Advancing antimicrobial peptides: Mechanisms, design, and applications in the post-antibiotic era
August 2026
The rapid emergence of multidrug-resistant and extensively drug-resistant bacteria has intensified the need for alternative antimicrobial strategies in the post-antibiotic era. Antimicrobial peptides...
Heat shock proteins as modulators of cardiovascular health and disease: From cellular stress to clinical targets
September 2026
Cardiovascular disease (CVD) is a result of complex pathophysiological processes affecting the heart and blood vessels. Heat shock proteins (HSPs) are evolutionarily conserved molecular chaperones that...
CD44v6- and VEGFR2-targeting antibody-drug conjugates: Enhancing precision and safety in cancer therapy through a dual-targeting strategy
August 2026
Bispecific antibody-drug conjugates (BsADCs) represent a promising therapeutic strategy to overcome single-target resistance. Here, we developed a dual-targeting BsADC that simultaneously recognizes...
Efficiency and specificity evaluation of imidazole derivatization reactions for histidine-containing peptides
August 2026
Histidine residues are crucial for protein structure and function, playing key roles in metal coordination, catalysis, and post translational modifications. Comprehensive profiling of functional histidine...
Structural and thermodynamic analysis of BRCA1 BRCT variants identified in Middle Eastern breast cancer cohorts
September 2026
BRCA1 is a critical tumor suppressor that maintains genomic integrity through its C-terminal BRCT tandem domain, which mediates phosphoprotein interactions involved in DNA damage response signaling....
Integrative multi-omics reveals that salvianolic acid a protects against septic liver injury by remodeling amino acid metabolism and redox homeostasis
September 2026
Sepsis-induced liver injury (SILI) is a severe complication of sepsis associated with high morbidity and mortality. Salvianolic acid A (Sal A), a bioactive phenolic compound isolated from Salvia miltiorrhiza...