Quality markers of GFDH pills based on multi-component qualitative and quantitative analysis combined with network pharmacology and chemometric analysis
September 2026
Guifu Dihuang (GFDH) Pills is a classic traditional Chinese medicine prescription for kidney yang deficiency. At present, its quality control only takes Paeonol as the single marker, which is difficult...
HPLC determination of two oxidative degradation impurities in exemestane active pharmaceutical ingredient
September 2026
Exemestane is prone to oxidative degradation, forming structurally similar isomeric impurities. This study established an high-performance liquid chromatography (HPLC) method for the determination of...
Exploring the mechanism of dandelion in treating helicobacter pylori-induced chronic gastritis based on network pharmacology
September 2026
Helicobacter pylori-induced chronic gastritis (HAG) is a significant healthcare burden in China due to its prevalence and carcinogenic potential. Current clinical management relies on antimicrobial...
Clinical utility of FEV1/FVC in asthma management: A data-driven model
September 2026
This study aimed to compare the real-world efficacy of budesonide/glycopyrronium/formoterol (BGF) and budesonide/formoterol (BF), and to develop and internally validate a FEV₁/FVC-based machine learning...
Therapeutic potential of Tanshinone ⅡA in periodontitis: An in vitro study revealing its anti-inflammatory effect through activation of autophagy in lipopolysaccharide-induced human periodontal ligament fibroblasts
September 2026
This study was designed to investigate the underlying mechanisms of Tanshinone ⅡA using an in vitro model of lipopolysaccharide (LPS)-induced human periodontal ligament fibroblasts (HPDLFs)....
Development and formulation of anti-diabetic capsules containing extract of E. denticulatum: Physicochemical study, encapsulation, and release kinetics
September 2026
Eucheuma denticulatum has been widely used to treat diabetes mellitus due to its several antidiabetic components. The current study aimed to formulate capsules containing the crude extract of E. de...
Progress in anti-IgE monoclonal antibody targeting therapy for allergic bronchial asthma: A review
September 2026
Allergic bronchial asthma is a prevalent chronic airway disease characterized by immunoglobulin E (IgE)-mediated inflammation. For patients with moderate-to-severe diseases that remain inadequately...
In silico discovery of novel benzenesulfonamide-tetrahydropyrimidine hybrids as dual target inhibitors of EGFR and thymidylate synthase
September 2026
Breast cancer remains a major global health challenge, characterized by high heterogeneity and frequent resistance to single-target therapies. Multi-target drug design offers a promising strategy to...
From chemometrics to foundation models in pharmaceutical analysis: Current evidence, limitations, and future directions
September 2026
Pharmaceutical analysis has always been shaped by a careful dialogue between measurement and meaning. Early chemometric approaches brought structure to this dialogue, allowing scientists to uncover...
Exploitation of Ziziphus lotus Fruit as a Functional Culture Medium: Impact of Yeast Fermentation on Bioactive Composition, Antioxidant Activity, and In Silico Evaluation
Available online 20 August 2026
The fermentation of Ziziphus lotus fruit medium by Saccharomyces cerevisiae was investigated to elucidate the biotransformation of phenolic constituents and their potential molecular mechanisms of ...
Integrating serum pharmacochemistry and network pharmacology to uncover Chaihu Lizhong formula alleviates MAFLD via PI3K/AKT/mTOR-mediated autophagy activation
July 2026
Metabolic-associated fatty liver disease (MAFLD) is characterized by excessive hepatic fat accumulation and can lead to severe complications, highlighting the need for effective treatments. This study...
Analytical approaches for the quantification of dipyridamole in various matrices: A comprehensive review
July 2026
Dipyridamole (DPD) is a crucial antiplatelet and vasodilatory agent widely used to prevent thromboembolic disorders and stroke; however, its quantitative assay remains challenging due to poor solubility,...
Ion-pair chromatography in pharmaceutical analysis: A practical guide to method development
July 2026
Ion-pair chromatography (IPC) has emerged as a complementary analytical tool, for the analysis of polar and ionizable compounds poorly retained under conventional chromatographic conditions. Its versatility...
Sulforaphane suppresses periodontitis via the NF-κB signaling pathway inhibition and attenuation of inflammation and osteoclast differentiation
July 2026
Aggressive periodontitis (AgP) is closely associated with inflammatory responses and osteoclast differentiation mediated by the NF-κB pathway. Sulforaphane (SFN) possesses anti-inflammatory and anti-osteoclastogenic...
Research progresses on natural product monomers in the treatment of rheumatoid arthritis
July 2026
Rheumatoid arthritis (RA) is a chronic autoimmune disease with substantial global health implications. Although conventional synthetic disease modifying antirheumatic drugs (DMARDs) afford symptomatic...
Uncaria rhynchophylla exerts a neuroprotective effect against febrile seizures by inhibiting NMDAR-mediated neuronal excitability
July 2026
Uncaria rhynchophylla (UR) is a traditional Chinese medicine widely used for disorders of the nervous and cardiovascular systems. Febrile seizures (FS), the most prevalent cause of seizures in young...
Sheng-Xian-Tang alleviates endoplasmic reticulum stress, autophagy, and apoptosis through the PI3K/AKT/mTOR pathway in pulmonary fibrosis
July 2026
Pulmonary fibrosis (PF) is a progressive interstitial lung disease with high morbidity and mortality. Sheng-Xian-Tang (SXT) has shown therapeutic potential against PF. This study aimed to elucidate...
Phytoconstituent based formulations and phenolic compounds in acne management with a comprehensive review of traditional remedies, modern strategies, and therapeutic innovations
July 2026
Acne vulgaris, a prevalent dermatological disorder, has traditionally been managed with pharmacological treatments, but there is a growing interest in herbal remedies due to their perceived safety and...
Real-World Adverse Event Signals of Immunotherapeutic Agents in Lung Cancer: A Pharmacovigilance Data Mining Approach
Available online 14 July 2026
Real-world safety data for immune checkpoint inhibitors nivolumab, pembrolizumab, and durvalumab are essential to guide their clinical use for the treatment of lung cancer. This study analyzed their...
Current Status and Prospects of Microbial Ecology and Detection Strategies in Pharmaceutical Water Systems
Available online 3 July 2026
Pharmaceutical water systems constitute a critical utility within the pharmaceutical manufacturing. Water plays a pivotal role in various stages—including synthesis, formulation, and cleaning—yet simultaneously...
Pharmacological target study of CST1 and TOX in pediatric allergic rhinitis based on molecular docking
June 2026
Allergic rhinitis (AR) is a chronic, IgE‑mediated inflammation of the nasal mucosa that often begins in childhood and is driven by immune dysregulation. Treating pediatric AR remains challenging, and...
Implementation of analytical quality by design (AQbD) in RP-HPLC method development for quantification of allopurinol in pure and commercial formulations
June 2026
Robust analytical methods are essential to ensure the quality, safety, and efficacy of pharmaceutical dosage forms. Analytical quality by design (AQbD) offers a systematic approach for method development...
Determination of lipophilicity of naphthylhydroxamic acids through various methods to assist drug discovery
June 2026
Lipophilicity is a crucial physicochemical property that substantially impacts a compound potential as a drug candidate by affecting its drug absorption, distribution, and membrane permeability. The...