Targeting cancer pathways with phytochemicals: Molecular mechanisms and clinical potential
December 2026
Cancer progression is driven by dysregulated signaling networks that control proliferation, apoptosis, inflammation, angiogenesis, invasion, oxidative stress adaptation, and epigenetic remodeling. Phytochemicals...
TRIM15 mediates ubiquitination and degradation of HOXD11 to promote IL-1β-induced chondrocyte injury
October 2026
•HOXD11 is lowly expressed in LPS-induced ATDC5 cells.•Overexpression of HOXD11 inhibits the apoptosis and inflammation in LPS-induced ATDC5 cells.•TRIM15 mediates the ubiquitination modification and...
Research on prognostic markers and targeted therapy for oral squamous cell carcinoma based on immunogenic cell death
October 2026
•CTLA4, TNFRSF4, and CD5 are identified as the core prognostic markers for OSCC based on ICD.•The constructed ICD-related prognostic risk model can stratify OSCC patients into significantly distinct...
Pyrazole derivatives: A comprehensive review of synthesis, antimicrobial activity, structure-activity relationships, and therapeutic potential
October 2026
Pyrazole derivatives constitute a pharmacologically important category of nitrogenous heterocyclic chemicals with various therapeutic uses. Their structural complexity and diverse biological actions...
Impact of obstructive sleep apnea syndrome on serum and plasma S100B concentrations: a systematic review and meta-analysis of observational studies with experimental validation
October 2026
Obstructive sleep apnea–hypopnea syndrome (OSAHS) is the most prevalent type of sleep apnea. S100B, an astrocyte-derived calcium-binding protein, has been reported to be associated with OSAHS, but the...
Exploration of the immunogenomics connection between chronic obstructive pulmonary disease and lung cancer: The role of liquid biopsy in early diagnosis and precision prognosis
October 2026
Chronic obstructive pulmonary disease (COPD) and lung cancer (LC) are among the most prevalent and lethal respiratory disorders worldwide. COPD patients present a significantly higher risk of developing...
IREB2 overexpression inhibited the malignant progression of cervical cancer by inducing ferroptosis
October 2026
Ferroptosis is an iron-dependent form of regulated cell death driven by lipid peroxidation and has shown potential relevance in cancer therapy. Iron-responsive element-binding protein 2 (IREB2) is a...
Integrated transcriptomics, WGCNA and machine learning identify key biomarkers associated with tumor progression in diffuse large B-cell lymphoma
October 2026
Diffuse large B-cell lymphoma (DLBCL) is a highly heterogeneous and aggressive malignancy, yet its key biomarkers and underlying molecular mechanisms remain unclear....
Cross-regulation of trophoblast function by DNA methylation, histone modification, and metabolism: Epigenetic–metabolic crosstalk in placental disorders and offspring metabolic programming
October 2026
Trophoblast cells are core components of the placental tissue. Abnormalities in their differentiation, invasion, and material exchange functions directly lead to placenta-originated pregnancy disorders,...
The bidirectional relationship between gut microbiota and the development of colorectal cancer
October 2026
As a core component of the human intestinal microecosystem, the gut microbiota has been increasingly recognized for its pivotal role in colorectal cancer (CRC), a globally prevalent malignancy with...
An exploratory study in potential biomarkers discovery for LNM risk assessment in Chinese patients with esophageal squamous cell carcinoma at pT1a (mucosal) stage
October 2026
Esophageal cancer (EC) is a major global malignant neoplasm, with China accounting for over 40% of cases. Esophageal squamous cell carcinoma (ESCC), the predominant subtype, continues to show poor long-term...
SPI1 transcriptionally regulates WDR66 to promote oxaliplatin resistance in esophageal squamous cell carcinoma
October 2026
•WDR66 and SPI1 are highly expressed in ESCC tumor tissues and cells.•SPI1 positively regulates the transcriptional expression of WDR66.•Knockdown of WDR66 reduces the malignant phenotypes of oxaliplatin-resistant...
Ubiquitin ligase NEDD4L regulates ferroptosis and mitochondrial damage in esophageal cancer cells by ubiquitinating and degrading TRIB3
October 2026
•High TRIB3 correlates with poor prognosis, drives EC malignancy, and inhibits ferroptosis.•NEDD4L degrades TRIB3 via K48-linked polyubiquitination.•NEDD4L suppresses EC via TRIB3-dependent downregulation...
