Identification of diagnostic biomarkers and therapeutic targets for abdominal aortic aneurysms based on disulfidptosis mechanism
April 2025
Currently, there is a lack of hallmark diagnostic markers for abdominal aortic aneurysms (AAA). Recent evidence has suggested the efficacy of gene signature related to Disulfidptosis (a novel form of...
The role of Salvia miltiorrhiza compounds in hepatocellular carcinoma: a preliminary investigation based on computational analysis and liquid chromatography-tandem mass spectrometry
April 2025
The potential therapeutic effect of Salvia miltiorrhiza on hepatocellular carcinoma (HCC) has been expounded. This study commenced to identify the diagnostic biomarkers and predict the role of Salvia...
Ginsenoside Rg1 alleviates D-galactose-induced hepatic senescence in mice
April 2025
Aging-associated liver injury, driven by oxidative stress and chronic inflammation, poses a significant clinical challenge with limited therapeutic options. Ginsenoside Rg1, a bioactive saponin from...
A systematic and comprehensive review of the properties and synthesis of anticancer heterocyclic natural products
March 2025
Heterocyclic natural products are abundant in variety and have useful bioactivities. Cancer, being one of the most widespread sets of potentially lethal diseases, has attracted a great deal of attention...
Impurity profiling and forced degradation studies of angiotensin (AT1) blockers: A review
March 2025
This review looks at the latest developments in some analytical techniques employed for impurity profiling and forced degradation studies for sartans, or angiotensin (AT1) receptor blockers, which are...
Single-cell data and network pharmacology screen hub genes related to oxidative stress response in myeloid cell of osteoarthritis
March 2025
Oxidative stress response exerts essential roles in the pathogenesis of osteoarthritis (OA), especially the infiltration of myeloid cells (such as Neutrophil). This study set out to reveal the hub genes...
Computational investigation of Plectranthus neochilus essential oil phytochemicals interaction with dipeptidyl peptidase 4: A potential avenue for antidiabetic drug discovery
March 2025
This study explores the antidiabetic potential of essential oil compounds from Plectranthus neochilus through molecular docking and pharmacological analysis targeting dipeptidyl peptidase-4 (DPP-4),...
Chaigui Bitong decoction inhibits rheumatoid arthritis fibroblast-like synoviocyte injury through regulating the ferroptosis signaling pathway via Nrf2/HO-1/GPX4 axis
March 2025
The present work analyzed the mechanisms of Chaigui Bitong Decoction (CBD) in rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs), with a particular focus on the effects of its disassembled...
An acyl pyrrole compound 361B promotes angiogenesis and improves hindlimb ischemia recovery
March 2025
Diabetes is the most common type of chronic diseases word wide, accompanied by inadequate local angiogenesis and vascular lesions which is characterized by a gradual disorder function of the endothelial...
Nanotechnology based electrochemical (bio)sensors for insulin/hormone sensing
February 2025
Insulin is an essential biomarker, mainly found in the bloodstream and controls carbohydrate metabolism. Biosensors are contemporary engineering vehicles that can be usually employed for assorted technological...
Nutraceuticals potential of Zingiber officinale and Linum usitatissimum: A comprehensive analysis of macroscopic, microscopic, physico-chemical and phyto-chemical properties
February 2025
Ginger (Zingiber officinale) and flaxseed (Linum usitatissimum) demonstrate a diverse spectrum of anti-inflammatory and antioxidant properties, with therapeutic applications in integrative medicine,...
Bioinformatic methods uncover 5 diagnostic biomarkers associated with drug resistance and metastasis for gastrointestinal stromal tumor
February 2025
Gastrointestinal stromal tumor (GIST) is a prevalent neoplasm in digestive tract, drug resistance and metastasis remain the major challenges during treatment. This work commenced to identify novel diagnostic...
Therapeutic potential of natural products in stress granules: Underlying molecular mechanisms and future perspectives
February 2025
Stress granules (SGs) are non-membranous structures that form in response to various cellular stress conditions. Natural compounds, derived from plants, animals, microorganisms, and marine organisms,...
The role of Ursolic acid, a pharmacologically active compound from Ocimum sanctum L. as a potential chemotherapeutic agent
February 2025
The global cancer burden is predicted to rise by 40 % around the year 2030. Cancer-related mortality is exacerbated by the fact that the disease is becoming increasingly resistant to standard treatments....
Integrated lipidomics and computational analyses reveal cardiolipin dysregulation as a therapeutic target in bortezomib-induced peripheral neuropathy
February 2025
Multiple myeloma (MM), a common blood cancer driven by abnormal plasma cells, is frequently treated with bortezomib (BTZ), which often triggers peripheral neuropathy (BIPN). While mitochondrial dysfunction...
Emerging trends and hot topics in the application of multi-omics in drug discovery: A bibliometric and visualized study
December 2024
The application of multi-omics in drug discovery is rapidly advancing, but its trends and hotspots have not been fully analyzed. By reviewing key achievements and research hotspots in this field, the...
Advances in drug discovery based on network pharmacology and omics technology
December 2024
Drug discovery plays a crucial role in cancer treatment. Traditional drug discovery methods mainly rely on in vivo animal experiments and in vitro drug screening, which are not only costly but also...
Advancing pharmaceutical research: A comprehensive review of cutting-edge tools and technologies
December 2024
This comprehensive review investigates the cutting-edge tools and technologies that are revolutionizing modern pharmaceutical research. We analyze the integration of artificial intelligence and machine...
