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ISSN: 1874-4672
e-ISSN: 1874-4702

Large language models in drug development: Current progress and future directions

2025

Anqi Lin | Xiuhui Fang | Aimin Jiang | Chang Qi | Wenyi Gan | Lingxuan Zhu | Weiming Mou | Dongqiang Zeng | Mingjia Xiao | Guangdi Chu | Shengkun Peng | Hank Z.H. Wong | Lin Zhang | Hengguo Zhang | Xinpei Deng | Quan Cheng | Haoran Zhang | Zhuocheng Zhong | Zhengrui Li | Bufu Tang | Peng Luo

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Intra-tumor DKK1 and CALML5 heterogeneity as a novel biomarker for prognosis and immunotherapy response in head and neck squamous cell carcinoma

2025

Yuhui Li | Rongxi Chen | Lizao Zhang | Yanping Jiang | Siqi Ren | Songjiu Li | Hongfeng Xu | Yongmei Tan | Suling Chen | Xiao Tan | Lianxi Mai | Guoxin Huang | Fan Wu | Xin Liu | Peisheng Liang | Shijia Kuang | Liansheng Wang | Jingkang Liu | Jintao Li | Yanyan Li | Qiuping Xu | Ziyao Su | Zijing Huang | Qunxing Li | Tianjun Lan | Haotian Cao | Huiqian Wu | Jinsong Li

Head and neck squamous cell carcinoma (HNSCC) is characterized by substantial molecular heterogeneity, and current biomarkers for predicting immunotherapy response, such as PD-L1 expression and tumor...

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L-theanine inhibits mammalian target of rapamycin-p70S6K pathway-mediated neuroexcitation induced by N-methyl-D-aspartate

2025

Koichi Kawada | Shinnosuke Yamaura | Chiaki Yamamoto | Koji Komori | Toshihiko Kinjo | Kyosuke Uno | Yutaro Higashiura | Kou Kawada | Nobuyuki Kuramoto

The phosphatidylinositol-3-kinase (PI3K)/Akt and the mammalian target of rapamycin (mTOR) signaling pathways are important for cell survival, proliferation, and migration. Therefore, mTOR signaling...

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