A multiscale biohybrid strategy using biostable and biodegradable polymers to develop a growth-accommodating heart valved conduit for children
September 2026
Congenital heart diseases affect nearly 1% of births and often require valve replacement. Current prostheses lack growth potential and regenerative capacity, necessitating repeated surgeries. Tissue-engineered...
Low-curvature microdome-based flexible sensing platform enables precision and multimodal in-brace monitoring for adolescent idiopathic scoliosis treatment
September 2026
Adolescents with moderate scoliosis require brace wear to prevent disease progression and achieve spinal correction. Traditional medical imaging for treatment efficacy evaluation necessitates multi-month...
Mechanically engineered extracellular vesicles technology: Regulatory mechanisms and therapeutic applications in orthopedic diseases
September 2026
An increasing number of studies have shown that extracellular vesicles (EVs), as key mediators of intercellular communication, serve as a crucial bridge between the mechanical microenvironment and bone...
One-step microfluidic technology for generating multifunctional quantum dot (QD) biomarker barcode particles for multiplex pathogen detection
June 2026
High throughput, multiplex analysis, and operational convenience are essential for biomedical diagnostics. Quantum dot (QD) barcode particles hold significant promise for biomarker detection due to...
Bacterial extracellular vesicle technology for precision cancer medicine: Biotechnological advances and applications
June 2026
Bacterial extracellular vesicles (BEVs) are nanoscale secretions containing proteins, lipids, nucleic acids, and metabolites that modulate immune pathways, reshape the tumor microenvironment, and influence...
Redox-responsive carrier-free nanoassemblies enable dual topoisomerase I/II inhibition for metastasis-suppressed breast cancer therapy
June 2026
Breast cancer remains a critical unmet clinical challenge due to its aggressive metastasis behavior and limited treatment options. Topoisomerase inhibitors are widely available clinically but fail to...
The pH-responsive permeation mechanism of zwitterionic polymers promotes transdermal insulin delivery
June 2026
The transdermal delivery of macromolecular drugs has long been limited by the barrier effect of the stratum corneum and the underlying active epidermis. A recent study published in Nature proposed a...
Dynamic mechanical properties of the rat aged spinal cord tissue: Characterization of elasticity, viscoelasticity, and non-linearity
June 2026
Ageing plays a pivotal role in spinal cord (SC)-related disorders, but the impact of ageing on the SC, especially with respect to its material properties, remains poorly understood. Prior investigations...
Adipose tissue as a universal organoid factory: bypassing single-cell processing for multilineage regeneration
June 2026
Human adult adipose tissue, obtained from routine liposuction, can directly generate functional organoids spanning all three germ layers without single-cell isolation or genetic manipulation. In the...
Next-generation 3D bioprinted inner ear organoids
June 2026
Inner ear is crucial for maintaining normal functions of human sensory perception. However, current perceptual reconstruction is mostly limited to symptomatic relief and lacks a radical cure for irreversible...
Intradermal delivery of N1-methylpseudouridine-modified BCL-2 mRNA as a programmable gene therapy to reverse UVB-induced skin photoaging
June 2026
Photoaging, driven by ultraviolet-B (UVB)–induced oxidative and inflammatory cascades, accelerates extracellular-matrix degradation and remains difficult to reverse with current small-molecule, topical,...
Decellularized extracellular matrix: Advanced bioplatforms for functional tissue restoration via innovative decellularization techniques
March 2026
In recent years, tissue engineering has experienced rapid development, with bioscaffolds emerging as a focal point of research due to their favorable bioactivity, biocompatibility, and capacity to provide...
Integrated tardigrade-based biomimetic strategy and stem cell expansion and differentiation for a novel radioprotection approach
March 2026
Tardigrades have attracted widespread research attention due to their extraordinary radiotolerance, of which the damage suppressor protein (DSUP) is regarded as a key molecule responsible for their...
Integrated strategy of collagen fiber arrangement-inspired magnetic nanochain-doped ordered biphasic scaffold and gradient magnetic field stimulation for osteochondral regeneration
March 2026
Osteochondral defects pose significant clinical challenges owing to the complex anisotropic collagen alignment of osteochondral tissue and its limited self-healing capacity. Although mechanically biomimetic...
Barcode screening reveals the key role of gold nanoparticle morphology in tumor targeting
March 2026
Currently, nanoparticles (NPs) still face challenges in achieving efficient tumor targeted delivery, especially in balancing in vivo distribution and cellular uptake efficiency. A recent study published...
Progress of computational biomechanical modelling for calcaneal fracture fixation
March 2026
Calcaneal fractures are among the most disabling and costly orthopaedic injuries, frequently requiring surgical fixation via open reduction and internal fixation (ORIF) or minimally invasive fixation...
Biocompatible screw-based biomechanical alignment technique for improving surgical effect in adolescent flexible flatfoot
March 2026
The surgical management of adolescent flexible flatfoot with accessory navicular injury remains controversial....
The biological association between programmed cell death function and osteoarthritis using multi-omic Mendelian Randomization
December 2025
Osteoarthritis (OA) is a degenerative joint disorder influenced by genetic, molecular, and environmental factors. Programmed cell death (PCD) pathways, including apoptosis, pyroptosis, necroptosis,...
Engineering biomimetic scaffolds for cultivated meats
December 2025
The emergence of cultivated meat has attracted much attention as a revolutionary product for meat. Biomaterial scaffolds are the key component and have been extensively studied in cultivated meat production,...
A high-throughput immunopeptidome platform for MHC II alleles to characterize antigen-specific CD4+ T cells
December 2025
CD4+ T cells play a pivotal role in adaptive immunity, recognizing peptide antigens presented by MHC II molecules during infections and tumor development. Identifying immunodominant MHC II epitopess...
Prodrug nanoassembly technology for colorectal cancer therapy
December 2025
The clinical efficacy of Irinotecan is constrained by individual variability in its enzymatic conversion to the active metabolite, SN38. While direct administration of SN38 bypasses this enzymatic process...
Precision and customization in regenerative medicine: The role of coaxial 3D printing
December 2025
Coaxial three-dimensional (3D) printing enables precise, multi-material deposition, demonstrating strong potential across diverse fields, including industrial monitoring, health sensing, artificial...
Adoptive cell therapy for HBV-associated liver diseases
December 2025
Chronic infection with the hepatitis B virus (HBV) is a common cause of liver disease worldwide, particularly in Asia and Africa, where it is highly prevalent. Currently, therapies for chronic HBV infection,...
Integrative cell subtype-to-drug discovery technology for angiomyolipomas treatment
December 2025
Tuberous sclerosis complex mutation renal angiomyolipomas (TSC-RAML) are benign tumors driven by abnormal growth of mesenchymal-derived cells. Although mTOR inhibitors are clinically used, drug resistance...
Targeting Fcgr1 to repress FAPy-adenine-induced osteoporosis in osteosarcoma receiving chemotherapy
December 2025
Chemotherapy-induced bone loss in patients with osteosarcoma (OS) has attracted increasing attention worldwide. Previous studies have revealed the interactions between OS cells and osteoclasts via secretion...
