Risk factors for prolonged intensive care unit stay after pediatric cardiac surgery: Data from national center for cardiovascular diseases in China
September 2025
After pediatric cardiac surgery, many patients require a prolonged stay in the intensive care unit. These patients require tremendous resources, which adds an additional burden to the healthcare systems....
The diagnostic accuracy of physical signs: practice experience compared with research evidence
September 2025
Physical diagnosis is the first course of clinical medicine and the first contact with patients during clinical practice. Evidence-based physical diagnosis is a helpful tool in both education and practice....
Role of natural active pharmaceuticals in the treatment of oral diseases
September 2025
Oral diseases include periodontal and oral tumors. Current treatment methods rely largely on surgical interventions and mechanical cleaning, with a lack of targeted pharmacological therapies. Regardless,...
Revisiting the role of liver cirrhosis in surgical treatment for hepatocellular carcinoma
September 2025
Perspective to clinical translation of radiotherapy-activated prodrugs: challenges and advances
June 2025
Global patterns of cervical cancer incidence and mortality: updated statistics and an overview of temporal trends from 2003 to 2017
June 2025
Global disparities exist in the burden of cervical cancer. This study aims to describe and analyze the global epidemiological landscape of cervical cancer in 2022, including recent trends in incide...
C-terminal amide-bearing proteins: emerging targets for protein homeostasis in health and disease
June 2025
This study highlights the role of C-terminal amide-bearing proteins (CTAPs) in protein homeostasis. Researchers discovered that CTAPs, formed under oxidative stress, are selectively recognized and degraded...
Risk factors analysis of adverse events after cardiac surgery in children with respiratory virus infection including SARS-CoV-2
June 2025
To explore the risk factors associated with adverse events following cardiac surgery in children with respiratory virus infections. The innovation particularly focuses on severe acute respiratory syndrome...
Transforming the landscape of cancer treatment with seven promising novel therapies: evolution and future perspectives
June 2025
The landscape of cancer treatment is rapidly evolving with the emergence of promising novel therapies, offering new hope for patients with challenging malignancies. This review explores key advancements,...
Targeting neural components in the tumor microenvironment as a novel therapeutic approach
March 2025
Progress in clinical research on allogeneic hematopoietic stem cell transplantation for the treatment of paroxysmal nocturnal hemoglobinuria
March 2025
Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal proliferative disease of hematopoietic stem cells that is clinically characterized by hemolysis, thrombosis, and bone marrow failure. In recent...
Progress and challenges in infectious disease surveillance and early warning
March 2025
The increasing incidence of emerging infectious diseases emphasizes the urgent need for timely and accurate global surveillance and early warning systems. In recent years, infectious disease surveillance...
A cross-sectional analysis of dietary intake and abdominal visceral fat content measured by ultrasound sonography
March 2025
The assessment of abdominal visceral fat (VF) warrants more applicable screening methods to detect individuals at risk of developing comorbidities. The purpose of this study was to identify a practical...
Anthracycline-induced cardiotoxicity: emerging mechanisms and therapies
March 2025
Chemotherapy-induced cardiovascular disease has become one of the main causes of death in cancer survivors. Several international authoritative societies have developed a number of guidelines to standardize...
Blood-based biomarkers of Alzheimer’s disease—A guideline for clinical use
December 2024
As the population ages, cognitive disorder has emerged as a prevalent condition among the elderly, with Alzheimer’s disease (AD) being the most common type. This presents a significant social and economic...
Structural and biochemical basis for the pathogenic mutations of methylmalonate semialdehyde dehydrogenase ALDH6A1
December 2024
Methylmalonate semialdehyde dehydrogenase (ALDH6A1), encoded by the ALDH6A1 gene, is essential for the metabolic degradation of valine and thymine. Genetic alterations in ALDH6A1 lead to methylmalonate...