A high-throughput immunopeptidome platform for MHC II alleles to characterize antigen-specific CD4+ T cells
December 2025
CD4+ T cells play a pivotal role in adaptive immunity, recognizing peptide antigens presented by MHC II molecules during infections and tumor development. Identifying immunodominant MHC II epitopess...
Prodrug nanoassembly technology for colorectal cancer therapy
December 2025
The clinical efficacy of Irinotecan is constrained by individual variability in its enzymatic conversion to the active metabolite, SN38. While direct administration of SN38 bypasses this enzymatic process...
Precision and customization in regenerative medicine: The role of coaxial 3D printing
December 2025
Coaxial three-dimensional (3D) printing enables precise, multi-material deposition, demonstrating strong potential across diverse fields, including industrial monitoring, health sensing, artificial...
Adoptive cell therapy for HBV-associated liver diseases
December 2025
Chronic infection with the hepatitis B virus (HBV) is a common cause of liver disease worldwide, particularly in Asia and Africa, where it is highly prevalent. Currently, therapies for chronic HBV infection,...
Integrative cell subtype-to-drug discovery technology for angiomyolipomas treatment
December 2025
Tuberous sclerosis complex mutation renal angiomyolipomas (TSC-RAML) are benign tumors driven by abnormal growth of mesenchymal-derived cells. Although mTOR inhibitors are clinically used, drug resistance...
Targeting Fcgr1 to repress FAPy-adenine-induced osteoporosis in osteosarcoma receiving chemotherapy
December 2025
Chemotherapy-induced bone loss in patients with osteosarcoma (OS) has attracted increasing attention worldwide. Previous studies have revealed the interactions between OS cells and osteoclasts via secretion...
Multi-omics advances in understanding cancer drug resistance
December 2025
Cancer drug resistance presents a significant challenge in modern oncology, necessitating detailed exploration of its underlying mechanisms and the development of effective counterstrategies. This review...
Microenvironment-feedback hydrogel for precise sequential repair of acute infectious wounds
December 2025
The healing of acute infected wounds is a multi-stage and sequential biological process. Traditional antibacterial dressings are usually a simple superposition of antibacterial properties and active...
Wireless bioelectric stimulation for bone regeneration using magnetoelectric PVDF/BaTiO3 – Fe80Ga20 laminates
December 2025
Fracture healing remains a significant clinical challenge, particularly in cases of delayed or impaired recovery, often hindered by inadequate vascularization, patient variability. Conventional stimulation...
Advanced 3D biomaterials and bioprinting strategies for in vitro modeling of neurodegenerative diseases
September 2025
Neurodegenerative diseases including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS) remain a major global health challenge due...
Targeting HSPA8 to repress GPX4 and induce ferroptosis in BCR-ABL positive leukemia
September 2025
BCR-ABL positive (BCR-ABL+) leukemia is driven by constitutive activation of tyrosine kinase activity, with tyrosine kinase inhibitors (TKIs) serving as the standard treatment. However, resistance to...
Recent advances in organic phosphorescent materials for bioimaging
September 2025
Organic room temperature phosphorescent (RTP) materials, characterized by their prolonged luminescence lifetime and superior biocompatibility, exhibit significant potential for applications in bioimaging....
Advancing biomimetic bone Scaffolds: From electrospun 2D membranes to functional 3D nanofiber constructs
September 2025
Advancing beyond traditional electrospun two-dimensional (2D) membranes, functional three-dimensional (3D) nanofiber constructs represent a transformative approach. Unlike planar 2D structures, these...
Advanced AI-based technologies for early detection and personalized management of cervical cancer
September 2025
Cervical cancer is one of the leading causes of cancer-related deaths among women worldwide, imposing a particularly heavy burden in low- and middle-income countries. In recent years, advanced artificial...
Direct ink writing of bioactive PCL/laponite bone Implants: Engineering the interplay of design, process, structure, and function
September 2025
Direct ink writing (DIW) is a room-temperature extrusion-based 3D printing technique that enables the fabrication of dense, customizable implants from viscous inks with precise spatial control. In this...
Gαi1 activation induced by short-term hypoxia promotes epidermal cell migration in wound healing through the Akt-mTOR pathway
June 2025
Hypoxia is commonly observed in the wound microenvironment; however, the specific mechanism by which it affects epidermal cell migration remains unclear. This study aimed to examine the impact of hypoxia...
Superparamagnetic hydrogels: Precision-driven platforms for biomedicine, robotics, and environmental remediation
June 2025
Hydrogels are widely recognized for their biocompatibility and structural adaptability in regenerative medicine and three-dimensional (3D) bioprinting, yet their inherent static nature fundamentally...