Integrating serum pharmacochemistry and network pharmacology to uncover Chaihu Lizhong formula alleviates MAFLD via PI3K/AKT/mTOR-mediated autophagy activation
July 2026
Metabolic-associated fatty liver disease (MAFLD) is characterized by excessive hepatic fat accumulation and can lead to severe complications, highlighting the need for effective treatments. This study...
Analytical approaches for the quantification of dipyridamole in various matrices: A comprehensive review
July 2026
Dipyridamole (DPD) is a crucial antiplatelet and vasodilatory agent widely used to prevent thromboembolic disorders and stroke; however, its quantitative assay remains challenging due to poor solubility,...
Ion-pair chromatography in pharmaceutical analysis: A practical guide to method development
July 2026
Ion-pair chromatography (IPC) has emerged as a complementary analytical tool, for the analysis of polar and ionizable compounds poorly retained under conventional chromatographic conditions. Its versatility...
Sulforaphane suppresses periodontitis via the NF-κB signaling pathway inhibition and attenuation of inflammation and osteoclast differentiation
July 2026
Aggressive periodontitis (AgP) is closely associated with inflammatory responses and osteoclast differentiation mediated by the NF-κB pathway. Sulforaphane (SFN) possesses anti-inflammatory and anti-osteoclastogenic...
Sheng-Xian-Tang alleviates endoplasmic reticulum stress, autophagy, and apoptosis through the PI3K/AKT/mTOR pathway in pulmonary fibrosis
July 2026
Pulmonary fibrosis (PF) is a progressive interstitial lung disease with high morbidity and mortality. Sheng-Xian-Tang (SXT) has shown therapeutic potential against PF. This study aimed to elucidate...
Phytoconstituent based formulations and phenolic compounds in acne management with a comprehensive review of traditional remedies, modern strategies, and therapeutic innovations
July 2026
Acne vulgaris, a prevalent dermatological disorder, has traditionally been managed with pharmacological treatments, but there is a growing interest in herbal remedies due to their perceived safety and...
HPLC determination of two oxidative degradation impurities in exemestane active pharmaceutical ingredient
Available online 18 July 2026
Exemestane is prone to oxidative degradation, forming structurally similar isomeric impurities. This study established an high-performance liquid chromatography (HPLC) method for the determination of...
Exploring the Mechanism of Dandelion in Treating Helicobacter pylori-Induced Chronic Gastritis Based on Network Pharmacology
Available online 18 July 2026
Helicobacter pylori-induced chronic gastritis (HAG) is a significant healthcare burden in China due to its prevalence and carcinogenic potential. Current clinical management relies on antimicrobial...
Real-World Adverse Event Signals of Immunotherapeutic Agents in Lung Cancer: A Pharmacovigilance Data Mining Approach
Available online 14 July 2026
Real-world safety data for immune checkpoint inhibitors nivolumab, pembrolizumab, and durvalumab are essential to guide their clinical use for the treatment of lung cancer. This study analyzed their...
Research progresses on natural product monomers in the treatment of rheumatoid arthritis
Available online 8 July 2026
Rheumatoid arthritis (RA) is a chronic autoimmune disease with substantial global health implications. Although conventional synthetic disease modifying antirheumatic drugs (DMARDs) afford symptomatic...
Uncaria rhynchophylla exerts a neuroprotective effect against febrile seizures by inhibiting NMDAR-mediated neuronal excitability
Available online 8 July 2026
Uncaria rhynchophylla (UR) is a traditional Chinese medicine widely used for disorders of the nervous and cardiovascular systems. Febrile seizures (FS), the most prevalent cause of seizures in young...
Current Status and Prospects of Microbial Ecology and Detection Strategies in Pharmaceutical Water Systems
Available online 3 July 2026
Pharmaceutical water systems constitute a critical utility within the pharmaceutical manufacturing. Water plays a pivotal role in various stages—including synthesis, formulation, and cleaning—yet simultaneously...
