Advancing orthodontic care through digital twin technology
July 2026
Digital twin technology represents a transformative innovation in healthcare, creating virtual replicas that enable real-time monitoring, simulation, and predictive analytics. At its core, a digital...
Ethical issues and coping strategies for artificial intelligence in medical research
October 2025
With the rapid development of artificial intelligence (AI) technologies, their applications in medical research have become increasingly widespread. However, the extensive use of AI has also raised...
Expert consensus on neoadjuvant immunochemotherapy for resectable locally advanced oral squamous cell carcinoma
April 2026
Immunotherapy has revolutionized the treatment of malignant tumors and is now recognized as a first-line option for various cancers. In resectable locally advanced oral squamous cell carcinoma (OSCC),...
Bioinformatics and AI in dental biomaterials: Applications in drug delivery for tissue engineering
January 2026
Dental biomaterials play a vital role in restorative dentistry and tissue regeneration, but their design and clinical translation remain challenging due to complex material–tissue interactions, patient-specific...
Pioneering the future of dentistry: AI-driven 3D bioprinting for next-generation clinical applications
January 2025
Artificial intelligence (AI) is revolutionizing dentistry by enhancing the analysis of complex medical imaging data, automating the identification of anatomical landmarks, and improving diagnostic accuracy...
Inflammaging and oral diseases: New sights from pathology to therapeutic consideration
April 2026
Population aging intensifies age-related oral diseases, severely damaging systemic health. Central to this is inflammaging, driven by interconnected mechanisms (immunosenescence, cellular senescence,...
Antimicrobial peptides in oral medicine: From mechanisms to clinical translation
October 2025
Oral diseases pose significant threats to global public health, while conventional antibiotic therapies face increasing challenges from bacterial resistance. Antimicrobial peptides (AMPs) have emerged...
Oral and maxillofacial mechanomedicine: Exploring biomechanical insights and their clinical implications
January 2025
The revolutionary integration of biology and engineering has had a significant impact on the field of oral and maxillofacial medicine. Historically, oral and maxillofacial medicine predominantly centered...
Recent advances of oral fluids-based point-of-care testing platforms for oral disease diagnosis
January 2025
Oral disease requires rapid and accurate diagnosis methods to adapt to the short turnround time in oral clinics. In recent years, point-of-care testing (POCT) platforms have gained increasing attention,...
The neonatal line in primary teeth: A systematic review and meta-analysis of its forensic, clinical, anthropological, and archaeological applications
April 2026
The neonatal line (NNL) is an accentuated histological feature of dental enamel formed around the time of birth. It provides a permanent marker of parturition and has been linked to maternal, perinatal,...
Comparison of autologous platelet concentrates versus blood clot as scaffolds in regenerative endodontics: A systematic review and meta-analysis
July 2026
Regenerative endodontics (RE) is among the first-choice treatments for patients with non-vital immature permanent teeth (IPT). This study compares the efficacy of autologous platelet concentrates (APCs)...
Perspective opportunities and challenges in translating dental materials into clinical practice
April 2026
The clinical translation of dental materials presents significant opportunities, driven by increasing market demand, supportive regulatory frameworks, and advancements in digital and additive manufacturing...
SMART PCR for adaptive low-abundance oral bacterial DNA detection through real-time fluorescence-guided thermal regulation
July 2026
Quantitative polymerase chain reaction (qPCR) is widely used for oral pathogen detection and molecular diagnostics; however, reliable detection of low-abundance bacterial DNA remains challenging. Conventional...
A digital translational framework for biomaterials validation: From evidence- to model-based dentistry
January 2026
Traditional evidence-based workflows, progressing sequentially from laboratory testing to animal studies and clinical trials, have ensured safety and standardization but remain slow, costly, and only...
Translating research evidence into dental practice
April 2025
Evidence-based dentistry relies on effectively translating research findings into dental practice to improve patient outcomes and population health. Translational research aims to bridge the gap between...
Harnessing plasma for peri-implantitis: Technical and clinical insights into its application on dental implants and abutments
January 2026
Dental implants have become an increasingly popular solution for the replacement of missing teeth in partially or fully edentulous patients. However, one of the most common causes of implant failure...
Accuracy of rest seat prepared by rigid constraint template for removable partial denture: An in vitro study
October 2025
To establish a design and fabrication method for a rigid constraint guiding template for preparing rest seats for removable partial dentures (RPDs) and to verify the feasibility and accuracy of template-guided...
Bionic repair strategy for craniomaxillofacial bone tissue reconstruction
July 2025
The clinical need for repairing craniofacial bone defects is significant, as relying solely on autologous bone grafts presents challenges such as resource deficiency and non-reusability. This has led...
Compression training enhanced tough hydrogel as Ca-P reservoir for tooth extraction socket
January 2026
To develop a customized hydrogel scaffold that unifies toughness and calcium-phosphorus (Ca-P) ion reservoir through compression training for the tooth extraction socket, and to evaluate its efficacy...
Liquid-liquid phase separation: A new pivot in the study of bone homeostasis
July 2026
Liquid-liquid phase separation (LLPS) is a key mechanism through which biomacromolecules undergo a phase transition to form dynamic membraneless condensates, playing fundamental roles in critical biological...
Inhibition of hyaluronic acid synthesis alleviates periodontitis through relieving periodontal inflammatory microenvironment
April 2026
Hyaluronic acid (HA) is one of the major components of the extracellular matrix (ECM), and hyaluronic acid synthase 2 (HAS2) is a key enzyme regulating its production. It has been reported that HA and...
Minimizing the ergonomic risks in the process of periodontal scaling and root planning: A narrative review
April 2025
Work–related musculoskeletal disorders (WMSDs) are a prevalent occupational health concern among periodontists, particularly affecting the neck, shoulder, and wrist due to the repetitive and static...
Platelet-rich plasma driven quiescence-activation reprogramming primes dental pulp stem cells for translational bone regeneration
April 2026
Dental pulp stem cells (DPSCs) are multipotent cells widely used in tissue repair and regeneration, making effective preconditioning strategies essential to maximize their therapeutic potential. Here,...
Artificial intelligence unlocks the future of oral organoid research
July 2025
Oral organoids, emerging as a powerful method for modeling oral development and diseases, show potential in fundamental research and clinical applications. However, their translational application in...
SiO2 nanoparticle-encapsulated metformin delivered by a poly(lactic-co-glycolic acid)/polycaprolactone electrospun nanofiber membrane promotes cell osteogenesis under high-glucose conditions: In vitro and in vivo studies
January 2025
Restoring diabetic bone defects presents ongoing challenges due to the intrinsic healing mechanisms that are compromised by hyperglycemia. Metformin (Met) shows substantial potential for hyperglycemia-induced...