Ethical issues and coping strategies for artificial intelligence in medical research
October 2025
With the rapid development of artificial intelligence (AI) technologies, their applications in medical research have become increasingly widespread. However, the extensive use of AI has also raised...
Pioneering the future of dentistry: AI-driven 3D bioprinting for next-generation clinical applications
January 2025
Artificial intelligence (AI) is revolutionizing dentistry by enhancing the analysis of complex medical imaging data, automating the identification of anatomical landmarks, and improving diagnostic accuracy...
Bioinformatics and AI in dental biomaterials: Applications in drug delivery for tissue engineering
January 2026
Dental biomaterials play a vital role in restorative dentistry and tissue regeneration, but their design and clinical translation remain challenging due to complex material–tissue interactions, patient-specific...
Antimicrobial peptides in oral medicine: From mechanisms to clinical translation
October 2025
Oral diseases pose significant threats to global public health, while conventional antibiotic therapies face increasing challenges from bacterial resistance. Antimicrobial peptides (AMPs) have emerged...
Recent advances of oral fluids-based point-of-care testing platforms for oral disease diagnosis
January 2025
Oral disease requires rapid and accurate diagnosis methods to adapt to the short turnround time in oral clinics. In recent years, point-of-care testing (POCT) platforms have gained increasing attention,...
The Neonatal Line in Primary Teeth: A Systematic Review and Meta-analysis of Its Forensic, Clinical, Anthropological, and Archaeological Applications
Available online 28 January 2026
The neonatal line (NNL) is an accentuated histological feature of dental enamel formed around the time of birth. It provides a permanent marker of parturition and has been linked to maternal, perinatal,...
Bionic repair strategy for craniomaxillofacial bone tissue reconstruction
July 2025
The clinical need for repairing craniofacial bone defects is significant, as relying solely on autologous bone grafts presents challenges such as resource deficiency and non-reusability. This has led...
Oral and maxillofacial mechanomedicine: Exploring biomechanical insights and their clinical implications
January 2025
The revolutionary integration of biology and engineering has had a significant impact on the field of oral and maxillofacial medicine. Historically, oral and maxillofacial medicine predominantly centered...
Translating research evidence into dental practice
April 2025
Evidence-based dentistry relies on effectively translating research findings into dental practice to improve patient outcomes and population health. Translational research aims to bridge the gap between...
Minimizing the ergonomic risks in the process of periodontal scaling and root planning: A narrative review
April 2025
Work–related musculoskeletal disorders (WMSDs) are a prevalent occupational health concern among periodontists, particularly affecting the neck, shoulder, and wrist due to the repetitive and static...
Perspective opportunities and challenges in translating dental materials into clinical practice
April 2026
The clinical translation of dental materials presents significant opportunities, driven by increasing market demand, supportive regulatory frameworks, and advancements in digital and additive manufacturing...
Expert consensus on neoadjuvant immunochemotherapy for resectable locally advanced oral squamous cell carcinoma
Available online 26 February 2026
Immunotherapy has revolutionized the treatment of malignant tumors and is now recognized as a first-line option for various cancers. In resectable locally advanced oral squamous cell carcinoma (OSCC),...
Harnessing plasma for peri-implantitis: Technical and clinical insights into its application on dental implants and abutments
January 2026
Dental implants have become an increasingly popular solution for the replacement of missing teeth in partially or fully edentulous patients. However, one of the most common causes of implant failure...
Artificial intelligence unlocks the future of oral organoid research
July 2025
Oral organoids, emerging as a powerful method for modeling oral development and diseases, show potential in fundamental research and clinical applications. However, their translational application in...
Compression training enhanced tough hydrogel as Ca-P reservoir for tooth extraction socket
January 2026
To develop a customized hydrogel scaffold that unifies toughness and calcium-phosphorus (Ca-P) ion reservoir through compression training for the tooth extraction socket, and to evaluate its efficacy...
A digital translational framework for biomaterials validation: From evidence- to model-based dentistry
January 2026
Traditional evidence-based workflows, progressing sequentially from laboratory testing to animal studies and clinical trials, have ensured safety and standardization but remain slow, costly, and only...
Accuracy of rest seat prepared by rigid constraint template for removable partial denture: An in vitro study
October 2025
To establish a design and fabrication method for a rigid constraint guiding template for preparing rest seats for removable partial dentures (RPDs) and to verify the feasibility and accuracy of template-guided...
Clinical evaluation of 3D-printed templates for accurate and safe mini-screw implantation
October 2025
To develop mini-screw templates using three-dimensional (3D) printing technology to prevent root damage during implantation, and to evaluate the accuracy and safety of the implantation process....
Quantum dot-engineered extracellular vesicles derived from human exfoliated deciduous teeth stem cells for the dynamic monitoring and synergistic therapy of ischemic stroke
October 2025
Ischemic stroke, marked by oxidative stress and neuroinflammation in the long-term injury process after reperfusion, remains a leading global cause of disability and mortality, urging the need for innovative...
Analgesic hydrogel patches formed by glutamic acid derivative for the treatment of oral mucosal wound
April 2025
Oral mucosal ulcerative diseases are one of the most prevalent oral diseases, which often interfere with the eating and speech of the patient and severely reduce the life quality. Currently, the main...
Fabrication of nano-structured biphasic calcium phosphate bioceramics to promote bone regeneration
July 2025
In recent years, inorganic non-metallic bone graft materials have attracted growing attention in bone defect repair. Among these, biphasic calcium phosphate (BCP) bioceramics, consisting of hydroxyapatite...
A digital cone beam computed tomography scan-based approach to transfer the preoperative maxillomandibular relation for immediate complete-arch interim restoration fabrication
October 2025
Achieving an accurate and stable maxillomandibular relation registration immediately following complete-arch implant placement surgery for interim restoration fabrication remains a significant clinical...
SiO2 nanoparticle-encapsulated metformin delivered by a poly(lactic-co-glycolic acid)/polycaprolactone electrospun nanofiber membrane promotes cell osteogenesis under high-glucose conditions: In vitro and in vivo studies
January 2025
Restoring diabetic bone defects presents ongoing challenges due to the intrinsic healing mechanisms that are compromised by hyperglycemia. Metformin (Met) shows substantial potential for hyperglycemia-induced...
Development and clinical evaluation of a personalised whole-mouth plaque removal device based on air-water bubbly jets
January 2025
Based on the principle of air-water bubbly jets and digital technology, this study aimed to develop a personalised whole-mouth plaque removal device (PRD) for fully automated intraoral plaque control...