Long non-coding RNAs in humans: Classification, genomic organization and function
April 2025
Long non-coding RNAs (lncRNAs) regulate numerous biological functions in animals. Despite recent advances in lncRNA research, their structural and functional annotation and classification remain an...
Discovery of a G-rich ultra stable human ncRNA G-quadruplex that binds ATP
August 2026
Thermostable RNA motifs have been shown to be a unique material for building nanoparticles for many applications (Guo lab, Nature Nanotechnology, 2020 PMID: 21102465; 2021 PMID: 21909084). Here, we...
COVID-19: Mechanisms, risk factors, genetics, non-coding RNAs and neurologic impairments
June 2023
The novel coronavirus infection (COVID-19) causes a severe acute illness with the development of respiratory distress syndrome in some cases. COVID-19 is a global problem of mankind to this day. Among...
The emerging role of miRNAs in biological aging and age-related diseases
August 2025
Ageing is a complex biological process characterised by the accumulation of molecular and cellular damage leading to functional decline and an increased risk of chronic disease and geriatric syndromes....
The circular RNA landscape: Biogenesis, functions, identification pipelines, and biomedical applications
June 2026
Circular RNAs (circRNAs), a subtype of RNA molecules, possess distinctive characteristics, including their closed circular structure, stability, tissue specificity and long half-life compared to their...
LncRNA MIR22HG and miR-10a-5p: Pioneering serum biomarkers for pancreatic cancer diagnosis and progression assessment
October 2026
Pancreatic cancer (PC) endures as one of the most lethal malignancies, characterized by a dismal prognosis due to late-stage detection and limited therapeutic options. Circulating noncoding RNAs (ncRNAs)...
Stability of microRNAs in serum and plasma reveal promise as a circulating biomarker
December 2025
To verify the stability and reliability of circulating microRNA (miRNA) profiles in plasma and serum under different processing and storage conditions to inform future applications to circulating biomarker...
CRISPR decodes the RNA regulatory network in prostate cancer: A review from mechanisms to precision therapeutics
October 2026
Prostate cancer (PCa) remains one of the most prevalent and lethal malignancies in men worldwide. The pronounced heterogeneity and therapeutic resistance of PCa underscore the critical need to decipher...
The multifaceted role of microRNAs in colorectal cancer: pathogenesis and therapeutic implications
October 2025
MicroRNAs (miRNAs) are important regulators of gene expression and their dysregulation is involved in various diseases, including tumors. Among these, colorectal cancer (CRC) is the result of both genetic...
Functional role of long non-coding RNA MALAT1 and HOTAIR in lung cancer
August 2026
Long noncoding RNAs, particularly MALAT1 and HOTAIR, play a key role in regulating tumorigenesis, and therapeutic response. Current literature indicates their influence on key oncogenic pathways. Yet,...
The pachytene-specific lncRNA 1700008K24Rik is essential for mouse spermatogenesis and functions as a conserved piRNA precursor
August 2026
Spermatogenesis is a complex differentiation process requiring precise spatiotemporal gene regulation, yet the functions of most testis-enriched long noncoding RNAs (lncRNAs) remain elusive. Here, we...
Noncoding RNAs are indispensable architects and regulators of biomolecular condensates
June 2026
Liquid-liquid phase separation (LLPS) is a biophysical mechanism by which certain biomolecules demix from the cytosol or nucleoplasm to form membraneless organelles. These droplet-like assemblies are...
A conserved mammalian mecciRNA, mecciATP6, regulates mitochondrial homeostasis through interaction with HNRNPA3
August 2026
Circular RNAs (circRNAs) are covalently closed, single-stranded RNA molecules generated from both nuclear and mitochondrial genomes. Several nuclear-encoded circRNAs have been reported to be conserved...
Exploring the role of noncoding RNAs in cancer diagnosis, prognosis, and precision medicine
December 2024
This review article studies the complex field of noncoding RNAs (ncRNAs) in cancer biology, focusing on their potential use as biomarkers and therapeutic targets. NcRNAs include circular RNAs (circRNAs),...
Targeting lncRNA DSCAM-AS1 for disease diagnosis and therapy
August 2026
Long non-coding RNAs (lncRNAs) have emerged as critical regulators of gene expression and play essential roles in a wide range of biological processes and human diseases, particularly cancer. DSCAM...
CircEif3c/miR-96–5p/PHF20L1/MEOX2 axis in perivascular preadipocyte exosomes mediates fibroblast dysfunction and vascular remodeling
August 2026
Diabetes mellitus is a major modifiable risk factor for atherosclerotic cardiovascular disease and pathological vascular remodeling. During chronic hyperglycemia, exosomes serve as essential nanocarriers...
Targeting non-coding RNAs in the ferroptosis system: Molecular mechanisms and clinical translation for reversing doxorubicin resistance in breast cancer
August 2026
Breast cancer remains one of the leading causes of cancer-related morbidity and mortality in women worldwide, and the clinical efficacy of doxorubicin (DOX) is frequently compromised by chemoresistance....
Emerging roles of CircRNA-miRNA networks in cancer development and therapeutic response
February 2025
The complex interplay of epigenetic factors is essential in regulating the hallmarks of cancer and orchestrating intricate molecular interactions during tumor progression. Circular RNAs (circRNAs),...
Long noncoding RNA MALAT-1: A versatile regulator in cancer progression, metastasis, immunity, and therapeutic resistance
June 2024
Long noncoding RNAs (lncRNAs) are RNA transcripts longer than 200 nucleotides that do not code for proteins but have been linked to cancer development and metastasis. Metastasis-associated lung adenocarcinoma...
Recent advances in the development and clinical application of miRNAs in infectious diseases
February 2025
In the search for new biomarkers and therapeutic targets for infectious diseases, several molecules have been investigated. Small RNAs, known as microRNAs (miRs), are important regulators of gene expression,...
Dr. Jekyll or Mr. Hyde: The multifaceted roles of miR-145-5p in human health and disease
April 2025
MicroRNAs (miRNAs) are classified as small, non-coding RNAs that play crucial roles in diverse biological processes, including cellular development, differentiation, growth, and metabolism. MiRNAs regulate...
Advances in transdermal siRNAs delivery: A review of current research progress
September 2023
Small interfering RNA (siRNAs) is a double-stranded RNA molecule which can hybridize with a specific mRNA sequence and block the translation of numerous genes to regulate endogenous genes and to defend...
New mechanism of LncRNA: In addition to act as a ceRNA
December 2024
Long non-coding RNAs (LncRNAs) are a class of RNA molecules with nucleic acid lengths ranging from 200 bp to 100 kb that cannot code for proteins, which are diverse and widely expressed in both animals...
Emerging role of endogenous peptides encoded by non-coding RNAs in cancer biology
February 2025
Non-coding RNAs have long been recognized for their regulatory roles in various cellular processes, including cancer development and progression. Recent advancements have shed light on a novel aspect...
Identification of long non-coding RNAs involved in leukemogenesis and venetoclax response in acute myeloid leukemia through functional CRISPR-dCas9 interference screens
October 2026
Acute myeloid leukemia (AML) is a malignant hematologic disease with poor prognosis, and improved understanding of its biology is critical for patient outcomes. While protein-coding genes in AML are...