Controlled release of berberine modulates the wound microbiome to accelerate wound healing
Available online 12 March 2026
The wound microbiome has been shown to play a significant role in influencing the wound healing process. Coptis chinensis, a Traditional Chinese Medicine (TCM) known for its heat-clearing properties,...
MMP-9-responsive contact lens facilitating disease-adaptive and safer dexamethasone delivery for corneal neovascularization therapy
Available online 7 March 2026
Corneal neovascularization (CNV), an inflammation-driven pathological process responsible for irreversible vision loss, remains an urgent unmet challenge in ophthalmic medicine. Current interventions—ranging...
Dual-functional Self-assembled Nanosystems with Enhanced Protease Resistance: Promoting Bacterial Aggregation and Immune Activation for Multidrug-resistant Bacterial Infection
Available online 3 March 2026
Multidrug-resistant bacterial infections are increasing globally and posing a greater threat to human health. The application of direct bactericidal agents can induce secondary infections and treatment...
Molecular Origin, Discovery, Validation and Application of Neoantigens
Available online 3 March 2026
Neoantigens, tumor-specific peptides originating from somatic mutations, are pivotal targets for personalized cancer immunotherapy. This review synthesizes current neoantigen research, encompassing...
Advances in nanotechnology for the diagnosis and management of autoimmune diseases
Available online 1 March 2026
Autoimmune diseases (AIDs) are chronic, heterogeneous disorders that are often diagnosed after irreversible tissue damage and treated with broad immunosuppression that fails to deliver durable remission....
From bench to bedside: Unveiling the background and benefits of nanovaccines tested in clinics
February 2026
Despite the growing body of literature on nanovaccines, focused analyses of platforms tested in and undergoing clinical investigation remain limited. This review addresses this gap by critically examining...
Bacterial biosurfactant-reinforced chitooligosaccharide/polyvinyl alcohol hydrogels accelerate methicillin-resistant Staphylococcus aureus-infected wound healing by attenuating its virulence factors
February 2026
Methicillin-resistant Staphylococcus aureus (MRSA) causes widespread infections and poses serious public health concerns. Its high level of resistance to multiple antibiotics has garnered growing interest...
A novel mRNA nanovaccine with dual immunoregulation ameliorates rheumatoid arthritis and associated pneumonia
February 2026
Rheumatoid arthritis (RA) as a systemic autoimmune disease, frequently triggers various extra-articular symptoms, particularly the RA-associated pneumonia. Unfortunately, the RA-associated pneumonia...
Porous Baicalin-Fe(III) ICP@Propofol nanocomposites for enhanced anesthetic efficacy and reduced toxicity via neuroprotection and ultrasound assistance
February 2026
To enhance the anesthetic efficacy of propofol while mitigating its systemic toxicity and irreversible developmental neurotoxicity, we developed a strategy leveraging the neuroprotective effects of...
Inhalable stem cell-derived artificial nanovesicles for targeted siRNA delivery to effectively alleviate asthma symptoms
February 2026
Asthma, one of the most prevalent chronic inflammatory diseases, remains challenging to manage effectively. Current therapies commonly alleviate symptoms through broad immunosuppression and bronchodilation...
High-dose treatment of cathepsin B-activatable doxorubicin prodrug nanoparticles that induce tumor-specific immunogenic cell death for immunotherapy of melanoma with minimal systemic toxicity
February 2026
Highly potent chemotherapy provides rapid therapeutic efficacy in melanoma, but is often limited by drug resistance, off-target toxicity, and systemic toxicity. Combination therapy with chemotherapy...
Advances in nano-delivery systems for overcoming the challenges of applying siRNA drugs in tumor therapy
February 2026
Tumors pose a serious threat to human life and health. In recent years, gene therapy against tumors has garnered considerable attention. Small interfering RNAs (siRNAs), an important class of nucleic...
Carrier-free reduction-responsive self-assembling paclitaxel dimer nanoprodrug synergizing with celastrol for enhanced chemoimmunotherapy
February 2026
Chemotherapeutic paclitaxel (PTX) formulations are widely used in clinical cancer treatment; however, they are also associated with concomitant programmed death-ligand (PD-L1) upregulation and an immunosuppressive...
In vivo self-assembled siRNAs targeting VEGFR2 and mTOR for renal cell carcinoma treatment
February 2026
Renal cell carcinoma (RCC) is a challenging urologic malignancy characterized by its aggressive nature, including invasion, metastasis, and treatment resistance. To explore multi-targeted therapies,...
The evolution of lipid nanoparticles: Paving the way for next-generation nucleic acid medicines
February 2026
Nucleic acid-based therapies have emerged as promising strategies for the regulation of gene expression and the production of therapeutic antigens or proteins for a series of diseases, including cancers,...
Advances in molecular glue degraders for targeted protein degradation: Focus on NEK7, WEE1, CDK2, GSPT1 and VAV1
February 2026
Molecular glues (MGs), a class of small-molecule degraders, exhibit drug-like properties that generally conform to Lipinski's rule of five, while uniquely mediating the stabilization or induction of...
Freezing shock monocytes deliver antisense oligonucleotides via liposomes for the treatment of idiopathic pulmonary fibrosis
February 2026
Connective tissue growth factor (CTGF) is a key driver in the pathogenesis of idiopathic pulmonary fibrosis (IPF). This study presents a groundbreaking supramolecular cryo-shock bone marrow mononuclear...
Targeting macrophages in OA nanomedicine: Therapeutic opportunity or delivery delusion? A pragmatic reappraisal
February 2026
ACQ-FRET dual-functional near-infrared fluorescent probes for the bioimaging of nanocarriers
Available online 28 February 2026
Förster resonance energy transfer (FRET) and aggregation-caused quenching (ACQ) are well-established mechanisms with promising potential to eliminate interference from free probes in studies of in vivo...
An Exosome-Inspired Docetaxel Prodrug Nanoplatform for Potent STING Activation and Synergistic Chemoimmunotherapy
Available online 27 February 2026
The treatment of triple-negative breast cancer (TNBC) is significantly hampered by its immunosuppressive tumor microenvironment and limited T-cell infiltration. Activating the STING pathway presents...
Nose-to-brain delivery of donepezil within a small dose improves bioavailability and efficacy for Alzheimer’s disease treatment
Available online 13 February 2026
Oral administration of donepezil (Don) is the first-line medication for Alzheimer’s disease (AD); however, the dysphagia of elderly patients and severe gastrointestinal side effects substantially restrict...
Microneedle Technology in the Treatment of Ocular Diseases: Advances and Applications
Available online 31 January 2026
Microneedle (MN) technology has emerged as a transformative approach for treating ocular diseases, addressing the limitations of conventional drug delivery methods such as low bioavailability and poor...
Microneedle Vaccine Printer Enables Decentralized and Thermostable mRNA Vaccine Delivery
Available online 10 January 2026
Integrating CRISPR/Cas technology with clinical trials: Principles, progress and challenges
December 2025
CRISPR represent a groundbreaking genome-editing technology that has revolutionized genetic modification. This innovative tool offers an unparalleled revolution in the future treatment of genetic disorders,...
Exploring the frontier of oral nanomedicine in colorectal cancer therapy: Folate-targeted 5FU-Nisin-Selenium conjugates and probiotic-rich diets as a novel approach
December 2025
This study aimed to assess the therapeutic potential of nisin, 5-fluorouracil (5FU) and selenium encapsulated in folate-conjugated thiolated chitosan nanoparticles (N/5FU/Se@FTCsNPs), combined with...