The emerging role of miRNAs in biological aging and age-related diseases
August 2025
Ageing is a complex biological process characterised by the accumulation of molecular and cellular damage leading to functional decline and an increased risk of chronic disease and geriatric syndromes....
Share article
Long non-coding RNAs in humans: Classification, genomic organization and function
April 2025
Long non-coding RNAs (lncRNAs) regulate numerous biological functions in animals. Despite recent advances in lncRNA research, their structural and functional annotation and classification remain an...
Share article
Recent advances in the development and clinical application of miRNAs in infectious diseases
February 2025
In the search for new biomarkers and therapeutic targets for infectious diseases, several molecules have been investigated. Small RNAs, known as microRNAs (miRs), are important regulators of gene expression,...
Share article
RNA and liquid-liquid phase separation
June 2021
Liquid-Liquid Phase Separation (LLPS) is a biological phenomenon that refers to the components of similar properties form droplets condensate in cells. These droplets play an important role in maintaining...
Share article
Exploring the role of noncoding RNAs in cancer diagnosis, prognosis, and precision medicine
December 2024
This review article studies the complex field of noncoding RNAs (ncRNAs) in cancer biology, focusing on their potential use as biomarkers and therapeutic targets. NcRNAs include circular RNAs (circRNAs),...
Share article
Small non-coding RNAs as regulators of structural evolution and carcinogenesis
June 2017
Small non-coding RNAs (sncRNAs) are part of non-coding oligonucleotide regulators with wide physiologic and morphologic functions. They control genetic programing of cells, and may modulate processes...
Share article
The full recovery of mice (Mus Musculus C57BL/6 strain) from virus–induced sarcoma after treatment with a complex of DDMC delivery system and sncRNAs
June 2019
Virus-induced cellular genetic modifications result in the development of many human cancers....
Share article
Computational discovery of conserved RNA structures and functional characterization of a structured lncRNA in Leishmania braziliensis
October 2025
Leishmania parasites alternate between hosts, facing environmental changes that demand rapid gene expression adaptation. Lacking canonical RNA polymerase II promoters, transcription in these eukaryotes...
Share article
New mechanism of LncRNA: In addition to act as a ceRNA
December 2024
Long non-coding RNAs (LncRNAs) are a class of RNA molecules with nucleic acid lengths ranging from 200 bp to 100 kb that cannot code for proteins, which are diverse and widely expressed in both animals...
Share article
Palmitic acid reduces LDLR-dependent uptake of macrophage-derived extracellular vesicles by hepatoma cells
August 2025
Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterized by a complicated interaction of lipotoxicity and inflammation in the liver, yet the mechanisms linking these phenomena...
Share article
Emerging roles of CircRNA-miRNA networks in cancer development and therapeutic response
February 2025
The complex interplay of epigenetic factors is essential in regulating the hallmarks of cancer and orchestrating intricate molecular interactions during tumor progression. Circular RNAs (circRNAs),...
Share article
NEAT1 and paraspeckles in neurodegenerative diseases: A missing lnc found?
December 2018
Neurodegenerative diseases are among the most common causes of disability worldwide. Although neurodegenerative diseases are heterogeneous in both their clinical features and the underlying physiology,...
Share article
The multifaceted role of microRNAs in colorectal cancer: pathogenesis and therapeutic implications
October 2025
MicroRNAs (miRNAs) are important regulators of gene expression and their dysregulation is involved in various diseases, including tumors. Among these, colorectal cancer (CRC) is the result of both genetic...
Share article
Alternative transcription increases isoform complexity in Long Non-Coding RNAs and alters their functions in cancer
October 2025
Transcriptional start and end variance, a less-explored aspect of lncRNA biology, is a critical determinant of isoform diversity in human RNA. While alternative splicing (AS) has been extensively studied...
Share article
Maternal plasma microRNAs as potential biomarkers for triaging pregnancies of unknown location and ectopic pregnancy diagnosis
August 2025
Pregnancy of unknown location (PUL) is classified if an early pregnancy is not visualised on transvaginal ultrasonography (TVUS). Biomarkers currently used to triage PUL outcomes have varying accuracy....
Share article
Dr. Jekyll or Mr. Hyde: The multifaceted roles of miR-145-5p in human health and disease
April 2025
MicroRNAs (miRNAs) are classified as small, non-coding RNAs that play crucial roles in diverse biological processes, including cellular development, differentiation, growth, and metabolism. MiRNAs regulate...
Share article
Plant bioactive compounds driven microRNAs (miRNAs): A potential source and novel strategy targeting gene and cancer therapeutics
December 2024
Irrespective of medical technology improvements, cancer ranks among the leading causes of mortality worldwide. Although numerous cures and treatments exist, creating alternative cancer therapies with...
Share article
Characterization of small nucleolar RNA retaining transcripts in human normal and cancer cells
August 2025
Small nucleolar RNAs are non-coding RNAs typically encoded within the introns of both protein-coding and non-coding genes. Interestingly, a significant fraction of snoRNA sequences is found as retained...
Share article
CircRNA-based AntimiR therapy: A novel approach to hypertension treatment
August 2025
The increasing recognition of the types and functions of non-coding RNAs has opened new avenues for their use as novel therapeutic strategies in the treatment of chronic diseases such as hypertension....
Share article
LncRNA MEG3/CTCF-CXCR4 axis functions in the regulation of breast cancer cell migration
October 2025
Loss or decreased expression of lncRNA MEG3 is a frequent event in the progression of many different malignancies. Overexpression of MEG3 in breast cancer cell lines MCF7 or MDA-MB-231 prevented cell...
Share article
MiR-92a-1-5p contributes to cellular proliferation and survival in chronic myeloid leukemia and its inhibition enhances imatinib efficacy
October 2025
Tyrosine kinase inhibitors (TKI), such as imatinib, have revolutionized chronic myeloid leukemia (CML) treatment. Despite this success, TKI intolerance and resistance remain significant clinical challenges....
Share article
LncRNA levels in the central nervous system as novel potential players and biomarkers in amyotrophic lateral sclerosis
October 2025
Research in amyotrophic lateral sclerosis (ALS) faces major burdens, including the urgent need for sensitive and specific biomarkers, the identification of novel and effective therapeutic targets and...
Share article
Methods of miRNA delivery and possibilities of their application in neuro-oncology
December 2023
In the current phase of medical progress, practical neuro-oncology faces critical challenges. These include the quest for and development of innovative methodological approaches, as well as the enhancement...
Share article
The role of long non-coding RNAs in cardiovascular diseases: A comprehensive review
April 2025
Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide, posing significant challenges to healthcare systems. Despite advances in medical interventions, the molecular...
Share article
Biological functions and affected signaling pathways by Long Non-Coding RNAs in the immune system
February 2025
Recently, the various regulative functions of long non-coding RNAs (LncRNAs) have been well determined. Recently, the vital role of LncRNAs as gene regulators has been identified in the immune system,...
Share article
