Leading scientists’ contributions to organized research: Gu Fangzhou and the development of China’s attenuated live poliovirus vaccine
September 2026
This article examines Gu Fangzhou’s leadership in the development of China’s live poliovirus vaccine from the perspective of organized research. In response to the poliomyelitis (polio) epidemic of...
The value connotations and generative logic of Gu Fangzhou’s scientist spirit
September 2026
The scientist spirit of Gu Fangzhou can be understood through six dimensions: patriotism, innovation, truth-seeking, dedication, collaboration, and education. Together, they define what made Gu Fangzhou...
Robot-assisted laparoscopic resection of a retroperitoneal metastatic tumor encircling the left renal vein and inferior vena cava: A case report
September 2026
Robot-assisted laparoscopic surgery is a recently developed minimally invasive technique. Compared to traditional laparoscopy, it offers enhanced visualization and improved precision. Although it has...
Gonioscopy-assisted goniosynechialysis with fibrovascular membrane dissection for advanced neovascular glaucoma: A case report
September 2026
We report a case of a 26-year-old woman with poorly controlled type 2 diabetes who developed neovascular glaucoma in the left eye, with an intraocular pressure of 80 mmHg and nearly 360° synechial angle...
Haptoglobin as a multifaceted therapeutic agent targeting hemolysis-induced multi-organ injury
September 2026
Haptoglobin (Hp) is an acute-phase glycoprotein and the primary endogenous scavenger of cell-free hemoglobin. By forming stable Hp–hemoglobin complexes cleared by the CD163 receptor, Hp protects tissues...
Dental management of a 3-year-old boy with glucose-6-phosphate dehydrogenase deficiency under general anesthesia: A case report
September 2026
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a common X-linked recessive disorder that increases susceptibility to oxidative hemolysis, presenting potential safety concerns for pediatric dental...
The 3D genome in medicine: Technological advances, disease mechanisms, and translational challenges
September 2026
Three-dimensional (3D) genome organization has reshaped our understanding of human disease by revealing regulatory mechanisms that cannot be explained by the linear genome alone. Rapid advances in chromosome-conformation...
Gu Fangzhou: A monument to polio elimination in China
June 2026
Commemorating the centenary of Professor Gu Fangzhou’s birth, this memorial article documents his landmark contributions to eliminating poliomyelitis in China. It details his strategic prioritization...
Post-traumatic dementia: Advances in understanding neurodegenerative mechanisms
June 2026
Traumatic brain injury can trigger long-term neurodegenerative diseases beyond its devastating acute effects. This narrative review summarizes current understanding of the neurodegenerative mechanisms...
Dedication to a lifelong mission: Gu Fangzhou and the Chinese road to polio elimination
June 2026
This paper reviews Professor Gu Fangzhou’s contributions to polio control and elimination in China. Following the 1955 polio outbreak, he advocated for the live oral polio vaccine (OPV) route tailored...
Continuous wound infiltration with local anesthetics in adult patients undergoing cardiac surgery: A PRISMA-compliant systematic review and meta-analysis
June 2026
Effective postoperative analgesia is critical to recovery after cardiac surgery. Continuous wound infiltration (CWI) with local anesthetics (LAs) has been proposed as an opioid-sparing adjunct, but...
Global epidemiological and indirect economic burden of neurological, mental, and substance use disorders: An analysis based on the global burden of disease data
June 2026
To evaluate the global disease burden and indirect economic costs of neurological, mental, and substance use disorders (NMSDs) from 1990 to 2023....
A predictive model for heart failure in patients with hypertension and persistent atrial fibrillation: A retrospective single-center study
June 2026
This study aimed to develop and validate a predictive nomogram for heart failure in patients with hypertension and persistent atrial fibrillation (HT-PeAF)....
Good Data Governance Practice and a Grading Initiative for Life Sciences Data
March 2026
Life sciences have entered the era of big data, uncovering the complexity of human biological systems and advancing precision medicine and scientific wellness. In alignment with the Findable, Accessible,...
Endometrial Carcinoma Arising in Adenomyosis in the Myometrium with Uninvolved Endometrium: A Case Report
March 2026
Endometrial carcinoma arising in adenomyosis (EC-AIA) is a rare entity that originates deep within the myometrium and often spares the endometrial lining. We report a 53-year-old woman who presented...
Time-Dependent Neuroprotection and Precision Interventions in Acute Ischemic Stroke in the Reperfusion Era
March 2026
Acute ischemic stroke ranks as the second leading cause of mortality among noncommunicable diseases globally. Although recent advancements in intravenous thrombolysis and endovascular thrombectomy have...
Teaching Neuraxial Ultrasonography with a Virtual Reality Simulator of Spine: A Randomized Controlled Study
March 2026
To evaluate whether adjunctive virtual reality (VR) spine simulation in neuraxial ultrasound training improves performance competency among anesthesia residents compared with traditional didactic teaching...
Emergency Management of Crushing Perineal Avulsion with Complete Urethral Disruption: A Case Report
March 2026
High-energy machinery entrapment can result in catastrophic perineal injuries involving complete urethral disruption, extensive soft tissue avulsion, and associated orthopedic trauma. We report a 24-year-old...
Wartime Healers: The Collective Awakening and National Mission of PUMC Medical Community during the Chinese People's War of Resistance against Japanese Aggression
March 2026
This study focuses on eleven representative medical figures—including John Heng Liu and Robert K. S. Lim—to provide a historical account of their wartime service during the Chinese People's War of Resistance...
Risk Factors for Postoperative Pulmonary Complications Following Posterior Spinal Fusion in Adolescent Scoliosis: A Retrospective Cohort Study
March 2026
Scoliosis is a prevalent spinal deformity that severely impacts the physical and psychological well-being of adolescents and often requires surgical correction. This study aimed to investigate the risk...
Associated Factors for Chronic Neuropathic Cancer Pain in Outpatients From Pain Clinic: A Perspective Cross-Sectional Study
December 2025
To determine the prevalence, distribution, and associated clinical factors of chronic neuropathic cancer pain (CNCP) among outpatients with chronic cancer pain (CCP) and to inform improved recognition...
Standardizing Healthcare Datasets in China: Challenges and Strategies
December 2025
Standardized datasets are foundational to healthcare informatization by enhancing data quality and unleashing the value of data elements. Using bibliometrics and content analysis, this study examines...
Adamantinoma-like Ewing Sarcoma of Head and Neck: A Clinicopathologic Study of Three Cases Including One EWSR1-Negative Case with NF1 Mutation
December 2025
Adamantinoma-like Ewing sarcoma (ALES) is a rare variant of Ewing sarcoma that predominantly occurs in the head and neck region, characterized by epithelial differentiation and overlapping morphology...