Advances in understanding palmitoylation in female reproductive disorders: Mechanisms and future directions
March 2026
Protein palmitoylation modification is a key lipidated post-translational modification that dynamically regulates protein function, subcellular localization, and signaling pathways in eukaryotic cells,...
The nexus of mechanical stress, integrin signaling, and endocytosis in osteoarthritis
Available online 30 January 2026
Osteoarthritis (OA) is a degenerative disease characterized by cartilage degeneration and joint structural damage, with its pathogenesis closely associated with abnormal mechanical stress, cellular...
Turning foes into friends: neutrophils as a potential therapeutic target in glioblastoma
Available online 29 January 2026
The brain-bone axis: investigating the interaction between the central nervous system and skeletal homeostasis
December 2025
The brain serves as the core component of the central nervous system and plays a pivotal role in regulating the functions of various essential organs throughout the body. The skeletal system serves...
Engineering receptor-containing antibodies: a promising advance in malaria immunotherapy
December 2025
Proteolethargy: a novel mechanism linking oxidative stress to chronic disease via protein mobility dysfunction
December 2025
Polysaccharide-based pickering emulsions: a mini review on biomedical potential and functional interfaces
December 2025
Polysaccharide-based Pickering emulsions (PEs) have attracted increasing attention as next-generation colloidal systems owing to their excellent biocompatibility, environmental responsiveness, and structural...
An unusual case of ectopic adrenocorticotrophic hormone syndrome and syndrome of inappropriate antidiuretic hormone secretion
December 2025
Ectopic adrenocorticotrophic hormone (ACTH) syndrome (EAS) is a rare but severe condition characterized by intense hypercortisolism, which can occur independently of the underlying tumor. Surgical resection...
Mitochondrial RNA modifications and biological functions: opportunities and challenges
December 2025
Age at diabetes diagnosis, genetic susceptibility and dementia risk: a prospective study of 13,126 participants from the UK Biobank
December 2025
(1) To investigate the association between age at diabetes diagnosis and the incidence of all-cause dementia (ACD), Alzheimer’s disease (AD), and vascular dementia (VD) in individuals with diabetes....
Advancement of disease-modifying therapy of Alzheimer’s disease: from the perspective of new revised criteria for diagnosis and staging of Alzheimer’s disease
December 2025
Alzheimer’s disease (AD) imposes a substantial clinical and societal burden, yet currently approved symptomatic therapies do not modify the underlying disease biology. Recently, three anti-amyloid monoclonal...
Risk factors for prolonged intensive care unit stay after pediatric cardiac surgery: data from national center for cardiovascular diseases in China
September 2025
After pediatric cardiac surgery, many patients require a prolonged stay in the intensive care unit. These patients require tremendous resources, which adds an additional burden to the healthcare systems....
The diagnostic accuracy of physical signs: practice experience compared with research evidence
September 2025
Physical diagnosis is the first course of clinical medicine and the first contact with patients during clinical practice. Evidence-based physical diagnosis is a helpful tool in both education and practice....
Role of natural active pharmaceuticals in the treatment of oral diseases
September 2025
Oral diseases include periodontal and oral tumors. Current treatment methods rely largely on surgical interventions and mechanical cleaning, with a lack of targeted pharmacological therapies. Regardless,...
Revisiting the role of liver cirrhosis in surgical treatment for hepatocellular carcinoma
September 2025
Annexin A5 confers neuroprotection in ischemic stroke: insights from in vitro and in vivo models
September 2025
Ischemic stroke remains a leading cause of neurological disability worldwide. Effective therapeutic interventions for stroke treatment are still critically needed. Annexin A5, a calcium-dependent phospholipid-binding...
Radiotherapy, a double-edged sword: amphiregulin-mediated immune microenvironment remodeling in cancer metastasis
September 2025
tRNA methylation in cancer
September 2025
As the most prevalent post-transcriptional modification in transfer RNAs (tRNAs), methylation dynamically and reversibly regulates the biosynthesis and maturation of tRNAs, exerting direct impacts on...