CSE deficiency promotes osteoporotic bone loss through THBS1-associated extracellular matrix dysregulation and metabolic dysfunction
December 2026
Cystathionine-γ-lyase (CSE)/hydrogen sulfide (H2S) plays a critical role in skeletal homeostasis, but its precise pathophysiological function in osteoporosis remains unclear. This study aimed to clarify...
Methods and advances in infectious disease burden estimation
December 2026
Accurate estimation of infectious disease burden is essential for evidence-based public health decision-making, including resource allocation, priority setting, and evaluation of interventions. The...
The NAT10/ac4C axis in liver disease: an epitranscriptomic rheostat from steatosis to hepatocellular carcinoma
December 2026
N4-acetylcytidine (ac4C), once considered mainly as a modified nucleoside in tRNA and rRNA, has emerged as an mRNA modification that can modulate transcript stability and translation. Its best-characterized...
Interpreting the evidence and clinical implementation of anti-Aβ therapies in Alzheimer’s disease
December 2026
Artificial intelligence in osteosarcoma imaging: current applications, challenges, and translational pathways
December 2026
Osteosarcoma is the most common primary malignant bone tumor in children and adolescents. Imaging is essential for its diagnosis, staging, treatment planning, response assessment, and follow-up, but...
cGAS–STING signaling in immunity and disease: molecular mechanisms, context-dependent functions, and therapeutic modulation
December 2026
The cyclic GMP–AMP synthase-stimulator of interferon genes (cGAS–STING) pathway is a spatially organized DNA-sensing system that links microbial invasion, genome instability, mitochondrial damage, and...
From detection to decision in precision local therapy for pulmonary nodules
Available online 13 November 2026
Chinese expert consensus on multidisciplinary team (MDT) management of chronic graft-versus-host disease (2026 edition)
Available online 12 November 2026
This expert consensus on multidisciplinary team (MDT) management of chronic graft-versus-host disease (cGVHD) was developed to standardize the care pathway and to improve the coordination, consistency,...
Compound heat and ambient air pollution exposure and ocular trauma: a multicenter hospital-based study of acute risk, visual prognosis, and preventable burden in China
Available online 6 November 2026
Ocular trauma causes preventable vision loss, but whether short-term co-exposure to extreme heat and air pollution influences injury and recovery is unknown. We examined associations with hospitalized...
The role of ferroptosis in diabetes and its multiple complications
Available online 30 October 2026
Diabetes mellitus (DM) and its complications are major chronic diseases that pose a significant global health burden. However, the complex metabolic disorders and mechanisms underlying DM-associated...
Toward a global cradle brain health initiative
September 2026
LRP8: the cellular entry receptor for yellow fever virus
September 2026
The evolving landscape of mRNA-LNP medicine: advances, challenges, and future perspectives
September 2026
Messenger RNA lipid nanoparticle (mRNA-LNP) technology has developed from a successful pandemic vaccine platform into a versatile therapeutic approach applicable to infectious diseases, oncology, autoimmune...
Food preservative intake and cancer risk: a commentary on evidence from a large prospective cohort study
September 2026
Engineered microbe-based micro/nanorobots for interventional therapy of luminal cancers
September 2026
Luminal cancers, including gastrointestinal, genitourinary, and peritoneal cavity-associated malignancies, are, in principle, amenable to local intervention, yet durable therapeutic control remains...
From passive loading to network formation: click clotting inspires the next generation of bone repair materials
September 2026
Global mortality and DALY burden across major disease categories, 1990–2021: trends, SDI-related distribution, and drivers of DALY changes
September 2026
Global disease burden is being reshaped by epidemiological and demographic transitions. We assessed global trends, the sociodemographic index (SDI)-related distribution of mortality and disability-adjusted...
Axial length-stratified cataract phenotypes revealed by automated lens density quantification from IOL Master 700
September 2026
To evaluate automated lens average density from IOL Master 700 as a quantitative supplementary measure for cataract assessment, and whether cataract phenotypes and risk profiles differ by axial length...
Deep brain stimulation: from mechanism to application
September 2026
Deep brain stimulation (DBS) has emerged as a transformative neuromodulation therapy for a variety of neurological and psychiatric disorders, including Parkinson’s disease, epilepsy, and obsessive-compulsive...
