Interpretation of world health organization guideline on glucagon-like peptide-1 therapies for obesity in adults
Available online 19 September 2026
Effects of nemonoxacin monotherapy and nemonoxacin combined with minocycline on the prognosis in patients with non-severe Chlamydia psittaci pneumonia
Available online 9 September 2026
To analyze the effects of nemonoxacin monotherapy versus nemonoxacin combined with minocycline on the prognosis in patients with non-severe Chlamydia psittaci pneumonia (CPP)....
Research advances in established risk factors for community-acquired pneumonia
Available online 9 September 2026
To summarize recent advances in the risk factors for community-acquired pneumonia (CAP) and provide references for its prevention and treatment....
Comparison of the efficacy of nemonoxacin and moxifloxacin in the treatment of elderly patients with COPD complicated by acute lower respiratory tract infection
Available online 9 September 2026
To evaluate the efficacy of nemonoxacin versus moxifloxacin in the treatment of elderly patients with chronic obstructive pulmonary disease (COPD) complicated by acute lower respiratory tract infec...
Translating localized renal reprogramming to systemic protection: A comprehensive review of SGLT2 inhibitors in cardiovascular-kidney-metabolic syndrome
Available online 5 September 2026
Cardiovascular-kidney-metabolic syndrome is a multifaceted condition encompassing chronic kidney disease, end-stage renal disease, and cardiovascular diseases stemming from underlying cardiometabolic...
Efficacy and safety of nemonoxacin injection in the treatment of community-acquired pneumonia in adults and its effect on serum inflammatory factors
Available online 4 September 2026
To investigate the efficacy and safety of nemonoxacin injection in the treatment of community-acquired pneumonia (CAP) in adults, as well as its effect on serum inflammatory factors....
Determination of valproic acid concentration in human serum by LC-MS/MS and its application in therapeutic drug monitoring in patients with epilepsy
Available online 24 August 2026
Valproic acid (VPA), a first-line broad-spectrum antiepileptic drug, is widely used in the treatment of various types of epilepsy. It has a narrow effective therapeutic concentration range (50–100 μg·mL-1)...
Antihyperlipidemic and thrombolytic potential of medicinal plants: Mechanistic insights and precision medicine perspectives
June 2026
Hyperlipidemia and thrombosis are major contributors to cardiovascular morbidity and mortality worldwide. Although synthetic antihyperlipidemic and thrombolytic agents are clinically effective, their...
Phytochemical characterization, antioxidant and immunomodulatory evaluation of C-Health Forte: An ayurvedic proprietary medicine
June 2026
C-Health Forte (CHF) is an Ayurvedic proprietary formulation designed to promote overall health, well-being and immune regulation. It comprises eleven medicinal plants widely used in Ayurveda. This...
Integrated analysis of tissue-exosome Co--differentially expressed genes and their role in diagnosis and pathogenesis of colon cancer
June 2026
This study aimed to systematically identify co-differentially expressed genes (co-DEGs) by integrating transcriptomic data from colon cancer tissues and circulating exosomes, and to elucidate their...
Pharmacokinetic/pharmacodynamic target-based dose optimization of quinolones
June 2026
Quinolones are widely used for the treatment of bacterial infections because of their broad antimicrobial spectrum, favorable tissue penetration, and concentration-dependent bactericidal activity. Optimization...
Gut dysbiosis: An overlooked pharmacokinetic modifier in psychotropic therapy
June 2026
Growing evidence over recent years has established a bidirectional relationship between gut dysbiosis and mental health. This paper proposes that gut microbial imbalance and related functional disturbances...
Cell-penetrating peptides as a gateway for nanocarrier-mediated glioblastoma therapy
June 2026
The most virulent primary brain cancer is Glioblastoma Multiforme (GBM), which is defined mainly by poor survival and drug delivery failure as a therapy. The blood-brain barrier (BBB) restricts the...
A network meta-analysis of second-line immune checkpoint inhibitors and docetaxel for advanced non-small cell lung cancer: An economic evaluation from China
June 2026
Although previous studies have compared the economic benefits of single immune checkpoint inhibitors (ICIs) and docetaxel, few studies have conducted detailed comparisons of different ICIs within China's...
AI-driven precision cancer treatment: Multimodal data integration and real-time decision support for personalized oncology medication
Available online 29 June 2026
Artificial intelligence (AI) can be used to enhance precision oncology by utilizing multimodal data and real-time data provision to enhance cancer care. The analysis of digital pathology images is performed...
Blebbisomes: isolation, characterization, and functional role of organelle-rich giant vesicles
March 2026
Cells secrete a diverse array of extracellular vesicles (EVs) to mediate intercellular communication, profoundly influencing both physiological and pathological processes through the transfer of proteins,...
Epithelial-mesenchymal transition in cancer metastasis: Molecular mechanisms, microenvironmental regulation, and therapeutic targeting
March 2026
Epithelial-mesenchymal transition is a crucial driver of cancer metastasis, enabling cancer cells to acquire invasive and migratory characteristics. This review synthesizes the molecular mechanisms...
Challenges in utilizing the FAERS database for adverse drug reaction data mining: A critical analysis
March 2026
The FAERS database is a vital tool for identifying adverse drug reactions (ADRs). However, data mining in FAERS faces significant challenges, including data quality issues (e.g., integrity, consistency,...
Integrating precision medicine and artificial intelligence to prevent cardiotoxicity in cardiovascular drug therapy
March 2026
Precision medicine refers to tailoring therapeutic interventions to an individual’s genetic, molecular and phenotypic characteristics, while multi-omics integrates genomics, proteomics and metabolomics...
Spatiotemporal trends in the global burden of drug-induced chronic liver diseases in thirty years
March 2026
Drug-induced chronic liver disease (DICLD) is concerned due to its threat to health, but there are few data about its global burden. We evaluated the trends in the burden of DICLD in 204 countries in...
Reverse MIC drift of nemonoxacin and its advantages against Gram-positive bacteria: A 10-year multicenter surveillance study
March 2026
Antimicrobial resistance (AMR) threatens global health. Conventional fluoroquinolones have experienced accelerated resistance due to target‑enzyme mutations and are further constrained by safety concerns....
Role of nemonoxacin as a therapeutic option for community-acquired pneumonia in the era of atypical pathogens
March 2026
To systematically summarize the clinical data from phase II–IV studies of nemonoxacin malate and comprehensively evaluate the clinical efficacy of nemonoxacin in treating pneumonia caused by atypical...
Systematically investigating the pharmacological mechanism of Guizhi Gancao decoction in promoting thermogenesis during cold exposure by integrating HPLC-Q-TOF/MS analysis and network pharmacology
March 2026
Guizhi Gancao Decoction (GGD), a classic formula in Traditional Chinese Medicine (TCM), is composed of Ramulus Cinnamomi (RC) and Radix Glycyrrhizae (RG). It is traditionally used to restore heart Yang...
Long non-coding RNA PVT1 promotes cell proliferation in ERα+ breast cancer through the ERα-BTG2 axis
March 2026
Plasmacytoma variant translocation 1 (PVT1) is recognized as an oncogenic long non-coding RNA (lncRNA) in multiple cancer types including breast cancer (BC). Estrogen receptor alpha-positive (ERα+)...
Expert consensus on medication therapy for acid-related diseases
March 2026
Acid-related diseases (ARDs) are characterized by high incidence rates and significant disease burden. Excessive gastric acid secretion or heightened gastric acid sensitivity is the common pathogenesis...