Glue prevents complications after breast cancer surgery

Seroma and prolonged lymphorrhea are among the most frequent complications following axillary lymphadenectomy in patients with breast cancer. Such complications can delay recovery and postpone the initiation of adjuvant therapy, directly impacting oncologic outcomes.

In a study published in Chinese Journal of Plastic and Reconstructive Surgery, a team of researchers at Sechenov University evaluated the use of a latex-based tissue adhesive (LTA) as an intraoperative strategy to prevent seroma formation and prolonged lymphorrhea following axillary dissection.

Notably, the technique is simple, allows rapid polymerization, and is biocompatible. Unlike costly biological adhesives, the latex-based composition is affordable and easily implemented in clinical practice.

In the prospective study, 65 patients with stage IIb-III breast cancer were divided into two groups; in the LTA group, surgery was completed with the application of latex-based tissue adhesive without drain placement, while in the control group, standard silicone vacuum drains were used.

The team observed that by the tenth postoperative day, wound exudate volume in the LTA group was 84.8% lower compared to that in the control group (8.2 mL vs 54.1 mL). Patients in the LTA group were also discharged earlier (8-10 days vs 14-16), with the need for repeat aspirations being significantly lower. No complications, including infection or allergic reactions,  were observed even though suction drains were not used in this group.

"Our results indicate that tissue adhesive can either replace or complement drainage systems, reduce complications and accelerate recovery," says corresponding author Viktoriia Nebezheva. "This has direct relevance for the timely initiation of cancer treatment and for improving patients' quality of life."

Contact author details:

Dr. Viktoriia Nebezheva

Department of Oncology, Radiotherapy and Plastic Surgery

Sechenov First Moscow State Medical University

8 Trubetskaya Street, Moscow 119048, Russia

E-mail: nebezheva.vv@bk.ru

See the article:

Reshetov IV, Nebezheva VV, Sukortseva NS, Nebezhev AA. Prevention of postoperative complications in axillary lymphadenectomy through adhesive application. Chin J Plast Reconstr Surg. 2025;7(3):123-126. doi:10.1016/j.cjprs.2025.08.004