Integrative multi-omics and bioinformatics in the post-genomic era: From high-throughput sequencing to microbial systems biology
May 2026
Next-generation sequencing (NGS) has revolutionized microbial genomics by enabling high-throughput, accurate, and cost-effective exploration of microbial genetic and functional diversity. In the post-genomic...
Lactylation-related gene DDX21 modulates immune regulation and serves as a pivotal biomarker for breast cancer
May 2026
Lactylation is a novel form of post-translational modification. The role of lactylation in breast cancer (BRCA), especially its interplay with immune response and metabolism, remains to be explored....
ALDH1A1 expression correlates with platinum resistance and promotes malignant phenotypes in ovarian cancer
May 2026
Platinum-based chemotherapy is the standard first-line treatment for ovarian cancer; however, the development of platinum resistance frequently leads to tumor recurrence and poor prognosis. Therefore,...
PLMGraph-Ace: Species-specific lysine acetylation-site prediction via fusion of a protein language model and a sequence-distance graph
August 2026
Lysine acetylation is an important post-translational modification involved in diverse cellular regulatory processes. Because experimental identification of acetylation sites is labor-intensive and...
Assessment of colorectal cancer diagnosis and tumor burden using a panel of ctDNA methylation biomarkers
August 2026
Early diagnosis and precise non-invasive detection of colorectal cancer (CRC) is slated to greatly improve patient prognosis and promote the development of personalized treatment. Circulating tumor...
Advances in animal models and therapeutic strategies for ankylosing spondylitis
May 2026
Ankylosing spondylitis (AS) is a chronic, systemic inflammatory autoimmune disease that primarily involves the axial skeleton, especially the sacroiliac joints and spine. The condition poses a substantial...
Inhibition of METTL9 suppresses migration and proliferation of melanoma in cellular and animal models
August 2026
Melanoma is a highly aggressive skin malignancy with strong metastatic potential and limited long-term therapeutic benefit in some patients. Methyltransferase-like protein 9 (METTL9) has been implicated...
Single-cell transcriptomic and immune receptor profiling reveals distinct immune remodeling in SARS-CoV-2 convalescent individuals
Available online 12 June 2026
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection induces profound immune dysregulation during the acute phase; however, the extent and characteristics of immune remodeling after...
Molecular Mechanistic Analysis of the miR-503-5p/FOXK1 Signaling Axis–Mediated Promotion of Ovarian Cancer Proliferation and Invasion by LINC00273
Available online 14 July 2026
Ovarian cancer is an aggressive malignancy with poor prognosis, and its molecular mechanisms remain incompletely understood. This study investigated whether LINC00273 promotes ovarian cancer cell proliferation...
A multimodal deep learning framework to predict breast cancer sentinel lymph node metastasis in ultrasound images with metabolomics interpretation
Available online 24 July 2026
Detecting sentinel lymph node metastasis (SLNM) in breast cancer is important for treatment planning, but accurate and interpretable preoperative prediction remains challenging. We aimed to develop...
Identification of BIRC3 and SPOP as stable biomarkers for Alzheimer's disease by integrating ubiquitin‑proteasome system features
August 2026
In recent years, an increasing amount of evidence has shown that the ubiquitin-proteasome system (UPS) dysfunction is detected in Alzheimer's disease (AD). This study aimed to explore novel diagnostic...