Progress and challenges in infectious disease surveillance and early warning
March 2025
The increasing incidence of emerging infectious diseases emphasizes the urgent need for timely and accurate global surveillance and early warning systems. In recent years, infectious disease surveillance...
Transforming the landscape of cancer treatment with seven promising novel therapies: evolution and future perspectives
June 2025
The landscape of cancer treatment is rapidly evolving with the emergence of promising novel therapies, offering new hope for patients with challenging malignancies. This review explores key advancements,...
Large language models illuminate a progressive pathway to artificial intelligent healthcare assistant
June 2024
With the rapid development of artificial intelligence, large language models (LLMs) have shown promising capabilities in mimicking human-level language comprehension and reasoning. This has sparked...
Blood-based biomarkers of Alzheimer’s disease—A guideline for clinical use
December 2024
As the population ages, cognitive disorder has emerged as a prevalent condition among the elderly, with Alzheimer’s disease (AD) being the most common type. This presents a significant social and economic...
Development of tau phosphorylation-targeting therapies for the treatment of neurodegenerative diseases
December 2024
Hyperphosphorylation of microtubule-associated protein tau is a major driver in the etiology of multiple neurodegenerative diseases, such as Alzheimer’s disease (AD) and other tauopathies. Intracellular...
Boron neutron capture therapy of cancer: Recent progress
September 2024
Nitrate and body homeostasis
March 2024
Homeostasis is essential for the maintenance of health, and how it is maintained is the focus of attention in homeostatic medicine. As a natural dietary nutrient, nitrate is critical in regulating homeostasis....
Perspectives of autophagy-tethering compounds (ATTECs) in drug discovery
March 2024
Degrader technologies provide unprecedented strategies to tackle diseases caused by pathogenic proteins that are difficult to target by the traditional inhibitor approach. One pioneering technology,...
Global patterns of cervical cancer incidence and mortality: updated statistics and an overview of temporal trends from 2003 to 2017
June 2025
Global disparities exist in the burden of cervical cancer. This study aims to describe and analyze the global epidemiological landscape of cervical cancer in 2022, including recent trends in incide...
Role of natural active pharmaceuticals in the treatment of oral diseases
September 2025
Oral diseases include periodontal and oral tumors. Current treatment methods rely largely on surgical interventions and mechanical cleaning, with a lack of targeted pharmacological therapies. Regardless,...
Anthracycline-induced cardiotoxicity: emerging mechanisms and therapies
March 2025
Chemotherapy-induced cardiovascular disease has become one of the main causes of death in cancer survivors. Several international authoritative societies have developed a number of guidelines to standardize...
The diagnostic accuracy of physical signs: practice experience compared with research evidence
September 2025
Physical diagnosis is the first course of clinical medicine and the first contact with patients during clinical practice. Evidence-based physical diagnosis is a helpful tool in both education and practice....
Tumor deposits in colorectal and gastric cancers
June 2024
Tumor deposits (TDs), initially recognized in colorectal cancer (CRC), have been identified in various other cancer types, including gastric cancer (GC), rendering them a widely studied adverse prognostic...
Health research in the era of artificial intelligence: Advances in gene-editing study
June 2024
In recent years, gene editing technology, represented by clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) has made a revolutionary breakthrough....
Relationship between tight junctions of the BBB and astrocyte connective function in epilepsy: Albumin and astrocyte activation
September 2024
The blood-brain barrier (BBB) is a barrier system separating the central nervous system from blood circulation. Connections between cells within the BBB involve specialized endothelial tight junction...
Artificial intelligence in coronary computed tomography angiography
March 2024
The rapid development of artificial intelligence (AI) technologies, like machine learning, deep learning, and other algorithms applied to the intelligent diagnostic and decision making, image interpretation,...
Intracranial neurophysiological correlates of rumination: A cross-sectional observational study
September 2024
Rumination is a transdiagnostic psychological process that plays a prominent role in many common psychiatric disorders, albeit its neurophysiological basis remains elusive. Existing neuroimaging studies...
Risk factors for prolonged intensive care unit stay after pediatric cardiac surgery: data from national center for cardiovascular diseases in China
September 2025
After pediatric cardiac surgery, many patients require a prolonged stay in the intensive care unit. These patients require tremendous resources, which adds an additional burden to the healthcare systems....