2025 Bioactive Materials Best Paper Award Announcement

Published 18 December, 2025

The Best Paper Award is a prestigious honor presented to researchers whose published articles in Bioactive Materials have achieved outstanding academic metrics. Awarded strictly on merit, the core criterion is significant contributions to the field of bioactive materials.

Congratulations to the 2025 Winners!

The Bioactive Materials Best Paper Award Committee has announced the 2025 Best Paper Award winners following internal committee nominations:

NO.	Article Title
1	An ATP-activated spatiotemporally controlled hydrogel prodrug system for treating multidrug-resistant bacteria-infected pressure ulcers
2	Glucose oxidase: An emerging multidimensional treatment option for diabetic wound healing
3	Advancements in hydrogel design for articular cartilage regeneration: A comprehensive review
4	Periosteum-bone inspired hierarchical scaffold with endogenous piezoelectricity for neuro-vascularized bone regeneration
5	AI-driven 3D bioprinting for regenerative medicine: From bench to bedside
6	MMP-9 responsive hydrogel promotes diabetic wound healing by suppressing ferroptosis of endothelial cells
7	3D-printed manganese dioxide incorporated scaffold promotes osteogenic-angiogenic coupling for refractory bone defect by remodeling osteo-regenerative microenvironment
8	Copper-luteolin nanocomplexes for Mediating multifaceted regulation of oxidative stress, intestinal barrier, and gut microbiota in inflammatory bowel disease
9	Multifunctional DNA hydrogels with light-triggered gas-therapy and controlled G-Exos release for infected wound healing
10	Inhalable and bioactive lipid-nanomedicine based on bergapten for targeted acute lung injury therapy via orchestrating macrophage polarization
11	Enhancing bone regeneration through 3D printed biphasic calcium phosphate scaffolds featuring graded pore sizes
12	3D-printed zinc oxide nanoparticles modified barium titanate/ hydroxyapatite ultrasound-responsive piezoelectric ceramic composite scaffold for treating infected bone defects
13	Advances in biomaterial-based tissue engineering for peripheral nerve injury repair
14	3D bioprinting of engineered exosomes secreted from M2-polarized macrophages through immunomodulatory biomaterial promotes<i> in</i><i> vivo</i> wound healing and angiogenesis
15	An active shrinkage and antioxidative hydrogel with biomimetic mechanics functions modulates inflammation and fibrosis to promote skin regeneration
16	L-arginine modified mesoporous bioactive glass with ROS scavenging and NO release for periodontitis treatment
17	Anisotropic structure of nanofiber hydrogel accelerates diabetic wound healing via triadic synergy of immune-angiogenic-neurogenic microenvironments
18	Zn-DHM nanozymes regulate metabolic and immune homeostasis for early diabetic wound therapy
19	Copper doped bioactive glass promotes matrix vesicles-mediated biomineralization via osteoblast mitophagy and mitochondrial dynamics during bone regeneration
20	A supramolecular hydrogel leveraging hierarchical multi-strength hydrogen-bonds hinged strategy achieving a striking adhesive-mechanical balance
21	Dual-layer microneedles with NO/O2 releasing for diabetic wound healing via neurogenesis, angiogenesis, and immune modulation
22	Advanced biomaterials for targeting mature biofilms in periodontitis therapy
23	4D printing polymeric biomaterials for adaptive tissue regeneration
24	Engineered nanoplatform mediated gas therapy enhanced ferroptosis for tumor therapy in vivo
25	Sequential construction of vascularized and mineralized bone organoids using engineered ECM-DNA-CPO-based bionic matrix for efficient bone regeneration
26	Artificial multienzyme nanoflower composite hydrogel for efficiently promoting MRSA-infected diabetic wound healing via glucose-activated NO releasing and microenvironment regulation
27	Conductive polyphenol microneedles coupled with electroacupuncture to accelerate wound healing and alleviate depressive-like behaviors in diabetes
28	A microenvironment responsive polyetheretherketone implant with antibacterial and osteoimmunomodulatory properties facilitates osseointegration
