Antibody-conjugated lipid nanoparticles for in vivo CAR-T cell engineering: From concept to clinical translation
June 2026
Chimeric antigen receptor T cell therapy represents a transformative advancement in immunotherapy, wherein engineered T cells target tumor antigens, achieving high response rates in hematological malignancies....
A brief description of electrochemical glucose biosensors and their future challenges
September 2026
The demand for glucose detection has been on an increasing trend due to the rising diabetic population. An interesting aspect in glucose sensors is how to make the devices be more accurate and efficient,...
Optimizing design and exploring the dual potential of carbon quantum dots in environmental sensing and biomedical theranostics
June 2026
Carbon quantum dots (CQDs) have emerged as next-generation nanomaterials owing to their tunable photoluminescence, chemical stability, biocompatibility, and facile synthesis from renewable precursors....
Piezoelectric nanocellulose derivative for next generation cartilage biosensing: Progress in sustainable biosensing in clinical orthopaedics
September 2026
Piezoelectric nanocellulose derivatives combine the electromechanical properties of cellulose nanocrystals with chemically compatible functionalization and nanocomposite fabrication approaches, aiming...
Oral nanomaterial formulations for gastrointestinal therapeutics: Promises and challenges on the path to clinical translation
June 2026
The gastrointestinal (GI) tract is an important route of drug delivery in the human body, offering advantages such as ease of administration, high patient compliance, and systemic delivery or targeted...
Innovative applications of exosomes in precision medicine: From diagnostic biomarkers to engineered therapeutics
September 2026
Exosomes, as cell-derived nanoscale vesicles, are characterized by their ability to selectively encapsulate and transfer biomolecules—including proteins, nucleic acids, and lipids—from their parental...
Dimensionality and size effects in Surface-enhanced Raman scattering (SERS) substrates: From multidimensional nanomaterials to metal single-atom materials
September 2026
Surface-enhanced Raman scattering (SERS) has evolved from a fundamental phenomenon to a powerful analytical technique, heavily reliant on the properties of the substrate. This review comprehensively...
Advances in single-cell electrochemical analysis: From micro-nano electrodes to nanoscale sensing
September 2026
Single-cell is important target in bioelectrochemical analysis because essential life processes, such as the production, storage, and secretion of neurotransmitters and other key biomolecules, occur...
The application of nanomaterials in vaccine adjuvants
June 2026
Vaccines prevent infectious diseases by enhancing both innate and adaptive immune responses, while adjuvants amplify, accelerate, or prolong these responses, thereby increasing vaccine efficacy. This...
Eco-friendly synthesis of gallic acid-capped zinc oxide nanoparticles revealing antimicrobial, antioxidant, and anticancer activities
December 2026
The present study aims to synthesized zinc oxide nanoparticles (ZnO NPs) in an sustainable approach by using gallic acid (GA) as a stabilising and bio-reductant. The synthesized GA-ZnO NPs were characterized...
Lactate oxidase-integrated nanomaterials for tumor microenvironment modulation: Mechanisms and therapeutic applications
March 2026
The tumor microenvironment (TME) is dynamically remodeled by metabolic reprogramming, establishing lactate as a central orchestrator of immune evasion through acidosis, CD8⁺ T cell suppression, and...
Recent progress on the application of heavy metal nanoparticles in radiotherapy sensitization
June 2026
Radiotherapy remains one of the cornerstone modalities in the clinical treatment of malignant tumors. However, the intrinsic radioresistance of tumor cells—particularly hypoxia-induced tolerance within...
Engineered exosome based immunomodulation therapies: Advancements and clinical applications
March 2026
Exosome applications in biomedicine have gained momentum in the last two decades, mainly due to their remarkable versatility. Exosomes are extracellular vesicles that carry diverse nucleic acids, proteins,...
Ratiometric SERS platform of dual bioprobes for stable detection of circulating tumor cells
June 2026
Circulating tumor cells (CTCs) serve as crucial biomarkers for non-invasive cancer diagnostics through liquid biopsy. Surface-enhanced Raman spectroscopy (SERS) bioprobes offer high detection sensitivity...
Nanozymes in immune regulation: Applications and progress
March 2026
The immune system is essential for maintaining physiological balance, defending against pathogens, and eliminating abnormal cells. Immune dysregulation—manifesting as either suppression or hyperactivation—plays...
Neutrophils-based drug delivery systems in cancer therapy: Syntheses, strategies, challenges, and prospects
September 2026
Drug delivery systems (DDSs) face significant challenges of unsatisfactory biocompatibility, biological barrier obstruction, immune clearance and suboptimal targeting efficiency, which greatly limit...
Nanozyme with self-fueling and energy-blocking for enhancing reactive oxygen species-mediated tumor therapy by disrupting mitochondrial function
September 2026
Self-fueling and energy-blocking played important roles in enhancing the antitumor efficacy of reactive oxygen species (ROS) therapy. Here, a novel nanozyme (CuS@Pd/DHA@ZnO2) was constructed by loading...
Atomically engineered nanozymes (AEN): Revolutionizing catalytic immunemodulation for biomedical advances
March 2026
Immunotherapy holds enormous potential to improve treatment results, however, the low response rate remains a significant challenge. Conventional immunomodulatory methods often cause off-target effects,...
Transdermal drug delivery: Principles, technologies, therapeutic applications, and future directions
December 2026
Transdermal drug delivery systems (TDDS), as an important alternative to oral and injectable administration, offer significant advantages including non-invasive delivery, avoidance of first-pass metabolism,...
Biomimetic tumor cell membrane-coated nanomaterials combine gene therapy by Crispr/Cas9 and photothermal therapy in triple-negative breast cancer
June 2026
To explore potential therapeutic strategies for triple-negative breast cancer (TNBC) and investigate targeted CDK9 inhibitors with reduced toxicity, a CRISPR/Cas9-based bionic tumor cell membrane-encapsulated...
Carbon nanotubes as novel smart nano-carriers to augment ciprofloxacin and meropenem activity against Pseudomonas aeruginosa: In-vitro and In-vivo studies
June 2026
Antimicrobial resistance poses a critical challenge to global health, necessitating innovative drug delivery strategies to enhance antibiotic efficacy. This study investigated the therapeutic potential...
Engineering a robust wnt-related diagnostic model for lung adenocarcinoma via machine learning algorithms and multi-cohort validation
September 2026
Lung adenocarcinoma (LUAD) remains one of the leading causes of cancer-related deaths globally, necessitating more effective diagnostic and prognostic biomarkers. This study aims to identify and validate...
Selection of precursor for natural product-derived carbon dots and their biomedical applications
December 2026
Carbon dots (CDs), an emerging class of fluorescent carbon nanomaterials, have garnered considerable attention owing to their excellent optical properties and favorable biocompatibility. Among the diverse...
Research application of immunomodulatory nanomaterials in Alzheimer's disease vaccine development
March 2026
Alzheimer's disease (AD) is a common neurodegenerative disorder, and there is currently no effective treatment, which brings a significant burden to patients and their families. In recent years, immunomodulatory...
Bioinspired nanozymes with physical stimuli responsiveness: New frontiers in tumor immunotherapy
June 2026
Bioinspired nanozymes, a class of bio-nanomaterials with enzymatic-like activity, are garnering attention due to their high stability under harsh condition, ease of preparation, and wide-range application...