PLD4 mutations and SLE: insights from genetic and functional studies to clinical precision treatment
June 2026
Circadian rhythms in cardiovascular disease: a new perspective on inter-organ crosstalk
June 2026
Cardiovascular diseases (CVDs) constitute a global health crisis, responsible for approximately 31% of all-cause mortality, and increasingly manifest as multisystem disorders involving cardio-cerebral,...
VDAC2 deficiency: a new target for cancer immunotherapy and regulation of inflammatory responses
June 2026
Cardiovascular health benefits of physical activity: aerobic, muscle-strengthening, and combined exercise modalities
June 2026
Regular physical activity (PA) has been demonstrated as one of the simplest ways to reduce the risk of incident cardiovascular disease (CVD). The specific impacts of different types of PA on cardiovascular...
Deep learning for predicting lymph node metastasis in T1b gastric cancer using histopathology: a retrospective, multicenter study
Available online 21 May 2026
T1b gastric cancer (T1b-GC) carries a high risk of lymph node metastasis (LNM), which is a key determinant of treatment choice and prognosis. However, assessing LNM risk in T1b-GC remains challenging....
Electroactive materials for bioelectronics and regenerative medicine: mechanisms, interfaces, and applications
Available online 15 May 2026
Electroactive materials, capable of generating, transmitting, and modulating electrical signals in physiological environments, have emerged as a cornerstone for bioelectronic devices and regenerative...
Toward a global cradle brain health initiative
Available online 13 May 2026
Wearable device-measured moderate to vigorous physical activity and aortic valve stenosis: revisiting the preventability of degenerative aortic valve stenosis
Available online 23 April 2026
This study highlights the role of moderate-to-vigorous physical activity (MVPA) in preventing degenerative aortic valve stenosis (AS). Using 7-day wrist-worn accelerometer data from the UK Biobank,...
Advances in understanding palmitoylation in female reproductive disorders: mechanisms and future directions
March 2026
Protein palmitoylation modification is a key lipidated post-translational modification that dynamically regulates protein function, subcellular localization, and signaling pathways in eukaryotic cells,...
The nexus of mechanical stress, integrin signaling, and endocytosis in osteoarthritis
March 2026
Osteoarthritis (OA) is a degenerative disease characterized by cartilage degeneration and joint structural damage, with its pathogenesis closely associated with abnormal mechanical stress, cellular...
From pathogenesis to management: therapy-related myeloid neoplasms in survivors of female-specific cancers
March 2026
As advances in diagnosis and therapy have improved survival for breast cancer and gynecologic cancer, therapy-related myeloid neoplasms (t-MN) have become one of the worst long-term consequences of...
Comparison of hemodynamic responses to Treprostinil and postoperative outcomes in patients with pulmonary hypertension after Glenn or Fontan procedures
March 2026
To compare the hemodynamic effects of Treprostinil and postoperative outcomes in pediatric single-ventricle patients with pulmonary hypertension (PH, mean pulmonary artery pressure (mPAP) >15 mmHg)...
The brain-bone axis: investigating the interaction between the central nervous system and skeletal homeostasis
December 2025
The brain serves as the core component of the central nervous system and plays a pivotal role in regulating the functions of various essential organs throughout the body. The skeletal system serves...