TRIM15 mediates ubiquitination and degradation of HOXD11 to promote IL-1β-induced chondrocyte injury
October 2026
•HOXD11 is lowly expressed in LPS-induced ATDC5 cells.•Overexpression of HOXD11 inhibits the apoptosis and inflammation in LPS-induced ATDC5 cells.•TRIM15 mediates the ubiquitination modification and...
Research on prognostic markers and targeted therapy for oral squamous cell carcinoma based on immunogenic cell death
October 2026
•CTLA4, TNFRSF4, and CD5 are identified as the core prognostic markers for OSCC based on ICD.•The constructed ICD-related prognostic risk model can stratify OSCC patients into significantly distinct...
Pyrazole derivatives: A comprehensive review of synthesis, antimicrobial activity, structure-activity relationships, and therapeutic potential
October 2026
Pyrazole derivatives constitute a pharmacologically important category of nitrogenous heterocyclic chemicals with various therapeutic uses. Their structural complexity and diverse biological actions...
Impact of obstructive sleep apnea syndrome on serum and plasma S100B concentrations: a systematic review and meta-analysis of observational studies with experimental validation
October 2026
Obstructive sleep apnea–hypopnea syndrome (OSAHS) is the most prevalent type of sleep apnea. S100B, an astrocyte-derived calcium-binding protein, has been reported to be associated with OSAHS, but the...
Exploration of the immunogenomics connection between chronic obstructive pulmonary disease and lung cancer: The role of liquid biopsy in early diagnosis and precision prognosis
October 2026
Chronic obstructive pulmonary disease (COPD) and lung cancer (LC) are among the most prevalent and lethal respiratory disorders worldwide. COPD patients present a significantly higher risk of developing...
IREB2 overexpression inhibited the malignant progression of cervical cancer by inducing ferroptosis
October 2026
Ferroptosis is an iron-dependent form of regulated cell death driven by lipid peroxidation and has shown potential relevance in cancer therapy. Iron-responsive element-binding protein 2 (IREB2) is a...
Cross-regulation of trophoblast function by DNA methylation, histone modification, and metabolism: Epigenetic–metabolic crosstalk in placental disorders and offspring metabolic programming
October 2026
Trophoblast cells are core components of the placental tissue. Abnormalities in their differentiation, invasion, and material exchange functions directly lead to placenta-originated pregnancy disorders,...
The bidirectional relationship between gut microbiota and the development of colorectal cancer
October 2026
As a core component of the human intestinal microecosystem, the gut microbiota has been increasingly recognized for its pivotal role in colorectal cancer (CRC), a globally prevalent malignancy with...
An exploratory study in potential biomarkers discovery for LNM risk assessment in Chinese patients with esophageal squamous cell carcinoma at pT1a (mucosal) stage
October 2026
Esophageal cancer (EC) is a major global malignant neoplasm, with China accounting for over 40% of cases. Esophageal squamous cell carcinoma (ESCC), the predominant subtype, continues to show poor long-term...
SPI1 transcriptionally regulates WDR66 to promote oxaliplatin resistance in esophageal squamous cell carcinoma
October 2026
•WDR66 and SPI1 are highly expressed in ESCC tumor tissues and cells.•SPI1 positively regulates the transcriptional expression of WDR66.•Knockdown of WDR66 reduces the malignant phenotypes of oxaliplatin-resistant...
Ubiquitin ligase NEDD4L regulates ferroptosis and mitochondrial damage in esophageal cancer cells by ubiquitinating and degrading TRIB3
October 2026
•High TRIB3 correlates with poor prognosis, drives EC malignancy, and inhibits ferroptosis.•NEDD4L degrades TRIB3 via K48-linked polyubiquitination.•NEDD4L suppresses EC via TRIB3-dependent downregulation...
Integrative proteomic and transcriptomic analysis identifies MUC5B as an oncogenic mediator in lung adenocarcinoma: Potential regulation by UCHL1-dependent deubiquitination
October 2026
•Integrated transcriptomic-proteomic analysis identifies MUC5B as a novel therapeutic target in LUAD.•MUC5B silencing suppresses lung cancer cell proliferation, migration, and invasion.•MUC5B knockdown...
