Expert consensus on medication therapy for acid-related diseases
March 2026
Acid-related diseases (ARDs) are characterized by high incidence rates and significant disease burden. Excessive gastric acid secretion or heightened gastric acid sensitivity is the common pathogenesis...
Epithelial-mesenchymal transition in cancer metastasis: Molecular mechanisms, microenvironmental regulation, and therapeutic targeting
March 2026
Epithelial-mesenchymal transition is a crucial driver of cancer metastasis, enabling cancer cells to acquire invasive and migratory characteristics. This review synthesizes the molecular mechanisms...
Evidence-based pharmacological investigation of the clinical practice and rational use of metformin in prediabetes mellitus
June 2025
Prediabetes is a condition where blood glucose levels have deviated from the normal range but have not yet reached the diagnostic criteria for diabetes. It represents a transitional phase between health...
AI-driven precision cancer treatment: Multimodal data integration and real-time decision support for personalized oncology medication
September 2026
Artificial intelligence (AI) can be used to enhance precision oncology by utilizing multimodal data and real-time data provision to enhance cancer care. The analysis of digital pathology images is performed...
Integrative multi-omics approach for drug repositioning in Alzheimer's disease
September 2025
Alzheimer's disease (AD) is a progressive neurodegenerative disorder with an insidious onset, and effective therapeutic agents are urgently needed....
Pharmacokinetic/pharmacodynamic target-based dose optimization of quinolones
June 2026
Quinolones are widely used for the treatment of bacterial infections because of their broad antimicrobial spectrum, favorable tissue penetration, and concentration-dependent bactericidal activity. Optimization...
Determination of valproic acid concentration in human serum by LC-MS/MS and its application in therapeutic drug monitoring in patients with epilepsy
September 2026
Valproic acid (VPA), a first-line broad-spectrum antiepileptic drug, is widely used in the treatment of various types of epilepsy. It has a narrow effective therapeutic concentration range (50–100 μg·mL-1)...
Integrating precision medicine and artificial intelligence to prevent cardiotoxicity in cardiovascular drug therapy
March 2026
Precision medicine refers to tailoring therapeutic interventions to an individual’s genetic, molecular and phenotypic characteristics, while multi-omics integrates genomics, proteomics and metabolomics...
A comprehensive evaluation of ALK inhibitors in the first-line treatment of patients with ALK-positive non-small cell lung cancer
March 2025
There are currently six ALK inhibitors available for the first-line treatment of patients diagnosed with ALK-positive advanced non-small cell lung cancer (NSCLC). However, clinicians face challenges...
Challenges in utilizing the FAERS database for adverse drug reaction data mining: A critical analysis
March 2026
The FAERS database is a vital tool for identifying adverse drug reactions (ADRs). However, data mining in FAERS faces significant challenges, including data quality issues (e.g., integrity, consistency,...
Antihyperlipidemic and thrombolytic potential of medicinal plants: Mechanistic insights and precision medicine perspectives
June 2026
Hyperlipidemia and thrombosis are major contributors to cardiovascular morbidity and mortality worldwide. Although synthetic antihyperlipidemic and thrombolytic agents are clinically effective, their...
Translating localized renal reprogramming to systemic protection: A comprehensive review of SGLT2 inhibitors in cardiovascular-kidney-metabolic syndrome
September 2026
Cardiovascular-kidney-metabolic syndrome is a multifaceted condition encompassing chronic kidney disease, end-stage renal disease, and cardiovascular diseases stemming from underlying cardiometabolic...
Biologic therapy for immune-mediated inflammatory diseases during pregnancy and lactation: Efficacy, safety, and challenges
June 2025
Immune-mediated inflammatory diseases (IMIDs) commonly affect women of reproductive age, and concerns regarding the impact of therapeutic drugs on pregnancy outcomes, fetal development, and infant health...
Interpretation of the World Health Organization guideline on glucagon-like peptide-1 (GLP-1) therapies for the treatment of obesity in adults
September 2026
The World Health Organization (WHO) issued the Guideline on glucagon-like peptide-1 (GLP-1) therapies for the treatment of obesity in adults in 2025 to address the growing global burden of obesity,...
Application status of traditional computational methods and machine learning in cancer drug repositioning
December 2024
The escalating global burden of cancer has spurred extensive research and development efforts aimed at discovering effective anti-cancer agents. However, the prohibitively high costs associated with...
Advances and challenges in personalized diagnosis and therapies for the management of recurrent glioblastoma
September 2025
Recurrent glioblastoma (rGBM) remains one of the most formidable challenges in neuro-oncology due to its aggressive evolution, treatment resistance, and profound intratumoral heterogeneity. Despite...
Evaluation of the efficacy, safety and economy of different amphotericin B formulations in invasive fungal disease: A retrospective cohort study
September 2025
Fungal infections have emerged as an increasingly serious public health challenge globally. Four Formulations of amphotericin B are widely used in antifungal therapy. Despite the same active ingredient,...
Simultaneous determination of concentration of sulfamethoxazole and trimethoprim in human plasma by dual-quaternary HPLC and its clinical application
December 2024
Sulfamethoxazole compound, a combination of sulfamethoxazole and trimethoprim, is commonly prescribed to organ transplant recipients for infections caused by Nocardia, Burkholderia cepacia, and Pneumocystis...
Towards precision medicine: Leading with big data and multidisciplinary collaboration
November 2024
Precision medicine relies on individuals’ genetic information, omics characteristics, and environmental factors to achieve personalized disease prevention, diagnosis, and treatment. With the successful...
Cell-penetrating peptides as a gateway for nanocarrier-mediated glioblastoma therapy
June 2026
The most virulent primary brain cancer is Glioblastoma Multiforme (GBM), which is defined mainly by poor survival and drug delivery failure as a therapy. The blood-brain barrier (BBB) restricts the...
Research advances in established risk factors for community-acquired pneumonia
September 2026
Community-acquired pneumonia (CAP) remains an important cause of morbidity and mortality, with its risk factors varying across age groups, pathogen profiles, and individual clinical characteristics....
Precision individualized medication strategies and challenges for cardiovascular diseases
November 2024
With the ongoing societal development and changes in lifestyle, the incidence of cardiovascular diseases continues to rise. Although the most effective means of preventing atherosclerotic cardiovascular...
Unlocking precision medicine: Innovative strategies for druggable target identification and therapeutic enhancement
November 2024
Precision medication emphasizes tailored treatment approaches based on individual patient characteristics, yet the limitations in current drug target identification hinder therapeutic advancements....
A network meta-analysis of second-line immune checkpoint inhibitors and docetaxel for advanced non-small cell lung cancer: An economic evaluation from China
June 2026
Although previous studies have compared the economic benefits of single immune checkpoint inhibitors (ICIs) and docetaxel, few studies have conducted detailed comparisons of different ICIs within China's...
Anti-platelet aggregation effect of Compound Danshen dripping pill: An integrated study of meta-analysis, network pharmacology, and in vivo and vitro experiments
December 2025
Compound Danshen Dripping Pill (CDDP) is a marketed Chinese patent medicine, primarily efficacious in “promoting blood circulation to remove blood stasis, regulating Qi to relieve pain”. CDDP, as an...