Potential Cardioprotective Mechanisms of Bawu Junzi Decoction in Myocardial Infarction: Identification of CYP1B1 and ALDH2 as Key Mediators
Available online 28 September 2026
Bawu Junzi (BWJZ) decoction, shows efficacy in treating myocardial infarction (MI) but the specific mechanism remains unclear. This study aims to identify the therapeutic targets and mechanisms of BWJZ...
A Comparative Bibliometric Analysis of Natural Product-Based Combination Therapies in Lung Cancer: Insights into Analytical Strategies and Translational Challenges
Available online 24 September 2026
Natural products have attracted increasing attention in lung cancer because of their direct antitumor activity and their potential roles as sensitizers or synergistic agents in combination therapy....
Metabolic Reprogramming in Periodontitis: Evidence Stratification, Pharmacological Modulators, and Translational Challenges
Available online 24 September 2026
Periodontitis is a biofilm-associated inflammatory disease in which dysregulated host responses drive progressive destruction of the tooth-supporting tissues. Although recent reviews have emphasized...
Paeoniflorin alleviates sepsis-induced liver injury: insights from integrative transcriptomic and metabolomic analysis
Available online 23 September 2026
Sepsis-induced liver injury (SILI) is a critical complication of sepsis and contributes substantially to mortality. Paeoniflorin (PF), a bioactive compound derived from traditional Chinese medicine,...
In vitro evidence of Piperlongumine as a potential radiosensitizer in cervical cancer cells
Available online 17 September 2026
Radiotherapy has been applied for the treatment of cervical cancer (CC), and our current study aims to reveal the mechanism of Piperlongumine on strengthening radiotherapy sensitization in CC....
Integrating serum pharmacochemistry and network pharmacology to uncover Chaihu Lizhong formula alleviates MAFLD via PI3K/AKT/mTOR-mediated autophagy activation
July 2026
Metabolic-associated fatty liver disease (MAFLD) is characterized by excessive hepatic fat accumulation and can lead to severe complications, highlighting the need for effective treatments. This study...
Analytical approaches for the quantification of dipyridamole in various matrices: A comprehensive review
July 2026
Dipyridamole (DPD) is a crucial antiplatelet and vasodilatory agent widely used to prevent thromboembolic disorders and stroke; however, its quantitative assay remains challenging due to poor solubility,...
Ion-pair chromatography in pharmaceutical analysis: A practical guide to method development
July 2026
Ion-pair chromatography (IPC) has emerged as a complementary analytical tool, for the analysis of polar and ionizable compounds poorly retained under conventional chromatographic conditions. Its versatility...
Sulforaphane suppresses periodontitis via the NF-κB signaling pathway inhibition and attenuation of inflammation and osteoclast differentiation
July 2026
Aggressive periodontitis (AgP) is closely associated with inflammatory responses and osteoclast differentiation mediated by the NF-κB pathway. Sulforaphane (SFN) possesses anti-inflammatory and anti-osteoclastogenic...
Research progresses on natural product monomers in the treatment of rheumatoid arthritis
July 2026
Rheumatoid arthritis (RA) is a chronic autoimmune disease with substantial global health implications. Although conventional synthetic disease modifying antirheumatic drugs (DMARDs) afford symptomatic...
Uncaria rhynchophylla exerts a neuroprotective effect against febrile seizures by inhibiting NMDAR-mediated neuronal excitability
July 2026
Uncaria rhynchophylla (UR) is a traditional Chinese medicine widely used for disorders of the nervous and cardiovascular systems. Febrile seizures (FS), the most prevalent cause of seizures in young...
Sheng-Xian-Tang alleviates endoplasmic reticulum stress, autophagy, and apoptosis through the PI3K/AKT/mTOR pathway in pulmonary fibrosis
July 2026
Pulmonary fibrosis (PF) is a progressive interstitial lung disease with high morbidity and mortality. Sheng-Xian-Tang (SXT) has shown therapeutic potential against PF. This study aimed to elucidate...
Phytoconstituent based formulations and phenolic compounds in acne management with a comprehensive review of traditional remedies, modern strategies, and therapeutic innovations
July 2026
Acne vulgaris, a prevalent dermatological disorder, has traditionally been managed with pharmacological treatments, but there is a growing interest in herbal remedies due to their perceived safety and...
Current Status and Prospects of Microbial Ecology and Detection Strategies in Pharmaceutical Water Systems
Available online 3 July 2026
Pharmaceutical water systems constitute a critical utility within the pharmaceutical manufacturing. Water plays a pivotal role in various stages—including synthesis, formulation, and cleaning—yet simultaneously...
Pharmacological target study of CST1 and TOX in pediatric allergic rhinitis based on molecular docking
June 2026
Allergic rhinitis (AR) is a chronic, IgE‑mediated inflammation of the nasal mucosa that often begins in childhood and is driven by immune dysregulation. Treating pediatric AR remains challenging, and...
Implementation of analytical quality by design (AQbD) in RP-HPLC method development for quantification of allopurinol in pure and commercial formulations
June 2026
Robust analytical methods are essential to ensure the quality, safety, and efficacy of pharmaceutical dosage forms. Analytical quality by design (AQbD) offers a systematic approach for method development...
Determination of lipophilicity of naphthylhydroxamic acids through various methods to assist drug discovery
June 2026
Lipophilicity is a crucial physicochemical property that substantially impacts a compound potential as a drug candidate by affecting its drug absorption, distribution, and membrane permeability. The...
Involvement of the HMGB1/TLR4/NF-κB axis in the protective effect of safflower yellow injection against myocardial ischemia/reperfusion injury via regulation of endoplasmic reticulum stress
June 2026
Safflower yellow injection (SYI) has demonstrated cardioprotective effects on myocardial ischemia/reperfusion (MI/R) injury. This study aimed to explore its mechanistic basis....
Real-world comparative study of terminally sterilized oxaliplatin aqueous injection versus lyophilized formulations in adjuvant chemotherapy for colorectal cancer: A clinical and pharmacoeconomic analysis
June 2026
Oxaliplatin is a key component of XELOX chemotherapy for colorectal cancer. Conventional lyophilized formulations require reconstitution before administration, which may increase preparation time, contamination...
Integrated computational evaluation of 4-hydroxychalcone as a potential acetylcholinesterase inhibitor
June 2026
Alzheimer’s disease (AD) is a major neurodegenerative disorder characterized by cognitive decline, amyloid-β aggregation, neurofibrillary tangles, and cholinergic dysfunction. Acetylcholinesterase (AChE)...
Ginger oil based solid self nanoemulsifying drug delivery system of etoricoxib with improved oral bioavailability
May 2026
Etoricoxib is a selective cyclooxygenase 2 inhibitor with limited aqueous solubility and low oral bioavailability. The present study aimed to develop a ginger oil-based solid self-nanoemulsifying drug...
Integrated RP-HPLC-FTIR investigation of impurity interconversion and excipient-mediated degradation of venlafaxine tablets
May 2026
Mechanistically informed stability assessment is essential for reliable impurity interpretation and regulatory compliance. Conventional forced degradation studies often overlook analytical-condition-induced...
Network pharmacology reveals the underlying mechanisms of Dendrobium officinale on cardiovascular diseases: A perspective from myocardial infarction and intracerebral hemorrhage
May 2026
Dendrobium officinale (DEN) has long been a medicinal and functional food resource in China. This study employed network pharmacology to reveal its mechanisms of action in the treatment of cardiovascular...