Targeting Macrophages in OA Nanomedicine: Therapeutic Opportunity or Delivery Delusion? A Pragmatic Reappraisal
Available online 29 January 2026
Freezing shock monocytes deliver antisense oligonucleotides via liposomes for the treatment of idiopathic pulmonary fibrosis.
Available online 24 January 2026
Connective tissue growth factor (CTGF) is a key driver in the pathogenesis of idiopathic pulmonary fibrosis (IPF). This study presents a groundbreaking supramolecular cryo-shock bone marrow mononuclear...
Advances in Molecular Glue Degraders for Targeted Protein Degradation: Focus on NEK7, WEE1, CDK2, GSPT1 and VAV1
Available online 22 January 2026
Molecular glues (MGs), a class of small-molecule degraders, exhibit drug-like properties that generally conform to Lipinski's rule of five, while uniquely mediating the stabilization or induction of...
The Evolution of Lipid Nanoparticles: Paving the Way for Next-Generation Nucleic Acid Medicines
Available online 21 January 2026
Nucleic acid-based therapies have emerged as promising strategies for the regulation of gene expression and the production of therapeutic antigens or proteins for a series of diseases, including cancers,...
Carrier-free Reduction-responsive Self-assembling Paclitaxel Dimer Nanoprodrug Synergising with Celastrol for Enhanced Chemoimmunotherapy
Available online 20 January 2026
Chemotherapeutic paclitaxel (PTX) formulations are widely used in clinical cancer treatment; however, they are also associated with concomitant programmed death-ligand (PD-L1) upregulation and an immunosuppressive...
In vivo self-assembled siRNAs targeting VEGFR2 and mTOR for renal cell carcinoma treatment
Available online 20 January 2026
Renal cell carcinoma (RCC) is a challenging urologic malignancy characterized by its aggressive nature, including invasion, metastasis, and treatment resistance. To explore multi-targeted therapies,...
Advances in nano-delivery systems for overcoming the challenges of applying siRNA drugs in tumor therapy
Available online 14 January 2026
Tumors pose a serious threat to human life and health. In recent years, gene therapy against tumors has garnered considerable attention. Small interfering RNAs (siRNAs), an important class of nucleic...
High-Dose Treatment of Cathepsin B-Activatable Doxorubicin Prodrug Nanoparticles That Induce Tumor-specific Immunogenic Cell Death for Immunotherapy of Melanoma with Minimal Systemic Toxicity
Available online 13 January 2026
Highly potent chemotherapy provides rapid therapeutic efficacy in melanoma, but is often limited by drug resistance, off-target toxicity, and systemic toxicity. Combination therapy with chemotherapy...
Inhalable stem cell-derived artificial nanovesicles for targeted siRNA delivery to effectively alleviate asthma symptoms
Available online 12 January 2026
Asthma, one of the most prevalent chronic inflammatory diseases, remains challenging to manage effectively. Current therapies commonly alleviate symptoms through broad immunosuppression and bronchodilation...
Porous Baicalin-Fe(III) ICP@Propofol Nanocomposites for Enhanced Anesthetic Efficacy and Reduced Toxicity via Neuroprotection and Ultrasound Assistance
Available online 11 January 2026
To enhance the anesthetic efficacy of propofol while mitigating its systemic toxicity and irreversible developmental neurotoxicity, we developed a strategy leveraging the neuroprotective effects of...
Microneedle Vaccine Printer Enables Decentralized and Thermostable mRNA Vaccine Delivery
Available online 10 January 2026
Bacterial biosurfactant-reinforced chitooligosaccharide/polyvinyl alcohol hydrogels accelerate methicillin-resistant Staphylococcus aureus-infected wound healing by attenuating its virulence factors
Available online 10 January 2026
Methicillin-resistant Staphylococcus aureus (MRSA) causes widespread infections and poses serious public health concerns. Its high level of resistance to multiple antibiotics has garnered growing interest...
