RNA m6A modification: a key regulator in normal and malignant processes
June 2025
The dedicated control of gene abundance is essential for both biological and pathological processes in mammals. Multiple layers of gene expression regulation, including transcriptional, post-transcriptional,...
Oncolytic virotherapy offers hope for high-grade glioma treatment
June 2025
High-grade glioma continues to rank among the most lethal human cancers. Due to their high invasiveness, pronounced heterogeneity and complex carcinogenic mechanism, therapeutic options remain limited....
RNA-binding protein Roq modulates the Drosophila STING antiviral immune response
March 2025
The STING (stimulator of interferon genes) signaling pathway plays a pivotal role in the immune defense against viral infections in a wide range of vertebrates and invertebrates. However, the regulatory...
Increased co-expression of CTLA4/LAG3 predicted adverse clinical outcomes in patients with T-cell malignancies
March 2025
The application of immune checkpoint blockers (ICBs) in immunotherapy has markedly improved the prognosis for patients with solid tumors and B-cell lymphomas, and it holds promise as a novel therapeutic...
The molecular and immune microenvironmental landscape of brain metastases: Implications for novel treatment options
March 2025
Brain metastases (BM), in which cells from a primary malignant tumor spread through the circulatory system into the microvasculature of the brain, eventually progress despite multiple therapeutic programmes...
Multi-omics advances for molecular characterization, precision medicine, and prognostic implications in leukemia
March 2025
Leukemia encompasses a heterogeneous group of hematologic malignancies driven by complex molecular alterations. Recent advancements in genomics, transcriptomics and proteomics have uncovered pivotal...
The role of YTHDF2 in anti-tumor immunity
March 2025
RNA N6-methyladenosine (m6A) modification has been identified as the most abundant RNA modification and plays crucial roles in both physiological and pathological processes. YTHDF2 was the first identified...