Special Issue on Nanomedicine for Gene Therapy: Delivery Design and Clinical Translation
Published 09 July, 2026
Introduction:
Gene therapy is reshaping the treatment of inherited disorders, cancer, inflammatory disease and tissue injury, but therapeutic impact depends on precise delivery, controlled intracellular trafficking and robust evidence of safety. Nanomedicine provides adaptable materials that protect genetic cargo, direct it to selected tissues and control release at the cellular level.
This special issue presents the advances in translational nanomedicine for gene therapy, focusing on material design, biological targeting, endosomal escape, immune compatibility, dose control and clinically relevant assessment. Contributions will highlight nanoscale systems for DNA, RNA and genome-editing components, together with models and analytical methods that connect formulation properties with pharmacology and therapeutic effect. Emphasis is placed on reproducible characterisation, scalable manufacture, disease-relevant evaluation and studies that clarify how nanomedicines can turn genetic medicines into practical therapies with defined benefits and manageable risk.
Topics Covered:
- Nonviral nanomedicines for gene delivery
- Targeted delivery of genetic payloads
- Intracellular trafficking and endosomal escape
- Bioresponsive release and gene expression control
- Genome editing and gene silencing nanomedicines
- Immunocompatibility and safety assessment
- Pharmacology bioanalysis and biodistribution
- Manufacturing quality control and translational evaluation
Important Deadline:
Submission deadline: 30 June 2027
Submission Instructions:
Please read the Guide for Authors before submitting. All articles should be submitted online, please select [VSI: Gene Nanomedicine] on submission.
Guest Editors:
- Prof. Wenpei Fan, China Pharmaceutical University, China. wenpei.fan@cpu.edu.cn
- Dr. Ziyi Han, Zhongda Hospital, Southeast University, China. chemistryhzy1995@163.com
- Dr. Yao Tong, University of Wisconsin-Madison, USA. yao.tong@wisc.edu
- Dr. Jingcheng Zhu, University of Pennsylvania, USA. zhu555@seas.upenn.edu