RNA-binding protein Roq modulates the Drosophila STING antiviral immune response
March 2025
The STING (stimulator of interferon genes) signaling pathway plays a pivotal role in the immune defense against viral infections in a wide range of vertebrates and invertebrates. However, the regulatory...
Increased co-expression of CTLA4/LAG3 predicted adverse clinical outcomes in patients with T-cell malignancies
March 2025
The application of immune checkpoint blockers (ICBs) in immunotherapy has markedly improved the prognosis for patients with solid tumors and B-cell lymphomas, and it holds promise as a novel therapeutic...
The molecular and immune microenvironmental landscape of brain metastases: Implications for novel treatment options
March 2025
Brain metastases (BM), in which cells from a primary malignant tumor spread through the circulatory system into the microvasculature of the brain, eventually progress despite multiple therapeutic programmes...
Multi-omics advances for molecular characterization, precision medicine, and prognostic implications in leukemia
March 2025
Leukemia encompasses a heterogeneous group of hematologic malignancies driven by complex molecular alterations. Recent advancements in genomics, transcriptomics and proteomics have uncovered pivotal...
The role of YTHDF2 in anti-tumor immunity
March 2025
RNA N6-methyladenosine (m6A) modification has been identified as the most abundant RNA modification and plays crucial roles in both physiological and pathological processes. YTHDF2 was the first identified...