Hemorrhage in brain tumor – An unresolved issue
June 2022
Intratumoral hemorrhage (ITH) as a variant of intracranial hemorrhage (ICH) is a known, albeit rare, clinical entity. Hemorrhages within brain neoplasms seem to remain underreported, including angiomatous...
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Reliability of Siriraj stroke score to distinguish between hemorrhagic and ischemic stroke
March 2023
The aim of study was to establish a quick way to differentiate between hemorrhagic and ischemic stroke by using siriraj stroke score and find its specificity and sensitivity by comparing it with CT...
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Clinical treatment progress of small amounts thalamus hemorrhage
June 2021
Thalamic hemorrhage is one of deep-seating cerebral lesions. Conservative therapy is preferred to patients with minor thalamic hemorrhage, and external ventricular drainage is usually applied in patients...
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Anticoagulant-associated intracerebral hemorrhage
March 2020
Intracerebral hemorrhage (ICH) is the most dangerous complication of oral anticoagulant treatment (OAT). Up to half of patients with OAT-related ICH experience early clinical deterioration due to active...
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Behavioral tests in rodent models of stroke
December 2020
Rodents are the most widely used experimental animals in stroke research due to their similar vascular anatomy, high reproductive rates, and availability of transgenic models. However, the difficulties...
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Falx interhemispheric subdural hematoma in a hypertensive patient with urticaria: A case report
February 2024
Falx interhemispheric subdural hematoma (FISH) is a rare subtype of subdural hematoma that occurs between the cerebral hemispheres along with falx cerebri. It represents less than 0.5% of all subdural...
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Cerebral vasospasm after subarachnoid hemorrhage: Developing treatments
March 2021
Subarachnoid hemorrhage (SAH) can be devastating with high morbidity and mortality. A common sequela is cerebral vasospasm, the narrowing of cerebral blood vessels that can lead to ischemic stroke if...
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The effect of cocaine and methamphetamine on saccular aneurysm formation and rupture: A literature review
September 2021
The pathophysiology of saccular aneurysm rupture (berry aneurysm) secondary to cocaine and methamphetamine use has been classically attributed to their effects on cerebrovasculature. We conducted a...
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Cerebral venous impairment and cerebral venous sinus thrombosis
June 2024
Cerebral veins are responsible for the outflow drainage of brain interstitial fluid (ISF). The importance of cerebral venous drainage has been emphasized in various neurological diseases. Impaired venous...
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Models of cerebral amyloid angiopathy-related intracerebral hemorrhage
December 2022
Cerebral amyloid angiopathy (CAA) is a cerebrovascular disease with vascular amyloid-β deposits and is commonly observed among the elderly. Often associated with Alzheimer’s disease, CAA is among the...
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The use of bioinformatic analysis to study intracerebral hemorrhage
August 2024
The integration of bioinformatics analysis into intracerebral hemorrhage (ICH)research represents a paradigm shift in our approach to understanding, diagnosing, and treating this complex neurological...
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Managing Mental Disorders in Intracranial Hemorrhage (ICH) Patients: A Case Study on The Importance of Early Recognition and Intervention
February 2024
Intracranial Hemorrhage (ICH) can lead to various clinical manifestations and complications. These include mental disorders that range from impaired cognitive function to disturbances in the sensorium,...
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Emerging regenerative medicine for hemorrhagic stroke: An update on stem cell therapies
March 2023
Hemorrhagic stroke (HS) is a disastrous occurrence with high mortality rates, however, there are no established treatments for this pathology. Given recent advances in stem cell therapies, concerted...
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Comparison of accuracy, sensitivity and specifity of Bahrudin score vs Siriraj score vs Gajah Mada algorithm in diagnosing type of stroke
December 2022
Rapid diagnosis is crucial for stroke patients since it is an emergency that may result in morbidity and mortality. The gold standard, which is a CT scan of the brain is not always feasible, hence,...
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Continuous arterial blood pressure indices and early hematoma expansion in patients with spontaneous intracerebral hemorrhage
Available online 12 June 2024
Blood pressure variability (BPV) and its potential association with early hematoma expansion (HE) in intracerebral hemorrhage (ICH) remains to be fully elucidated. Our study explores the potential link...
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Progress in the treatment of chronic intracranial large artery occlusion: Time for large, randomized trials?
December 2023
Chronic cerebral artery occlusion is an important cause of ischemic stroke, resulting in up to 45% of all ischemic strokes. Therefore, treatment of chronic cerebral artery occlusion is critical to improve...
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The blood brain barrier in cerebral ischemic injury – Disruption and repair
March 2020
With the emergence of novel technologies and ground breaking concepts in BBB basic research in the past decades, the researchers’ attention on the critical role of blood brain barrier (BBB) integrity...
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The role of crosstalk between cerebral immune cells and peripheral immune cells in the damage and protection of blood–brain barrier after intracerebral hemorrhage
June 2024
•We first introduce the role of CICs and PICs in BBB damage and protection after ICH, focusing on inflammatory response.•Next, we specifically discuss the crosstalk between CICs and PICs, such as brain-spleen...
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Collaterals in ischemic stroke
March 2020
Collateral flow plays a pivotal role, both in acute and chronic phases of cerebral ischemia. Recruitment of these redundant vascular networks maintains cerebral blood flow to ischemic areas, while primary...
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Beneficial effects of clazosentan add-on treatment on delayed cerebral microcirculatory disturbances after aneurysmal subarachnoid hemorrhage
April 2024
This retrospective study aimed to analyze the prospectively collected data of computed tomography (CT) perfusion imaging and to examine if clazosentan add-on administration prevented post-subarachnoid...
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Fluid balance management with loop diuretics in patients with aneurysmal subarachnoid hemorrhage treated with clazosentan: A case series
April 2024
Pulmonary edema is a common complication in patients receiving clazonsentan. Here, we report our experience in managing fluid balance with loop diuretics in patients with aneurysmal subarachnoid hemorrhage...
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Prognosis of recovery and death within 1–6 months of spontaneous cerebellar hemorrhage undergoing suboccipital craniotomy
Available online 28 May 2024
Suboccipital craniotomy is a considerable surgical approach for large spontaneous cerebellar hemorrhage, but its prognostic has not been comprehensively addressed. This study aims to report the surgical...
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Could clazosentan, first approved in Japan, improve neurological prognosis after subarachnoid hemorrhage in combination with modified water-electrolyte management?
April 2024
An aneurysmal subarachnoid hemorrhage (aSAH) is a devastating event associated with a high mortality and morbidity rate. Though numerous medications are used to prevent cerebral vasospasm and vasospasm-related...
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The function of astrocytes in cerebral infarction and potential therapeutic approaches
August 2024
Astrocytes, the most prevalent cells in the central nervous system, significantly contribute to the normal physiological functions of the brain. Following cerebral infarction, these astrocytes undergo...
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Effect of mesenchymal stem cell-derived exosomes on the inflammatory response after stroke
Available online 20 April 2024
Stroke, characterized by sudden onset and significant mortality rates, represents a critical challenge in effectively treating neuroinflammation to improve treatment efficacy. In this context, mesenchymal...
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