Design and in silico optimization of pyrazolopyridine-based pantothenate synthetase (PanC) inhibitors as novel anti-tuberculosis leads
September 2026
Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains a major global health challenge, particularly due to the rising prevalence of multidrug-resistant strains. Pantothenate synthetase (PanC),...
Quality markers of GFDH pills based on multi-component qualitative and quantitative analysis combined with network pharmacology and chemometric analysis
September 2026
Guifu Dihuang (GFDH) Pills is a classic traditional Chinese medicine prescription for kidney yang deficiency. At present, its quality control only takes Paeonol as the single marker, which is difficult...
HPLC determination of two oxidative degradation impurities in exemestane active pharmaceutical ingredient
September 2026
Exemestane is prone to oxidative degradation, forming structurally similar isomeric impurities. This study established an high-performance liquid chromatography (HPLC) method for the determination of...
Exploring the mechanism of dandelion in treating helicobacter pylori-induced chronic gastritis based on network pharmacology
September 2026
Helicobacter pylori-induced chronic gastritis (HAG) is a significant healthcare burden in China due to its prevalence and carcinogenic potential. Current clinical management relies on antimicrobial...
Clinical utility of FEV1/FVC in asthma management: A data-driven model
September 2026
This study aimed to compare the real-world efficacy of budesonide/glycopyrronium/formoterol (BGF) and budesonide/formoterol (BF), and to develop and internally validate a FEV₁/FVC-based machine learning...
Therapeutic potential of Tanshinone ⅡA in periodontitis: An in vitro study revealing its anti-inflammatory effect through activation of autophagy in lipopolysaccharide-induced human periodontal ligament fibroblasts
September 2026
This study was designed to investigate the underlying mechanisms of Tanshinone ⅡA using an in vitro model of lipopolysaccharide (LPS)-induced human periodontal ligament fibroblasts (HPDLFs)....
Development and formulation of anti-diabetic capsules containing extract of E. denticulatum: Physicochemical study, encapsulation, and release kinetics
September 2026
Eucheuma denticulatum has been widely used to treat diabetes mellitus due to its several antidiabetic components. The current study aimed to formulate capsules containing the crude extract of E. de...
Progress in anti-IgE monoclonal antibody targeting therapy for allergic bronchial asthma: A review
September 2026
Allergic bronchial asthma is a prevalent chronic airway disease characterized by immunoglobulin E (IgE)-mediated inflammation. For patients with moderate-to-severe diseases that remain inadequately...
In silico discovery of novel benzenesulfonamide-tetrahydropyrimidine hybrids as dual target inhibitors of EGFR and thymidylate synthase
September 2026
Breast cancer remains a major global health challenge, characterized by high heterogeneity and frequent resistance to single-target therapies. Multi-target drug design offers a promising strategy to...
From chemometrics to foundation models in pharmaceutical analysis: Current evidence, limitations, and future directions
September 2026
Pharmaceutical analysis has always been shaped by a careful dialogue between measurement and meaning. Early chemometric approaches brought structure to this dialogue, allowing scientists to uncover...
Exploitation of Ziziphus lotus fruit as a functional culture medium: Impact of yeast fermentation on bioactive composition, antioxidant activity, and In Silico evaluation
September 2026
The fermentation of Ziziphus lotus fruit medium by Saccharomyces cerevisiae was investigated to elucidate the biotransformation of phenolic constituents and their potential molecular mechanisms of ...
In vitro evidence of Piperlongumine as a potential radiosensitizer in cervical cancer cells
Available online 17 September 2026
Radiotherapy has been applied for the treatment of cervical cancer (CC), and our current study aims to reveal the mechanism of Piperlongumine on strengthening radiotherapy sensitization in CC....
Network Pharmacology and Molecular Docking Reveal the Active Compounds and Key Targets of JiaWei SiNi San in Hepatocellular Carcinoma
Available online 13 September 2026
This study aims to investigate the potential anti-tumor efficacy and mechanisms of JiaWei SiNi San (JWSNS) against hepatocellular carcinoma via network pharmacology....
Bioinformatics and Artificial Intelligence for the Discovery of Food-Derived Bioactive Compounds with Health Applications: Current Advances and Future Perspectives
Available online 13 September 2026
Food-derived bioactive compounds have attracted considerable attention because of their ability to modulate biological pathways involved in chronic disease prevention and management. However, the remarkable...
Quercetin suppresses the malignant phenotypes and epithelial-mesenchymal transition in head and neck squamous cell carcinoma cells by regulating the PI3K/AKT signaling pathway
Available online 12 September 2026
Quercetin (Que) has demonstrated anticancer potential against head and neck squamous cell carcinoma (HNSCC), but its role in regulating epithelial-mesenchymal transition (EMT) through the PI3K/AKT signaling...
Sustainable Synthetic Strategies for Active Pharmaceutical Ingredients Using Renewable Resources: A Systematic Review
Available online 12 September 2026
The manufacture of active pharmaceutical ingredients (APIs) is shifting towards sustainable feedstocks rather than petrochemicals, but the industrial viability and environmental attributes of renewable...
Schisandra lignans in hepatocellular carcinoma: multi-mechanistic insights and translational horizons
Available online 12 September 2026
Hepatocellular carcinoma (HCC) remains a leading cause of cancer mortality, with many patients presenting at advanced stages that necessitate systemic therapy. Schisandra-derived dibenzocyclooctadiene...
A Novel Stability indicating LC method for Simultaneous determination of Vildagliptin and Pioglitazone Hydrochloride in API and Marketed Formulations
Available online 10 September 2026
The purpose of this study was to develop and validate a simple, rapid, precise, accurate, stability-indicating, and environmentally sustainable RP-HPLC method for the simultaneous determination of Vildagliptin...
Association of Bevacizumab Added to Chemotherapy and Whole-Brain Radiotherapy with Peritumoral Edema and Prognosis in Patients with Brain Metastases from Non-Squamous Non-Small Cell Lung Cancer
Available online 5 September 2026
Peritumoral edema is a common complication of brain metastases from non-squamous non-small cell lung cancer (NSCLC) and may aggravate neurological symptoms and compromise patients’ tolerance to whole-brain...
Smilax glabra Roxb. Alleviates Gout through Targeting FOS and CD40LG: Insights from Multi-Omics Integration
Available online 2 September 2026
Smilax glabra Roxb. (SGB) is traditionally used for gout treatment, but the underlying mechanisms remain unclear. We aimed to explore the effect of SGB on Gout....
Refining Sedation Strategies in Elderly Patients: A Critical Analysis of Esketamine and Propofol Combination in Gastrointestinal Endoscopy
Available online 1 September 2026
Integrating serum pharmacochemistry and network pharmacology to uncover Chaihu Lizhong formula alleviates MAFLD via PI3K/AKT/mTOR-mediated autophagy activation
July 2026
Metabolic-associated fatty liver disease (MAFLD) is characterized by excessive hepatic fat accumulation and can lead to severe complications, highlighting the need for effective treatments. This study...
Analytical approaches for the quantification of dipyridamole in various matrices: A comprehensive review
July 2026
Dipyridamole (DPD) is a crucial antiplatelet and vasodilatory agent widely used to prevent thromboembolic disorders and stroke; however, its quantitative assay remains challenging due to poor solubility,...
Ion-pair chromatography in pharmaceutical analysis: A practical guide to method development
July 2026
Ion-pair chromatography (IPC) has emerged as a complementary analytical tool, for the analysis of polar and ionizable compounds poorly retained under conventional chromatographic conditions. Its versatility...