Global mortality and DALY burden across major disease categories, 1990–2021: trends, SDI-related distribution, and drivers of DALY changes
Available online 22 August 2026
Global disease burden is being reshaped by epidemiological and demographic transitions. We assessed global trends, the sociodemographic index (SDI)-related distribution of mortality and disability-adjusted...
From passive loading to network formation: click clotting inspires the next generation of bone repair materials
Available online 21 August 2026
Engineered microbe-based micro/nanorobots for interventional therapy of luminal cancers
Available online 18 August 2026
Luminal cancers, including gastrointestinal, genitourinary, and peritoneal cavity-associated malignancies, are, in principle, amenable to local intervention, yet durable therapeutic control remains...
Food preservative intake and cancer risk: a commentary on evidence from a large prospective cohort study
Available online 13 August 2026
The evolving landscape of mRNA-LNP medicine: advances, challenges and future perspectives
Available online 6 August 2026
Messenger RNA lipid nanoparticle (mRNA-LNP) technology has developed from a successful pandemic vaccine platform into a versatile therapeutic approach applicable to infectious diseases, oncology, autoimmune...
LRP8: the cellular entry receptor for yellow fever virus
Available online 31 July 2026
The hidden protection of maternal-induced immunity in neonates
Available online 29 July 2026
PLD4 mutations and SLE: insights from genetic and functional studies to clinical precision treatment
June 2026
Circadian rhythms in cardiovascular disease: a new perspective on inter-organ crosstalk
June 2026
Cardiovascular diseases (CVDs) constitute a global health crisis, responsible for approximately 31% of all-cause mortality, and increasingly manifest as multisystem disorders involving cardio-cerebral,...
VDAC2 deficiency: a new target for cancer immunotherapy and regulation of inflammatory responses
June 2026
Cardiovascular health benefits of physical activity: aerobic, muscle-strengthening, and combined exercise modalities
June 2026
Regular physical activity (PA) has been demonstrated as one of the simplest ways to reduce the risk of incident cardiovascular disease (CVD). The specific impacts of different types of PA on cardiovascular...
Electroactive materials for bioelectronics and regenerative medicine: mechanisms, interfaces, and applications
June 2026
Electroactive materials, capable of generating, transmitting, and modulating electrical signals in physiological environments, have emerged as a cornerstone for bioelectronic devices and regenerative...
Deep learning for predicting lymph node metastasis in T1b gastric cancer using histopathology: a retrospective, multicenter study
June 2026
T1b gastric cancer (T1b-GC) carries a high risk of lymph node metastasis (LNM), which is a key determinant of treatment choice and prognosis. However, assessing LNM risk in T1b-GC remains challenging....
The prevalence of comorbidities and the metabolic control status in patients with diabetes mellitus in Guangdong Province of China: a cross‐sectional study
June 2026
Diabetes mellitus (DM) is a highly prevalent chronic disease worldwide and is frequently accompanied by comorbidities such as hypertension and dyslipidemia, which substantially impair patients’ quality...
Survival after kidney-sparing surgery versus radical nephroureterectomy for ureteral urothelial carcinoma: a SEER-based propensity score-matched cohort study
June 2026
The optimal surgical approach for ureteral urothelial carcinoma (UUC) remains uncertain, particularly when balancing oncologic control against kidney preservation. We compared survival after kidney-sparing...
Toward a global cradle brain health initiative
Available online 13 May 2026
Advances in understanding palmitoylation in female reproductive disorders: mechanisms and future directions
March 2026
Protein palmitoylation modification is a key lipidated post-translational modification that dynamically regulates protein function, subcellular localization, and signaling pathways in eukaryotic cells,...