Computational pathology: A comprehensive review of recent developments in digital and intelligent pathology
April 2025
Computational pathology, a field at the intersection of computer science and pathology, leverages digital technology to enhance diagnostic accuracy and efficiency. With the digitization of pathology...
Regulatory sandbox expansion: Exploring the leap from fintech to medical artificial intelligence
April 2025
This paper explores the expansion from fintech-based regulatory sandboxes to those that include medical artificial intelligence (AI) by examining their potential to foster innovation and accelerate...
Virtual staining for pathology: Challenges, limitations and perspectives
April 2025
In pathological examinations, tissue must first be stained to meet specific diagnostic requirements, a meticulous process demanding significant time and expertise from specialists. With advancements...
AI dermatology: Reviewing the frontiers of skin cancer detection technologies
April 2025
The rapid advancements in artificial intelligence (AI) have significantly impacted modern healthcare, particularly for skin cancer detection in the field of dermatology. Skin cancer has become a considerable...
Medical multimodal large language models: A systematic review
October 2025
The rapid advancement of artificial intelligence (AI) has ushered in a new era of medical multimodal large language models (MLLMs), which integrate diverse data modalities such as text, imaging, physiological...
Deep learning in abdominal organ segmentation: A review
October 2025
Abdominal organ segmentation is an essential and fundamental medical procedure with many clinical and research applications. There is extensive variability in the size, location, and shape of the abdominal...
Artificial intelligence in clinical trials of lung cancer: Current and future prospects
January 2025
Lung cancer remains a leading cause of mortality globally, with particularly high incidence rates in China. This review investigates the pivotal role of artificial intelligence (AI) in the clinical...
Deep learning-based multimodal data fusion in bone tumor management: Advances in clinical decision support
July 2025
Bone tumors (BTs)—including osteosarcoma, Ewing sarcoma, and chondrosarcoma—are rare but biologically complex malignancies characterized by pronounced heterogeneity in anatomical location, histological...
A narrative review of the prediction of immunotherapy efficacy for treating NSCLC: An artificial intelligence perspective
July 2025
Immunotherapy efficacy in non-small cell lung cancer (NSCLC) remains variable, with traditional biomarkers (programmed death-ligand 1 [PD-L1] and tumor mutational burden) limited by heterogeneity and...
Artificial intelligence in surgical oncology: A comprehensive review from preoperative planning to postoperative care
October 2025
While artificial intelligence (AI) has demonstrated significant potential across medical fields, its surgical applications, particularly in oncology remain largely exploratory. This review synthesizes...
Current status and prospects of artificial intelligence in liver cancer management
July 2025
Liver cancer is an extremely heterogeneous malignant tumor characterized by high morbidity and mortality rates. Despite significant advancements in cancer care, the outcomes of liver cancer patients...
UD-TN: A comprehensive ultrasound dataset for benign and malignant thyroid nodule classification
April 2025
The automatic classification of thyroid nodules in ultrasound images is a critical research focus in medical imaging. However, publicly available thyroid ultrasound datasets remain scarce. In this study,...
A fully automated quantitative analysis method based on deep learning algorithms for immunohistochemical staining expression intensities
July 2025
This paper focuses primarily on exploring the application of deep learning techniques and image processing algorithms in immunohistochemistry analysis, specifically targeting automated quantitative...
Artificial intelligence in tumor drug resistance: Mechanisms and treatment prospects
April 2025
Artificial intelligence (AI) demonstrates unprecedented potential in the study of tumor drug resistance and precision therapy. With the rapid growth of multi-omics data and biomedical information, AI...
Deep learning applications in motion management for radiotherapy
July 2025
The aim of radiotherapy (RT) is to deliver prescribed doses to tumors while sparing neighboring organs at risk. As the demand for treatment precision increases in modern RT, intrafractional motion management...
AI-driven network biology identifies SRC as a therapeutic target in metastatic pancreatic adenocarcinoma
July 2025
Pancreatic adenocarcinoma (PAAD) is notorious for its limited treatment options and dismal prognosis, underscoring an urgent need for innovative therapeutic strategies. This study leverages advanced...
Assessing quantitative performance and expert review of multiple deep learning-based frameworks for computed tomography-based abdominal organ auto-segmentation
April 2025
Segmentation of abdominal organs in computed tomography (CT) images within clinical oncological workflows is crucial for ensuring effective treatment planning and follow-up. However, manually generated...
Discovery of novel EGFR and BRAF inhibitors by machine learning approach
January 2025
In the pharmaceutical industry, epidermal growth factor receptor (EGFR) and B-Raf proto-oncogene, serine/threonine kinase (BRAF) are the primary targets for targeted cancer therapy....
Multi-omics synergy in oncology: Unraveling the complex interplay of radiomic, genoproteomic, and pathological data
January 2025
The advent of multi-omics approaches has revolutionized the field of oncology by enabling a comprehensive understanding of cancer biology through the integration of diverse biological data. This review...
Performance evaluation of artificial intelligence–assisted diagnostic tools for human papillomavirus–related cervical and anal cancers and their precancerous lesions: A systematic review and meta-analysis
October 2025
Detection of high-grade squamous intraepithelial lesions (HSILs) is key for the prevention of human papillomavirus (HPV)–related cancers. In this study, we aimed to identify and consolidate the existing...
Graph attention network enables multipurpose prediction of imaging mass cytometry in a hepatocellular carcinoma clinical trial
October 2025
Imaging mass cytometry (IMC) enables the high-resolution spatial profiling of tumor microenvironment, but its clinical utility for prospective prediction remains underdeveloped. In this study, we integrated...
AWCDL: Automatic weight calibration deep learning for detecting HER2 status in whole-slide breast cancer image
April 2025
Defining an ERBB2 (HER2/neu) gene amplification status is critical to guiding human epidermal growth factor receptor 2 (HER2)-targeted therapy in breast cancer. Up to 40% of breast cancer patients are...
Virtual cells in intelligent oncology
October 2025
Development and validation of AI delineation of the thoracic RTOG organs at risk with deep learning on multi-institutional datasets
January 2025
Accurate contouring of thoracic organs at risk (OARs) is essential for minimizing complications in radiation treatment. Manual contouring of thoracic OARs is not only time-consuming but also prone to...
Deep learning-based localization of preoperative parathyroid glands in secondary hyperparathyroidism patients using dual-phase unenhanced and contrast-enhanced computed tomography data
October 2025
Accurate preoperative localization of parathyroid glands (PGs) is crucial for patients with secondary hyperparathyroidism scheduled for parathyroidectomy. However, despite its importance, localization...