29	3D bioprinting of high-performance hydrogel with in-situ birth of stem cell spheroids
30	An engineered M2 macrophage-derived exosomes-loaded electrospun biomimetic periosteum promotes cell recruitment, immunoregulation, and angiogenesis in bone regeneration
31	Restoring tendon microenvironment in tendinopathy: Macrophage modulation and tendon regeneration with injectable tendon hydrogel and tendon-derived stem cells exosomes
32	Lipidomic analysis of plant-derived extracellular vesicles for guidance of potential anti-cancer therapy
33	Protocol for engineering bone organoids from mesenchymal stem cells
34	Smart design in biopolymer-based hemostatic sponges: From hemostasis to multiple functions
35	Biomimetic multizonal scaffolds for the reconstruction of zonal articular cartilage in chondral and osteochondral defects
36	Self-assembled PROTACs enable protein degradation to reprogram the tumor microenvironment for synergistically enhanced colorectal cancer immunotherapy
37	Silver-quercetin-loaded honeycomb-like Ti-based interface combats infection-triggered excessive inflammation via specific bactericidal and macrophage reprogramming
38	Injectable double-crosslinked bone cement with enhanced bone adhesion and improved osteoporotic pathophysiological microenvironment for osteoregeneration in osteoporosis
39	A self-hygroscopic, rapidly self-gelling polysaccharide-based sponge with robust wet adhesion for non-compressible hemorrhage control and infected wounds healing
40	Injectable acellular matrix microgel assembly with stem cell recruitment and chondrogenic differentiation functions promotes microfracture-based articular cartilage regeneration
41	Metal-phenolic-network-coated gold nanoclusters for enhanced photothermal/chemodynamic/immunogenic cancer therapy
42	3D bioprinted multi-layered cell constructs with gradient core-shell interface for tendon-to-bone tissue regeneration
43	Tailoring hyaluronic acid hydrogels: Impact of cross-linker length and density on skin rejuvenation as injectable dermal fillers and their potential effects on the MAPK signaling pathway suppression
44	Degradation products of magnesium implant synergistically enhance bone regeneration: Unraveling the roles of hydrogen gas and alkaline environment
45	Continuous mechanical-gradient hydrogel with on-demand distributed Mn2+/Mg-doped hydroxyapatite@Fe3O4 for functional osteochondral regeneration
46	Epitope-imprinted biomaterials with tailor-made molecular targeting for biomedical applications
47	Multidimensional treatment of periprosthetic joint infection using fusion peptide-grafted chitosan coated porous tantalum scaffold
48	Scaffolds functionalized with matrix metalloproteinase-responsive release of miRNA for synergistic magnetic hyperthermia and sensitizing chemotherapy of drug-tolerant breast cancer
49	Enhanced healing of critical-sized bone defects using degradable scaffolds with tailored composition through immunomodulation and angiogenesis
50	Multifunctional magneto-electric and exosome-loaded hydrogel enhances neuronal differentiation and immunoregulation through remote non-invasive electrical stimulation for neurological recovery after spinal cord injury

Selection Process

The 2025 Best Paper Awards are selected by a dedicated committee of seasoned experts in the field. The award recognizes exceptional research published in 2025, with the committee conducting thorough reviews of nominations based on criteria including societal impact, scientific significance, conceptual innovation, and technical breakthroughs.

Award Benefits

Winners will receive:

An official electronic certificate.
An invitation to submit a featured article to Bioactive Materials with the Article Processing Charge (APC) waived, valid for one year, in recognition of their achievement.
Permanent featuring of winners' profiles on the Bioactive Materials website.

To obtain the electronic certificate, please contact Publisher Jessica Wang at jessica.wang@keaipublishing.com.

Back to Bioactive Materials Awards

Stay Informed

First name *

Surname *

Email address *

KeAi may contact you to share the latest updates about products, services, promotions, and events. If you do not wish to receive such messages, please check this box.