IGFBP1 is a potential monitoring biomarker of disease activity in elderly patients with inflammatory bowel disease
2026
Inflammatory bowel disease (IBD) is a chronic intestinal inflammatory disorder affecting individuals of all ages. Elderly IBD patients present distinct disease manifestations compared to young counterparts....
Gramine suppresses triple-negative breast cancer by inducing ferroptosis via CUL3-mediated ubiquitination of MTDH
2026
Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer lacking effective targeted therapies and frequently exhibiting chemotherapy resistance. Natural compounds are valued...
The mechanism of lactylation modification in the progression and drug resistance of lung cancer: A review
2026
Lactylation is a newly identified post-translational modification of proteins that occurs in both histones and non-histones. Studies have shown that lactylation plays a key role in the progression of...
TREM-1 receptor: A key player in inflammatory diseases
2026
Triggering receptor expressed on myeloid cells-1 (TREM-1) is a cell-surface receptor primarily expressed on myeloid cells, including macrophages, monocytes, and neutrophils, where it functions as a...
Lactobacillus rhamnosus CMU-pb-7 Alleviates Diabetic Nephropathy in a High-Fat Diet-Streptozotocin Rat Model
Available online 21 March 2026
Lactobacillus rhamnosus CMU-pb-7, one of the normal intestinal floras, can regulate intestinal micro-ecology and improve the body's anti-oxidative stress function, yet its protective role in diabetic...
Targeting fPRDM16 to Restore Collagen Phagocytosis: A Mechanism to Counteract the Persistent Fibrosis in Aging Lungs
Available online 18 March 2026
Aging impairs the resolution of bleomycin-induced pulmonary fibrosis (PF) in mice. As extracellular matrix degradation is crucial for PF reversal, we investigated whether aging compromises collagen...
Intra-tumor DKK1 and CALML5 heterogeneity as a novel biomarker for prognosis and immunotherapy response in head and neck squamous cell carcinoma
2025
Head and neck squamous cell carcinoma (HNSCC) is characterized by substantial molecular heterogeneity, and current biomarkers for predicting immunotherapy response, such as PD-L1 expression and tumor...
L-theanine inhibits mammalian target of rapamycin-p70S6K pathway-mediated neuroexcitation induced by N-methyl-D-aspartate
2025
The phosphatidylinositol-3-kinase (PI3K)/Akt and the mammalian target of rapamycin (mTOR) signaling pathways are important for cell survival, proliferation, and migration. Therefore, mTOR signaling...
The mechanisms and therapeutic applications of phenolic acids in vascular cognitive impairment: A comprehensive review
2025
Vascular cognitive impairment (VCI), the second most common form of cognitive dysfunction after Alzheimer's disease (AD), is characterized by a multifactorial pathogenesis involving cerebrovascular...
TCF/LEF-mediated transcriptional regulation in the canonical Wnt pathway
2025
The canonical Wnt signaling pathway is an evolutionarily conserved pathway that regulates embryonic development, tissue homeostasis, and stem cell maintenance. Central to this pathway, T-cell factor/lymphoid...
Computational strategies for antimicrobial discovery: From machine learning to multiscale simulation
2025
Antimicrobial resistance (AMR) has become a major threat to global public health, and there is an urgent need to develop innovative antimicrobial research and development strategies. Traditional experimental...
MIAT, HEIH, and HOTAIR: A novel LncRNA signature in non-metastatic hepatocellular carcinoma patients
2025
Hepatocellular carcinoma (HCC) presents a significant global health burden, with poor prognosis primarily due to delayed diagnosis and limited therapeutic options. Long non-coding RNAs (lncRNAs) have...
Melatonin: Diagnostic evidence and therapeutic roles in systemic lupus erythematosus
2025
Melatonin, a molecule synthesized by the pineal gland and possibly all other organs, demonstrates promise as a therapeutic agent for systemic lupus erythematosus (SLE) and its severe complication, lupus...
Sedative-hypnotic properties and mitochondrial effects of coenzyme Q2 in mice
2025
Anesthetics are fascinating drugs capable of inducing reversible unconsciousness. Functional targets of these agents exist within mitochondria and disruption of bioenergetic capacity plays a role in...
Bacterial resistance to phage therapy: Mechanisms and strategies to overcome it
2025
The escalating global threat of antibiotic-resistant bacterial pathogens has prompted a critical search for alternative therapeutic strategies, among which bacteriophage (phage) therapy has emerged...