A comprehensive study on anaerobic digestion of organic solid waste: A review on configurations, operating parameters, techno-economic analysis and current trends
2024
The excessive discharge and accumulation of solid organic waste into the environment is of severe concern across the globe. Thus, an efficient waste management system is important to mitigate health...
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Organ-on-chip technology: Opportunities and challenges
2024
Organ-on-chip (OOC) technology is an innovative approach that reproduces human organ structures and functions on microfluidic platforms, offering detailed insights into intricate physiological processes....
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Decoding dye degradation: Microbial remediation of textile industry effluents
2023
The extensive use of chemical dyes, primarily Azo and anthraquinone dyes, in textiles has resulted in their alarming release into the environment by textile industries. The introduction of heavy metals...
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Ribosome purification from Escherichia coli by ultracentrifugation
2022
With more and more researchers conducting extensive research on all aspects of ribosomes, how to extract ribosomes with good effect and high activity has become a fundamental problem. In this article,...
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Synthetic biology in Europe: current community landscape and future perspectives
2022
Synthetic biology has captivated scientists' imagination. It promises answers to some of the grand challenges society is facing: worsening climate crisis, insufficient food supplies for ever growing...
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Synthetic biology in Indonesia: Potential and projection in a country with mega biodiversity
2023
Synthetic biology has gained many interest around the globe in the last two decades, not only due to its rapid development but also the potential to provide addressable solutions using standardized...
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Development of destabilized mCherry fluorescent proteins for applications in the model yeast Saccharomyces cerevisiae
2022
Fluorescent proteins are widely used molecular reporters in studying gene expression and subcellular protein localization. To enable the monitoring of transient cellular events in the model yeast Saccharomyces...
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Identifying Chlorella vulgaris and Chlorella sorokiniana as sustainable organisms to bioconvert glucosamine into valuable biomass
2024
Chitin is a major component of various wastes such as crustacean shells, filamentous fungi, and insects. Recently, food-safe biological and chemical processes converting chitin to glucosamine have been...
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Understanding virus retention mechanisms on protein a chromatography based on using different wash buffers – Evaluating the possibility for a generic wash buffer toolbox to improve virus clearance capacity
2024
During manufacturing of mammalian-cell derived monoclonal antibodies (mAbs) virus clearance capacity of the downstream process has to be demonstrated. The protein A chromatography step typically achieves...
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CRISPR/Cas9 improves targeted knock-in efficiency in Aspergillusoryzae
2024
Aspergillus oryzae is an important fungus in food and industrial enzyme production. In A. oryzae, targeted knock-in transformation is primarily limited to homologous recombination (HR)-based systems,...
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Circular mRNA: A novel therapeutic agent
2023
Circular mRNA (circmRNA) is a covalent closed loop formed by reverse splicing of the 3′ end to the 5′ end of mRNA. Compared to traditional linear mRNAs, circmRNAs can mediate efficient, stable, and...
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Incorporating omics-based tools into endophytic fungal research
2024
Fungal endophytes are valuable sources of bioactive compounds with diverse applications. The exploration of these compounds not only contributes to our understanding of ecological interactions but also...
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"Therapeutic advancements in nanomedicine: The multifaceted roles of silver nanoparticles"
2024
Nanotechnology has the advantages of enhanced bioactivity, reduced toxicity, target specificity, and sustained release and NPs can penetrate cell membranes. The small size of silver nanoparticles, AgNPs,...
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Exploration on the expression and assembly of virus-like particles
2021
Virus-like particles (VLPs) have a great application prospect in vaccines and molecule delivery carriers. In this study, in order to solve the problem of low expression and low assembly efficiency of...
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Antibiotic susceptibility and virulence factors of bacterial species among cancer patients
2024
Antibiotic resistance is one of the most significant challenges of the 20-s century, and the misuse of antibiotics is a driver of antimicrobial resistance. This study aimed to assess the prevalence...
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The potential of copper oxide nanoparticles in nanomedicine: A comprehensive review
2024
Nanotechnology is a modern scientific discipline that uses nanoparticles of metals like copper, silver, gold, platinum, and zinc for various applications. Copper oxide nanoparticles (CuONPs) are effective...
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Synthetic biology landscape in the UK
2022
The UK is home to a vibrant and diverse synthetic biology community. Many of its successes in research innovation and technological commercialisation can be attributed to a strong base of dedicated...
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Construction of an ultra-strong PtacM promoter via engineering the core-element spacer and 5′ untranslated region for versatile applications in Corynebacterium glutamicum
2022
As one of the most important synthetic biology elements in transcriptional regulation, promoters play irreplaceable roles in metabolic engineering. For the industrial microorganism Corynebacterium glutamicum,...
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Engineered microbial consortia for next-generation feedstocks
2024
Addressing urgent environmental challenges, this commentary emphasizes the need for green, bio-based solutions in chemical production from renewable feedstocks. It highlights advanced metabolic engineering...
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The need for integrated systems biology approaches for biotechnological applications
2021
Biotechnology applications have contributed significantly to “factory in a lab” research. Although the largely adopted Design–Build–Test–Learn cycle has considerably improved synthetic biology and metabolic...
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Hyperuricemia and the small intestine: Transport mechanisms and co-morbidities
2022
There is a global increase in cases of hyperuricemia over the last 10 years. A critical component of serum uric acid control is the transport of uric acid to the intestinal lumen, which accounts for...
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Substrate promiscuity of the NdmCDE N7-demethylase enzyme complex
2021
Methylxanthines, including caffeine and theophylline, are a class of natural and synthetic compounds with important roles in food, cosmetics, and medicine. These compounds are metabolized by bacteria...
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Potential application of menadione for antimicrobial coating of surgical sutures
2023
Staphylococcal-associated surgical site infections (SSI) are common nosocomial infections in healthcare facilities worldwide. The use of antiseptic-coated sutures has been recommended to minimise the...
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Development of a polymer-based antimicrobial coating for efficacious urinary catheter protection
2021
This study reports the development of a polymer-based catheter coating to facilitate controlled release of antimicrobial peptides (AMP) to target both planktonic bacteria and biofilm in the urinary...
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Bio-conversion of organic wastes towards polyhydroxyalkanoates
2023
The bio-manufacturing of products with substantial commercial value, particularly polyhydroxyalkanoates (PHA), using cost-effective carbon sources through microorganisms, has garnered heightened attention...
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