Advances in the development of amorphous solid dispersions: The role of polymeric carriers
July 2023
Amorphous solid dispersion (ASD) is one of the most effective approaches for delivering poorly soluble drugs. In ASDs, polymeric materials serve as the carriers in which the drugs are dispersed at the...
A review on phospholipids and their main applications in drug delivery systems
April 2015
Phospholipids have the characteristics of excellent biocompatibility and a especial amphiphilicity. These unique properties make phospholipids most appropriate to be employed as important pharmaceutical...
CRISPR/Cas9 systems: Delivery technologies and biomedical applications
November 2023
The emergence of the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) genome-editing system has brought about a significant revolution in the realm...
Development of 3D bioprinting: From printing methods to biomedical applications
September 2020
Biomanufacturing of tissues/organs in vitro is our big dream, driven by two needs: organ transplantation and accurate tissue models. Over the last decades, 3D bioprinting has been widely applied in...
Extrusion–spheronization a promising pelletization technique: In-depth review
December 2016
First, different steps such as granulation, extrusion, spheronization and drying of the extrusion–spheronization process are mentioned. Then the parameters that can influence the pellet quality which...
Advances in molecular glue degraders for targeted protein degradation: Focus on NEK7, WEE1, CDK2, GSPT1 and VAV1
February 2026
Molecular glues (MGs), a class of small-molecule degraders, exhibit drug-like properties that generally conform to Lipinski's rule of five, while uniquely mediating the stabilization or induction of...
Film forming systems for topical and transdermal drug delivery
November 2017
After application of the film forming system to the skin, the composition of the film forming system changes significantly due to the loss of the volatile components of the vehicle which results in...
A practical guide to pharmaceutical polymorph screening & selection
August 2014
Prevalence and importance of polymorphism occurring in pharmaceutical compounds are well recognized. It is of great importance to prepare and select the right form from the beginning during drug discovery...
Pharmaceutical particle technologies: An approach to improve drug solubility, dissolution and bioavailability
December 2014
Pharmaceutical particle technology is employed to improve poor aqueous solubility of drug compounds that limits in vivo bioavailability owing to their low dissolution rate in the gastrointestinal fluids...
Alginate and alginate composites for biomedical applications
May 2021
Alginate is an edible heteropolysaccharide that abundantly available in the brown seaweed and the capsule of bacteria such as Azotobacter sp. and Pseudomonas sp. Owing to alginate gel forming capability,...
Plant-derived exosome-like nanoparticles and their therapeutic activities
January 2022
Nanotechnologies have been successfully applied to the treatment of various diseases. Plant-derived exosome-like nanoparticles (PENs) are expected to become effective therapeutic modalities for treating...
Overview of milling techniques for improving the solubility of poorly water-soluble drugs
July 2015
Milling involves the application of mechanical energy to physically break down coarse particles to finer ones and is regarded as a “top–down” approach in the production of fine particles. Fine drug...
Targeted delivery of glucocerebrosidase to lysosomes: The LYSOTAC (LYSOsome-TArgeting Chimera) technology
April 2026
Lysosomal storage diseases (LSDs) are a group of inherited metabolic disorders caused by misfolding of lysosomal proteins and their degradation via endoplasmic reticulum-associated degradation (ERAD)....
Ginseng-derived exosome-like nanovesicles protect against liver fibrosis by regulating TIMP2 pathways and gut dysbiosis
December 2025
Metabolic dysfunction-associated fatty liver disease (MASLD) and alcohol-associated liver disease (ALD) are prevalent chronic liver diseases that can progress to steatohepatitis, fibrosis, cirrhosis,...
Integrating CRISPR/Cas technology with clinical trials: Principles, progress and challenges
December 2025
CRISPR represent a groundbreaking genome-editing technology that has revolutionized genetic modification. This innovative tool offers an unparalleled revolution in the future treatment of genetic disorders,...
The evolution of lipid nanoparticles: Paving the way for next-generation nucleic acid medicines
February 2026
Nucleic acid-based therapies have emerged as promising strategies for the regulation of gene expression and the production of therapeutic antigens or proteins for a series of diseases, including cancers,...
Advances in nano-delivery systems for overcoming the challenges of applying siRNA drugs in tumor therapy
February 2026
Tumors pose a serious threat to human life and health. In recent years, gene therapy against tumors has garnered considerable attention. Small interfering RNAs (siRNAs), an important class of nucleic...
Gastro-retentive drug delivery systems and their in vivo success: A recent update
October 2016
Gastro-retentive drug delivery system (GRDDS) has gained immense popularity in the field of oral drug delivery recently. It is a widely employed approach to retain the dosage form in the stomach for...
Sprinkle formulations—A review of commercially available products
May 2020
Currently, sixty-five original sprinkle drug products are available in various dosage forms including tablets, powders, granules, immediate-release capsules, extended-release capsules, delayed-release...
From bench to bedside: Unveiling the background and benefits of nanovaccines tested in clinics
February 2026
Despite the growing body of literature on nanovaccines, focused analyses of platforms tested in and undergoing clinical investigation remain limited. This review addresses this gap by critically examining...
Antibacterial biomaterials for skin wound dressing
May 2022
Bacterial infection and the ever-increasing bacterial resistance have imposed severe threat to human health. And bacterial contamination could significantly menace the wound healing process. Considering...
Microneedle technology in the treatment of ocular diseases: Advances and applications
April 2026
Microneedle (MN) technology has emerged as a transformative approach for treating ocular diseases, addressing the limitations of conventional drug delivery methods such as low bioavailability and poor...