Incretin Hormones: Mechanisms, Therapeutic Implications, and Future Directions in Glucose Regulation and Diabetes Management
April 2025
Type 2 diabetes (T2D) is a global health crisis, currently affecting over 540 million individuals. Its prevalence continues to rise due to aging populations, sedentary lifestyles, and unhealthy diets....
Targeting the unexplored 'dark proteome': Novel approaches in drug discovery
June 2025
The dark proteome, consisting of disordered, transient, and flexible regions of proteins, remains largely unexplored despite its potential for novel drug discovery. These regions, which lack stable...
Structure-based virtual screening and molecular dynamics simulation for the identification of novel potential inhibitors for the NDM-1 of Klebsiella Pneumoniae from the marine natural products
February 2026
The emergence of antibiotic-resistant bacteria, especially New Delhi Metallo-β-lactamase-1 (NDM-1) of Klebsiella pneumoniae, is a significant threat to serious public health. The aim of this study was...
Decoding disorder: Advances in predicting intrinsically disordered proteins
June 2025
Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) play critical roles in cellular signaling, transcriptional regulation, and dynamic protein-protein interactions....
Docking and AI-based classification cum recurrent neural network validation for predicting anti-tubercular leads against dprE-1 enzyme targeter
April 2025
Tuberculosis (TB) continues to pose a major global health challenge, highlighting the need for the development of new therapeutic agents....
Advances in machine learning for optimizing pharmaceutical drug discovery
April 2025
The integration of advanced machine learning methodologies has revolutionized the field of pharmaceutical drug discovery by addressing critical challenges in efficiency, scalability, and accuracy. This...
The progress and prospects of single-cell sequencing, multi-omics integration analysis, and immunotherapy targeting strategies in lung cancer research
December 2025
Lung cancer is a highly prevalent and lethal malignant tumor globally, imposing a heavy burden on public health. Traditional treatments such as surgery, chemotherapy, and radiotherapy have significant...
Immune biomarkers as key targets in managing tuberculosis: A systematic review
October 2025
Tuberculosis remains a major global health challenge and is one of the leading causes of mortality worldwide. In recent years, the resurgence of the disease has intensified research efforts aimed at...
A Multimodal artificial intelligence framework for mechanistic discovery and digital twin construction in cardiovascular medicine
October 2025
Multimodal artificial intelligence (AI) is reshaping contemporary cardiovascular medicine. Its contribution has moved far beyond early successes in image recognition, arrhythmia detection, and automated...
Advances in the combination of immunotherapy and radiotherapy for microsatellite-stable metastatic colorectal cancer
October 2025
Combining immunotherapy with radiotherapy has emerged as a novel and promising approach for treating microsatellite-stable metastatic colorectal cancer (MSS mCRC). This review offers an in-depth analysis...
Comprehensive omics profiling in acute myeloid leukemia: From molecular landscape to clinical translation
June 2025
Acute Myeloid Leukemia (AML) is a molecularly heterogeneous hematologic malignancy driven by diverse genetic, epigenetic, and transcriptomic alterations. Recent advancements in high-throughput omics...
In silico design and evaluation of a multi-epitope vaccine targeting SARS-CoV-2 structural proteins
April 2026
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to pose a serious global health threat....
A research status and prospects of edible fungal-derived fibrinolytic enzymes: breakthroughs based on multi-omics and intelligent delivery technologies
February 2026
Thrombotic diseases represent a significant global health burden. Current clinical thrombolytic agents are plagued by limitations including short half-lives, high bleeding risks, and exorbitant costs....
Applications and challenges of tear proteomics in unveiling the molecular mechanisms and biomarkers of dry eye disease
February 2026
Dry Eye Disease (DED) stands as one of the most prevalent ocular surface disorders globally, with an increasing incidence that significantly impairs patients’ visual function and quality of life. Conventional...
Deciphering Rab32-associated antibacterial responses: Proteomics reveals the heterogeneity of macrophage defense against bacterial pathogen infection
April 2026
•Rab32, a Ras superfamily GTPase, exhibits broad-spectrum antimicrobial activity in macrophages against various bacterial pathogens.•Proteomic analysis reveals Rab32 deficiency alters host cell response...
Spatial omics: Deciphering heterogeneity in the tumor immune microenvironment and resistance to immunotherapy
October 2025
Drug resistance in tumor immunotherapy is a significant challenge, stemming from the high heterogeneity and intricate spatial architecture of the tumor immune microenvironment. Traditional omics technologies...
Isolupalbigenin as a multi-target natural scaffold targeting HER2, EGFR, IGF-1R, and BCL-2 in breast cancer: An integrated docking, molecular dynamics, and DFT study
April 2026
This study aimed to identify potential multi-target natural compounds capable of interacting with key breast cancer–associated proteins using an integrated computational framework....
Applications of artificial intelligence and large language models in cancer immunotherapy
October 2025
With the rapid advancement of artificial intelligence (AI) technologies, particularly the widespread adoption of large language models (LLMs), the field of cancer immunotherapy is experiencing unprecedented...
The characterization and immunoinformatic analysis of HN and F genes from the first reported XIII.2.1 Newcastle disease virus sub-genotype in Iran
August 2025
The global poultry industry faces considerable economic losses due to pathogenic strains of the Newcastle disease virus (NDV)....
GRHL3 promotes tumor growth and metastasis via the TGF-β signaling pathway in human epithelial ovarian cancer
December 2025
Grainyhead-like 3 (GRHL3) has been implicated in the biology of several epithelial malignancies, yet its function in epithelial ovarian cancer (EOC) remains insufficiently defined. Given the high mortality...
The expanding tool landscape of proteomics: From high-throughput quantification to intelligent data analysis
December 2025
Compounds isolated from Rhabdophyllum arnoldianum: promising new molecules for cancer treatment through their inhibitory properties on tyrosine kinases and dihydrofolate reductase, revealed by molecular docking
October 2025
Resistance to current anticancer therapies drives the demand for novel, multitarget agents with improved safety. We screened flavonoid-derived phytochemicals isolated from Rhabdophyllum arnoldianum...
Identification of key fatty acid metabolism genes and lncRNAs in Tibial cortex transverse traction therapy for diabetic foot Ulcers
December 2025
To explore the potential molecular mechanisms of tibial cortex transverse traction (TTT) in diabetic foot ulcer (DFU) healing by identifying key fatty acid metabolism genes and long non-coding RNAs...
Advances in bioinformatics techniques for ophthalmic diseases
February 2025
As the population ages and lifestyles evolve, the prevalence of ophthalmic diseases such as diabetic retinopathy, age-related macular degeneration, and glaucoma continues to rise, imposing a significant...
Lipopolysaccharide activates platelet via the TLR4/MYD88 pathway to protect against bacterial lung injury
April 2026
•Platelet treatment protected against lung injury of S. pneumonia-infected mice.•Platelet treatment inhibited immune response, inflammation and oxidative stress in S. pneumonia-infected mice.•LPS induced...