MuSE‐Promoter: a multi-scale feature fusion and weighted ensemble learning method for identifying promoters across multiple cell lines
2026
Promoters are central to regulating gene transcription by orchestrating cell-type- and developmental-stage-specific expression programs. However, the intrinsic heterogeneity of transcription factor...
P2Y2 signaling in cancer: mechanisms, biomarkers, and therapeutic horizons
2026
Purinergic P2 receptors have long been attractive therapeutic targets, as evidenced by the clinical success of P2Y12 and P2X3 receptor antagonists. However, P2Y2 receptor remains underexplored in oncology,...
Breast cancer organoids: a precision platform for modeling heterogeneity and advancing personalized therapy
2026
Breast cancer remains the most prevalent malignancy among women worldwide, characterized by profound heterogeneity and therapeutic resistance that pose significant challenges to both research and clinical...
Integrating multimodal neuroimaging genetics and deep learning to predict Alzheimer's disease: a systematic review
2026
Elucidating the pathological mechanisms and enabling early, precise diagnosis of Alzheimer's disease (AD) are critical goals in clinical practice. Neuroimaging genetics provides a powerful framework...
Histamine signaling and antihistamines in cancer progression and immunotherapy: current perspectives
2026
Despite advances in treatment, cancer remains a leading cause of death worldwide. Immunotherapy has revolutionized clinical oncology, extending survival for many patients with advanced disease; however,...
Cell-free DNA analysis for cancer management: Technologies, features, and clinical translation
2026
The rising incidence and mortality of malignant tumors worldwide call for more effective early cancer screening strategies. Liquid biopsy, particularly the analysis of plasma cell-free DNA (cfDNA),...