Incretin Hormones: Mechanisms, Therapeutic Implications, and Future Directions in Glucose Regulation and Diabetes Management
April 2025
Type 2 diabetes (T2D) is a global health crisis, currently affecting over 540 million individuals. Its prevalence continues to rise due to aging populations, sedentary lifestyles, and unhealthy diets....
Ion channels as emerging drug targets: Pharmacological insights and therapeutic advances
August 2026
Ion channels are crucial regulators of cellular signaling and homeostasis, and their failure is associated with various clinical illnesses, including neurological disorders, cardiovascular diseases,...
Pyrazole derivatives: A comprehensive review of synthesis, antimicrobial activity, structure-activity relationships, and therapeutic potential
October 2026
Pyrazole derivatives constitute a pharmacologically important category of nitrogenous heterocyclic chemicals with various therapeutic uses. Their structural complexity and diverse biological actions...
The anti-aging effect and mechanism of a compound peptide on sensitive skin
June 2026
•Complex peptides exhibit no toxic effects on primary keratinocytes and fibroblasts within a certain concentration range.•Complex peptides could suppress inflammatory responses and promote barrier repair...
Proteomics advances in screening early diagnostic biomarkers for non-alcoholic fatty liver disease
August 2026
Non-alcoholic fatty liver disease (NAFLD) has emerged as a global public health burden with an exponential rise in prevalence, encompassing a spectrum of pathological conditions from simple steatosis...
Leukemia stem cell differentiation in acute myeloid leukemia: Molecular mechanisms and multi-omics insights
April 2026
Acute myeloid leukemia (AML) arises from blocked myeloid differentiation and subsequent accumulation of immature myeloid progenitors. Leukemia stem cells (LSCs) sustain AML hierarchical architecture...
Tenascin C: a multifaceted interplayer in the rheumatoid arthritis pathogenesis and progression - insights and implications
April 2026
Tenascin-C (TNC) has emerged as an endogenous damage-associated molecular pattern (DAMP) molecule that sustains the inflammatory milieu in RA joints, because it acts not merely as a structural matrix...
Applications and challenges of tear proteomics in unveiling the molecular mechanisms and biomarkers of dry eye disease
February 2026
Dry Eye Disease (DED) stands as one of the most prevalent ocular surface disorders globally, with an increasing incidence that significantly impairs patients’ visual function and quality of life. Conventional...
Targeting the unexplored 'dark proteome': Novel approaches in drug discovery
June 2025
The dark proteome, consisting of disordered, transient, and flexible regions of proteins, remains largely unexplored despite its potential for novel drug discovery. These regions, which lack stable...
Antioxidant defense gene expression associated with lung cancer pathology: implications for diagnostic and therapeutic targets
June 2025
Lung cancer is the leading cause of cancer-related mortality, and oxidative stress plays a central role in its pathogenesis. Antioxidant enzymes such as catalase (CAT) are crucial for maintaining redox...
Emerging therapeutic approaches in amyotrophic lateral sclerosis: From gene therapy and stem cells to autophagy and nanotechnology
August 2026
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive motor neuron loss. This review summarizes recent advances in therapeutic strategies, with particular...
Advances in deciphering lung cancer immune microenvironment heterogeneity and immunotherapy response using single-cell and multi-omics technologies
August 2026
PD-1/PD-L1 immunotherapy has transformed lung cancer treatment, but resistance and variable responses persist due to tumor immune microenvironment (TIME) heterogeneity....
The evolving landscape of immunotherapy in lung cancer: From mechanism to clinical translation
June 2026
Lung cancer is the leading cause of cancer-related mortality worldwide, accounting for 12.4% of all incident cancers and 18.7% of total cancer deaths globally. Most patients are diagnosed at advanced...
Advances in machine learning for optimizing pharmaceutical drug discovery
April 2025
The integration of advanced machine learning methodologies has revolutionized the field of pharmaceutical drug discovery by addressing critical challenges in efficiency, scalability, and accuracy. This...
Structure-based virtual screening and molecular dynamics simulation for the identification of novel potential inhibitors for the NDM-1 of Klebsiella Pneumoniae from the marine natural products
February 2026
The emergence of antibiotic-resistant bacteria, especially New Delhi Metallo-β-lactamase-1 (NDM-1) of Klebsiella pneumoniae, is a significant threat to serious public health. The aim of this study was...
Machine learning-driven plasma proteomics identifies MBP/PSMD10 panel for stratification of mild-to-moderate clinical Alzheimer's disease
August 2026
•Plasma proteomics identifies MBP/SOD2 as AD diagnostic biomarkers in a pilot cohort.•MBP/PSMD10 panel detects mild-to-moderate AD with AUC=0.996 in a pilot cohort.•Mitochondrial dysfunction links to...
The bidirectional relationship between gut microbiota and the development of colorectal cancer
October 2026
As a core component of the human intestinal microecosystem, the gut microbiota has been increasingly recognized for its pivotal role in colorectal cancer (CRC), a globally prevalent malignancy with...
The progress and prospects of single-cell sequencing, multi-omics integration analysis, and immunotherapy targeting strategies in lung cancer research
December 2025
Lung cancer is a highly prevalent and lethal malignant tumor globally, imposing a heavy burden on public health. Traditional treatments such as surgery, chemotherapy, and radiotherapy have significant...
The interplay of Drp1 post-translational modifications as a regulatory network driving mitochondrial fission in diabetic kidney disease
April 2026
Diabetic Kidney Disease (DKD) is the primary cause of end-stage renal disease (ESRD), with renal interstitial fibrosis being the core driver of its progression. Mitochondrial dynamics imbalance, particularly...
Immune biomarkers as key targets in managing tuberculosis: A systematic review
October 2025
Tuberculosis remains a major global health challenge and is one of the leading causes of mortality worldwide. In recent years, the resurgence of the disease has intensified research efforts aimed at...
Investigation into the mechanisms of collagen deposition and extracellular matrix remodeling in keloid formation using multi-omics analysis, machine learning, and weighted gene co-expression network analysis
August 2026
•ASPN was identified as a hub gene exhibiting the most pronounced upregulation in keloid fibroblasts.•ASPN knockdown significantly inhibited collagen deposition, facilitated ECM remodeling, and suppressed...
In-Silico and Machine Learning-Based Evaluation of Dipeptide Inhibitors Targeting Isoleucyl-tRNA Synthetase in Dermatophytic Fungal Infection
August 2026
Dermatophytosis is one of the most widespread fungal infections caused by dermatophytes such as Trichophyton, Microsporum, and Epidermophyton. The increasing prevalence of antifungal resistance has...
TRIM15 mediates ubiquitination and degradation of HOXD11 to promote IL-1β-induced chondrocyte injury
October 2026
•HOXD11 is lowly expressed in LPS-induced ATDC5 cells.•Overexpression of HOXD11 inhibits the apoptosis and inflammation in LPS-induced ATDC5 cells.•TRIM15 mediates the ubiquitination modification and...
Multi-omics analysis reveals molecular characteristics and potential therapeutic targets of primary central nervous system lymphoma
August 2025
Primary central nervous system lymphoma (PCNSL) is a rare and aggressive extranodal lymphoma, which is distinct from nodal diffuse large B-cell lymphoma (DLBCL) in clinical presentation, molecular pathology,...
Identification of ORM1 in acute myocardial infarction via proteomics plus machine learning and exploring its diagnostic value and function
June 2026
•ORM1 was identified as a biomarker for AMI via proteomics and machine learning.•ORM1 was upregulated in AMI and exhibited good diagnostic value for AMI.•ORM1 knockdown alleviated cell apoptosis, inflammatory...