Autophagy inhibition by sevoflurane reduces neutrophil extracellular trap formation and alleviates organ injury and inflammation in sepsis
May 2026
Sevoflurane, a widely used anesthetic, has been reported to modulate inflammatory responses in sepsis models. However, its influence on autophagy-related neutrophil extracellular trap (NET) formation...
Advances in liver injury drug development: Integrating natural small molecules, genomic targets, and network pharmacology
May 2026
In summary, the convergence of natural products, target-specific therapeutic strategies, and network pharmacology represents a promising direction in liver injury drug development. By addressing current...
Quantitative determination of combination of amlodipine besylate and telmisartan in tablets using 1H-qNMR and its comparison to HPLC for further validation
May 2026
HPLC and LC–MS are traditional drug-analysis methods, while 1H-qNMR is increasingly popular as it is a non-destructive technique which does not require standards and enables efficient analysis of complex...
In silico design of some potent antioxidant compounds using 2D-QSAR, molecular docking and ADMET studies
May 2026
Oxidative stress caused by free radicals plays a major role in the development of ageing and several degenerative disorders, including cancer, cardiovascular diseases, diabetes, and Alzheimer’s disease....
Comparative study on the differential chemical composition of Radix Paeoniae Rubra and Radix Paeoniae Alba and their ameliorative effects in a rat model of cold coagulation, Qi stagnation, and blood stasis
May 2026
Radix Paeoniae Rubra (RPR) and Radix Paeoniae Alba (RPA) exhibit distinct clinical efficacy in blood stasis syndrome, yet their compositional differences and pharmacological mechanisms remain uncle...
Network pharmacology reveals the underlying mechanisms of Dendrobium officinale on cardiovascular diseases: A perspective from myocardial infarction and intracerebral hemorrhage
May 2026
Dendrobium officinale (DEN) has long been a medicinal and functional food resource in China. This study employed network pharmacology to reveal its mechanisms of action in the treatment of cardiovascular...
Ginger oil based solid self nanoemulsifying drug delivery system of etoricoxib with improved oral bioavailability
May 2026
Etoricoxib is a selective cyclooxygenase 2 inhibitor with limited aqueous solubility and low oral bioavailability. The present study aimed to develop a ginger oil-based solid self-nanoemulsifying drug...
Integrated RP-HPLC-FTIR investigation of impurity interconversion and excipient-mediated degradation of venlafaxine tablets
May 2026
Mechanistically informed stability assessment is essential for reliable impurity interpretation and regulatory compliance. Conventional forced degradation studies often overlook analytical-condition-induced...
Implementation of Analytical Quality by Design (AQbD) in RP-HPLC Method Development for Quantification of Allopurinol in Pure and Commercial Formulations
Available online 30 April 2026
Robust analytical methods are essential to ensure the quality, safety, and efficacy of pharmaceutical dosage forms. Analytical quality by design (AQbD) offers a systematic approach for method development...
Wastewater-based epidemiology for monitoring cocaine and cannabis: A review of methods and applications
April 2026
Wastewater-based epidemiology (WBE) is an effective tool for monitoring public health, drug use, chemical exposure, and lifestyle habits. This review summarises and discusses analytical protocols for...
Pharmacological basis and antifibrotic potential of Zhuang medicine huanggen in hepatic and pulmonary fibrosis
April 2026
Fibrosis is a dynamic yet a stage that poses therapeutic challenges in chronic liver diseases and other systemic disorders. Huanggen (HG), the dried root of Prismatomeris connata or Prismatomeris tetrandra,...
Jiawei Guilu Erxian Decoction enhances CD8⁺ T-cell activation and cytotoxicity via JNK/c-JUN activation to suppress non-small cell lung cancer tumor growth in vivo
April 2026
The immunological effects of Jiawei Guilu Erxian Decoction (JGED) in non-small cell lung cancer (NSCLC) have not been fully defined. This study investigated whether JGED influences CD8⁺ T-cell activity...
The pharmacological actions of berberine: From a traditional medicine to modern polypharmacology
April 2026
Screening the effective metabolites of Mosla soochowensis Matsuda on LPS-induced inflammation in RAW264.7 cells by integrated LC-triple TOF-MS/MS and network pharmacology
April 2026
Mosla soochowensis Matsuda (MSM) is a traditional Chinese herbal medicine empirically used for treating inflammatory conditions such as tonsillitis and the common cold. Previous studies focused solely...
Computational design and evaluation of novel thienopyrimidine PI3Kδ inhibitors for diffuse large b-cell lymphoma: QSAR, docking, molecular dynamics, and density functional theory studies
April 2026
Phosphoinositide 3-kinase delta (PI3Kδ) is a key regulator of B-cell receptor signalling and a validated therapeutic target in diffuse large B-cell lymphoma (DLBCL). The development of selective and...
HPLC–DAD quantitative analysis via multiomics elucidated the potential HSP90AB1-targeted mechanism of the Scutellaria–Coptis herb pair in high-risk prostate cancer
April 2026
The core mechanism and potential intervention targets of Scutellaria–Coptis in the treatment of high-risk prostate cancer were systematically explored on the basis of network pharmacology and molecular...
Advances in analytical strategies for fixed-dose gliflozin combinations: A comprehensive evaluation
April 2026
Fixed-dose combinations (FDCs) containing gliflozin derivatives have become important therapeutic options in type 2 diabetes, offering complementary mechanisms and improved treatment adherence. Their...
Pharmacological Target Study of CST1 and TOX in Pediatric Allergic Rhinitis Based on Molecular Docking
Available online 17 April 2026
The present study aims to provide novel targets and translational evidence for pediatric allergic rhinitis (AR) immunotherapy, offering potential for personalized intervention strategies....
Effects of different doses of esketamine combined with propofol on gastrointestinal endoscopy in elderly patients
March 2026
Propofol alone for painless gastroscopy/colonoscopy in elderly patients causes frequent movement and respiratory depression due to poor analgesia. Esketamine, the only intravenous anesthetic with analgesic...
Advances in electroanalytical techniques for pharmaceuticals and biological samples: Insights from the last decade
March 2026
Over the past decade, electroanalytical techniques have emerged as powerful and sustainable alternatives to conventional spectroscopic and chromatographic methods for pharmaceutical and biological analysis....
Nigellidine from Nigella sativa Targets AKT1 and GAPDH in rectal cancer: Insights from network pharmacology and molecular dynamics simulations
March 2026
Rectal cancer continues to pose a significant therapeutic challenge, underscoring the need for novel multi-target treatment strategies. Nigella sativa is rich in bioactive phytochemicals with reported...
Stability of Ketamine-Xylazine-Butorphanol formulation to establish an evidence-based beyond-use date
March 2026
A combination injection formulation containing 8.3 % w/v ketamine (K), 0.83 % w/v xylazine (X), and 0.083 % w/v butorphanol (B) is frequently used for sedation and anesthesia in New World Camelids....
Formulation and simultaneous estimation of sustained release bilayer tablet containing polythiazide and reserpine
March 2026
Hypertension management often requires combination therapy for optimal control. This study developed a bilayer tablet combining immediate-release Polythiazide (2 mg) with sustained-release Reserpine...
Advances in traditional Chinese medicine for the treatment of acute radiation-induced oral mucositis: A review from clinical efficacy to pharmacological and analytical insights
March 2026
Acute radiation-induced oral mucositis (ROM) is a debilitating complication of radiotherapy for head and neck cancer. Despite advances in supportive care, current therapies remain suboptimal. Traditional...
