due to asymmetric centrosome distribution...