Bacterial resistance to phage therapy: Mechanisms and strategies to overcome it
2025
The escalating global threat of antibiotic-resistant bacterial pathogens has prompted a critical search for alternative therapeutic strategies, among which bacteriophage (phage) therapy has emerged...
TREM-1 receptor: A key player in inflammatory diseases
2026
Triggering receptor expressed on myeloid cells-1 (TREM-1) is a cell-surface receptor primarily expressed on myeloid cells, including macrophages, monocytes, and neutrophils, where it functions as a...
TCF/LEF-mediated transcriptional regulation in the canonical Wnt pathway
2025
The canonical Wnt signaling pathway is an evolutionarily conserved pathway that regulates embryonic development, tissue homeostasis, and stem cell maintenance. Central to this pathway, T-cell factor/lymphoid...
Oncology drug resistance prediction tools: Database infrastructure, algorithmic innovation, and clinical translation
2026
Tumor drug resistance remains a major obstacle in cancer therapy, leading to the failure of chemotherapy, targeted therapy, and immunotherapy. This review explores how artificial intelligence (AI),...
Gramine suppresses triple-negative breast cancer by inducing ferroptosis via CUL3-mediated ubiquitination of MTDH
2026
Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer lacking effective targeted therapies and frequently exhibiting chemotherapy resistance. Natural compounds are valued...
IGFBP1 is a potential monitoring biomarker of disease activity in elderly patients with inflammatory bowel disease
2026
Inflammatory bowel disease (IBD) is a chronic intestinal inflammatory disorder affecting individuals of all ages. Elderly IBD patients present distinct disease manifestations compared to young counterparts....
Functional and molecular characterization of the first large cell neuroendocrine prostate cancer cell line
2026
Prostate cancer is the fourth most common cancer worldwide. Despite the high incidence rate, in vitro research of prostate cancer has been limited to fewer than ten commonly available cell lines. The...
Computational strategies for antimicrobial discovery: From machine learning to multiscale simulation
2025
Antimicrobial resistance (AMR) has become a major threat to global public health, and there is an urgent need to develop innovative antimicrobial research and development strategies. Traditional experimental...
Targeting fPRDM16 to restore collagen phagocytosis: A mechanism to counteract the persistent fibrosis in aging lungs
2026
Aging impairs the resolution of bleomycin-induced pulmonary fibrosis (PF) in mice. As extracellular matrix degradation is crucial for PF reversal, we investigated whether aging compromises collagen...
Optimization of bioinformatics-designed thiazolide derivatives as SARS-CoV-2 nucleocapsid protein inhibitors
2026
The continuous emergence of SARS-CoV-2 variants highlights the need for antiviral agents targeting conserved viral proteins. The N-terminal domain of the SARS-CoV-2 nucleocapsid protein plays a critical...
MiR-29a as a molecular target in cancer: Prevention strategies with natural products
2026
Cancer is one of the foremost causes of mortality worldwide and is characterized by uninterrupted cell growth, metastasis, and resistance to therapy. The present approach in molecular biology has emphasised...
A comprehensive study using multiple experimental models validated the potential blood pressure reduction effect of rivaroxaban
2026
Rivaroxaban is primarily utilized in patients with atrial fibrillation (AF) to decrease the risk of thrombosis. Drug repositioning strategies have been regarded as beneficial in identifying the potential...
The mechanism of lactylation modification in the progression and drug resistance of lung cancer: A review
2026
Lactylation is a newly identified post-translational modification of proteins that occurs in both histones and non-histones. Studies have shown that lactylation plays a key role in the progression of...
Lactobacillus rhamnosus CMU-pb-7 alleviates diabetic nephropathy in a high-fat diet-streptozotocin rat model
2026
Lactobacillus rhamnosus CMU-pb-7, one of the normal intestinal floras, can regulate intestinal micro-ecology and improve the body's anti-oxidative stress function, yet its protective role in diabetic...
Integrative transcriptomic and metabolomic analyses of puerarin against cholestatic liver fibrosis
2026
Cholestatic liver fibrosis is a common pathological manifestation of various biliary tract diseases. Given the limited efficacy of current pharmacotherapies, there is a clear need to develop novel and...
Melatonin: Diagnostic evidence and therapeutic roles in systemic lupus erythematosus
2025
Melatonin, a molecule synthesized by the pineal gland and possibly all other organs, demonstrates promise as a therapeutic agent for systemic lupus erythematosus (SLE) and its severe complication, lupus...
Metabolic reprogramming and epigenetic regulation: The dual role of lactate and lactylation in pancreatic ductal adenocarcinoma progression and therapeutics
2026
Pancreatic ductal adenocarcinoma is a highly aggressive gastrointestinal malignancy with an extremely poor prognosis. Metabolic reprogramming serves as a key driver of its growth and invasion. Substantial...
PVT1&EIF4A1 promote metastasis through regulating Notch-1 signaling pathway via STC-1 in gastric cancer
2026
Tumor metastasis is the primary cause of poor survival in gastric cancer (GC) patients. PVT1 and EIF4A1 have been shown to synergistically promote GC metastasis and invasion. However, the underlying...
The mechanisms and therapeutic applications of phenolic acids in vascular cognitive impairment: A comprehensive review
2025
Vascular cognitive impairment (VCI), the second most common form of cognitive dysfunction after Alzheimer's disease (AD), is characterized by a multifactorial pathogenesis involving cerebrovascular...
HNMT promotes hepatocellular carcinoma progression by up-regulation of VTN/ECM axis
2026
The ECM-receptor interaction signaling pathway is essential for the progression of various tumors. Histamine N-methyltransferase (HNMT), a histamine metabolic enzyme, is significantly upregulated in...
Intra-tumor DKK1 and CALML5 heterogeneity as a novel biomarker for prognosis and immunotherapy response in head and neck squamous cell carcinoma
2025
Head and neck squamous cell carcinoma (HNSCC) is characterized by substantial molecular heterogeneity, and current biomarkers for predicting immunotherapy response, such as PD-L1 expression and tumor...
MIAT, HEIH, and HOTAIR: A novel LncRNA signature in non-metastatic hepatocellular carcinoma patients
2025
Hepatocellular carcinoma (HCC) presents a significant global health burden, with poor prognosis primarily due to delayed diagnosis and limited therapeutic options. Long non-coding RNAs (lncRNAs) have...
Microtubule dynamics as a candidate molecular mechanism underlying propofol-associated dreaming
Available online 12 August 2026
Galectin−1 suppresses FBP1 to activate RAS/ERK signaling and facilitate intrahepatic cholangiocarcinoma progression
2026
Intrahepatic cholangiocarcinoma (ICC) is a highly malignant tumor with limited therapeutic options. Galectin−1 (Gal−1) has been implicated in tumor progression in several cancers; however, its roles...