From molecular classification to targeted delivery: machine learning, multi-omics, biomarker-guided systemic therapy, and nanomedicine in gastric cancer precision oncology
October 2026
•Machine learning enables compact multi-omics gastric-cancer subtype assays.•Single-cell and spatial profiling reveal immune and stromal resistance states.•Validated biomarkers guide HER2, CLDN18.2...
Immunoinformatics-guided design of a self-assembling peptide nanoparticle vaccine based on a native Helicobacter pylori coiled-coil domain
October 2026
•Need to develop a novel platform for constructing vaccine against Helicobacter pylori (H. pylori).•Introducing an α-helical coiled-coil motif from H. pylori proteome.•Designing a novel SAPN vaccine...
Integrated transcriptomics, WGCNA and machine learning identify key biomarkers associated with tumor progression in diffuse large B-cell lymphoma
Available online 22 September 2026
Diffuse large B-cell lymphoma (DLBCL) is a highly heterogeneous and aggressive malignancy, yet its key biomarkers and underlying molecular mechanisms remain unclear....
Psoralen induces osteoblast differentiation by increasing ESR1 expression in human osteoblasts
August 2026
•Psoralen upregulated ESR1 expression in hFOB1.19 cells.•Psoralen treatment promoted ALP activity and contents and enhanced hFOB1.19 cell mineralization ability.•Psoralen treatment also increased the...
Dysregulation of circadian clock genes in hepatocellular carcinoma: Development of a four-gene prognostic signature
August 2026
Hepatocellular carcinoma (HCC) is one of the most lethal malignancies worldwide. Dysregulation of circadian clock genes (CCGs) plays a vital role in the progression of various cancers, including HCC....
In-Silico and Machine Learning-Based Evaluation of Dipeptide Inhibitors Targeting Isoleucyl-tRNA Synthetase in Dermatophytic Fungal Infection
August 2026
Dermatophytosis is one of the most widespread fungal infections caused by dermatophytes such as Trichophyton, Microsporum, and Epidermophyton. The increasing prevalence of antifungal resistance has...
NFIC transcriptionally activates DUSP1 to attenuate high glucose-induced mesangial cell injury in diabetic nephropathy: insights from integrative transcriptomics and functional studies
August 2026
•Integrative transcriptomic analysis identified 63 dysregulated genes in DN.•NFIC is downregulated in DN and directly promotes the transcription of DUSP1.•NFIC overexpression alleviates HG-induced ECM...
Advances in deciphering lung cancer immune microenvironment heterogeneity and immunotherapy response using single-cell and multi-omics technologies
August 2026
PD-1/PD-L1 immunotherapy has transformed lung cancer treatment, but resistance and variable responses persist due to tumor immune microenvironment (TIME) heterogeneity....
Investigation into the mechanisms of collagen deposition and extracellular matrix remodeling in keloid formation using multi-omics analysis, machine learning, and weighted gene co-expression network analysis
August 2026
•ASPN was identified as a hub gene exhibiting the most pronounced upregulation in keloid fibroblasts.•ASPN knockdown significantly inhibited collagen deposition, facilitated ECM remodeling, and suppressed...
Machine learning-driven plasma proteomics identifies MBP/PSMD10 panel for stratification of mild-to-moderate clinical Alzheimer's disease
August 2026
•Plasma proteomics identifies MBP/SOD2 as AD diagnostic biomarkers in a pilot cohort.•MBP/PSMD10 panel detects mild-to-moderate AD with AUC=0.996 in a pilot cohort.•Mitochondrial dysfunction links to...
NEDD4 and HDAC1 impair SMAD5-mediated osteogenic differentiation of human bone marrow mesenchymal stem cells via ubiquitination and deacetylation
August 2026
Osteoporosis is a bone disease characterized by reduced bone mass and microstructural deterioration, leading to increased fragility and fracture risk, which significantly impairs patient health and...
Ion channels as emerging drug targets: Pharmacological insights and therapeutic advances
August 2026
Ion channels are crucial regulators of cellular signaling and homeostasis, and their failure is associated with various clinical illnesses, including neurological disorders, cardiovascular diseases,...
Methylation-driven inactivation of TFPI2 functions as a tumor suppressor in esophageal squamous cell carcinoma: an exploratory study in Kazakh patients
August 2026
•5‑aza‑CdR alters Eca109 cell morphology and gene expression.•In non-tumor tissues and 5-aza-CdR-treated cells, TFPI2 expression increases while promoter methylation decreases.•TFPI2 overexpression...