Transdermal drug delivery: Principles, technologies, therapeutic applications, and future directions
December 2026
Transdermal drug delivery systems (TDDS), as an important alternative to oral and injectable administration, offer significant advantages including non-invasive delivery, avoidance of first-pass metabolism,...
Antibody-conjugated lipid nanoparticles for in vivo CAR-T cell engineering: From concept to clinical translation
June 2026
Chimeric antigen receptor T cell therapy represents a transformative advancement in immunotherapy, wherein engineered T cells target tumor antigens, achieving high response rates in hematological malignancies....
A brief description of electrochemical glucose biosensors and their future challenges
September 2026
The demand for glucose detection has been on an increasing trend due to the rising diabetic population. An interesting aspect in glucose sensors is how to make the devices be more accurate and efficient,...
Formulation, development and in vivo characterization of tioconazole PLGA microparticles loaded microneedle array patches for fungal infection as long-acting transdermal delivery
December 2026
Fungal infections affect over 500 million people annually, with bacterial vaginosis accounting for 29%. Candida recurrence occurs in 9% of women, and azole resistance is rising, while biofilms and pH...
Eco-friendly synthesis of gallic acid-capped zinc oxide nanoparticles revealing antimicrobial, antioxidant, and anticancer activities
December 2026
The present study aims to synthesized zinc oxide nanoparticles (ZnO NPs) in an sustainable approach by using gallic acid (GA) as a stabilising and bio-reductant. The synthesized GA-ZnO NPs were characterized...
Selection of precursor for natural product-derived carbon dots and their biomedical applications
December 2026
Carbon dots (CDs), an emerging class of fluorescent carbon nanomaterials, have garnered considerable attention owing to their excellent optical properties and favorable biocompatibility. Among the diverse...
Bone repair therapy: The emerging role of exosomes in bone regeneration and repair
December 2026
Bone defect repair remains a major challenge in clinical orthopedics. Current gold-standard therapies, such as autologous bone grafting, are constrained by limited donor availability, donor-site morbidity,...
Biomimetic shielding of dental enamel: Advances in peptide-based and mineralising agents against acid erosion
December 2026
Dental enamel cannot regenerate after acid damage. Fluoride merely retards demineralisation without restoring enamel's hierarchical nanostructure. This review critically discusses recent biomimetic...
The leaky gate: Engineering biomaterial barriers for pancreatic fistula
December 2026
Postoperative pancreatic fistula (POPF) represents the most prevalent and perilous complication following pancreatic resection, frequently precipitating severe infection, hemorrhage, and multiple organ...
Innovative applications of exosomes in precision medicine: From diagnostic biomarkers to engineered therapeutics
September 2026
Exosomes, as cell-derived nanoscale vesicles, are characterized by their ability to selectively encapsulate and transfer biomolecules—including proteins, nucleic acids, and lipids—from their parental...
Metal-based nanomaterials for cancer therapy: Modulating the tumor microenvironment for enhanced treatment efficacy
December 2026
Cancer remains one of the most pressing global health challenges, with current treatments often limited by toxicity and poor targeting. Metal-based nanomaterials (MNMs) have emerged as promising candidates...
Optimizing design and exploring the dual potential of carbon quantum dots in environmental sensing and biomedical theranostics
June 2026
Carbon quantum dots (CQDs) have emerged as next-generation nanomaterials owing to their tunable photoluminescence, chemical stability, biocompatibility, and facile synthesis from renewable precursors....
Recent progress on the application of heavy metal nanoparticles in radiotherapy sensitization
June 2026
Radiotherapy remains one of the cornerstone modalities in the clinical treatment of malignant tumors. However, the intrinsic radioresistance of tumor cells—particularly hypoxia-induced tolerance within...
Role of baicalein-modified carbon nanodots in cancer therapy: A narrative review
December 2026
Baicalein is a multi-target flavonoid with broad preclinical anticancer activity, but its clinical translation is limited by poor aqueous solubility, chemical instability, rapid metabolism, and low...
Dimensionality and size effects in Surface-enhanced Raman scattering (SERS) substrates: From multidimensional nanomaterials to metal single-atom materials
September 2026
Surface-enhanced Raman scattering (SERS) has evolved from a fundamental phenomenon to a powerful analytical technique, heavily reliant on the properties of the substrate. This review comprehensively...
The application of nanomaterials in vaccine adjuvants
June 2026
Vaccines prevent infectious diseases by enhancing both innate and adaptive immune responses, while adjuvants amplify, accelerate, or prolong these responses, thereby increasing vaccine efficacy. This...
Biomimetic tumor cell membrane-coated nanomaterials combine gene therapy by Crispr/Cas9 and photothermal therapy in triple-negative breast cancer
June 2026
To explore potential therapeutic strategies for triple-negative breast cancer (TNBC) and investigate targeted CDK9 inhibitors with reduced toxicity, a CRISPR/Cas9-based bionic tumor cell membrane-encapsulated...
Oral nanomaterial formulations for gastrointestinal therapeutics: Promises and challenges on the path to clinical translation
June 2026
The gastrointestinal (GI) tract is an important route of drug delivery in the human body, offering advantages such as ease of administration, high patient compliance, and systemic delivery or targeted...
Lactate oxidase-integrated nanomaterials for tumor microenvironment modulation: Mechanisms and therapeutic applications
March 2026
The tumor microenvironment (TME) is dynamically remodeled by metabolic reprogramming, establishing lactate as a central orchestrator of immune evasion through acidosis, CD8⁺ T cell suppression, and...
Piezoelectric nanocellulose derivative for next generation cartilage biosensing: Progress in sustainable biosensing in clinical orthopaedics
September 2026
Piezoelectric nanocellulose derivatives combine the electromechanical properties of cellulose nanocrystals with chemically compatible functionalization and nanocomposite fabrication approaches, aiming...
Neutrophils-based drug delivery systems in cancer therapy: Syntheses, strategies, challenges, and prospects
September 2026
Drug delivery systems (DDSs) face significant challenges of unsatisfactory biocompatibility, biological barrier obstruction, immune clearance and suboptimal targeting efficiency, which greatly limit...
Advances in single-cell electrochemical analysis: From micro-nano electrodes to nanoscale sensing
September 2026
Single-cell is important target in bioelectrochemical analysis because essential life processes, such as the production, storage, and secretion of neurotransmitters and other key biomolecules, occur...
Engineered exosome based immunomodulation therapies: Advancements and clinical applications
March 2026
Exosome applications in biomedicine have gained momentum in the last two decades, mainly due to their remarkable versatility. Exosomes are extracellular vesicles that carry diverse nucleic acids, proteins,...
Nanozymes in immune regulation: Applications and progress
March 2026
The immune system is essential for maintaining physiological balance, defending against pathogens, and eliminating abnormal cells. Immune dysregulation—manifesting as either suppression or hyperactivation—plays...
siRNA-based nanotherapeutics for malignant and non-malignant diffuse parenchymal lung diseases
June 2026
The diffuse parenchymal lung diseases (DPLD) such as lung fibrosis and lung cancer are diagnosed by conventional radiological and pathological techniques. Nanotheranostics based on RNA interference...