Risk factors for prolonged intensive care unit stay after pediatric cardiac surgery: data from national center for cardiovascular diseases in China
September 2025
After pediatric cardiac surgery, many patients require a prolonged stay in the intensive care unit. These patients require tremendous resources, which adds an additional burden to the healthcare systems....
The diagnostic accuracy of physical signs: practice experience compared with research evidence
September 2025
Physical diagnosis is the first course of clinical medicine and the first contact with patients during clinical practice. Evidence-based physical diagnosis is a helpful tool in both education and practice....
Role of natural active pharmaceuticals in the treatment of oral diseases
September 2025
Oral diseases include periodontal and oral tumors. Current treatment methods rely largely on surgical interventions and mechanical cleaning, with a lack of targeted pharmacological therapies. Regardless,...
Revisiting the role of liver cirrhosis in surgical treatment for hepatocellular carcinoma
September 2025
Annexin A5 confers neuroprotection in ischemic stroke: insights from in vitro and in vivo models
September 2025
Ischemic stroke remains a leading cause of neurological disability worldwide. Effective therapeutic interventions for stroke treatment are still critically needed. Annexin A5, a calcium-dependent phospholipid-binding...
Radiotherapy, a double-edged sword: amphiregulin-mediated immune microenvironment remodeling in cancer metastasis
September 2025
tRNA methylation in cancer
September 2025
As the most prevalent post-transcriptional modification in transfer RNAs (tRNAs), methylation dynamically and reversibly regulates the biosynthesis and maturation of tRNAs, exerting direct impacts on...
Perspective to clinical translation of radiotherapy-activated prodrugs: challenges and advances
June 2025
Global patterns of cervical cancer incidence and mortality: updated statistics and an overview of temporal trends from 2003 to 2017
June 2025
Global disparities exist in the burden of cervical cancer. This study aims to describe and analyze the global epidemiological landscape of cervical cancer in 2022, including recent trends in incide...
C-terminal amide-bearing proteins: emerging targets for protein homeostasis in health and disease
June 2025
This study highlights the role of C-terminal amide-bearing proteins (CTAPs) in protein homeostasis. Researchers discovered that CTAPs, formed under oxidative stress, are selectively recognized and degraded...
Risk factors analysis of adverse events after cardiac surgery in children with respiratory virus infection including SARS-CoV-2
June 2025
To explore the risk factors associated with adverse events following cardiac surgery in children with respiratory virus infections. The innovation particularly focuses on severe acute respiratory syndrome...
Transforming the landscape of cancer treatment with seven promising novel therapies: evolution and future perspectives
June 2025
The landscape of cancer treatment is rapidly evolving with the emergence of promising novel therapies, offering new hope for patients with challenging malignancies. This review explores key advancements,...
Targeting neural components in the tumor microenvironment as a novel therapeutic approach
March 2025
Progress in clinical research on allogeneic hematopoietic stem cell transplantation for the treatment of paroxysmal nocturnal hemoglobinuria
March 2025
Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal proliferative disease of hematopoietic stem cells that is clinically characterized by hemolysis, thrombosis, and bone marrow failure. In recent...
Progress and challenges in infectious disease surveillance and early warning
March 2025
The increasing incidence of emerging infectious diseases emphasizes the urgent need for timely and accurate global surveillance and early warning systems. In recent years, infectious disease surveillance...
A cross-sectional analysis of dietary intake and abdominal visceral fat content measured by ultrasound sonography
March 2025
The assessment of abdominal visceral fat (VF) warrants more applicable screening methods to detect individuals at risk of developing comorbidities. The purpose of this study was to identify a practical...
Anthracycline-induced cardiotoxicity: emerging mechanisms and therapies
March 2025
Chemotherapy-induced cardiovascular disease has become one of the main causes of death in cancer survivors. Several international authoritative societies have developed a number of guidelines to standardize...