Nanomaterials: An innovative integrative paradigm for hepatocellular carcinoma adjuvant treatment
June 2026
This review systematically examines the application of nanomaterials in adjuvant therapy for hepatocellular carcinoma (HCC) following surgical resection, with the aim of synergistically inhibiting tumor...
Photothermal-Detonated Functional Macrophage Membrane-Camouflaged Nano-Crackers Induce Tumor Cell Wandering-Anoikis
Available online 4 June 2026
Cancer-associated fibroblasts (CAFs) are the primary source of collagen I, which contributes to the formation of a dense tumor extracellular matrix (ECM). Non-selective targeting of collagen I through...
Red Ginseng-Derived Nanovesicles to Modulate Osteoblast and Osteoclastogenesis for Osteoporosis Therapy
Available online 1 June 2026
Osteoporosis is a skeletal disorder characterized by an imbalance between bone formation and resorption, which leads to progressive bone loss and increased fracture risk. While current treatments either...
Chimeric biohybrid nanovesicles induce immunogenic cell death for targeted and immune-potentiated glioblastoma therapy
Available online 30 May 2026
Glioblastoma (GBM) is shielded by both the blood-brain barrier (BBB) and an immunosuppressive tumor microenvironment. Here, we develop a chimeric biohybrid nanovesicle (BEV-RVG29-PTX) that integrates...
Hydrogel Co-delivery of 5-Fluorouracil and siRNA Attenuates TGF-β1-Mediated MMT to Prevent Postoperative Peritoneal Metastasis and Adhesion in Colorectal Cancer
Available online 30 May 2026
Cytoreductive surgery is the treatment protocol for colorectal cancer. Nonetheless, a major medical challenge remains to fully eliminate malignant tumor cells, along with a number of complications such...
Scavenger receptor–mediated lung-targeted delivery of anti-miR-155 oligoDNA nanomicelles with curcumin for acute lung injury therapy
Available online 29 May 2026
Antisense oligonucleotides offer a powerful strategy for suppressing pro-inflammatory microRNAs, but efficient long-term delivery after systemic administration remains challenging. In this study, we...
Mesoporous Polydopamine Nanoplatform Enhances IL-2 immunotherapy for Hepatocellular Carcinoma via Mild Photothermal Therapy and Lactate Regulation
Available online 27 May 2026
Hepatocellular carcinoma (HCC) is commonly diagnosed at intermediate or advanced stages. While transcatheter arterial embolization (TAE) is the accepted locoregional therapy, embolization inevitably...
Unraveling the complex role of intestinal microbiota in drug permeability: Insights from N-Acetylcysteine
Available online 22 May 2026
Traditional Chinese medicine ingredients integrated microneedles: A promising strategy for transdermal treatment
Available online 20 May 2026
Traditional Chinese medicine (TCM) has abundant medicinal resources and distinctive pharmacological properties. So, TCM presents considerable promise in clinical treatments. However, challenges such...
Bispecific antibody vesicles: a multifunctional bioactive drug delivery platform for the treatment of Pseudomonas aeruginosa infection
Available online 17 May 2026
Pseudomonas aeruginosa (P. aeruginosa) is a major pulmonary pathogen that establishes chronic infection through Psl polysaccharide-mediated adhesion and biofilm formation, while accelerating acute disease...
Synergistic Antimicrobial Nanocomposite: Protamine-Loaded PVP-Capped Silver Nanoparticles for Combating Multidrug-Resistant Infections
Available online 7 May 2026
The emergence of multidrug-resistant (MDR) bacterial infections has become a critical global health concern, driving the urgent need for innovative therapeutic strategies beyond conventional antibiotics....
Microneedle technology in the treatment of ocular diseases: Advances and applications
April 2026
Microneedle (MN) technology has emerged as a transformative approach for treating ocular diseases, addressing the limitations of conventional drug delivery methods such as low bioavailability and poor...
Nose-to-brain delivery of donepezil within a small dose improves bioavailability and efficacy for Alzheimer’s disease treatment
April 2026
Oral administration of donepezil (Don) is the first-line medication for Alzheimer’s disease (AD); however, the dysphagia of elderly patients and severe gastrointestinal side effects substantially restrict...
An exosome-inspired docetaxel prodrug nanoplatform for potent STING activation and synergistic chemoimmunotherapy
April 2026
The treatment of triple-negative breast cancer (TNBC) is significantly hampered by its immunosuppressive tumor microenvironment and limited T-cell infiltration. Activating the STING pathway presents...
ACQ-FRET dual-functional near-infrared fluorescent probes for the bioimaging of nanocarriers
April 2026
Förster resonance energy transfer (FRET) and aggregation-caused quenching (ACQ) are well-established mechanisms with promising potential to eliminate interference from free probes in studies of in vivo...
Advances in nanotechnology for the diagnosis and management of autoimmune diseases
April 2026
Autoimmune diseases (AIDs) are chronic, heterogeneous disorders that are often diagnosed after irreversible tissue damage and treated with broad immunosuppression that fails to deliver durable remission....
Dual-functional self-assembled nanosystems with enhanced protease resistance: Promoting bacterial aggregation and immune activation for multidrug-resistant bacterial infection
April 2026
Multidrug-resistant bacterial infections are increasing globally and posing a greater threat to human health. The application of direct bactericidal agents can induce secondary infections and treatment...
Molecular origin, discovery, validation and application of neoantigens
April 2026
Neoantigens, tumor-specific peptides originating from somatic mutations, are pivotal targets for personalized cancer immunotherapy. This review synthesizes current neoantigen research, encompassing...
MMP-9-responsive contact lens facilitating disease-adaptive and safer dexamethasone delivery for corneal neovascularization therapy
April 2026
Corneal neovascularization (CNV), an inflammation-driven pathological process responsible for irreversible vision loss, remains an urgent unmet challenge in ophthalmic medicine. Current interventions—ranging...
Controlled release of berberine modulates the wound microbiome to accelerate wound healing
April 2026
The wound microbiome has been shown to play a significant role in influencing the wound healing process. Coptis chinensis, a traditional Chinese medicine (TCM) known for its heat-clearing properties,...
Targeted delivery of glucocerebrosidase to lysosomes: The LYSOTAC (LYSOsome-TArgeting Chimera) technology
April 2026
Lysosomal storage diseases (LSDs) are a group of inherited metabolic disorders caused by misfolding of lysosomal proteins and their degradation via endoplasmic reticulum-associated degradation (ERAD)....
A programmable nanoreactor for photothermal immunotherapy via NIR-II triggered enzyme-catalyzed immunogenic tumor microenvironment remodeling
April 2026
The complicated and immunosuppressive tumor microenvironment usually obstruct the efficiencies of various therapeutic schedules including immunotherapy. Here, we report a programmable polymer-based...
Cascade-Activatable Small-Molecule Theranostic Nanomicelles for Photodynamic-Immunotherapy of Immune-Cold Lung Tumors
Available online 29 April 2026
Lung cancer is the most frequently diagnosed malignancy worldwide and remains the leading cause of cancer-related mortality. Effective treatment of immune-cold lung tumors remains particularly challenging...
From bench to bedside: Unveiling the background and benefits of nanovaccines tested in clinics
February 2026
Despite the growing body of literature on nanovaccines, focused analyses of platforms tested in and undergoing clinical investigation remain limited. This review addresses this gap by critically examining...