Cover article collection released by Synthetic and Systems Biotechnology

Published 10 September, 2026

As an open-access, peer-reviewed journal dedicated to advancing synthetic and systems biology, Synthetic and Systems Biotechnology (SSB) provides a premier platform for publishing cutting-edge research in metabolic engineering, genome editing, and biomanufacturing. We are pleased to present a curated collection of our recent cover articles, featuring breakthroughs ranging from enzyme–chemical interaction prediction, genome-scale modeling and novel biosensor development to metabolic engineering of industrially relevant microbial hosts and next-generation gene-editing tools. These studies highlight the field's rapid evolution from fundamental tool discovery to translational industrial applications.

All articles are freely available for download. We invite you to explore these featured works and hope they inspire new ideas and collaborations.

1. Volume 9, Issue 2, 2024

Descriptor-augmented machine learning for enzyme-chemical interaction predictions

2. Volume 9, Issue 3, 2024

A hybrid RNA-protein biosensor for high-throughput screening of adenosylcobalamin biosynthesis

3. Volume 9, Issue 4, 2024

Auxotrophy-based curation improves the consensus genome-scale metabolic model of yeast

4. Volume 10, Issue 1, 2025

Engineering artificial cross-species promoters with different transcriptional strengths

5. Volume 10, Issue 2, 2025

Metabolic engineering of Glarea lozoyensis for high-level production of pneumocandin B0

6. Volume 10, Issue 3, 2025

T7 RNA polymerase-guided base editor for accelerated continuous evolution in Bacillus subtilis

7. Volume 10, Issue 4, 2025

Metabolic engineering of Escherichia coli for squalene overproduction

8. Volume 11, 2026

CRISPy-web 3.0: A unified platform for multi-modal guide RNA design for CRISPR and TnpB genome editing applications

9. Volume 12, 2026

Truncation of LPD1 promoter and adaptive evolution increase cytosolic acetyl-CoA supply in yeast

10. Volume 13, 2026

Formate-driven efficient pyruvate biosynthesis in Vibrio natriegens

 

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