MT-125 as a promising targeted therapy for glioblastoma through NMII inhibition and ROS-mediated apoptosis
Available online 26 April 2026
In a 2025 Cell study, Kenchappa et al. evaluated MT-125, a selective dual inhibitor of non-muscle myosin IIA/B (NMIIA/B) derived from the pan-myosin II inhibitor blebbistatin, as a therapeutic agent...
Circadian rhythms in cardiovascular disease: a new perspective on inter-organ crosstalk
Available online 23 April 2026
Cardiovascular diseases (CVDs) constitute a global health crisis, responsible for approximately 31% of all-cause mortality, and increasingly manifest as multisystem disorders involving cardio-cerebral,...
Wearable device-measured moderate to vigorous physical activity and aortic valve stenosis: revisiting the preventability of degenerative aortic valve stenosis
Available online 23 April 2026
This study highlights the role of moderate-to-vigorous physical activity (MVPA) in preventing degenerative aortic valve stenosis (AS). Using 7-day wrist-worn accelerometer data from the UK Biobank,...
VDAC2 deficiency: a new target for cancer immunotherapy and regulation of inflammatory responses
Available online 23 April 2026
Immunotherapy has become a pivotal cancer treatment following surgery, radiotherapy, and chemotherapy, with the major form including adoptive cell therapy (ACT) and immune checkpoint blockade (ICB)....
Cardiovascular health benefits of physical activity: aerobic, muscle-strengthening, and combined exercise modalities
Available online 23 April 2026
Regular physical activity (PA) has been demonstrated as one of the simplest ways to reduce the risk of incident cardiovascular disease (CVD). The specific impacts of different types of PA on cardiovascular...
Suitcordance: redefining device evolution for the era of early-onset panvascular disease
Available online 10 April 2026
Advances in understanding palmitoylation in female reproductive disorders: mechanisms and future directions
March 2026
Protein palmitoylation modification is a key lipidated post-translational modification that dynamically regulates protein function, subcellular localization, and signaling pathways in eukaryotic cells,...
The nexus of mechanical stress, integrin signaling, and endocytosis in osteoarthritis
March 2026
Osteoarthritis (OA) is a degenerative disease characterized by cartilage degeneration and joint structural damage, with its pathogenesis closely associated with abnormal mechanical stress, cellular...
From pathogenesis to management: therapy-related myeloid neoplasms in survivors of female-specific cancers
March 2026
As advances in diagnosis and therapy have improved survival for breast cancer and gynecologic cancer, therapy-related myeloid neoplasms (t-MN) have become one of the worst long-term consequences of...
Comparison of hemodynamic responses to Treprostinil and postoperative outcomes in patients with pulmonary hypertension after Glenn or Fontan procedures
March 2026
To compare the hemodynamic effects of Treprostinil and postoperative outcomes in pediatric single-ventricle patients with pulmonary hypertension (PH, mean pulmonary artery pressure (mPAP) >15 mmHg)...
The brain-bone axis: investigating the interaction between the central nervous system and skeletal homeostasis
December 2025
The brain serves as the core component of the central nervous system and plays a pivotal role in regulating the functions of various essential organs throughout the body. The skeletal system serves...
Engineering receptor-containing antibodies: a promising advance in malaria immunotherapy
December 2025
Proteolethargy: a novel mechanism linking oxidative stress to chronic disease via protein mobility dysfunction
December 2025
Polysaccharide-based pickering emulsions: a mini review on biomedical potential and functional interfaces
December 2025
Polysaccharide-based Pickering emulsions (PEs) have attracted increasing attention as next-generation colloidal systems owing to their excellent biocompatibility, environmental responsiveness, and structural...
An unusual case of ectopic adrenocorticotrophic hormone syndrome and syndrome of inappropriate antidiuretic hormone secretion
December 2025
Ectopic adrenocorticotrophic hormone (ACTH) syndrome (EAS) is a rare but severe condition characterized by intense hypercortisolism, which can occur independently of the underlying tumor. Surgical resection...