Antihyperlipidemic and thrombolytic potential of medicinal plants: Mechanistic insights and precision medicine perspectives
June 2026
Hyperlipidemia and thrombosis are major contributors to cardiovascular morbidity and mortality worldwide. Although synthetic antihyperlipidemic and thrombolytic agents are clinically effective, their...
Phytochemical characterization, antioxidant and immunomodulatory evaluation of C-Health Forte: An ayurvedic proprietary medicine
June 2026
C-Health Forte (CHF) is an Ayurvedic proprietary formulation designed to promote overall health, well-being and immune regulation. It comprises eleven medicinal plants widely used in Ayurveda. This...
Integrated analysis of tissue-exosome Co--differentially expressed genes and their role in diagnosis and pathogenesis of colon cancer
June 2026
This study aimed to systematically identify co-differentially expressed genes (co-DEGs) by integrating transcriptomic data from colon cancer tissues and circulating exosomes, and to elucidate their...
Pharmacokinetic/pharmacodynamic target-based dose optimization of quinolones
June 2026
Quinolones are widely used for the treatment of bacterial infections because of their broad antimicrobial spectrum, favorable tissue penetration, and concentration-dependent bactericidal activity. Optimization...
Gut dysbiosis: An overlooked pharmacokinetic modifier in psychotropic therapy
June 2026
Growing evidence over recent years has established a bidirectional relationship between gut dysbiosis and mental health. This paper proposes that gut microbial imbalance and related functional disturbances...
Cell-penetrating peptides as a gateway for nanocarrier-mediated glioblastoma therapy
June 2026
The most virulent primary brain cancer is Glioblastoma Multiforme (GBM), which is defined mainly by poor survival and drug delivery failure as a therapy. The blood-brain barrier (BBB) restricts the...
A network meta-analysis of second-line immune checkpoint inhibitors and docetaxel for advanced non-small cell lung cancer: An economic evaluation from China
June 2026
Although previous studies have compared the economic benefits of single immune checkpoint inhibitors (ICIs) and docetaxel, few studies have conducted detailed comparisons of different ICIs within China's...
AI-driven precision cancer treatment: Multimodal data integration and real-time decision support for personalized oncology medication
Available online 29 June 2026
Artificial intelligence (AI) can be used to enhance precision oncology by utilizing multimodal data and real-time data provision to enhance cancer care. The analysis of digital pathology images is performed...
Blebbisomes: isolation, characterization, and functional role of organelle-rich giant vesicles
March 2026
Cells secrete a diverse array of extracellular vesicles (EVs) to mediate intercellular communication, profoundly influencing both physiological and pathological processes through the transfer of proteins,...
Epithelial-mesenchymal transition in cancer metastasis: Molecular mechanisms, microenvironmental regulation, and therapeutic targeting
March 2026
Epithelial-mesenchymal transition is a crucial driver of cancer metastasis, enabling cancer cells to acquire invasive and migratory characteristics. This review synthesizes the molecular mechanisms...
Challenges in utilizing the FAERS database for adverse drug reaction data mining: A critical analysis
March 2026
The FAERS database is a vital tool for identifying adverse drug reactions (ADRs). However, data mining in FAERS faces significant challenges, including data quality issues (e.g., integrity, consistency,...
Integrating precision medicine and artificial intelligence to prevent cardiotoxicity in cardiovascular drug therapy
March 2026
Precision medicine refers to tailoring therapeutic interventions to an individual’s genetic, molecular and phenotypic characteristics, while multi-omics integrates genomics, proteomics and metabolomics...
Spatiotemporal trends in the global burden of drug-induced chronic liver diseases in thirty years
March 2026
Drug-induced chronic liver disease (DICLD) is concerned due to its threat to health, but there are few data about its global burden. We evaluated the trends in the burden of DICLD in 204 countries in...
Reverse MIC drift of nemonoxacin and its advantages against Gram-positive bacteria: A 10-year multicenter surveillance study
March 2026
Antimicrobial resistance (AMR) threatens global health. Conventional fluoroquinolones have experienced accelerated resistance due to target‑enzyme mutations and are further constrained by safety concerns....
Role of nemonoxacin as a therapeutic option for community-acquired pneumonia in the era of atypical pathogens
March 2026
To systematically summarize the clinical data from phase II–IV studies of nemonoxacin malate and comprehensively evaluate the clinical efficacy of nemonoxacin in treating pneumonia caused by atypical...
Systematically investigating the pharmacological mechanism of Guizhi Gancao decoction in promoting thermogenesis during cold exposure by integrating HPLC-Q-TOF/MS analysis and network pharmacology
March 2026
Guizhi Gancao Decoction (GGD), a classic formula in Traditional Chinese Medicine (TCM), is composed of Ramulus Cinnamomi (RC) and Radix Glycyrrhizae (RG). It is traditionally used to restore heart Yang...
Long non-coding RNA PVT1 promotes cell proliferation in ERα+ breast cancer through the ERα-BTG2 axis
March 2026
Plasmacytoma variant translocation 1 (PVT1) is recognized as an oncogenic long non-coding RNA (lncRNA) in multiple cancer types including breast cancer (BC). Estrogen receptor alpha-positive (ERα+)...
Expert consensus on medication therapy for acid-related diseases
March 2026
Acid-related diseases (ARDs) are characterized by high incidence rates and significant disease burden. Excessive gastric acid secretion or heightened gastric acid sensitivity is the common pathogenesis...
Molecular aspects of metformin’s anti-aging properties for muscle function and longevity in Drosophila melanogaster
December 2025
Muscle aging, characterized by the progressive loss of muscle mass and function, presents a significant clinical challenge, contributing to sarcopenia and age-related frailty. Recent research highlights...
Predictive potential of five genes of cuproptosis for survival in LGG
December 2025
Low-grade glioma (LGG) is a common primary tumor in the central nervous system. The function of several types of cell death has been proved in tumorigenesis of low-grade glioma (LGG). Cuproptosis, a...
Anti-platelet aggregation effect of Compound Danshen dripping pill: An integrated study of meta-analysis, network pharmacology, and in vivo and vitro experiments
December 2025
Compound Danshen Dripping Pill (CDDP) is a marketed Chinese patent medicine, primarily efficacious in “promoting blood circulation to remove blood stasis, regulating Qi to relieve pain”. CDDP, as an...
Multi-omics mendelian randomization identifies ferroptosis-related genetic variants linked to NAFLD risk
December 2025
Ferroptosis, an iron-dependent cell death, contributes to non-alcoholic fatty liver disease (NAFLD), but causal genes remain unclear. This study identifies ferroptosis-related genes driving NAFLD to...
Adverse drug event signal detection and risk factor analysis of blinatumomab in ten years of post-marketing use
December 2025
To analyze factors influencing the safety of blinatumomab based on real-world adverse drug event (ADE) reports collected from the U.S. Food and Drug Administration Adverse Event Reporting System (FAERS)...
Efficacy and safety of semaglutide in patients with heart failure: A meta-analysis
December 2025
The pleiotropic effects of semaglutide make it a breakthrough therapy for managing diabetes and obesity, particularly in patients with comorbid cardiovascular diseases. However, its clinical application...
Evaluation of the efficacy, safety and economy of different amphotericin B formulations in invasive fungal disease: A retrospective cohort study
September 2025
Fungal infections have emerged as an increasingly serious public health challenge globally. Four Formulations of amphotericin B are widely used in antifungal therapy. Despite the same active ingredient,...