Alendronate-mineralized nanoparticles loaded with ALK-PROTAC reverse the resistance and rebound effects of ALK+ NSCLC to PROTAC therapy by disrupting the mitochondria-linked feedback
Available online 6 October 2026
Targeted protein degradation technologies—particularly proteolysis-targeting chimeras (PROTACs)—have recently emerged as powerful tools in cancer therapy. However, it remains unclear whether tumor cells...
Multifunctional Vesicle-Secreting Bioadhesive Dermatomimetic Hydrogel for Enhanced Extensive Wound Healing
Available online 25 September 2026
Extensive skin wounds pose significant clinical challenges due to delayed healing, persistent inflammation and insufficient tissue regeneration. Here, we develop a photocrosslinked dermatomimetic hydrogel...
Spatiotemporally-stratified nanoassemblies for precisely halting the immunothrombotic vicious cycle in acute lung inflammation
Available online 23 September 2026
Acute lung injury and acute respiratory distress syndrome have high mortality. Extensive pulmonary microvascular thrombosis occurs in over 80% of patients who die from severe pneumonia. Inflammation...
Mitochondria–Neutrophil Hybrid Membrane Nanovesicles for Photo-Driven Calcium Overload and Suppression of Phototherapy-Evoked Inflammation and Metastasis
Available online 20 September 2026
Phototherapy holds great potential for localized tumor treatment but is limited by sublethal stress-induced thermal resistance, therapy-triggered inflammatory amplification, myeloid-derived suppressor...
Inflammation-Triggered Andrographolide Nanoprodrug Platform for Lung-Targeted Delivery and Immune Homeostasis Recovery: A Therapeutic Strategy Against Cytokine Storm
Available online 12 September 2026
Acute lung injury (ALI) leads to severe pulmonary inflammation and alveolar-capillary barrier disruption, with therapy limited by poor solubility and bioavailability of anti-inflammatory agents. To...
Spatiotemporal control of protein degradation: Advances in stimuli-responsive nano-PROTACs for precision cancer therapy
Available online 10 September 2026
Proteolysis-targeting chimeras (PROTACs) have shown great promise in recent years as a new class of drugs capable of targeting and degrading difficult-to-treat proteins. However, the clinical translation...
Platycodon grandiflorus-derived exosome-like nanovesicles drive AMPK-dependent glycolytic beige remodeling to ameliorate obesity
Available online 7 September 2026
Obesity is a pandemic with limited therapeutic options. Recent pharmacotherapies are constrained by tolerability, durability, accessibility, and incomplete resolution of adipose tissue dysfunction....
Natural Polysaccharide Microspheres for Ocular Drug Delivery: Sources, Design Strategies, and Therapeutic Applications
Available online 1 September 2026
Ocular drug delivery is constrained by anatomical barriers, continuous clearance, and compartment-specific homeostasis, which together reduce bioavailability and shorten exposure at target tissues....
Hydrogel co-delivery of 5-fluorouracil and siRNA attenuates TGF-β1-mediated MMT to prevent postoperative peritoneal metastasis and adhesion in colorectal cancer
August 2026
Cytoreductive surgery is the treatment protocol for colorectal cancer. Nonetheless, a major medical challenge remains to fully eliminate malignant tumor cells, along with a number of complications such...
A barrier-crossing and immune checkpoint-blocking antibody fusion protein for enhanced glioma-targeted immunotherapy
August 2026
With low five-year survival estimates, poor prognosis, and high recurrence probabilities, glioma is considered one of the most intractable malignant tumors. Despite the discovery of lymphatic vascular...
Artificial intelligence in pharmaceutics: Why prediction without formulation is incomplete
August 2026
Image, graphical abstract...
Carrier-free doxorubicin nanomedicine integrates chemotherapy and chemodynamic therapy to achieve anti-tumor efficacy
August 2026
Nanomedicines have been constructed to enhance the efficacy and safety of traditional anti-cancer drugs. However, the clinical translation of these nanomedicines was hindered by the complexity of carrier...
Melatonin-inspired hybrid spheroids accelerate intestinal repair via YAP-driven fetal reprogramming
August 2026
Following injury, prostaglandin E2 (PGE2) drives intestinal epithelial repair by inducing revival stem cells (RSCs), which compensate for the loss of homeostatic Lgr5+ stem cells. Using intestinal organoid...
A drug-repurposing nanotheranostic for synergistic management of resistant bacterial pneumonia
August 2026
The rising threat of antibiotic resistance severely compromises the treatment of bacterial pneumonia, underscoring the urgent need for innovative and comprehensive therapeutic strategies. Here, we developed...
Janus microneedles enabling orderly vitiligo treatment through spatiotemporal sequential promoting melanogenesis to transfer via PAR2 activation
August 2026
Vitiligo is characterized by a complex pathogenesis involving multiple factors, necessitating therapeutic strategies that simultaneously achieve immune regulation, melanocyte regeneration, and melanosome...
Engineered GLUT1-targeted STING polyproagonists: Redox-triggered activation and enhanced endosomal escape for cancer immunotherapy
August 2026
The stimulator of interferon genes (STING) pathway plays a critical role in bridging innate and adaptive antitumor immunity, representing a promising target in cancer immunotherapy. However, the clinical...
Oral probiotic delivery-based therapeutic strategies for inflammatory bowel disease
August 2026
Over the past decade, accumulating evidence supporting the efficacy of probiotics in gut microbiota modulation has spurred interest in their therapeutic potential for inflammatory bowel disease (IBD),...
Injectable dual-affinity self-assembling peptide hydrogels for local controlled delivery of therapeutic antibodies
August 2026
Therapeutic monoclonal antibodies have revolutionized the treatment of cancers, infectious diseases and immune disorders; however, their efficacy is compromised by limitations associated with systemic...
Bioactive hydrogels for bone tissue engineering: Design strategies, bioactive cargo delivery, and artificial intelligence–assisted clinical translation
August 2026
The functional reconstruction of bone defects caused by trauma, infection, surgical resection and degenerative diseases poses substantial clinical challenges. Bone tissue engineering (BTE) holds immense...
Nanomaterials: An innovative integrative paradigm for hepatocellular carcinoma adjuvant treatment
June 2026
This review systematically examines the application of nanomaterials in adjuvant therapy for hepatocellular carcinoma (HCC) following surgical resection, with the aim of synergistically inhibiting tumor...
Cascade-activatable small-molecule theranostic nanomicelles for photodynamic-immunotherapy of immune-cold lung tumors
June 2026
Lung cancer is the most frequently diagnosed malignancy worldwide and remains the leading cause of cancer-related mortality. Effective treatment of immune-cold lung tumors remains particularly challenging...
Synergistic antimicrobial nanocomposite: Protamine-loaded PVP-capped silver nanoparticles for combating multidrug-resistant infections
June 2026
The emergence of multidrug-resistant (MDR) bacterial infections has become a critical global health concern, driving the urgent need for innovative therapeutic strategies beyond conventional antibiotics....
Bispecific antibody vesicles: A multifunctional bioactive drug delivery platform for the treatment of Pseudomonas aeruginosa infection
June 2026
Pseudomonas aeruginosa (P. aeruginosa) is a major pulmonary pathogen that establishes chronic infection through Psl polysaccharide-mediated adhesion and biofilm formation, while accelerating acute disease...
Traditional Chinese medicine ingredients integrated microneedles: A promising strategy for transdermal treatment
June 2026
Traditional Chinese medicine (TCM) has abundant medicinal resources and distinctive pharmacological properties. So, TCM presents considerable promise in clinical treatments. However, challenges such...