Lactylation-related gene DDX21 modulates immune regulation and serves as a pivotal biomarker for breast cancer
May 2026
Lactylation is a novel form of post-translational modification. The role of lactylation in breast cancer (BRCA), especially its interplay with immune response and metabolism, remains to be explored....
Integrative multi-omics and bioinformatics in the post-genomic era: From high-throughput sequencing to microbial systems biology
May 2026
Next-generation sequencing (NGS) has revolutionized microbial genomics by enabling high-throughput, accurate, and cost-effective exploration of microbial genetic and functional diversity. In the post-genomic...
Advances in animal models and therapeutic strategies for ankylosing spondylitis
May 2026
Ankylosing spondylitis (AS) is a chronic, systemic inflammatory autoimmune disease that primarily involves the axial skeleton, especially the sacroiliac joints and spine. The condition poses a substantial...
ALDH1A1 expression correlates with platinum resistance and promotes malignant phenotypes in ovarian cancer
May 2026
Platinum-based chemotherapy is the standard first-line treatment for ovarian cancer; however, the development of platinum resistance frequently leads to tumor recurrence and poor prognosis. Therefore,...
Epigenetic regulation in hepatocellular carcinoma: Mechanism insights and therapeutic implications
May 2026
Single-cell genomics insights into cancer evolution and precision medicine
May 2026
Our manuscript synthesizes recent breakthroughs in single-cell genomics and their impact on cancer research. We highlight how high-resolution, single-cell technologies now enable systematic dissection...
Single-cell transcriptomic and immune receptor profiling reveals distinct immune remodeling in SARS-CoV-2 convalescent individuals
Available online 12 June 2026
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection induces profound immune dysregulation during the acute phase; however, the extent and characteristics of immune remodeling after...