Incretin Hormones: Mechanisms, Therapeutic Implications, and Future Directions in Glucose Regulation and Diabetes Management
April 2025
Type 2 diabetes (T2D) is a global health crisis, currently affecting over 540 million individuals. Its prevalence continues to rise due to aging populations, sedentary lifestyles, and unhealthy diets....
Targeting the unexplored 'dark proteome': Novel approaches in drug discovery
June 2025
The dark proteome, consisting of disordered, transient, and flexible regions of proteins, remains largely unexplored despite its potential for novel drug discovery. These regions, which lack stable...
Structure-based virtual screening and molecular dynamics simulation for the identification of novel potential inhibitors for the NDM-1 of Klebsiella Pneumoniae from the marine natural products
February 2026
The emergence of antibiotic-resistant bacteria, especially New Delhi Metallo-β-lactamase-1 (NDM-1) of Klebsiella pneumoniae, is a significant threat to serious public health. The aim of this study was...
The progress and prospects of single-cell sequencing, multi-omics integration analysis, and immunotherapy targeting strategies in lung cancer research
December 2025
Lung cancer is a highly prevalent and lethal malignant tumor globally, imposing a heavy burden on public health. Traditional treatments such as surgery, chemotherapy, and radiotherapy have significant...
In silico design and evaluation of a multi-epitope vaccine targeting SARS-CoV-2 structural proteins
April 2026
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to pose a serious global health threat....
Advances in machine learning for optimizing pharmaceutical drug discovery
April 2025
The integration of advanced machine learning methodologies has revolutionized the field of pharmaceutical drug discovery by addressing critical challenges in efficiency, scalability, and accuracy. This...
Decoding disorder: Advances in predicting intrinsically disordered proteins
June 2025
Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) play critical roles in cellular signaling, transcriptional regulation, and dynamic protein-protein interactions....
Isolupalbigenin as a multi-target natural scaffold targeting HER2, EGFR, IGF-1R, and BCL-2 in breast cancer: An integrated docking, molecular dynamics, and DFT study
April 2026
This study aimed to identify potential multi-target natural compounds capable of interacting with key breast cancer–associated proteins using an integrated computational framework....
Applications and challenges of tear proteomics in unveiling the molecular mechanisms and biomarkers of dry eye disease
February 2026
Dry Eye Disease (DED) stands as one of the most prevalent ocular surface disorders globally, with an increasing incidence that significantly impairs patients’ visual function and quality of life. Conventional...
Deciphering Rab32-associated antibacterial responses: Proteomics reveals the heterogeneity of macrophage defense against bacterial pathogen infection
April 2026
•Rab32, a Ras superfamily GTPase, exhibits broad-spectrum antimicrobial activity in macrophages against various bacterial pathogens.•Proteomic analysis reveals Rab32 deficiency alters host cell response...
A Multimodal artificial intelligence framework for mechanistic discovery and digital twin construction in cardiovascular medicine
October 2025
Multimodal artificial intelligence (AI) is reshaping contemporary cardiovascular medicine. Its contribution has moved far beyond early successes in image recognition, arrhythmia detection, and automated...
Leukemia stem cell differentiation in acute myeloid leukemia: Molecular mechanisms and multi-omics insights
April 2026
Acute myeloid leukemia (AML) arises from blocked myeloid differentiation and subsequent accumulation of immature myeloid progenitors. Leukemia stem cells (LSCs) sustain AML hierarchical architecture...
Platelet activationprotects againstbacterial lung injury via the TLR4/MYD88 pathway
April 2026
•Platelet treatment protected against lung injury of S. pneumonia-infected mice.•Platelet treatment inhibited immune response, inflammation and oxidative stress in S. pneumonia-infected mice.•LPS induced...
Spatial omics: Deciphering heterogeneity in the tumor immune microenvironment and resistance to immunotherapy
October 2025
Drug resistance in tumor immunotherapy is a significant challenge, stemming from the high heterogeneity and intricate spatial architecture of the tumor immune microenvironment. Traditional omics technologies...
Comprehensive omics profiling in acute myeloid leukemia: From molecular landscape to clinical translation
June 2025
Acute Myeloid Leukemia (AML) is a molecularly heterogeneous hematologic malignancy driven by diverse genetic, epigenetic, and transcriptomic alterations. Recent advancements in high-throughput omics...
Immune biomarkers as key targets in managing tuberculosis: A systematic review
October 2025
Tuberculosis remains a major global health challenge and is one of the leading causes of mortality worldwide. In recent years, the resurgence of the disease has intensified research efforts aimed at...
A research status and prospects of edible fungal-derived fibrinolytic enzymes: breakthroughs based on multi-omics and intelligent delivery technologies
February 2026
Thrombotic diseases represent a significant global health burden. Current clinical thrombolytic agents are plagued by limitations including short half-lives, high bleeding risks, and exorbitant costs....
Design and synthesis of heterocyclic biphenyl-resultant novel pyrazole scaffolds: In-vitro and In-silico studies for potent antimicrobial agents
April 2026
•Novel biphenyl–heterocyclic pyrazole frameworks (4a–4 h) designed and synthesized.•Structures validated via FT-IR, NMR, and HRMS analyses.•Docking against Escherichia coli DNA gyrase B revealed strong...
Advances in the combination of immunotherapy and radiotherapy for microsatellite-stable metastatic colorectal cancer
October 2025
Combining immunotherapy with radiotherapy has emerged as a novel and promising approach for treating microsatellite-stable metastatic colorectal cancer (MSS mCRC). This review offers an in-depth analysis...
Docking and AI-based classification cum recurrent neural network validation for predicting anti-tubercular leads against dprE-1 enzyme targeter
April 2025
Tuberculosis (TB) continues to pose a major global health challenge, highlighting the need for the development of new therapeutic agents....
Proteomic insights into myogenic progression in cultured muscle cells of Lates calcarifer (Bloch, 1790)
April 2026
Muscle cell lines serve as valuable models for investigating mechanisms underlying muscle proliferation and differentiation. This study aimed to characterize proteomic changes during passage progression...
The mechanism of active components of Panax japonicus in mediating the HIF-VEGF signaling pathway to promote fracture healing: An investigation utilizing serum pharmacochemistry and network pharmacology approaches
February 2026
To establish a tibial fracture model in rats and preliminarily investigate the intervention mechanisms of Panax japonicus on the tibial fracture healing process based on the angiogenesis mechanisms...
MCM2, AURKA and MCM6: potential diagnostic biomarkers for cervical cancer
February 2026
•MCM2, AURKA and MCM6 are highly expressed in CC tissues.•MCM2, AURKA and MCM6 can be used as diagnostic biomarkers for CC.•MCM2, AURKA and MCM6 are correlated with immune infiltration....
Silencing of KLF9 alleviates palmitic acid-induced insulin resistance and inflammation in undifferentiated myoblasts by targeting GRB14, unveiling a pathogenic axis in Type 2 diabetic myopathy
February 2026
Skeletal muscle insulin resistance and inflammation are key drivers in the progression of skeletal muscle atrophy in Type 2 diabetes (T2D). This study aimed to identify novel molecular regulators underlying...
Synthesis, antimicrobial evaluation, and molecular docking of novel pyrene-functionalized pyrazole derivatives
June 2026
•Novel polynuclear pyrene-based pyrazoles were efficiently designed and synthesized.•Structures were confirmed by NMR and mass spectrometric analyses.•Pyrazoles showed broad-spectrum antibacterial and...
