Application and future directions of brain-computer interfaces in neurological disorders: Technological advances, clinical practices, and challenges
December 2025
Brain-Computer Interfaces (BCIs) represent an innovative frontier in technology, establishing a direct link between the brain and external devices. This rapidly evolving field is increasingly recognized...
Perioperative management of brain hemorrhage: Advances in anesthetic strategies and translational medicine
April 2026
•Brain hemorrhage presents perioperative challenges, requiring optimized anesthetic strategies.•Anesthesia choice and agent selection significantly influence perioperative outcomes.•Advanced neuromonitoring...
Neural decoding for EEG-BCI: from conventional machine learning to deep learning models
Available online 12 January 2026
Brain–computer interfaces (BCIs) decode neural signals to support alternative communication for individuals with motor and speech impairments, including severe speech disorders. We review EEG-BCI decoding...
Reversible cerebral vasoconstriction syndrome: not just a “reversible” condition. Retrospective observational study and literature review
August 2026
This study aims to critically evaluate the evolving understanding of reversible cerebral vasoconstriction syndrome (RCVS) by examining its potential for long-term complications. While reversible cerebral...
Cerebral vasospasm after subarachnoid hemorrhage: Developing treatments
March 2021
Subarachnoid hemorrhage (SAH) can be devastating with high morbidity and mortality. A common sequela is cerebral vasospasm, the narrowing of cerebral blood vessels that can lead to ischemic stroke if...
Hemorrhage in brain tumor – An unresolved issue
June 2022
Intratumoral hemorrhage (ITH) as a variant of intracranial hemorrhage (ICH) is a known, albeit rare, clinical entity. Hemorrhages within brain neoplasms seem to remain underreported, including angiomatous...
Cerebral venous impairment and cerebral venous sinus thrombosis
June 2024
Cerebral veins are responsible for the outflow drainage of brain interstitial fluid (ISF). The importance of cerebral venous drainage has been emphasized in various neurological diseases. Impaired venous...
The TLR4/MyD88 axis: Orchestrator of neuroinflammation from molecular initiation to systemic crosstalk
June 2026
Neuroinflammation is a convergent feature of neurodegenerative diseases, hemorrhagic and ischemic stroke, and spinal cord injury. Central to this process is the Toll-like receptor 4 (TLR4) and myeloid...
Anticoagulant-associated intracerebral hemorrhage
March 2020
Intracerebral hemorrhage (ICH) is the most dangerous complication of oral anticoagulant treatment (OAT). Up to half of patients with OAT-related ICH experience early clinical deterioration due to active...
Behavioral tests in rodent models of stroke
December 2020
Rodents are the most widely used experimental animals in stroke research due to their similar vascular anatomy, high reproductive rates, and availability of transgenic models. However, the difficulties...
Reliability of Siriraj stroke score to distinguish between hemorrhagic and ischemic stroke
March 2023
The aim of study was to establish a quick way to differentiate between hemorrhagic and ischemic stroke by using siriraj stroke score and find its specificity and sensitivity by comparing it with CT...
Progress in the treatment of chronic intracranial large artery occlusion: Time for large, randomized trials?
December 2023
Chronic cerebral artery occlusion is an important cause of ischemic stroke, resulting in up to 45% of all ischemic strokes. Therefore, treatment of chronic cerebral artery occlusion is critical to improve...
Link between heart failure and stroke: a comprehensive review
October 2025
Heart failure and stroke are two major cardiovascular conditions that significantly contribute to morbidity and mortality worldwide.1 While the link between heart failure and ischemic stroke is well...
Digital twins for stroke prediction and management
June 2026
•Digital twins: dynamic computational replicas integrating multimodal patient data.•Patient-specific left atrial modelling stratifies AF-related embolic risk.•Imaging-informed cerebrovascular hemodynamics...
Clinical treatment progress of small amounts thalamus hemorrhage
June 2021
Thalamic hemorrhage is one of deep-seating cerebral lesions. Conservative therapy is preferred to patients with minor thalamic hemorrhage, and external ventricular drainage is usually applied in patients...
“ICH-CARE”: ICH-integrated care for accelerated response to intracerebral hemorrhage using a phased approach
Available online 17 August 2026
Intracerebral hemorrhage (ICH) is a deadly stroke subtype requiring ultra-early bundled interventions. The Mayo Clinic Comprehensive Stroke Center implemented a “ICH Phases” three-tiered communication...
Hemodynamic variables in cerebral Aneurysms: integrating CFD-based computational modeling and clinical insight
Available online 1 September 2026
Hemodynamic forces play a central role in the initiation, growth, and rupture of cerebral aneurysms. Although numerous computational fluid dynamics (CFD)-derived hemodynamic variables have been proposed,...
Inflammatory biomarkers in patients with intracranial aneurysms
April 2026
Intracranial aneurysm (IA) is a serious cerebrovascular disease. This study aimed to investigate the clinical characteristics and plasma biomarkers associated with IA....
Models of cerebral amyloid angiopathy-related intracerebral hemorrhage
December 2022
Cerebral amyloid angiopathy (CAA) is a cerebrovascular disease with vascular amyloid-β deposits and is commonly observed among the elderly. Often associated with Alzheimer’s disease, CAA is among the...
Inflammatory response in sepsis and hemorrhagic stroke
June 2023
Exaggerated/deregulated inflammatory response is a major medical problem that is often associated with bad outcomes or even the death of the patient. Sepsis and severe hemorrhagic stroke are two illustrative...
IRRAflow active irrigation and drainage system: A glimpse into the future of cerebrospinal fluid shunts
December 2025
Chronic hydrocephalus after subarachnoid hemorrhage may become inevitable, necessitating a permanent cerebrospinal fluid shunt. We report a 40-year-old woman with SAH and a CHESS score of 6. We implemented...
Falx interhemispheric subdural hematoma in a hypertensive patient with urticaria: A case report
February 2024
Falx interhemispheric subdural hematoma (FISH) is a rare subtype of subdural hematoma that occurs between the cerebral hemispheres along with falx cerebri. It represents less than 0.5% of all subdural...
Current state of endovascular treatment for cavernous and petrous internal carotid artery aneurysms
October 2026
Cavernous and petrous internal carotid artery (ICA) aneurysms have similar clinical characteristics, making it feasible to discuss these two types of aneurysms together. Currently, endovascular treatment...
Advancing deep learning for automated stroke detection: a review
October 2025
Stroke remains a leading cause of death and disability worldwide, necessitating improved diagnostic tools for early detection and classification. Machine learning (ML) techniques have shown promise...
Decoding the spatiotemporal pleiotropy of CCL2-CCR2 signaling to guide staged therapies in central nervous system injury
Available online 26 August 2026
Intracerebral hemorrhage (ICH) and other acute central nervous system (CNS) injuries share a devastating pathological hallmark: neuroinflammation. Within this complex immune network, the CCL2-CCR2 signaling...
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