Advances in analytical strategies for fixed-dose gliflozin combinations: A comprehensive evaluation
April 2026
Fixed-dose combinations (FDCs) containing gliflozin derivatives have become important therapeutic options in type 2 diabetes, offering complementary mechanisms and improved treatment adherence. Their...
Effects of different doses of esketamine combined with propofol on gastrointestinal endoscopy in elderly patients
March 2026
Propofol alone for painless gastroscopy/colonoscopy in elderly patients causes frequent movement and respiratory depression due to poor analgesia. Esketamine, the only intravenous anesthetic with analgesic...
Advances in electroanalytical techniques for pharmaceuticals and biological samples: Insights from the last decade
March 2026
Over the past decade, electroanalytical techniques have emerged as powerful and sustainable alternatives to conventional spectroscopic and chromatographic methods for pharmaceutical and biological analysis....
Nigellidine from Nigella sativa Targets AKT1 and GAPDH in rectal cancer: Insights from network pharmacology and molecular dynamics simulations
March 2026
Rectal cancer continues to pose a significant therapeutic challenge, underscoring the need for novel multi-target treatment strategies. Nigella sativa is rich in bioactive phytochemicals with reported...
Stability of Ketamine-Xylazine-Butorphanol formulation to establish an evidence-based beyond-use date
March 2026
A combination injection formulation containing 8.3 % w/v ketamine (K), 0.83 % w/v xylazine (X), and 0.083 % w/v butorphanol (B) is frequently used for sedation and anesthesia in New World Camelids....
Formulation and simultaneous estimation of sustained release bilayer tablet containing polythiazide and reserpine
March 2026
Hypertension management often requires combination therapy for optimal control. This study developed a bilayer tablet combining immediate-release Polythiazide (2 mg) with sustained-release Reserpine...
Advances in traditional Chinese medicine for the treatment of acute radiation-induced oral mucositis: A review from clinical efficacy to pharmacological and analytical insights
March 2026
Acute radiation-induced oral mucositis (ROM) is a debilitating complication of radiotherapy for head and neck cancer. Despite advances in supportive care, current therapies remain suboptimal. Traditional...
Sponging innovations: A new era of porous nanocarriers in drug delivery and biomedical applications
March 2026
Nanosponges (NSs) are highly crosslinked porous, colloidal carriers that possess a unique three-dimensional, sponge-like structure. It is this special structure that enables them to entrap a broad range...
The protective effect of folic acid against ischemic stroke: revealing the key genes and pathways through network pharmacology and molecular docking
Available online 25 March 2026
Rapid UPLC-MS/MS Detection of UTI Pathogen Metabolic Markers for Precision Nursing
Available online 24 March 2026
This study establishes a rapid diagnostic platform using UPLC-MS/MS to quantify urinary tract infection biomarkers within 8minutes. Targeting phenylacetylglycine (PAG, E. coli), cyclic diguanylate monophosphate...
Analytical advances in the quantitative and qualitative determination of clonidine and methyldopa: A review
January 2026
Clonidine and methyldopa are centrally acting antihypertensive agents that lower blood pressure by stimulating α₂-adrenoceptors in the brain stem, thereby reducing sympathetic outflow. While clonidine...
Exploring the potential anti-hepatocarcinoma mechanism of Ruangan Lidan Decoction through UHPLC-Q-TOF-MS/MS analysis and network pharmacology approaches
January 2026
Hepatocellular carcinoma (HCC) remains a highly aggressive malignancy with limited therapeutic options. Although Ruangan Lidan Decoction (RGLD), a traditional Chinese medicine (TCM) formula, shows clinical...
Ferulic acid targets AKT1/STAT3/EGFR signaling to induce apoptosis and inhibit metastasis in gastric cancer cells
January 2026
Identification of potential anti-tubercular inhibitors through virtual screening, DFT, and molecular dynamics simulation studies
January 2026
Tuberculosis (TB) continues to pose a significant threat to global health, a problem intensified by the rise of strains of Mycobacterium tuberculosis that resist multiple drugs. Identifying novel inhibitors...
Immunomodulatory and skin-compatible effects of Amaranthus retroflexus volatile compounds: An in-silico network and pathway-based approach
January 2026
This study investigated the phytochemical profile, in silico skin sensitization, cosmetic toxicity, and endocrine-disrupting potential of compounds from Amaranthus retroflexus identified through GC-MS...
Identification of key molecular targets and mechanism of action in acute kidney injury by integrating network pharmacology and molecular docking
January 2026
Acute kidney injury (AKI) is a frequent renal complication in surgical settings. This study aimed to identify key molecular targets for AKI and to elucidate the mechanism of action of drugs that targeted...
A narrative literature review on revolutionizing traditional Chinese medicine: Exploring the potential of spectral imaging technology
January 2026
Spectral imaging facilitates the spatially resolved detection of chemical components within pharmaceutical compounds through established techniques including fluorescence, near-infrared chemical, mid-infrared,...
RP-HPLC method development and validation for the simultaneous estimation of Piceatannol and L-Arginine in pharmaceutical formulations
January 2026
Dental caries results from microbial dysbiosis, making microbiota balance a superior strategy to antibiotics, which can disrupt oral flora and promote resistance. The Piceatannol–L-Arginine combination...
Trifluridine/tipiracil exhibits potent antitumor activity in triple-negative breast cancer by targeting SKP2 and inducing cell cycle arrest and apoptosis
January 2026
Trifluridine/Tipiracil (TFTD) is an innovative oral medication comprising trifluridine and tipiracil. While TFTD has shown efficacy in metastatic colorectal cancer, its therapeutic potential in triple-negative...
Integrating metabolomics, DPPH assay, and literature mining for quality marker prediction and the establishment of a quality control strategy for Ampelopsis grossedentata
January 2026
A member of Vitaceae, Ampelopsis grossedentata (AG) is well-studied for its rich phytochemistry and bioactivities, indicating high medicinal value; yet, a reliable method for comprehensive quality control...
Identification and characterization of the Fd+ 16 Da fragment impurity in therapeutic CD47 monoclonal antibodies expressed in CHO-K1 cell lines
November 2025
Monoclonal antibodies (mAbs) are typically produced using mammalian expression systems—with Chinese hamster ovary (CHO) cells being the most widely employed. To guarantee the efficacy, safety, and consistency...
Chemical characterization, antioxidant effect and xanthine oxidase inhibition of Micromeria fruticosa (L.) druce hexane extract
November 2025
Micromeria fruticosa (L.) Druce, a medicinal plant applied for several diseases, is recognized for its essential oils and bioactive constituents. However, there is a lack of data concerning the phytochemical...
