Proteomic insights into myopia development: Differential protein expression and the role of calcium signaling in form deprivation myopia in Guinea pigs
September 2024
This study aims to explore the changes in the vitreous proteomics of form deprivation myopia (FDM) in guinea pigs, in order to reveal the molecular mechanisms involved in the onset and development of...
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The therapeutic efficacy of post-symptom 3,4-diaminopyridine treatment in cosmetic injection-induced botulism using a novel animal model
September 2024
In recent years, the incidence of cosmetic injection-induced botulism has remarkably increased due to the frequent usage of botulinum neurotoxin type A (BoNT/A). To mimic and investigate this new clinical...
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Biomaterials for cardiovascular diseases
September 2024
Cardiovascular disease (CVD) remains a leading cause of mortality worldwide, claiming countless lives and posing a formidable health challenge. Extensive efforts have been dedicated to combating this...
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Nano-enhanced nature medicine for ischemic stroke: Opportunities and challenges
September 2024
Ischemic stroke (IS), a major cause of death and disability globally, requires innovative therapeutic approaches due to its complex pathology. Nature medicine (NM) offers promising treatments through...
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Effect of orthotic insole on symptomatic flexible flatfoot in school-age children: Meta-analysis and 1-year follow-up study
September 2024
This study aimed to investigate the efficacy of orthopedic insoles, specifically three-dimensional (3D)-printed orthopedic insoles, for treatment of symptomatic flexible flatfoot in school-age chil...
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Emerging strategies for the treatment of endometriosis
September 2024
Endometriosis is an estrogen-dependent disorder of the reproductive tract, affecting approximately 10 % of women. The symptoms of this condition are vague and not correlated with the disease's stage....
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Bio-inspired hierarchical particles for bioassays
June 2024
Bioassay technology has been proved important in the field of environmental monitoring, disease diagnosis and clinical treatment. At present, diverse bioassay technologies have achieved reliability,...
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Nanomaterials for wound healing: Current status and futuristic frontier
June 2024
Wound healing is a complex process that involves a variety of physical, chemical, and biological processes. Because of their remarkable characteristics and capabilities, nanomaterials have recently...
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A computational model to assess the effectiveness of adhesive materials in restoration of crown-root fractures
June 2024
Fragment reattachment for crown root fractures has become a routinely employed treatment modality with the advancements in adhesive dentistry. Among the majority of documented dental trauma cases, this...
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Application of gas molecules in cancer therapy
June 2024
Gas therapy is currently popular in cancer treatment because of its controllability, effectiveness, and biosafety, as well as the fast development of carriers for gas delivery. Here, we introduce the...
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Polyaryletherketones: Properties and applications in modern medicine
June 2024
Polyaryletherketones (PAEKs) are a family of durable, multifunctional, thermoplastic biopolymers. This article first provides necessary context and thorough information regarding the mechanical, physical,...
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A review on selenium nanoparticles and their biomedical applications
June 2024
Nanotechnology has enormous promise for a wide range of applications in biology. Nanoparticles (NPs) have the benefit of improving bioactivity, decreasing toxicity, allowing for precision targeting,...
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Pitolisant nanofibers: A promising frontier in drug delivery for narcolepsy - Formulation, optimisation, and characterization insights
June 2024
The study focuses on developing a new way to deliver the narcolepsy medication pitolisant. Electrospinning was used to make polyvinyl alcohol (PVA) and hyperbranched polyglycerol (HPG) polymers into...
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Multiscale polymeric fibers for drug delivery and tissue engineering
March 2024
Owing to their superior capacity for building structures, polymeric fibers with diameters varying from a few nanometers to hundreds of microns have been explored in biomedical applications as drug carriers...
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Review of the efficacy of nanoparticle-based drug delivery systems for cancer treatment
March 2024
This review evaluates the literature on nanoparticle-based drug delivery systems for cancer treatment and assesses their efficacy. Nanoparticles have shown potential for improving anticancer agent delivery,...
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Integrin-based prognostic model predicts survival, immunotherapy response, and drug sensitivity in gastric cancer
March 2024
Extracellular matrix (ECM) acts as a physical barrier to tumors, resulting in the lysis or delay of drug delivery. Integrins (ITGs) are essential for tumor cell-ECM interactions. Thus, we established...
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Exploring mitochondrial DNA content as a novel biomarker to improve embryo implantation potential: A review
March 2024
According to the society of assisted reproductive technologies (SART), the top fertility clinics in North America have reported overall pregnancy rates of up to 50% in good prognosis patients. Although...
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A novel approach for assessing osteoporosis utilizing DXA, HU and VBQ
March 2024
To precisely assess preoperative osteoporosis in patients, a more precise method for evaluating osteoporosis is being developed to better guide the use of bone cement reinforced screws....
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Application of nucleic acid signal amplification in biosensing and bioimaging
March 2024
Nucleic acid amplification techniques are broadly employed in nucleic acid testing due to their efficient accumulation of nucleic acid sequences. With the development of biotechnology, they are further...
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Characterization of aggrephagy-related genes to predict the progression of liver fibrosis from multi-omics profiles
March 2024
Liver fibrosis is recognized as a consequence of persistent liver damage. Hence, understanding the mechanisms of liver fibrosis could help patients reverse this process. Aggrephagy is a selective type...
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Bone regeneration and antibacterial properties of calcium-phosphorus coatings induced by gentamicin-loaded polydopamine on magnesium alloys
March 2024
Improving the corrosion resistance, osteogenic activity, and antimicrobial capacity of the magnesium-based implant is considered the key to promoting their large-scale clinical application. In this...
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Applications of 3D printing in tumor treatment
March 2024
As an emerging technology relevant to materials science, 3D printing technology simplifies material production process, shortens the preparation cycle, and provides a broader space for disease treatment....
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Functional hydrogels for treatment of dental caries
March 2024
As the most popular teeth problem, dental caries can result in pain, suffering, impaired function, and diminished quality of life among communities, which calls for new strategies to improve the therapeutic...
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A scientific debate: The sword that cleaves chaos of DNAzyme catalysis research
December 2023
Therapeutic DNAzymes with RNA depleting effect are multifunctional building blocks for constructing biological materials. In a recent work published in Nature Chemistry, Holliger group and Chaput group...
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Overcoming melanoma resistance to immune checkpoint blockade therapy using nano-strategies
December 2023
Monoclonal antibodies targeting CTLA-4, PD-1/PD-L1 axis, and LAG-3, have shown unprecedented clinical success in melanoma. However, such immune checkpoint blockade (ICB) therapies failed to initiate...
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