Implementation of analytical quality by design (AQbD) in RP-HPLC method development for quantification of allopurinol in pure and commercial formulations
June 2026
Robust analytical methods are essential to ensure the quality, safety, and efficacy of pharmaceutical dosage forms. Analytical quality by design (AQbD) offers a systematic approach for method development...
Advances in drug discovery based on network pharmacology and omics technology
December 2024
Drug discovery plays a crucial role in cancer treatment. Traditional drug discovery methods mainly rely on in vivo animal experiments and in vitro drug screening, which are not only costly but also...
Advancing pharmaceutical research: A comprehensive review of cutting-edge tools and technologies
December 2024
This comprehensive review investigates the cutting-edge tools and technologies that are revolutionizing modern pharmaceutical research. We analyze the integration of artificial intelligence and machine...
RP-HPLC method development and validation for the simultaneous estimation of Piceatannol and L-Arginine in pharmaceutical formulations
January 2026
Dental caries results from microbial dysbiosis, making microbiota balance a superior strategy to antibiotics, which can disrupt oral flora and promote resistance. The Piceatannol–L-Arginine combination...
Quantitative determination of combination of amlodipine besylate and telmisartan in tablets using 1H-qNMR and its comparison to HPLC for further validation
May 2026
HPLC and LC–MS are traditional drug-analysis methods, while 1H-qNMR is increasingly popular as it is a non-destructive technique which does not require standards and enables efficient analysis of complex...
Emerging trends and hot topics in the application of multi-omics in drug discovery: A bibliometric and visualized study
December 2024
The application of multi-omics in drug discovery is rapidly advancing, but its trends and hotspots have not been fully analyzed. By reviewing key achievements and research hotspots in this field, the...
In silico design of some potent antioxidant compounds using 2D-QSAR, molecular docking and ADMET studies
May 2026
Oxidative stress caused by free radicals plays a major role in the development of ageing and several degenerative disorders, including cancer, cardiovascular diseases, diabetes, and Alzheimer’s disease....
Formulation and evaluation of apigenin-loaded microsponge gel for effective angioedema therapy
April 2025
The objective of this project was to create a microsponge gel loaded with apigenin to improve medication release to treat angioedema....
Implementation of QbD approach in RP-HPLC method optimization and validation for concurrent estimation of Deflazacort and Tamsulosin hydrochloride under ICH Q14 and Q2R2 framework
November 2025
The simultaneous estimation of Tamsulosin Hydrochloride (TAM) and Deflazacort (DEF) in capsule dosage form requires a reliable analytical method. Reverse-phase high-performance liquid chromatography...
Analytical approaches for the quantification of dipyridamole in various matrices: A comprehensive review
July 2026
Dipyridamole (DPD) is a crucial antiplatelet and vasodilatory agent widely used to prevent thromboembolic disorders and stroke; however, its quantitative assay remains challenging due to poor solubility,...
Formulation and simultaneous estimation of sustained release bilayer tablet containing polythiazide and reserpine
March 2026
Hypertension management often requires combination therapy for optimal control. This study developed a bilayer tablet combining immediate-release Polythiazide (2 mg) with sustained-release Reserpine...
Ginger oil based solid self nanoemulsifying drug delivery system of etoricoxib with improved oral bioavailability
May 2026
Etoricoxib is a selective cyclooxygenase 2 inhibitor with limited aqueous solubility and low oral bioavailability. The present study aimed to develop a ginger oil-based solid self-nanoemulsifying drug...
Integrated RP-HPLC-FTIR investigation of impurity interconversion and excipient-mediated degradation of venlafaxine tablets
May 2026
Mechanistically informed stability assessment is essential for reliable impurity interpretation and regulatory compliance. Conventional forced degradation studies often overlook analytical-condition-induced...
Advances in electroanalytical techniques for pharmaceuticals and biological samples: Insights from the last decade
March 2026
Over the past decade, electroanalytical techniques have emerged as powerful and sustainable alternatives to conventional spectroscopic and chromatographic methods for pharmaceutical and biological analysis....
Impurity profiling and forced degradation studies of angiotensin (AT1) blockers: A review
March 2025
This review looks at the latest developments in some analytical techniques employed for impurity profiling and forced degradation studies for sartans, or angiotensin (AT1) receptor blockers, which are...
Pharmacological target study of CST1 and TOX in pediatric allergic rhinitis based on molecular docking
June 2026
Allergic rhinitis (AR) is a chronic, IgE‑mediated inflammation of the nasal mucosa that often begins in childhood and is driven by immune dysregulation. Treating pediatric AR remains challenging, and...
Design, synthesis, and therapeutic potential of pyridazinone-based molecules: An updated comprehensive review
August 2025
Drug discovery involves the design, synthesis and pharmacological evaluation of new chemical entities. Heterocyclic compounds are ring structures in which a carbon atom is replaced by heteroatoms such...
Method Development and validation for determination of Parthenolide in mice plasma using reverse phase high performance liquid chromatography
September 2025
For accurate, fast, and selective determination of PTL, a RP-HPLC method was developed and validated. The objective of the study is to develop a reverse-phase high-performance liquid chromatography...
Ion-pair chromatography in pharmaceutical analysis: A practical guide to method development
July 2026
Ion-pair chromatography (IPC) has emerged as a complementary analytical tool, for the analysis of polar and ionizable compounds poorly retained under conventional chromatographic conditions. Its versatility...
Comparative study on the differential chemical composition of Radix Paeoniae Rubra and Radix Paeoniae Alba and their ameliorative effects in a rat model of cold coagulation, Qi stagnation, and blood stasis
May 2026
Radix Paeoniae Rubra (RPR) and Radix Paeoniae Alba (RPA) exhibit distinct clinical efficacy in blood stasis syndrome, yet their compositional differences and pharmacological mechanisms remain uncle...
Wastewater-based epidemiology for monitoring cocaine and cannabis: A review of methods and applications
April 2026
Wastewater-based epidemiology (WBE) is an effective tool for monitoring public health, drug use, chemical exposure, and lifestyle habits. This review summarises and discusses analytical protocols for...
Network pharmacology reveals the underlying mechanisms of Dendrobium officinale on cardiovascular diseases: A perspective from myocardial infarction and intracerebral hemorrhage
May 2026
Dendrobium officinale (DEN) has long been a medicinal and functional food resource in China. This study employed network pharmacology to reveal its mechanisms of action in the treatment of cardiovascular...
In silico exploration of Aloe vera leaf compounds as dual AChE and BChE inhibitors for Alzheimer’s disease therapy
April 2025
Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes are therapeutic targets associated with Alzheimer's disease. In this study, we focused on bioactive compounds from Aloe vera leaves,...
Sponging innovations: A new era of porous nanocarriers in drug delivery and biomedical applications
March 2026
Nanosponges (NSs) are highly crosslinked porous, colloidal carriers that possess a unique three-dimensional, sponge-like structure. It is this special structure that enables them to entrap a broad range...
Autophagy inhibition by sevoflurane reduces neutrophil extracellular trap formation and alleviates organ injury and inflammation in sepsis
May 2026
Sevoflurane, a widely used anesthetic, has been reported to modulate inflammatory responses in sepsis models. However, its influence on autophagy-related neutrophil extracellular trap (NET) formation...