Gαi1 activation induced by short-term hypoxia promotes epidermal cell migration in wound healing through the Akt-mTOR pathway
June 2025
Hypoxia is commonly observed in the wound microenvironment; however, the specific mechanism by which it affects epidermal cell migration remains unclear. This study aimed to examine the impact of hypoxia...
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Superparamagnetic hydrogels: Precision-driven platforms for biomedicine, robotics, and environmental remediation
June 2025
Hydrogels are widely recognized for their biocompatibility and structural adaptability in regenerative medicine and three-dimensional (3D) bioprinting, yet their inherent static nature fundamentally...
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A noninvasive accelerated quantitative MR technique to distinguish drug resistance in prolactinomas: Early results
June 2025
Management of dopamine agonist (DA) resistance in prolactinoma (PRLoma) remains challenging due to the lack of detecting approach and reliable imaging marker. In this cross-sectional study, PRLoma patients...
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A comprehensive review of cancer drug nanoparticles synthesis, processing technology and its effect in drug delivery
June 2025
The advent of nanotechnology has significantly advanced cancer treatment by introducing innovative approaches to targeted drug delivery and enhanced therapeutic efficiency. Nano drugs and nanocarriers,...
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Integrated bioinformatics analysis and machine learning approach for the identification of immune-related genes in the diagnosis of aortic valve calcification with periodontitis
June 2025
Aortic valve calcification (AVC) represents a progressive, age-associated disorder characterized by substantial mortality, yet effective early diagnostic markers for AVC complicated by periodontitis,...
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Antibacterial hydrogels for bacteria-infected wound treatment
March 2025
Bacteria-infected wounds are enormous clinical obstacles and cause huge burdens to patients and society. Recently, many biomaterials are designed to treat bacterial infected wounds. Among various biomaterials,...
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Biomaterial-based circular RNA therapeutic strategy for repairing intervertebral disc degeneration
March 2025
Intervertebral disc degeneration (IDD) is the leading cause of low-back pain, which brings huge threaten to patients' life and workability. However, IDD's pathophysiology is still a puzzle, thus conventional...
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Developing biotechnologies in organoids for liver cancer
March 2025
Organoids, three-dimensional cellular constructs, have revolutionized in vitro culture by replicating the histological and physiological functions of organs, offering a model that closely mimics physiological...
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Space manufacturing of a bone tissue destined for patients on Earth?
March 2025
Space exploration is perhaps one of the most difficult tasks ever undertaken since the emergence of humankind. The International Space Station is a unique platform for advanced technology research that...
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Embracing the future: The application of regenerative biomaterials in the spinal disorders
March 2025
Spinal disorders, particularly disc degeneration, vertebral fractures, and loss of spinal stability, have become a major health problem affecting quality of life worldwide. Although conventional treatments...
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Virus-inspired biogenic delivery system for advancing cancer therapy
March 2025
Virus-inspired particles have been utilized in various applications, including vaccination, gene therapy, drug therapy, and diagnostics. Biogenic delivery systems imitating the natural structure of...
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Progress of metal-organic frameworks in improving the effect of sonodynamic therapy
March 2025
Sonodynamic therapy (SDT) is a new non-invasive and precise tumor treatment method, which is a promising anticancer treatment and is becoming a cutting-edge interdisciplinary research field. Based on...
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Breathable functional aerogel dressings facilitate the healing of diabetic wounds
March 2025
Due to the complexity of the microenvironment and healing process of diabetic wounds, developing wound dressings that offer good biocompatibility, breathability, and promote vascular regeneration is...
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Publisher's note
March 2025
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Comparative exploration of deep convolutional neural networks using real-time endoscopy images
December 2024
Until now various deep convolutional neural networks are designed and trained for the purpose of classifying different medical conditions related to the domain of gastroenterology. Most of the study...
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Biomaterials that passively and actively target macrophages promote the regeneration of injured tissues
December 2024
Modulation of the immune system has gained significant attention in regenerative medicine. Although most tissues possess intrinsic self-repair capabilities, large-sized defects and complex pathological...
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HFF-Net: A hybrid convolutional neural network for diabetic retinopathy screening and grading
December 2024
Diabetic Retinopathy (DR) is a leading cause of vision loss among diabetic patients, necessitating effective screening and grading for timely intervention. Regular screening significantly increases...
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Electrospinning drug-loaded polycaprolactone/polycaprolactone-gelatin multi-functional bilayer nanofibers composite scaffold for postoperative wound healing of cutaneous squamous cell carcinoma
December 2024
Cutaneous squamous cell carcinoma (cSCC) tumor resection surgery poses challenges due to incomplete cancer cell removal, which increases the risk of local recurrence and micrometastasis, while large-scale...
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D2 receptor antagonist raclopride regulates glutamatergic neuronal activity in the pedunculopontine nucleus in a rat model of Parkinson's disease
December 2024
Parkinson disease (PD) is defined by the loss of dopamine (DA). Changes in the pedunculopontine nucleus (PPN), particularly in local field potential (LFP), can be attributed to deficits in DA and DA...
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HMS-TENet: A hierarchical multi-scale topological enhanced network based on EEG and EOG for driver vigilance estimation
December 2024
Driving vigilance estimation is an important task for traffic safety. Nowadays, electroencephalography (EEG) and electrooculography (EOG) have made some achievements in vigilance estimation, but there...
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Ordered micro-nano structured biomaterials for wound healing
December 2024
The complexity of wound healing, influenced by both external factors and internal pathological mechanisms, presents a significant challenge in clinical treatment. However, strategically designed micro-nano...
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Proteomic insights into myopia development: Differential protein expression and the role of calcium signaling in form deprivation myopia in Guinea pigs
September 2024
This study aims to explore the changes in the vitreous proteomics of form deprivation myopia (FDM) in guinea pigs, in order to reveal the molecular mechanisms involved in the onset and development of...
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The therapeutic efficacy of post-symptom 3,4-diaminopyridine treatment in cosmetic injection-induced botulism using a novel animal model
September 2024
In recent years, the incidence of cosmetic injection-induced botulism has remarkably increased due to the frequent usage of botulinum neurotoxin type A (BoNT/A). To mimic and investigate this new clinical...
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Biomaterials for cardiovascular diseases
September 2024
Cardiovascular disease (CVD) remains a leading cause of mortality worldwide, claiming countless lives and posing a formidable health challenge. Extensive efforts have been dedicated to combating this...
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Nano-enhanced nature medicine for ischemic stroke: Opportunities and challenges
September 2024
Ischemic stroke (IS), a major cause of death and disability globally, requires innovative therapeutic approaches due to its complex pathology. Nature medicine (NM) offers promising treatments through...
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