Space manufacturing of a bone tissue destined for patients on Earth?
March 2025
Space exploration is perhaps one of the most difficult tasks ever undertaken since the emergence of humankind. The International Space Station is a unique platform for advanced technology research that...
Embracing the future: The application of regenerative biomaterials in the spinal disorders
March 2025
Spinal disorders, particularly disc degeneration, vertebral fractures, and loss of spinal stability, have become a major health problem affecting quality of life worldwide. Although conventional treatments...
Virus-inspired biogenic delivery system for advancing cancer therapy
March 2025
Virus-inspired particles have been utilized in various applications, including vaccination, gene therapy, drug therapy, and diagnostics. Biogenic delivery systems imitating the natural structure of...
Progress of metal-organic frameworks in improving the effect of sonodynamic therapy
March 2025
Sonodynamic therapy (SDT) is a new non-invasive and precise tumor treatment method, which is a promising anticancer treatment and is becoming a cutting-edge interdisciplinary research field. Based on...
Breathable functional aerogel dressings facilitate the healing of diabetic wounds
March 2025
Due to the complexity of the microenvironment and healing process of diabetic wounds, developing wound dressings that offer good biocompatibility, breathability, and promote vascular regeneration is...
Publisher's note
March 2025
Comparative exploration of deep convolutional neural networks using real-time endoscopy images
December 2024
Until now various deep convolutional neural networks are designed and trained for the purpose of classifying different medical conditions related to the domain of gastroenterology. Most of the study...
Biomaterials that passively and actively target macrophages promote the regeneration of injured tissues
December 2024
Modulation of the immune system has gained significant attention in regenerative medicine. Although most tissues possess intrinsic self-repair capabilities, large-sized defects and complex pathological...
HFF-Net: A hybrid convolutional neural network for diabetic retinopathy screening and grading
December 2024
Diabetic Retinopathy (DR) is a leading cause of vision loss among diabetic patients, necessitating effective screening and grading for timely intervention. Regular screening significantly increases...
Electrospinning drug-loaded polycaprolactone/polycaprolactone-gelatin multi-functional bilayer nanofibers composite scaffold for postoperative wound healing of cutaneous squamous cell carcinoma
December 2024
Cutaneous squamous cell carcinoma (cSCC) tumor resection surgery poses challenges due to incomplete cancer cell removal, which increases the risk of local recurrence and micrometastasis, while large-scale...
D2 receptor antagonist raclopride regulates glutamatergic neuronal activity in the pedunculopontine nucleus in a rat model of Parkinson's disease
December 2024
Parkinson disease (PD) is defined by the loss of dopamine (DA). Changes in the pedunculopontine nucleus (PPN), particularly in local field potential (LFP), can be attributed to deficits in DA and DA...
HMS-TENet: A hierarchical multi-scale topological enhanced network based on EEG and EOG for driver vigilance estimation
December 2024
Driving vigilance estimation is an important task for traffic safety. Nowadays, electroencephalography (EEG) and electrooculography (EOG) have made some achievements in vigilance estimation, but there...
Ordered micro-nano structured biomaterials for wound healing
December 2024
The complexity of wound healing, influenced by both external factors and internal pathological mechanisms, presents a significant challenge in clinical treatment. However, strategically designed micro-nano...
Proteomic insights into myopia development: Differential protein expression and the role of calcium signaling in form deprivation myopia in Guinea pigs
September 2024
This study aims to explore the changes in the vitreous proteomics of form deprivation myopia (FDM) in guinea pigs, in order to reveal the molecular mechanisms involved in the onset and development of...
The therapeutic efficacy of post-symptom 3,4-diaminopyridine treatment in cosmetic injection-induced botulism using a novel animal model
September 2024
In recent years, the incidence of cosmetic injection-induced botulism has remarkably increased due to the frequent usage of botulinum neurotoxin type A (BoNT/A). To mimic and investigate this new clinical...
Biomaterials for cardiovascular diseases
September 2024
Cardiovascular disease (CVD) remains a leading cause of mortality worldwide, claiming countless lives and posing a formidable health challenge. Extensive efforts have been dedicated to combating this...
Nano-enhanced nature medicine for ischemic stroke: Opportunities and challenges
September 2024
Ischemic stroke (IS), a major cause of death and disability globally, requires innovative therapeutic approaches due to its complex pathology. Nature medicine (NM) offers promising treatments through...
Effect of orthotic insole on symptomatic flexible flatfoot in school-age children: Meta-analysis and 1-year follow-up study
September 2024
This study aimed to investigate the efficacy of orthopedic insoles, specifically three-dimensional (3D)-printed orthopedic insoles, for treatment of symptomatic flexible flatfoot in school-age chil...
Emerging strategies for the treatment of endometriosis
September 2024
Endometriosis is an estrogen-dependent disorder of the reproductive tract, affecting approximately 10 % of women. The symptoms of this condition are vague and not correlated with the disease's stage....