A novel mRNA nanovaccine with dual immunoregulation ameliorates rheumatoid arthritis and associated pneumonia
Available online 10 January 2026
Rheumatoid arthritis (RA) as a systemic autoimmune disease, frequently triggers various extra-articular symptoms, particularly the RA-associated pneumonia. Unfortunately, the RA-associated pneumonia...
From bench to bedside: Unveiling the background and benefits of nanovaccines tested in clinics
Available online 9 January 2026
Despite the growing body of literature on nanovaccines, focused analyses of platforms tested in and undergoing clinical investigation remain limited. This review addresses this gap by critically examining...
Integrating CRISPR/Cas technology with clinical trials: Principles, progress and challenges
December 2025
CRISPR represent a groundbreaking genome-editing technology that has revolutionized genetic modification. This innovative tool offers an unparalleled revolution in the future treatment of genetic disorders,...
Exploring the frontier of oral nanomedicine in colorectal cancer therapy: Folate-targeted 5FU-Nisin-Selenium conjugates and probiotic-rich diets as a novel approach
December 2025
This study aimed to assess the therapeutic potential of nisin, 5-fluorouracil (5FU) and selenium encapsulated in folate-conjugated thiolated chitosan nanoparticles (N/5FU/Se@FTCsNPs), combined with...
Development and preclinical evaluation of a novel FGFR3-targeted antibody-drug conjugate in bladder cancer
December 2025
Given the critical shortage of antibody-drug conjugates (ADCs) for bladder cancer (BCa), we developed a novel FGFR3-targeted ADC, LZU-WZLYFG001, composed of a humanized anti-FGFR3 IgG1 monoclonal antibody,...
The strategies and advances of mRNA translation booster
December 2025
The therapeutic efficacy and safety of mRNA-based drugs in immunological and nonimmunological applications are critically dependent on the translated protein yield, which requires precise modulation...
Ginseng-derived exosome-like nanovesicles protect against liver fibrosis by regulating TIMP2 pathways and gut dysbiosis
December 2025
Metabolic dysfunction-associated fatty liver disease (MASLD) and alcohol-associated liver disease (ALD) are prevalent chronic liver diseases that can progress to steatohepatitis, fibrosis, cirrhosis,...
Critical quality attributes of lipid nanoparticles and in vivo fate
December 2025
Lipid nanoparticles (LNPs) have emerged as versatile carriers for the delivery of genetic medicines and small-molecule drugs, offering desired benefits for therapeutic applications. Optimization of...
Artificial polysaccharide-binding protein mediates co-assembly of nanodrug and probiotics against drug-resistant infectious enteritis
December 2025
Intestinal drug-resistant pathogens, e.g., Salmonella enterica subsp. enterica serovar Typhimurium (S. Tm) and enteropathogenic Escherichia coli (E. coli), frequently cause life-threatening infectious...
A ROS/photo dual-responsive prodrug unimolecular micelle for boosted cancer immunotherapy
December 2025
Integrating photodynamic therapy (PDT) with immunosuppression reversal represents a promising synergistic approach to boost cancer immunotherapy. However, the complicated components and cumbersome preparation...
Hypoxia-responsive hybrid nanoparticles loaded with fingolimod and colistin against multidrug-resistant Klebsiella pneumoniae with mature biofilm
December 2025
Multidrug-resistant Klebsiella pneumoniae (MDR-KP) is characterized by high mortality and risk of nosocomial transmission, and biofilm constitutes the primary challenge in the treatment of its implant-associated...
Magnetic continuum soft robot-driven precise delivery of prodrug nanoassemblies for gastric cancer chemo-immunotherapy
December 2025
Local precise drug delivery is conducive to improving therapeutic efficacy and minimizing off-target toxicity. Current local delivery approaches are focused mostly on superficial or postoperative tumor...
Biomaterials-mediated sequential drug delivery: Emerging trends for wound healing
December 2025
Wound healing is a series of complex biological events that are tightly coordinated by the body. However, this physiological process is compromised in a pathological setting and underlie conditions...