Pharmacological target study of CST1 and TOX in pediatric allergic rhinitis based on molecular docking
June 2026
Allergic rhinitis (AR) is a chronic, IgE‑mediated inflammation of the nasal mucosa that often begins in childhood and is driven by immune dysregulation. Treating pediatric AR remains challenging, and...
Implementation of analytical quality by design (AQbD) in RP-HPLC method development for quantification of allopurinol in pure and commercial formulations
June 2026
Robust analytical methods are essential to ensure the quality, safety, and efficacy of pharmaceutical dosage forms. Analytical quality by design (AQbD) offers a systematic approach for method development...
Determination of lipophilicity of naphthylhydroxamic acids through various methods to assist drug discovery
June 2026
Lipophilicity is a crucial physicochemical property that substantially impacts a compound potential as a drug candidate by affecting its drug absorption, distribution, and membrane permeability. The...
Involvement of the HMGB1/TLR4/NF-κB axis in the protective effect of safflower yellow injection against myocardial ischemia/reperfusion injury via regulation of endoplasmic reticulum stress
June 2026
Safflower yellow injection (SYI) has demonstrated cardioprotective effects on myocardial ischemia/reperfusion (MI/R) injury. This study aimed to explore its mechanistic basis....
Real-world comparative study of terminally sterilized oxaliplatin aqueous injection versus lyophilized formulations in adjuvant chemotherapy for colorectal cancer: A clinical and pharmacoeconomic analysis
June 2026
Oxaliplatin is a key component of XELOX chemotherapy for colorectal cancer. Conventional lyophilized formulations require reconstitution before administration, which may increase preparation time, contamination...
Integrated computational evaluation of 4-hydroxychalcone as a potential acetylcholinesterase inhibitor
June 2026
Alzheimer’s disease (AD) is a major neurodegenerative disorder characterized by cognitive decline, amyloid-β aggregation, neurofibrillary tangles, and cholinergic dysfunction. Acetylcholinesterase (AChE)...
Quality Markers of GFDH Pills Based on Multi-component Qualitative and Quantitative Analysis Combined with Network Pharmacology and Chemometric Analysis
Available online 28 June 2026
Guifu Dihuang (GFDH) Pills is a classic traditional Chinese medicine prescription for kidney yang deficiency. At present, its quality control only takes Paeonol as the single marker, which is difficult...
Design and In Silico Optimization of Pyrazolopyridine-Based Pantothenate Synthetase (PanC) Inhibitors as Novel Anti-Tuberculosis Leads
Available online 1 June 2026
Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains a major global health challenge, particularly due to the rising prevalence of multidrug-resistant strains. Pantothenate synthetase (PanC),...
Autophagy inhibition by sevoflurane reduces neutrophil extracellular trap formation and alleviates organ injury and inflammation in sepsis
May 2026
Sevoflurane, a widely used anesthetic, has been reported to modulate inflammatory responses in sepsis models. However, its influence on autophagy-related neutrophil extracellular trap (NET) formation...
Advances in liver injury drug development: Integrating natural small molecules, genomic targets, and network pharmacology
May 2026
In summary, the convergence of natural products, target-specific therapeutic strategies, and network pharmacology represents a promising direction in liver injury drug development. By addressing current...
Quantitative determination of combination of amlodipine besylate and telmisartan in tablets using 1H-qNMR and its comparison to HPLC for further validation
May 2026
HPLC and LC–MS are traditional drug-analysis methods, while 1H-qNMR is increasingly popular as it is a non-destructive technique which does not require standards and enables efficient analysis of complex...
In silico design of some potent antioxidant compounds using 2D-QSAR, molecular docking and ADMET studies
May 2026
Oxidative stress caused by free radicals plays a major role in the development of ageing and several degenerative disorders, including cancer, cardiovascular diseases, diabetes, and Alzheimer’s disease....