Oral probiotic delivery-based therapeutic strategies for inflammatory bowel disease
August 2026
Over the past decade, accumulating evidence supporting the efficacy of probiotics in gut microbiota modulation has spurred interest in their therapeutic potential for inflammatory bowel disease (IBD),...
Extrusion–spheronization a promising pelletization technique: In-depth review
December 2016
First, different steps such as granulation, extrusion, spheronization and drying of the extrusion–spheronization process are mentioned. Then the parameters that can influence the pellet quality which...
Advances in the development of amorphous solid dispersions: The role of polymeric carriers
July 2023
Amorphous solid dispersion (ASD) is one of the most effective approaches for delivering poorly soluble drugs. In ASDs, polymeric materials serve as the carriers in which the drugs are dispersed at the...
Melatonin-inspired hybrid spheroids accelerate intestinal repair via YAP-driven fetal reprogramming
August 2026
Following injury, prostaglandin E2 (PGE2) drives intestinal epithelial repair by inducing revival stem cells (RSCs), which compensate for the loss of homeostatic Lgr5+ stem cells. Using intestinal organoid...
Film forming systems for topical and transdermal drug delivery
November 2017
After application of the film forming system to the skin, the composition of the film forming system changes significantly due to the loss of the volatile components of the vehicle which results in...
Development of 3D bioprinting: From printing methods to biomedical applications
September 2020
Biomanufacturing of tissues/organs in vitro is our big dream, driven by two needs: organ transplantation and accurate tissue models. Over the last decades, 3D bioprinting has been widely applied in...
A review on phospholipids and their main applications in drug delivery systems
April 2015
Phospholipids have the characteristics of excellent biocompatibility and a especial amphiphilicity. These unique properties make phospholipids most appropriate to be employed as important pharmaceutical...
Red ginseng-derived nanovesicles to modulate osteoblast and osteoclastogenesis for osteoporosis therapy
June 2026
Osteoporosis is a skeletal disorder characterized by an imbalance between bone formation and resorption, which leads to progressive bone loss and increased fracture risk. While current treatments either...
A practical guide to pharmaceutical polymorph screening & selection
August 2014
Prevalence and importance of polymorphism occurring in pharmaceutical compounds are well recognized. It is of great importance to prepare and select the right form from the beginning during drug discovery...
Gastro-retentive drug delivery systems and their in vivo success: A recent update
October 2016
Gastro-retentive drug delivery system (GRDDS) has gained immense popularity in the field of oral drug delivery recently. It is a widely employed approach to retain the dosage form in the stomach for...
A drug-repurposing nanotheranostic for synergistic management of resistant bacterial pneumonia
August 2026
The rising threat of antibiotic resistance severely compromises the treatment of bacterial pneumonia, underscoring the urgent need for innovative and comprehensive therapeutic strategies. Here, we developed...
Pharmaceutical particle technologies: An approach to improve drug solubility, dissolution and bioavailability
December 2014
Pharmaceutical particle technology is employed to improve poor aqueous solubility of drug compounds that limits in vivo bioavailability owing to their low dissolution rate in the gastrointestinal fluids...
CRISPR/Cas9 systems: Delivery technologies and biomedical applications
November 2023
The emergence of the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) genome-editing system has brought about a significant revolution in the realm...
Plant-derived exosome-like nanoparticles and their therapeutic activities
January 2022
Nanotechnologies have been successfully applied to the treatment of various diseases. Plant-derived exosome-like nanoparticles (PENs) are expected to become effective therapeutic modalities for treating...
Phyto-phospholipid complexes (phytosomes): A novel strategy to improve the bioavailability of active constituents
May 2019
Although active constituents extracted from plants show robust in vitro pharmacological effects, low in vivo absorption greatly limits the widespread application of these compounds. A strategy of using...
Advances in molecular glue degraders for targeted protein degradation: Focus on NEK7, WEE1, CDK2, GSPT1 and VAV1
February 2026
Molecular glues (MGs), a class of small-molecule degraders, exhibit drug-like properties that generally conform to Lipinski's rule of five, while uniquely mediating the stabilization or induction of...
Janus microneedles enabling orderly vitiligo treatment through spatiotemporal sequential promoting melanogenesis to transfer via PAR2 activation
August 2026
Vitiligo is characterized by a complex pathogenesis involving multiple factors, necessitating therapeutic strategies that simultaneously achieve immune regulation, melanocyte regeneration, and melanosome...
Ginseng-derived exosome-like nanovesicles protect against liver fibrosis by regulating TIMP2 pathways and gut dysbiosis
December 2025
Metabolic dysfunction-associated fatty liver disease (MASLD) and alcohol-associated liver disease (ALD) are prevalent chronic liver diseases that can progress to steatohepatitis, fibrosis, cirrhosis,...
The evolution of lipid nanoparticles: Paving the way for next-generation nucleic acid medicines
February 2026
Nucleic acid-based therapies have emerged as promising strategies for the regulation of gene expression and the production of therapeutic antigens or proteins for a series of diseases, including cancers,...
Hair follicle-targeting drug delivery strategies for the management of hair follicle-associated disorders
May 2022
The hair follicle is not only a critical penetration route in percutaneous absorption but also has been recognized to be a target for hair follicle-associated disorders, such as androgenetic alopecia...
Traditional Chinese medicine ingredients integrated microneedles: A promising strategy for transdermal treatment
June 2026
Traditional Chinese medicine (TCM) has abundant medicinal resources and distinctive pharmacological properties. So, TCM presents considerable promise in clinical treatments. However, challenges such...
Alginate and alginate composites for biomedical applications
May 2021
Alginate is an edible heteropolysaccharide that abundantly available in the brown seaweed and the capsule of bacteria such as Azotobacter sp. and Pseudomonas sp. Owing to alginate gel forming capability,...
Nanomaterials: An innovative integrative paradigm for hepatocellular carcinoma adjuvant treatment
June 2026
This review systematically examines the application of nanomaterials in adjuvant therapy for hepatocellular carcinoma (HCC) following surgical resection, with the aim of synergistically inhibiting tumor...