Multi-omics advances in understanding cancer drug resistance
December 2025
Cancer drug resistance presents a significant challenge in modern oncology, necessitating detailed exploration of its underlying mechanisms and the development of effective counterstrategies. This review...
Microenvironment-feedback hydrogel for precise sequential repair of acute infectious wounds
December 2025
The healing of acute infected wounds is a multi-stage and sequential biological process. Traditional antibacterial dressings are usually a simple superposition of antibacterial properties and active...
Wireless bioelectric stimulation for bone regeneration using magnetoelectric PVDF/BaTiO3 – Fe80Ga20 laminates
December 2025
Fracture healing remains a significant clinical challenge, particularly in cases of delayed or impaired recovery, often hindered by inadequate vascularization, patient variability. Conventional stimulation...
Advanced 3D biomaterials and bioprinting strategies for in vitro modeling of neurodegenerative diseases
September 2025
Neurodegenerative diseases including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS) remain a major global health challenge due...
Targeting HSPA8 to repress GPX4 and induce ferroptosis in BCR-ABL positive leukemia
September 2025
BCR-ABL positive (BCR-ABL+) leukemia is driven by constitutive activation of tyrosine kinase activity, with tyrosine kinase inhibitors (TKIs) serving as the standard treatment. However, resistance to...
Recent advances in organic phosphorescent materials for bioimaging
September 2025
Organic room temperature phosphorescent (RTP) materials, characterized by their prolonged luminescence lifetime and superior biocompatibility, exhibit significant potential for applications in bioimaging....
Advancing biomimetic bone Scaffolds: From electrospun 2D membranes to functional 3D nanofiber constructs
September 2025
Advancing beyond traditional electrospun two-dimensional (2D) membranes, functional three-dimensional (3D) nanofiber constructs represent a transformative approach. Unlike planar 2D structures, these...
Advanced AI-based technologies for early detection and personalized management of cervical cancer
September 2025
Cervical cancer is one of the leading causes of cancer-related deaths among women worldwide, imposing a particularly heavy burden in low- and middle-income countries. In recent years, advanced artificial...
Direct ink writing of bioactive PCL/laponite bone Implants: Engineering the interplay of design, process, structure, and function
September 2025
Direct ink writing (DIW) is a room-temperature extrusion-based 3D printing technique that enables the fabrication of dense, customizable implants from viscous inks with precise spatial control. In this...
Gαi1 activation induced by short-term hypoxia promotes epidermal cell migration in wound healing through the Akt-mTOR pathway
June 2025
Hypoxia is commonly observed in the wound microenvironment; however, the specific mechanism by which it affects epidermal cell migration remains unclear. This study aimed to examine the impact of hypoxia...
Superparamagnetic hydrogels: Precision-driven platforms for biomedicine, robotics, and environmental remediation
June 2025
Hydrogels are widely recognized for their biocompatibility and structural adaptability in regenerative medicine and three-dimensional (3D) bioprinting, yet their inherent static nature fundamentally...
A noninvasive accelerated quantitative MR technique to distinguish drug resistance in prolactinomas: Early results
June 2025
Management of dopamine agonist (DA) resistance in prolactinoma (PRLoma) remains challenging due to the lack of detecting approach and reliable imaging marker. In this cross-sectional study, PRLoma patients...
A comprehensive review of cancer drug nanoparticles synthesis, processing technology and its effect in drug delivery
June 2025
The advent of nanotechnology has significantly advanced cancer treatment by introducing innovative approaches to targeted drug delivery and enhanced therapeutic efficiency. Nano drugs and nanocarriers,...
Integrated bioinformatics analysis and machine learning approach for the identification of immune-related genes in the diagnosis of aortic valve calcification with periodontitis
June 2025
Aortic valve calcification (AVC) represents a progressive, age-associated disorder characterized by substantial mortality, yet effective early diagnostic markers for AVC complicated by periodontitis,...
Antibacterial hydrogels for bacteria-infected wound treatment
March 2025
Bacteria-infected wounds are enormous clinical obstacles and cause huge burdens to patients and society. Recently, many biomaterials are designed to treat bacterial infected wounds. Among various biomaterials,...
Biomaterial-based circular RNA therapeutic strategy for repairing intervertebral disc degeneration
March 2025
Intervertebral disc degeneration (IDD) is the leading cause of low-back pain, which brings huge threaten to patients' life and workability. However, IDD's pathophysiology is still a puzzle, thus conventional...
Developing biotechnologies in organoids for liver cancer
March 2025
Organoids, three-dimensional cellular constructs, have revolutionized in vitro culture by replicating the histological and physiological functions of organs, offering a model that closely mimics physiological...
Space manufacturing of a bone tissue destined for patients on Earth?
March 2025
Space exploration is perhaps one of the most difficult tasks ever undertaken since the emergence of humankind. The International Space Station is a unique platform for advanced technology research that...
Embracing the future: The application of regenerative biomaterials in the spinal disorders
March 2025
Spinal disorders, particularly disc degeneration, vertebral fractures, and loss of spinal stability, have become a major health problem affecting quality of life worldwide. Although conventional treatments...
Virus-inspired biogenic delivery system for advancing cancer therapy
March 2025
Virus-inspired particles have been utilized in various applications, including vaccination, gene therapy, drug therapy, and diagnostics. Biogenic delivery systems imitating the natural structure of...
Progress of metal-organic frameworks in improving the effect of sonodynamic therapy
March 2025
Sonodynamic therapy (SDT) is a new non-invasive and precise tumor treatment method, which is a promising anticancer treatment and is becoming a cutting-edge interdisciplinary research field. Based on...
