Publisher's note
March 2025
Comparative exploration of deep convolutional neural networks using real-time endoscopy images
December 2024
Until now various deep convolutional neural networks are designed and trained for the purpose of classifying different medical conditions related to the domain of gastroenterology. Most of the study...
Biomaterials that passively and actively target macrophages promote the regeneration of injured tissues
December 2024
Modulation of the immune system has gained significant attention in regenerative medicine. Although most tissues possess intrinsic self-repair capabilities, large-sized defects and complex pathological...
HFF-Net: A hybrid convolutional neural network for diabetic retinopathy screening and grading
December 2024
Diabetic Retinopathy (DR) is a leading cause of vision loss among diabetic patients, necessitating effective screening and grading for timely intervention. Regular screening significantly increases...
Electrospinning drug-loaded polycaprolactone/polycaprolactone-gelatin multi-functional bilayer nanofibers composite scaffold for postoperative wound healing of cutaneous squamous cell carcinoma
December 2024
Cutaneous squamous cell carcinoma (cSCC) tumor resection surgery poses challenges due to incomplete cancer cell removal, which increases the risk of local recurrence and micrometastasis, while large-scale...
D2 receptor antagonist raclopride regulates glutamatergic neuronal activity in the pedunculopontine nucleus in a rat model of Parkinson's disease
December 2024
Parkinson disease (PD) is defined by the loss of dopamine (DA). Changes in the pedunculopontine nucleus (PPN), particularly in local field potential (LFP), can be attributed to deficits in DA and DA...
HMS-TENet: A hierarchical multi-scale topological enhanced network based on EEG and EOG for driver vigilance estimation
December 2024
Driving vigilance estimation is an important task for traffic safety. Nowadays, electroencephalography (EEG) and electrooculography (EOG) have made some achievements in vigilance estimation, but there...
Ordered micro-nano structured biomaterials for wound healing
December 2024
The complexity of wound healing, influenced by both external factors and internal pathological mechanisms, presents a significant challenge in clinical treatment. However, strategically designed micro-nano...
Proteomic insights into myopia development: Differential protein expression and the role of calcium signaling in form deprivation myopia in Guinea pigs
September 2024
This study aims to explore the changes in the vitreous proteomics of form deprivation myopia (FDM) in guinea pigs, in order to reveal the molecular mechanisms involved in the onset and development of...
The therapeutic efficacy of post-symptom 3,4-diaminopyridine treatment in cosmetic injection-induced botulism using a novel animal model
September 2024
In recent years, the incidence of cosmetic injection-induced botulism has remarkably increased due to the frequent usage of botulinum neurotoxin type A (BoNT/A). To mimic and investigate this new clinical...
Biomaterials for cardiovascular diseases
September 2024
Cardiovascular disease (CVD) remains a leading cause of mortality worldwide, claiming countless lives and posing a formidable health challenge. Extensive efforts have been dedicated to combating this...
Nano-enhanced nature medicine for ischemic stroke: Opportunities and challenges
September 2024
Ischemic stroke (IS), a major cause of death and disability globally, requires innovative therapeutic approaches due to its complex pathology. Nature medicine (NM) offers promising treatments through...
Effect of orthotic insole on symptomatic flexible flatfoot in school-age children: Meta-analysis and 1-year follow-up study
September 2024
This study aimed to investigate the efficacy of orthopedic insoles, specifically three-dimensional (3D)-printed orthopedic insoles, for treatment of symptomatic flexible flatfoot in school-age chil...
Emerging strategies for the treatment of endometriosis
September 2024
Endometriosis is an estrogen-dependent disorder of the reproductive tract, affecting approximately 10 % of women. The symptoms of this condition are vague and not correlated with the disease's stage....
Bio-inspired hierarchical particles for bioassays
June 2024
Bioassay technology has been proved important in the field of environmental monitoring, disease diagnosis and clinical treatment. At present, diverse bioassay technologies have achieved reliability,...
Nanomaterials for wound healing: Current status and futuristic frontier
June 2024
Wound healing is a complex process that involves a variety of physical, chemical, and biological processes. Because of their remarkable characteristics and capabilities, nanomaterials have recently...
A computational model to assess the effectiveness of adhesive materials in restoration of crown-root fractures
June 2024
Fragment reattachment for crown root fractures has become a routinely employed treatment modality with the advancements in adhesive dentistry. Among the majority of documented dental trauma cases, this...
Application of gas molecules in cancer therapy
June 2024
Gas therapy is currently popular in cancer treatment because of its controllability, effectiveness, and biosafety, as well as the fast development of carriers for gas delivery. Here, we introduce the...
