Intra-tumor DKK1 and CALML5 heterogeneity as a novel biomarker for prognosis and immunotherapy response in head and neck squamous cell carcinoma
2025
Head and neck squamous cell carcinoma (HNSCC) is characterized by substantial molecular heterogeneity, and current biomarkers for predicting immunotherapy response, such as PD-L1 expression and tumor...
L-theanine inhibits mammalian target of rapamycin-p70S6K pathway-mediated neuroexcitation induced by N-methyl-D-aspartate
2025
The phosphatidylinositol-3-kinase (PI3K)/Akt and the mammalian target of rapamycin (mTOR) signaling pathways are important for cell survival, proliferation, and migration. Therefore, mTOR signaling...
The mechanisms and therapeutic applications of phenolic acids in vascular cognitive impairment: A comprehensive review
2025
Vascular cognitive impairment (VCI), the second most common form of cognitive dysfunction after Alzheimer's disease (AD), is characterized by a multifactorial pathogenesis involving cerebrovascular...
TCF/LEF-mediated transcriptional regulation in the canonical Wnt pathway
2025
The canonical Wnt signaling pathway is an evolutionarily conserved pathway that regulates embryonic development, tissue homeostasis, and stem cell maintenance. Central to this pathway, T-cell factor/lymphoid...
Computational strategies for antimicrobial discovery: From machine learning to multiscale simulation
2025
Antimicrobial resistance (AMR) has become a major threat to global public health, and there is an urgent need to develop innovative antimicrobial research and development strategies. Traditional experimental...
MIAT, HEIH, and HOTAIR: A novel LncRNA signature in non-metastatic hepatocellular carcinoma patients
2025
Hepatocellular carcinoma (HCC) presents a significant global health burden, with poor prognosis primarily due to delayed diagnosis and limited therapeutic options. Long non-coding RNAs (lncRNAs) have...
Melatonin: Diagnostic evidence and therapeutic roles in systemic lupus erythematosus
2025
Melatonin, a molecule synthesized by the pineal gland and possibly all other organs, demonstrates promise as a therapeutic agent for systemic lupus erythematosus (SLE) and its severe complication, lupus...