Advances in drug discovery based on network pharmacology and omics technology
December 2024
Drug discovery plays a crucial role in cancer treatment. Traditional drug discovery methods mainly rely on in vivo animal experiments and in vitro drug screening, which are not only costly but also...
Advancing pharmaceutical research: A comprehensive review of cutting-edge tools and technologies
December 2024
This comprehensive review investigates the cutting-edge tools and technologies that are revolutionizing modern pharmaceutical research. We analyze the integration of artificial intelligence and machine...
Emerging trends and hot topics in the application of multi-omics in drug discovery: A bibliometric and visualized study
December 2024
The application of multi-omics in drug discovery is rapidly advancing, but its trends and hotspots have not been fully analyzed. By reviewing key achievements and research hotspots in this field, the...
Method development and validation of orlistat by using RP-HPLC
June 2025
To accurately quantify orlistat, an anti-obesity drug that is a pancreatic lipase inhibitor thus Depending on the assay system, orlistat illustrates studies at intestines receptors by temporarily blocking...
Design, synthesis, and therapeutic potential of pyridazinone-based molecules: An updated comprehensive review
August 2025
Drug discovery involves the design, synthesis and pharmacological evaluation of new chemical entities. Heterocyclic compounds are ring structures in which a carbon atom is replaced by heteroatoms such...
Exploring the therapeutic effect of flavonoids on kidney health
June 2025
Chronic kidney disease (CKD) is a progressive systemic disease that changes the function and structure of the kidneys irreversibly over months or years. The final common pathological manifestation of...
The role of Ursolic acid, a pharmacologically active compound from Ocimum sanctum L. as a potential chemotherapeutic agent
February 2025
The global cancer burden is predicted to rise by 40 % around the year 2030. Cancer-related mortality is exacerbated by the fact that the disease is becoming increasingly resistant to standard treatments....
Impurity profiling and forced degradation studies of angiotensin (AT1) blockers: A review
March 2025
This review looks at the latest developments in some analytical techniques employed for impurity profiling and forced degradation studies for sartans, or angiotensin (AT1) receptor blockers, which are...
Formulation and evaluation of apigenin-loaded microsponge gel for effective angioedema therapy
April 2025
The objective of this project was to create a microsponge gel loaded with apigenin to improve medication release to treat angioedema....
Design and validation of a stability-indicating RP-HPLC technique for quantifying ivacaftor in bulk and commercial formulations
April 2025
Aim of this study is to develop a novel Reverse Phase-High performance liquid chromatography (RP-HPLC) method was design and validated for accurately estimating ivacaftor (IVF) in granule form, including...
In silico exploration of Aloe vera leaf compounds as dual AChE and BChE inhibitors for Alzheimer’s disease therapy
April 2025
Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes are therapeutic targets associated with Alzheimer's disease. In this study, we focused on bioactive compounds from Aloe vera leaves,...
Sida cordifolia L. fraction ameliorate renal injury, inflammation, apoptosis and gene expression on cisplatin induced acute kidney injury: Network pharmacology, in vivo and in vitro studies
May 2025
Acute kidney injury (AKI) is known to involve oxidative stress, apoptosis and inflammation and becoming global health issue. Sida cordifolia L. is a medicinal plant having numerous pharmacological properties....
DFT, molecular docking and receptor inhibition analysis of neuromodulatory molecule- dopamine
May 2025
Although dopamine is an essential neurotransmitter involved in many neurological processes, little is known about its structural characteristics and receptor-binding patterns. The advancement of neuropsychiatric...
Exploring the potential mechanism of the active components of Rhizoma Coptidis in tendinopathy treatment applying network pharmacology and molecular docking analysis
August 2025
Rhizoma Coptidis (RC) possesses detoxifying and anti-inflammatory properties, yet its therapeutic mechanism in tendinopathy is unclear. This study investigated the protective effects and molecular mechanisms...
Exploring antiproliferative potential, in silico docking, and molecular dynamics of pyrimidine-morpholine hybrid molecules
May 2025
Cancer remains a leading cause of death worldwide, highlighting the urgent need for novel therapeutic agents. Pyrimidine-morpholine hybrid compounds have been synthesized as potential multitarget anticancer...
Therapeutic potential of natural products in stress granules: Underlying molecular mechanisms and future perspectives
February 2025
Stress granules (SGs) are non-membranous structures that form in response to various cellular stress conditions. Natural compounds, derived from plants, animals, microorganisms, and marine organisms,...
Nanotechnology based electrochemical (bio)sensors for insulin/hormone sensing
February 2025
Insulin is an essential biomarker, mainly found in the bloodstream and controls carbohydrate metabolism. Biosensors are contemporary engineering vehicles that can be usually employed for assorted technological...
Nutraceuticals potential of Zingiber officinale and Linum usitatissimum: A comprehensive analysis of macroscopic, microscopic, physico-chemical and phyto-chemical properties
February 2025
Ginger (Zingiber officinale) and flaxseed (Linum usitatissimum) demonstrate a diverse spectrum of anti-inflammatory and antioxidant properties, with therapeutic applications in integrative medicine,...
Computational investigation of Plectranthus neochilus essential oil phytochemicals interaction with dipeptidyl peptidase 4: A potential avenue for antidiabetic drug discovery
March 2025
This study explores the antidiabetic potential of essential oil compounds from Plectranthus neochilus through molecular docking and pharmacological analysis targeting dipeptidyl peptidase-4 (DPP-4),...
A systematic and comprehensive review of the properties and synthesis of anticancer heterocyclic natural products
March 2025
Heterocyclic natural products are abundant in variety and have useful bioactivities. Cancer, being one of the most widespread sets of potentially lethal diseases, has attracted a great deal of attention...
Single-cell data and network pharmacology screen hub genes related to oxidative stress response in myeloid cell of osteoarthritis
March 2025
Oxidative stress response exerts essential roles in the pathogenesis of osteoarthritis (OA), especially the infiltration of myeloid cells (such as Neutrophil). This study set out to reveal the hub genes...
Identification of diagnostic biomarkers and therapeutic targets for abdominal aortic aneurysms based on disulfidptosis mechanism
April 2025
Currently, there is a lack of hallmark diagnostic markers for abdominal aortic aneurysms (AAA). Recent evidence has suggested the efficacy of gene signature related to Disulfidptosis (a novel form of...
Integrated lipidomics and computational analyses reveal cardiolipin dysregulation as a therapeutic target in bortezomib-induced peripheral neuropathy
February 2025
Multiple myeloma (MM), a common blood cancer driven by abnormal plasma cells, is frequently treated with bortezomib (BTZ), which often triggers peripheral neuropathy (BIPN). While mitochondrial dysfunction...
Colorimetric detection and quantification of glutathione in human serum using the peroxidase-like activity of MOF-808FA frameworks
September 2025
The measurement of GSH plays a crucial role in the timely diagnosis, treatment, and overall management of many diseases, significantly impacting human health. In this research, MOF-808FA has been employed...
Ginsenoside Rg1 alleviates D-galactose-induced hepatic senescence in mice
April 2025
Aging-associated liver injury, driven by oxidative stress and chronic inflammation, poses a significant clinical challenge with limited therapeutic options. Ginsenoside Rg1, a bioactive saponin from...
