Antibody-conjugated lipid nanoparticles for in vivo CAR-T cell engineering: From concept to clinical translation
June 2026
Chimeric antigen receptor T cell therapy represents a transformative advancement in immunotherapy, wherein engineered T cells target tumor antigens, achieving high response rates in hematological malignancies....
Optimizing design and exploring the dual potential of carbon quantum dots in environmental sensing and biomedical theranostics
June 2026
Carbon quantum dots (CQDs) have emerged as next-generation nanomaterials owing to their tunable photoluminescence, chemical stability, biocompatibility, and facile synthesis from renewable precursors....
Oral nanomaterial formulations for gastrointestinal therapeutics: Promises and challenges on the path to clinical translation
June 2026
The gastrointestinal (GI) tract is an important route of drug delivery in the human body, offering advantages such as ease of administration, high patient compliance, and systemic delivery or targeted...
Recent progress on the application of heavy metal nanoparticles in radiotherapy sensitization
June 2026
Radiotherapy remains one of the cornerstone modalities in the clinical treatment of malignant tumors. However, the intrinsic radioresistance of tumor cells—particularly hypoxia-induced tolerance within...
Biomimetic tumor cell membrane-coated nanomaterials combine gene therapy by Crispr/Cas9 and photothermal therapy in triple-negative breast cancer
June 2026
To explore potential therapeutic strategies for triple-negative breast cancer (TNBC) and investigate targeted CDK9 inhibitors with reduced toxicity, a CRISPR/Cas9-based bionic tumor cell membrane-encapsulated...
Engineered exosome based immunomodulation therapies: Advancements and clinical applications
March 2026
Exosome applications in biomedicine have gained momentum in the last two decades, mainly due to their remarkable versatility. Exosomes are extracellular vesicles that carry diverse nucleic acids, proteins,...
Bioinspired nanozymes with physical stimuli responsiveness: New frontiers in tumor immunotherapy
June 2026
Bioinspired nanozymes, a class of bio-nanomaterials with enzymatic-like activity, are garnering attention due to their high stability under harsh condition, ease of preparation, and wide-range application...
The application of nanomaterials in vaccine adjuvants
June 2026
Vaccines prevent infectious diseases by enhancing both innate and adaptive immune responses, while adjuvants amplify, accelerate, or prolong these responses, thereby increasing vaccine efficacy. This...
Nanozymes in immune regulation: Applications and progress
March 2026
The immune system is essential for maintaining physiological balance, defending against pathogens, and eliminating abnormal cells. Immune dysregulation—manifesting as either suppression or hyperactivation—plays...
siRNA-based nanotherapeutics for malignant and non-malignant diffuse parenchymal lung diseases
June 2026
The diffuse parenchymal lung diseases (DPLD) such as lung fibrosis and lung cancer are diagnosed by conventional radiological and pathological techniques. Nanotheranostics based on RNA interference...
Ratiometric SERS platform of dual bioprobes for stable detection of circulating tumor cells
June 2026
Circulating tumor cells (CTCs) serve as crucial biomarkers for non-invasive cancer diagnostics through liquid biopsy. Surface-enhanced Raman spectroscopy (SERS) bioprobes offer high detection sensitivity...
Lactate oxidase-integrated nanomaterials for tumor microenvironment modulation: Mechanisms and therapeutic applications
March 2026
The tumor microenvironment (TME) is dynamically remodeled by metabolic reprogramming, establishing lactate as a central orchestrator of immune evasion through acidosis, CD8⁺ T cell suppression, and...
Atomically engineered nanozymes (AEN): Revolutionizing catalytic immunemodulation for biomedical advances
March 2026
Immunotherapy holds enormous potential to improve treatment results, however, the low response rate remains a significant challenge. Conventional immunomodulatory methods often cause off-target effects,...
Research application of immunomodulatory nanomaterials in Alzheimer's disease vaccine development
March 2026
Alzheimer's disease (AD) is a common neurodegenerative disorder, and there is currently no effective treatment, which brings a significant burden to patients and their families. In recent years, immunomodulatory...
Carbon nanotubes as novel smart nano-carriers to augment ciprofloxacin and meropenem activity against Pseudomonas aeruginosa: In-vitro and In-vivo studies
June 2026
Antimicrobial resistance poses a critical challenge to global health, necessitating innovative drug delivery strategies to enhance antibiotic efficacy. This study investigated the therapeutic potential...
Therapeutic applications of immunomodulatory nanomaterials in bladder cancer
March 2026
Bladder cancer (BC) exhibits limited responsiveness to conventional therapies such as intravesical immunotherapy and chemotherapy, alongside high recurrence rates and significant treatment costs. Recent...
Design of nanomaterials for enhanced cancer immunotherapy: A review
March 2026
Nanomaterials for precise tumor targeting have entered the era of intelligent medicine, where their versatile applications are being widely studied. In the field of tumor treatment, nanomaterial-based...
Recent advances and future trends in regulating transintestinal cholesterol excretion: Potential for nano-based therapeutic strategies
June 2026
Cardiovascular disease (CVD)-related mortality continues to increase, imposing persistently high social and economic burdens. Accumulating evidences have indicated that plasma cholesterol concentration...
Recent progress in nanomaterials for the detection of rheumatoid arthritis-related biomarkers: A clinical perspective
March 2026
Rheumatoid arthritis (RA) is a chronic and highly disabling autoimmune disorder. Highly sensitive detection and accurate quantification of biomarkers associated with RA are crucial for early diagnosis...
Piezoelectric nanocellulose derivative for next generation cartilage biosensing: Progress in sustainable biosensing in clinical orthopaedics
September 2026
Piezoelectric nanocellulose derivatives combine the electromechanical properties of cellulose nanocrystals with chemically compatible functionalization and nanocomposite fabrication approaches, aiming...
A brief description of electrochemical glucose biosensors and their future challenges
September 2026
The demand for glucose detection has been on an increasing trend due to the rising diabetic population. An interesting aspect in glucose sensors is how to make the devices be more accurate and efficient,...
Dimensionality and size effects in Surface-enhanced Raman scattering (SERS) substrates: From multidimensional nanomaterials to metal single-atom materials
September 2026
Surface-enhanced Raman scattering (SERS) has evolved from a fundamental phenomenon to a powerful analytical technique, heavily reliant on the properties of the substrate. This review comprehensively...
Advances in single-cell electrochemical analysis: From micro-nano electrodes to nanoscale sensing
September 2026
Single-cell is important target in bioelectrochemical analysis because essential life processes, such as the production, storage, and secretion of neurotransmitters and other key biomolecules, occur...
Innovative applications of exosomes in precision medicine: From diagnostic biomarkers to engineered therapeutics
September 2026
Exosomes, as cell-derived nanoscale vesicles, are characterized by their ability to selectively encapsulate and transfer biomolecules—including proteins, nucleic acids, and lipids—from their parental...
Neutrophils-based drug delivery systems in cancer therapy: Syntheses, strategies, challenges, and prospects
September 2026
Drug delivery systems (DDSs) face significant challenges of unsatisfactory biocompatibility, biological barrier obstruction, immune clearance and suboptimal targeting efficiency, which greatly limit...