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ISSN: 2665-9069

Synthetic biology in Europe: current community landscape and future perspectives

Synthetic biology has captivated scientists' imagination. It promises answers to some of the grand challenges society is facing: worsening climate crisis, insufficient food supplies for ever growing...

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A SynBio community comes of age: Political, academical, industrial, and societal developments in the Netherlands

Synthetic biology (SynBio) is a rapidly growing scientific discipline. In the Netherlands, various universities and companies are tackling a variety of opportunities and challenges within this field....

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Synthetic biology landscape in the UK

The UK is home to a vibrant and diverse synthetic biology community. Many of its successes in research innovation and technological commercialisation can be attributed to a strong base of dedicated...

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Synthetic biology landscape and community in Germany

Despite its start in the early 2000s, synthetic biology is still overall perceived as a young discipline. In some countries, such as the US, synthetic biology is academically and industrially established,...

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De novo synthesis of synthetic biology ecosystem in Slovakia: Challenges and opportunities

Synthetic biology is an engineering discipline that applies engineering principles to rationally design novel biological systems. It has the potential to contribute to solving major global challenges...

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Following the organism to map synthetic genomics

Synthetic genomics, or engineering biology at the level of whole genomes and whole organisms, is an emerging outgrowth of parts-based synthetic biology. This nascent subfield is also diverse and difficult...

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Driving innovation in biotechnology with Private-Public Partnerships: A Singapore perspective

Public and private sector institutions share different goals and perspectives, but they can form a formidable innovation drive when they join forces. Private-Public Partnerships (PPPs), common in biomedical...

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Exploration on the expression and assembly of virus-like particles

Virus-like particles (VLPs) have a great application prospect in vaccines and molecule delivery carriers. In this study, in order to solve the problem of low expression and low assembly efficiency of...

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Model-based dynamic engineering of Escherichia coli for N-acetylglucosamine overproduction

N-acetylglucosamine (GlcNAc), a glucosamine derivative, has a wide range of applications in pharmaceutical fields, and there is an increasing interest in the efficient production of GlcNAc genetic engineered...

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Immunomodulatory effects of Abelmoschus esculentus water extract through MAPK and NF-κB signaling in RAW 264.7 cells

During the current COVID-19 pandemic, the world is facing a new, highly contagious virus that suppresses innate immunity as one of its early virulence mechanisms. Therefore, finding new methods to enhance...

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Strategy exploration for developing robust lyophilized cell-free systems

Cell-free protein synthesis system is emerging as a powerful tool for rapid expression of therapeutic proteins. However, one drawback of cell-free technology is the necessity to store the major components...

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Development of a polymer-based antimicrobial coating for efficacious urinary catheter protection

This study reports the development of a polymer-based catheter coating to facilitate controlled release of antimicrobial peptides (AMP) to target both planktonic bacteria and biofilm in the urinary...

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Hyperuricemia and the small intestine: Transport mechanisms and co-morbidities

There is a global increase in cases of hyperuricemia over the last 10 years. A critical component of serum uric acid control is the transport of uric acid to the intestinal lumen, which accounts for...

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Resveratrol production of a recombinant Scheffersomyces stipitis strain from molasses

Resveratrol is a plant-derived aromatic compound with beneficial properties and it is required to develop a resveratrol production process from inexpensive biomass feedstocks. Here, we investigated...

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Coupled synthetic pathways improve the production of 3-hydroxypropionic acid in recombinant Escherichia coli strains

To improve the production of 3-HP with glucose as a substrate, the malonyl-CoA and propionyl-CoA pathways were coupled to regulate NADP+/NADPH regeneration in the recombinant E. coli. The strain Ec-AM...

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Engineered probiotics modulate the endocannabinoid system

Butyrate is a key microbial metabolite known to enhance host metabolic processes by reducing blood glucose levels and promoting energy metabolism, thereby potentially suppressing the risk of developing...

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The need for integrated systems biology approaches for biotechnological applications

Biotechnology applications have contributed significantly to “factory in a lab” research. Although the largely adopted Design–Build–Test–Learn cycle has considerably improved synthetic biology and metabolic...

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Directed evolution of VanR biosensor specificity in yeast

Allosterically regulated transcription factors (aTFs) based biosensors from prokaryotes have been widely used to screen large gene libraries, stabilize engineered microbes from evolutionary drifting,...

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The transport of triterpenoids

Triterpenoids are a group of natural products with promising biological activities. Studying the transport of triterpenoids is of vital importance for designing novel microbial cell factory for efficient...

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Improving Spinach2-and Broccoli-based biosensors for single and double analytes

The use of “Spinach”-based RNA sensors for the detection of small metabolites and proteins has received growing interest in the recent years. While this approach can be used in vivo for cell sensing...

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Substrate promiscuity of the NdmCDE N7-demethylase enzyme complex

Methylxanthines, including caffeine and theophylline, are a class of natural and synthetic compounds with important roles in food, cosmetics, and medicine. These compounds are metabolized by bacteria...

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Mapping QTLs for important agronomic traits in an Iniadi-derived immortal population of pearl millet

Pearl millet [Pennisetum glaucum (L.) R. Br.] is a climate-hardy nutricereal and an essential staple for the people living in dry regions. Substantial improvement has been achieved for seed yield stability...

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Copper-tripeptide complexes for rapid inactivation of Bacillus subtilis endospores

Bacterial endospores can be pathogenic to human beings. However, they are robust and thus difficult to kill due to their rigid structure. Conventional methods such as autoclaving for inactivating endospores...

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