Incretin Hormones: Mechanisms, Therapeutic Implications, and Future Directions in Glucose Regulation and Diabetes Management
April 2025
Type 2 diabetes (T2D) is a global health crisis, currently affecting over 540 million individuals. Its prevalence continues to rise due to aging populations, sedentary lifestyles, and unhealthy diets....
The anti-aging effect and mechanism of a compound peptide on sensitive skin
June 2026
•Complex peptides exhibit no toxic effects on primary keratinocytes and fibroblasts within a certain concentration range.•Complex peptides could suppress inflammatory responses and promote barrier repair...
Targeting the unexplored 'dark proteome': Novel approaches in drug discovery
June 2025
The dark proteome, consisting of disordered, transient, and flexible regions of proteins, remains largely unexplored despite its potential for novel drug discovery. These regions, which lack stable...
Ion channels as emerging drug targets: Pharmacological insights and therapeutic advances
August 2026
Ion channels are crucial regulators of cellular signaling and homeostasis, and their failure is associated with various clinical illnesses, including neurological disorders, cardiovascular diseases,...
Applications and challenges of tear proteomics in unveiling the molecular mechanisms and biomarkers of dry eye disease
February 2026
Dry Eye Disease (DED) stands as one of the most prevalent ocular surface disorders globally, with an increasing incidence that significantly impairs patients’ visual function and quality of life. Conventional...
Leukemia stem cell differentiation in acute myeloid leukemia: Molecular mechanisms and multi-omics insights
April 2026
Acute myeloid leukemia (AML) arises from blocked myeloid differentiation and subsequent accumulation of immature myeloid progenitors. Leukemia stem cells (LSCs) sustain AML hierarchical architecture...
The evolving landscape of immunotherapy in lung cancer: From mechanism to clinical translation
June 2026
Lung cancer is the leading cause of cancer-related mortality worldwide, accounting for 12.4% of all incident cancers and 18.7% of total cancer deaths globally. Most patients are diagnosed at advanced...
Synthesis, antimicrobial evaluation, and molecular docking of novel pyrene-functionalized pyrazole derivatives
June 2026
•Novel polynuclear pyrene-based pyrazoles were efficiently designed and synthesized.•Structures were confirmed by NMR and mass spectrometric analyses.•Pyrazoles showed broad-spectrum antibacterial and...
Structure-based virtual screening and molecular dynamics simulation for the identification of novel potential inhibitors for the NDM-1 of Klebsiella Pneumoniae from the marine natural products
February 2026
The emergence of antibiotic-resistant bacteria, especially New Delhi Metallo-β-lactamase-1 (NDM-1) of Klebsiella pneumoniae, is a significant threat to serious public health. The aim of this study was...
Advances in machine learning for optimizing pharmaceutical drug discovery
April 2025
The integration of advanced machine learning methodologies has revolutionized the field of pharmaceutical drug discovery by addressing critical challenges in efficiency, scalability, and accuracy. This...
Isolupalbigenin as a multi-target natural scaffold targeting HER2, EGFR, IGF-1R, and BCL-2 in breast cancer: An integrated docking, molecular dynamics, and DFT study
April 2026
This study aimed to identify potential multi-target natural compounds capable of interacting with key breast cancer–associated proteins using an integrated computational framework....
The progress and prospects of single-cell sequencing, multi-omics integration analysis, and immunotherapy targeting strategies in lung cancer research
December 2025
Lung cancer is a highly prevalent and lethal malignant tumor globally, imposing a heavy burden on public health. Traditional treatments such as surgery, chemotherapy, and radiotherapy have significant...
Comprehensive omics profiling in acute myeloid leukemia: From molecular landscape to clinical translation
June 2025
Acute Myeloid Leukemia (AML) is a molecularly heterogeneous hematologic malignancy driven by diverse genetic, epigenetic, and transcriptomic alterations. Recent advancements in high-throughput omics...
Tenascin C: a multifaceted interplayer in the rheumatoid arthritis pathogenesis and progression - insights and implications
April 2026
Tenascin-C (TNC) has emerged as an endogenous damage-associated molecular pattern (DAMP) molecule that sustains the inflammatory milieu in RA joints, because it acts not merely as a structural matrix...
In-Silico and Machine Learning-Based Evaluation of Dipeptide Inhibitors Targeting Isoleucyl-tRNA Synthetase in Dermatophytic Fungal Infection
August 2026
Dermatophytosis is one of the most widespread fungal infections caused by dermatophytes such as Trichophyton, Microsporum, and Epidermophyton. The increasing prevalence of antifungal resistance has...
Spatial omics: Deciphering heterogeneity in the tumor immune microenvironment and resistance to immunotherapy
October 2025
Drug resistance in tumor immunotherapy is a significant challenge, stemming from the high heterogeneity and intricate spatial architecture of the tumor immune microenvironment. Traditional omics technologies...
Decoding disorder: Advances in predicting intrinsically disordered proteins
June 2025
Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) play critical roles in cellular signaling, transcriptional regulation, and dynamic protein-protein interactions....
A Multimodal artificial intelligence framework for mechanistic discovery and digital twin construction in cardiovascular medicine
October 2025
Multimodal artificial intelligence (AI) is reshaping contemporary cardiovascular medicine. Its contribution has moved far beyond early successes in image recognition, arrhythmia detection, and automated...
In silico design and evaluation of a multi-epitope vaccine targeting SARS-CoV-2 structural proteins
April 2026
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to pose a serious global health threat....
Immune biomarkers as key targets in managing tuberculosis: A systematic review
October 2025
Tuberculosis remains a major global health challenge and is one of the leading causes of mortality worldwide. In recent years, the resurgence of the disease has intensified research efforts aimed at...
Psoralen induces osteoblast differentiation by increasing ESR1 expression in human osteoblasts
August 2026
•Psoralen upregulated ESR1 expression in hFOB1.19 cells.•Psoralen treatment promoted ALP activity and contents and enhanced hFOB1.19 cell mineralization ability.•Psoralen treatment also increased the...
Identification of ORM1 in acute myocardial infarction via proteomics plus machine learning and exploring its diagnostic value and function
June 2026
•ORM1 was identified as a biomarker for AMI via proteomics and machine learning.•ORM1 was upregulated in AMI and exhibited good diagnostic value for AMI.•ORM1 knockdown alleviated cell apoptosis, inflammatory...
Regulation of macrophage efferocytosis and immune homeostasis by natural bioactive compounds: A novel therapeutic mechanism for rheumatic autoimmune diseases
June 2026
Rheumatic immune diseases (RID), mainly encompassing rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), systemic sclerosis (SSc) and Sjögren’s syndrome (SS), belong to a group of chronic...
The interplay of Drp1 post-translational modifications as a regulatory network driving mitochondrial fission in diabetic kidney disease
April 2026
Diabetic Kidney Disease (DKD) is the primary cause of end-stage renal disease (ESRD), with renal interstitial fibrosis being the core driver of its progression. Mitochondrial dynamics imbalance, particularly...
Identification of ferroptosis-related biomarker in breast cancer and analysis of its role in breast cancer progression
June 2026
•The study identified BUB1B as a candidate hub gene.•Expression levels of BUB1B were significantly correlated with immune cell infiltration.•Silencing BUB1B significantly inhibited BC cell proliferation...