Enhancing efficacy and stability of nanoemulsions in cosmetics
Published 20 November, 2025
A recent review in the Journal of Dermatologic Science and Cosmetic Technology examined the efficacy and stability of nanoemulsions in cosmetics. Nanoemulsions are nanoscale dispersions of oil and water stabilized by surfactants, typically ranging between 20 and 200 nm in droplet size. They exhibit kinetic stability, resisting phase separation and maintaining uniformity over extended periods. These systems can be prepared using high-energy techniques such as ultrasonication or homogenization, and low-energy methods like phase inversion temperature. The small droplet size contributes to enhanced optical clarity, greater surface area, and superior interaction with skin barriers — making them especially suitable for cosmetic applications.
In cosmetic formulations, nanoemulsions serve as efficient carriers for active ingredients, enabling deeper skin penetration and improved bioavailability. Their stability prevents degradation of sensitive compounds such as vitamins and antioxidants, thus maintaining product efficacy. Furthermore, nanoemulsions provide sustained release of actives, ensuring prolonged effects and reducing the need for frequent application. These attributes make them highly desirable for developing anti-aging creams, sunscreens, and moisturizing formulations.
Further, the versatility of nanoemulsions allows encapsulation of both hydrophilic and lipophilic compounds, thereby broadening their potential use. Their compatibility with biocompatible and non-toxic materials enhances their safety profile, making them suitable for sensitive skin and long-term use.
“Apart from those qualities, translucent appearance of nanoemulsion enhances the aesthetic appeal of cosmetic products, aligning with modern consumer expectations for clean and elegant formulations,” shares so author of the review Enes Deveci.
The review also highlights the challenges associated with large-scale production, stability under fluctuating temperatures, and compliance with safety regulations. The author emphasizes the need for systematic evaluation of formulation variables—such as surfactant type, oil phase ratio, and preparation technique—and how these parameters influence skin penetration, release kinetics, and overall efficacy.
Contact author: Enes Deveci
Faculty of Pharmacy, Lokman Hekim University, Ankara 06510, Turkey
Institute of Health Sciences, Hacettepe University, Ankara 06100, Turkey
Faculty of Pharmacy, Hacettepe University, Ankara 06100, Turkey
Conflict of interest: The author declares that there is no conflict of interest regarding the publication of this paper.
See the article: https://www.sciencedirect.com/science/article/pii/S2950306X25000408#coi0005