Special issue on Organoid Engineering for Medicine

Introduction:

Organoid models, organ chips, and microphysiological systems are opening new ways to study human biology and disease. By bringing together stem cell biology, tissue engineering, bioactive materials, biofabrication and 3D bioprinting, microfluidics, bioelectronics, computational modeling, and artificial intelligence, these platforms can recapitulate key physiological features of the human body. They provide powerful human-relevant models for understanding development, disease progression, drug responses, toxicity, and patient-specific therapeutic outcomes. As these technologies continue to mature, they are becoming valuable tools for precision medicine, regenerative medicine, pharmaceutical development, and reducing reliance on animal models. This special issue aims to highlight recent advances in organoids, organ-on-chip technologies, and microphysiological systems, as well as their broad applications in biomedical research and medicine. Particular emphasis will be placed on engineering strategies that improve organoid organization, maturation, functionality, reproducibility, and translational potential. Submissions as research articles or review articles are welcome. Topics of interest include, but are not limited to: stem-cell-derived and patient-specific organoids; disease modeling; organoid engineering, maturation, and functional phenotyping; vascularized, immune-integrated, innervated, and multi-lineage organoid systems; organ chips and body-on-chip platforms; microfluidic, sensing, imaging, and automation technologies; biomaterials, biofabrication, and 3D printing; high-throughput and standardized platforms; AI, digital twins, and organoid intelligence; drug screening, toxicity testing, and translational studies connecting human models with clinical data.

Topics Covered:

• Organoids, organ chips, and microphysiological systems
• Human-centered and patient-specific models
• Stem cell engineering and tissue engineering
• Bioactive materials, biofabrication, 3D bioprinting, and microfluidic platforms
• Artificial intelligence, computational modeling, digital twins, and organoid intelligence
• Drug screening, toxicity testing, regenerative medicine, and translational medicine

Important Deadline:

Submission deadline: 31 December 2026

Submission Instructions:

Please read the [Guide for Authors] before submitting. All articles should be [submitted online], please select [Organoid Engineering] on submission.

 Guest Editors:

• Feng Guo

Affiliation: Indiana University Bloomington, USA

Email: fengguo@iu.edu 

• Qi Gu

Affiliation: Institute of Zoology, Chinese Academy of Sciences, China

Email: qgu@ioz.ac.cn

• Kazuo Takayama

Affiliation: Institute of Science Tokyo, Japan

Email: takayama.kazuo@tmd.ac.jp

• Ann-Na Cho

Affiliation: University of Sydney, Australia

Email: ann.cho@sydney.edu.au