Evidence-based pharmacological investigation of the clinical practice and rational use of metformin in prediabetes mellitus
June 2025
Prediabetes is a condition where blood glucose levels have deviated from the normal range but have not yet reached the diagnostic criteria for diabetes. It represents a transitional phase between health...
Integrating precision medicine and artificial intelligence to prevent cardiotoxicity in cardiovascular drug therapy
March 2026
Precision medicine refers to tailoring therapeutic interventions to an individual’s genetic, molecular and phenotypic characteristics, while multi-omics integrates genomics, proteomics and metabolomics...
Efficacy and safety of semaglutide in patients with heart failure: A meta-analysis
December 2025
The pleiotropic effects of semaglutide make it a breakthrough therapy for managing diabetes and obesity, particularly in patients with comorbid cardiovascular diseases. However, its clinical application...
A comprehensive evaluation of ALK inhibitors in the first-line treatment of patients with ALK-positive non-small cell lung cancer
March 2025
There are currently six ALK inhibitors available for the first-line treatment of patients diagnosed with ALK-positive advanced non-small cell lung cancer (NSCLC). However, clinicians face challenges...
Advances and challenges in personalized diagnosis and therapies for the management of recurrent glioblastoma
September 2025
Recurrent glioblastoma (rGBM) remains one of the most formidable challenges in neuro-oncology due to its aggressive evolution, treatment resistance, and profound intratumoral heterogeneity. Despite...
Biologic therapy for immune-mediated inflammatory diseases during pregnancy and lactation: Efficacy, safety, and challenges
June 2025
Immune-mediated inflammatory diseases (IMIDs) commonly affect women of reproductive age, and concerns regarding the impact of therapeutic drugs on pregnancy outcomes, fetal development, and infant health...
Molecular aspects of metformin’s anti-aging properties for muscle function and longevity in Drosophila melanogaster
December 2025
Muscle aging, characterized by the progressive loss of muscle mass and function, presents a significant clinical challenge, contributing to sarcopenia and age-related frailty. Recent research highlights...
Surgical pharmacy for catalyzing pharmacy service throughout surgical continuum
November 2024
The greater the complementarity between pharmacists’ knowledge and doctors’ knowledge, the more significant the role pharmacists can play in clinical practice. Physicians extensively use drugs for disease...
Precision individualized medication strategies and challenges for cardiovascular diseases
November 2024
With the ongoing societal development and changes in lifestyle, the incidence of cardiovascular diseases continues to rise. Although the most effective means of preventing atherosclerotic cardiovascular...
Challenges in utilizing the FAERS database for adverse drug reaction data mining: A critical analysis
March 2026
The FAERS database is a vital tool for identifying adverse drug reactions (ADRs). However, data mining in FAERS faces significant challenges, including data quality issues (e.g., integrity, consistency,...
A micro review on the role of recently emerged Artificial Intelligence (AI) tools and algorithms in microbiome-gut-brain-axis associated disease therapy via psychobiotics
September 2025
The microbiome-gut-brain axis involves the bidirectional connection between the gastrointestinal tract, gut microbiome, and central nervous system, and it is pivotal for mental well-being. Imbalances...
Towards precision medicine: Leading with big data and multidisciplinary collaboration
November 2024
Precision medicine relies on individuals’ genetic information, omics characteristics, and environmental factors to achieve personalized disease prevention, diagnosis, and treatment. With the successful...
Evaluation of the efficacy, safety and economy of different amphotericin B formulations in invasive fungal disease: A retrospective cohort study
September 2025
Fungal infections have emerged as an increasingly serious public health challenge globally. Four Formulations of amphotericin B are widely used in antifungal therapy. Despite the same active ingredient,...
Epithelial-mesenchymal transition in cancer metastasis: Molecular mechanisms, microenvironmental regulation, and therapeutic targeting
March 2026
Epithelial-mesenchymal transition is a crucial driver of cancer metastasis, enabling cancer cells to acquire invasive and migratory characteristics. This review synthesizes the molecular mechanisms...
Expert consensus on medication therapy for acid-related diseases
March 2026
Acid-related diseases (ARDs) are characterized by high incidence rates and significant disease burden. Excessive gastric acid secretion or heightened gastric acid sensitivity is the common pathogenesis...
Therapeutic drug monitoring for promotion of rational medication in the elderly: Overview, challenges and opportunities
November 2024
In the context of rapid development of clinical pharmacy in China, therapeutic drug monitoring (TDM) has become a vital tool for rational medication and is widely concerned. TDM combines the knowledge...
Blebbisomes: isolation, characterization, and functional role of organelle-rich giant vesicles
March 2026
Cells secrete a diverse array of extracellular vesicles (EVs) to mediate intercellular communication, profoundly influencing both physiological and pathological processes through the transfer of proteins,...
Integrative multi-omics approach for drug repositioning in Alzheimer's disease
September 2025
Alzheimer's disease (AD) is a progressive neurodegenerative disorder with an insidious onset, and effective therapeutic agents are urgently needed....
Unlocking precision medicine: Innovative strategies for druggable target identification and therapeutic enhancement
November 2024
Precision medication emphasizes tailored treatment approaches based on individual patient characteristics, yet the limitations in current drug target identification hinder therapeutic advancements....
Simultaneous determination of concentration of sulfamethoxazole and trimethoprim in human plasma by dual-quaternary HPLC and its clinical application
December 2024
Sulfamethoxazole compound, a combination of sulfamethoxazole and trimethoprim, is commonly prescribed to organ transplant recipients for infections caused by Nocardia, Burkholderia cepacia, and Pneumocystis...
Anti-platelet aggregation effect of Compound Danshen dripping pill: An integrated study of meta-analysis, network pharmacology, and in vivo and vitro experiments
December 2025
Compound Danshen Dripping Pill (CDDP) is a marketed Chinese patent medicine, primarily efficacious in “promoting blood circulation to remove blood stasis, regulating Qi to relieve pain”. CDDP, as an...
Study on administration timing and combination therapy of NSAIDs for preventing post-ERCP pancreatitis
March 2025
To determine the optimal timing, dosage, and efficacy of combination NSAID therapy in preventing post-ERCP pancreatitis....
Quality evaluation of the guidelines for vericiguat treatment of heart failure with reduced ejection fraction
June 2025
Heart failure (HF) bears a heavy disease burden, and vericiguat is the only guanylate cyclase stimulator proved to improve its prognosis. However, its clinical use needs a further improvement....
Application status of traditional computational methods and machine learning in cancer drug repositioning
December 2024
The escalating global burden of cancer has spurred extensive research and development efforts aimed at discovering effective anti-cancer agents. However, the prohibitively high costs associated with...
Current status and prospects of nucleic acid mass spectrometry in clinical pharmacogenomics
November 2024
Pharmacogenomics is an essential means to achieve personalized medicine. Multi-gene and multi-loci panel testing is an inevitable trend in its development, comprehensively analyzing the impact of genes...