The role of artificial intelligence in shaping dentistry through advancement in data acquisition, clinical practice, education, and research
January 2026
Artificial intelligence (AI) is rapidly transforming dentistry through innovations in clinical practice, education, and research. Machine learning, and deep learning in particular, support disease diagnosis,...
An “anaerobic invisible” genetically engineered bacterium for periodontitis treatment through temporal modulation on microenvironment
January 2026
Periodontitis is a highly prevalent chronic inflammatory disease, primarily driven by microbial dysbiosis and subsequent dysregulation of host immune responses. Therefore, targeting the pathogenesis,...
Anterior disc displacement in the temporomandibular joint and orthodontic treatment
January 2026
Anterior disc displacement (ADD) in the temporomandibular joint (TMJ) is highly prevalent and difficult to treat. It significantly affects craniofacial structures and functions, as well as orthodontic...
Therapeutic applications of cell membrane-coated nanoparticles in oral diseases: Opportunities, challenges, and future perspectives
January 2026
Nanotechnology holds great promise for disease therapy; however, the therapeutic efficacy of nanoparticles (NPs) is often limited by rapid recognition and clearance by the immune system. Recent studies...
Raman spectral fingerprinting links molecular and transcriptomic changes in mesenchymal stem cells during skeletal aging
January 2026
The functional decline of bone marrow mesenchymal stem cells (BMMSCs) critically contributes to skeletal aging. However, rapid and label-free methods to assess this decline remain limited. Here, we...
Salivary large extracellular vesicle associated bacterial DNA reflects periodontal disease status and non-surgical periodontal therapy response
January 2026
Periodontitis is associated with microbial dysbiosis and an imbalanced host response. We investigated whether salivary large extracellular vesicles (EVs) associated bacterial DNA can reflect periodontal...
Two-dimensional FeCu-metal-organic-framework boosts peroxidase activity for antibacterial application
January 2026
The overuse of antibiotics has led to the emergence of drug-resistant bacteria, posing a serious threat to human health and increasing the medical burden. Metal–organic frameworks (MOFs) have shown...
Effect of print parameters on the accuracy and fit of 3D-printed resin-based ceramic crowns
January 2026
This study evaluated the influence of print angle and layer thickness on the accuracy and fit of resin-based ceramic crowns fabricated using digital light processing (DLP). A mandibular first molar...
Inaugural editorial: Advancing the frontier of innovation in stomatology and interdisciplinary sciences
January 2026
Necroptosis of stem cell aggregates suppresses bone regeneration via necroptosis-derived extracellular vesicles
April 2026
Despite the therapeutic promise of stem cell aggregates in bone regeneration, clinical outcomes remain unstable due to the complex and incompletely understood fate of transplanted cells. Here, we investigated...
Exosome-mediated lymphatic regeneration: Mechanisms, therapeutic strategies, and translational opportunities
April 2026
Lymphatic dysfunction, clinically presenting as secondary lymphedema and chronic inflammatory conditions, remains a significant clinical challenge following oncologic therapy and tissue trauma. Current...
Oral and systemic diseases under the framework of homeostatic medicine
April 2026
Homeostatic Medicine is an emerging integrative discipline that focuses on decoding the pivotal role of homeostasis in health and diseases and exploring strategies to restore inherent homeostasis for...
Excessive fibrin deposition disrupts immune-epithelial crosstalk and impairs resolution of diabetes-associated periodontitis
April 2026
Diabetic periodontitis is a refractory complication of diabetes with limited therapeutic options. Here, we identify excessive fibrin deposition as a key perpetuator of chronic inflammation in diabetic...
Interfacial binding and mechanistic insights into enzyme-mediated homogeneous mineralization on TiO₂ nanotubes: A combined experimental and multi-scale computational study
April 2026
Enzyme-mediated mineralization offers a versatile strategy for developing advanced composite biomaterials, yet the precise mechanisms involving kinetic mineral-interface bonding and mineral growth remain...
Exosome-microneedle patches accelerate oral ulcer healing by remodeling macrophage-epithelial crosstalk via TSP‑1/CD47/NF‑κB signaling
April 2026
Oral ulcers are among the most common inflammatory lesions of the oral mucosa and often cause severe pain. However, current treatments are limited by short mucosal retention, suboptimal therapeutic...
Notch signalling in alveolar bone development and regeneration: A critical regulator for osteoblasts to osteocytes transitioning
April 2026
Cell fate determination is controlled by a complex network of cell signalling pathways. The process of osteoblasts transforming into osteocytes can be described as several distinct stages: from osteoblasts...
Use of fluoride varnish with functionalized tricalcium phosphate for prevention of early childhood caries: A randomised clinical trial
April 2026
The aim of this study is to compare the caries-preventive effect of 5% sodium fluoride (NaF) varnish with and without functionalized tricalcium phosphate (fTCP) on young children with untreated active...