Development of 3D bioprinting: From printing methods to biomedical applications
September 2020
Biomanufacturing of tissues/organs in vitro is our big dream, driven by two needs: organ transplantation and accurate tissue models. Over the last decades, 3D bioprinting has been widely applied in...
Ginseng-derived exosome-like nanovesicles protect against liver fibrosis by regulating TIMP2 pathways and gut dysbiosis
December 2025
Metabolic dysfunction-associated fatty liver disease (MASLD) and alcohol-associated liver disease (ALD) are prevalent chronic liver diseases that can progress to steatohepatitis, fibrosis, cirrhosis,...
Advances in the development of amorphous solid dispersions: The role of polymeric carriers
July 2023
Amorphous solid dispersion (ASD) is one of the most effective approaches for delivering poorly soluble drugs. In ASDs, polymeric materials serve as the carriers in which the drugs are dispersed at the...
CRISPR/Cas9 systems: Delivery technologies and biomedical applications
November 2023
The emergence of the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) genome-editing system has brought about a significant revolution in the realm...
Pharmaceutical particle technologies: An approach to improve drug solubility, dissolution and bioavailability
December 2014
Pharmaceutical particle technology is employed to improve poor aqueous solubility of drug compounds that limits in vivo bioavailability owing to their low dissolution rate in the gastrointestinal fluids...
A review on phospholipids and their main applications in drug delivery systems
April 2015
Phospholipids have the characteristics of excellent biocompatibility and a especial amphiphilicity. These unique properties make phospholipids most appropriate to be employed as important pharmaceutical...
Extrusion–spheronization a promising pelletization technique: In-depth review
December 2016
First, different steps such as granulation, extrusion, spheronization and drying of the extrusion–spheronization process are mentioned. Then the parameters that can influence the pellet quality which...
Advances in molecular glue degraders for targeted protein degradation: Focus on NEK7, WEE1, CDK2, GSPT1 and VAV1
February 2026
Molecular glues (MGs), a class of small-molecule degraders, exhibit drug-like properties that generally conform to Lipinski's rule of five, while uniquely mediating the stabilization or induction of...
Film forming systems for topical and transdermal drug delivery
November 2017
After application of the film forming system to the skin, the composition of the film forming system changes significantly due to the loss of the volatile components of the vehicle which results in...
Plant-derived exosome-like nanoparticles and their therapeutic activities
January 2022
Nanotechnologies have been successfully applied to the treatment of various diseases. Plant-derived exosome-like nanoparticles (PENs) are expected to become effective therapeutic modalities for treating...
Gastro-retentive drug delivery systems and their in vivo success: A recent update
October 2016
Gastro-retentive drug delivery system (GRDDS) has gained immense popularity in the field of oral drug delivery recently. It is a widely employed approach to retain the dosage form in the stomach for...
Alginate and alginate composites for biomedical applications
May 2021
Alginate is an edible heteropolysaccharide that abundantly available in the brown seaweed and the capsule of bacteria such as Azotobacter sp. and Pseudomonas sp. Owing to alginate gel forming capability,...
A practical guide to pharmaceutical polymorph screening & selection
August 2014
Prevalence and importance of polymorphism occurring in pharmaceutical compounds are well recognized. It is of great importance to prepare and select the right form from the beginning during drug discovery...
Overview of milling techniques for improving the solubility of poorly water-soluble drugs
July 2015
Milling involves the application of mechanical energy to physically break down coarse particles to finer ones and is regarded as a “top–down” approach in the production of fine particles. Fine drug...
Biomaterials-mediated sequential drug delivery: Emerging trends for wound healing
December 2025
Wound healing is a series of complex biological events that are tightly coordinated by the body. However, this physiological process is compromised in a pathological setting and underlie conditions...
Sprinkle formulations—A review of commercially available products
May 2020
Currently, sixty-five original sprinkle drug products are available in various dosage forms including tablets, powders, granules, immediate-release capsules, extended-release capsules, delayed-release...
Integrating CRISPR/Cas technology with clinical trials: Principles, progress and challenges
December 2025
CRISPR represent a groundbreaking genome-editing technology that has revolutionized genetic modification. This innovative tool offers an unparalleled revolution in the future treatment of genetic disorders,...
Development and preclinical evaluation of a novel FGFR3-targeted antibody-drug conjugate in bladder cancer
December 2025
Given the critical shortage of antibody-drug conjugates (ADCs) for bladder cancer (BCa), we developed a novel FGFR3-targeted ADC, LZU-WZLYFG001, composed of a humanized anti-FGFR3 IgG1 monoclonal antibody,...
Light-stimulated smart thermo-responsive constructs for enhanced wound healing: A streamlined command approach
August 2025
Efficient reconstruction of severe cutaneous wounds necessitates the orchestration of effective cell-mediated matrix remodeling and robust protection against microbial invasion. Herein, we engineered...
Antibacterial biomaterials for skin wound dressing
May 2022
Bacterial infection and the ever-increasing bacterial resistance have imposed severe threat to human health. And bacterial contamination could significantly menace the wound healing process. Considering...
Application of chitosan-based nanoparticles in skin wound healing
May 2022
The rising prevalence of impaired wound healing and the consequential healthcare burdens have gained increased attention over recent years. This has prompted research into the development of novel wound...
Critical quality attributes of lipid nanoparticles and in vivo fate
December 2025
Lipid nanoparticles (LNPs) have emerged as versatile carriers for the delivery of genetic medicines and small-molecule drugs, offering desired benefits for therapeutic applications. Optimization of...