Long non-coding RNAs in humans: Classification, genomic organization and function
April 2025
Long non-coding RNAs (lncRNAs) regulate numerous biological functions in animals. Despite recent advances in lncRNA research, their structural and functional annotation and classification remain an...
The role of long non-coding RNAs in cardiovascular diseases: A comprehensive review
April 2025
Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide, posing significant challenges to healthcare systems. Despite advances in medical interventions, the molecular...
The emerging role of miRNAs in biological aging and age-related diseases
August 2025
Ageing is a complex biological process characterised by the accumulation of molecular and cellular damage leading to functional decline and an increased risk of chronic disease and geriatric syndromes....
CircEif3c/miR-96–5p/PHF20L1/MEOX2 axis in perivascular preadipocyte exosomes mediates fibroblast dysfunction and vascular remodeling
August 2026
Diabetes mellitus is a major modifiable risk factor for atherosclerotic cardiovascular disease and pathological vascular remodeling. During chronic hyperglycemia, exosomes serve as essential nanocarriers...
Stability of microRNAs in serum and plasma reveal promise as a circulating biomarker
December 2025
To verify the stability and reliability of circulating microRNA (miRNA) profiles in plasma and serum under different processing and storage conditions to inform future applications to circulating biomarker...
Recent advances in the development and clinical application of miRNAs in infectious diseases
February 2025
In the search for new biomarkers and therapeutic targets for infectious diseases, several molecules have been investigated. Small RNAs, known as microRNAs (miRs), are important regulators of gene expression,...
The circular RNA landscape: Biogenesis, functions, identification pipelines, and biomedical applications
June 2026
Circular RNAs (circRNAs), a subtype of RNA molecules, possess distinctive characteristics, including their closed circular structure, stability, tissue specificity and long half-life compared to their...
Noncoding RNAs are indispensable architects and regulators of biomolecular condensates
June 2026
Liquid-liquid phase separation (LLPS) is a biophysical mechanism by which certain biomolecules demix from the cytosol or nucleoplasm to form membraneless organelles. These droplet-like assemblies are...
Dr. Jekyll or Mr. Hyde: The multifaceted roles of miR-145-5p in human health and disease
April 2025
MicroRNAs (miRNAs) are classified as small, non-coding RNAs that play crucial roles in diverse biological processes, including cellular development, differentiation, growth, and metabolism. MiRNAs regulate...
Diagnostic potential of circular RNAs in carotid atherosclerotic plaque vulnerability
June 2026
Vulnerable carotid atherosclerotic plaques are prone to cap rupture and thrombosis, yet definitive assessment still relies on postoperative histology. We investigated whether circulating circular RNAs...
Exploring the role of noncoding RNAs in cancer diagnosis, prognosis, and precision medicine
December 2024
This review article studies the complex field of noncoding RNAs (ncRNAs) in cancer biology, focusing on their potential use as biomarkers and therapeutic targets. NcRNAs include circular RNAs (circRNAs),...
Targeting lncRNA DSCAM-AS1 for disease diagnosis and therapy
August 2026
Long non-coding RNAs (lncRNAs) have emerged as critical regulators of gene expression and play essential roles in a wide range of biological processes and human diseases, particularly cancer. DSCAM...
Long non-coding RNAs: Mechanism of action and functional utility
October 2016
Recent RNA sequencing studies have revealed that most of the human genome is transcribed, but very little of the total transcriptomes has the ability to encode proteins. Long non-coding RNAs (lncRNAs)...
Emerging roles of CircRNA-miRNA networks in cancer development and therapeutic response
February 2025
The complex interplay of epigenetic factors is essential in regulating the hallmarks of cancer and orchestrating intricate molecular interactions during tumor progression. Circular RNAs (circRNAs),...
Advances in transdermal siRNAs delivery: A review of current research progress
September 2023
Small interfering RNA (siRNAs) is a double-stranded RNA molecule which can hybridize with a specific mRNA sequence and block the translation of numerous genes to regulate endogenous genes and to defend...
Long noncoding RNA MALAT-1: A versatile regulator in cancer progression, metastasis, immunity, and therapeutic resistance
June 2024
Long noncoding RNAs (lncRNAs) are RNA transcripts longer than 200 nucleotides that do not code for proteins but have been linked to cancer development and metastasis. Metastasis-associated lung adenocarcinoma...
RNA and liquid-liquid phase separation
June 2021
Liquid-Liquid Phase Separation (LLPS) is a biological phenomenon that refers to the components of similar properties form droplets condensate in cells. These droplets play an important role in maintaining...
New mechanism of LncRNA: In addition to act as a ceRNA
December 2024
Long non-coding RNAs (LncRNAs) are a class of RNA molecules with nucleic acid lengths ranging from 200 bp to 100 kb that cannot code for proteins, which are diverse and widely expressed in both animals...
A conserved mammalian mecciRNA, mecciATP6, regulates mitochondrial homeostasis through interaction with HNRNPA3
August 2026
Circular RNAs (circRNAs) are covalently closed, single-stranded RNA molecules generated from both nuclear and mitochondrial genomes. Several nuclear-encoded circRNAs have been reported to be conserved...
Exosomal miRNA-218–5p derived from low-passage dermal papilla cells modulates hair follicle growth and development
June 2026
Exosomes are nanoscale particles that participate in multiple biological processes and are secreted by various cell types. Exosomes derived from dermal papilla cells (DPC-Exos) regulate hair follicle...
miR-423–5p/NDUFS7-mediated mitochondrial function modulation contributes to quercetin-induced attenuation of pulmonary fibrosis via extracellular matrix remodeling regulation
June 2026
Idiopathic pulmonary fibrosis (IPF) is a type of interstitial lung disease that is critically influenced by epigenetic regulation and mitochondrial function during its pathogenesis and progression....
CircSMAD4 shapes matrix-remodeling TAMs in lung adenocarcinoma
August 2026
Lung adenocarcinoma (LUAD) progression is strongly shaped by tumor-associated macrophages (TAMs), yet the post-transcriptional mechanisms that sustain matrix-remodeling TAM states remain incompletely...
Small RNA sequencing in individually selected sperm: Biomarkers for male subfertility and predictors of pregnancy success
February 2026
Sperm quality defined by motility and morphology has critical implications for fertility and pregnancy outcomes. Small RNAs, including microRNAs (miRNAs) and Piwi-interacting RNAs (piRNAs), play regulatory...
LncRNA-EME1 enhances BRCA1 recruitment and alters repair of DNA damage in cervical cancer radioresistance
February 2026
Cervical cancer is a significant cause of mortality in women globally, and radioresistance limits the effectiveness of standard radiotherapy treatment. Exploring the molecular mechanisms that contribute...
Exploring CSF microRNA signatures as diagnostic biomarkers in adult-type diffuse gliomas
June 2026
Mutations in isocitrate dehydrogenase (IDH) genes, specifically IDH1 and IDH2, are frequently observed in diffuse gliomas (DG) and define distinct molecular subtypes, namely IDH-wildtype and IDH-mutant....