Integrative proteomic and transcriptomic analysis identifies MUC5B as an oncogenic mediator in lung adenocarcinoma: Potential regulation by UCHL1-dependent deubiquitination
October 2026
•Integrated transcriptomic-proteomic analysis identifies MUC5B as a novel therapeutic target in LUAD.•MUC5B silencing suppresses lung cancer cell proliferation, migration, and invasion.•MUC5B knockdown...
From molecular classification to targeted delivery: machine learning, multi-omics, biomarker-guided systemic therapy, and nanomedicine in gastric cancer precision oncology
October 2026
•Machine learning enables compact multi-omics gastric-cancer subtype assays.•Single-cell and spatial profiling reveal immune and stromal resistance states.•Validated biomarkers guide HER2, CLDN18.2...
Immunoinformatics-guided design of a self-assembling peptide nanoparticle vaccine based on a native Helicobacter pylori coiled-coil domain
October 2026
•Need to develop a novel platform for constructing vaccine against Helicobacter pylori (H. pylori).•Introducing an α-helical coiled-coil motif from H. pylori proteome.•Designing a novel SAPN vaccine...
Curcumol inhibits epithelial-mesenchymal transition in hepatocellular carcinoma stem-like cells by blocking the Jak2/Stat3 pathway
October 2026
Hepatocellular carcinoma (HCC) remains a leading cause of cancer‑related mortality worldwide. Cancer stem‑like cells contribute to HCC metastasis and recurrence partly through epithelial‑mesenchymal...
A histone deacetylase-linked gene signature supports prognostic stratification and is associated with immune features in osteosarcoma
October 2026
Osteosarcoma (OS) is an aggressive malignant bone tumor with a high risk of metastasis. This study aimed to develop a histone deacetylase (HDAC)-related prognostic signature and explore its associations...
NEDD4L modulates AURKB stability through ubiquitination to regulate inflammatory response and pro-inflammatory microglial activation in lipopolysaccharide-induced BV2 microglial cells
October 2026
Neuropathic pain (NP) remains one of the most challenging problems in the world. This study aims to investigate the role of aurora kinase B (AURKB) and developmentally downregulated protein 4-like (NEDD4L)...
TRIM37 promotes ERα proteasomal degradation and aggravates ox-LDL-induced endothelial injury in vitro
October 2026
The incidence of coronary heart disease (CHD), a complication of atherosclerosis (AS), is higher in postmenopausal women. Estrogen receptor α (ERα, encoded by ESR1) expression is decreased in this population,...
Impact of post-translational modifications in Alzheimer’s disease: An overview
October 2026
Alzheimer’s disease (AD) is the leading cause of dementia worldwide and is characterized by progressive cognitive decline, amyloid-β (Aβ) plaque deposition, neurofibrillary tangle formation, synaptic...
ELAVL1 stabilizes KLF7 mRNA to promote retinal pigment epithelial cell ferroptosis via PTGS2 transcriptional activation in diabetic retinopathy
October 2026
Diabetic retinopathy (DR) is an ocular complication caused by diabetes that primarily affects the retina. Although literature reports significantly elevated expression of krüppel-like factor 7 (KLF7)...
Mangiferin inhibits ferroptosis and promotes osteogenic differentiation of human bone marrow mesenchymal stem cells by upregulating the SPI1/BMP2 pathway in postmenopausal osteoporosis
October 2026
Postmenopausal osteoporosis (PMOP) is a chronic metabolic disorder of the bones. Estrogen deficiency and excess iron accumulation are associated with PMOP. Mangiferin (MF) is a xanthonoid glucoside...
Proteomic profiling analysis of aqueous humor in patients with retinal diseases
October 2026
Retinal diseases have distinct clinical features but may share molecular pathways related to vascular dysfunction, inflammation, extracellular-matrix remodeling, and neurodegeneration. Previous aqueous-humor...
Lysine succinylation and SIRT5 in sepsis: Proteomic perspectives on an emerging immunometabolic biomarker
October 2026
Sepsis is a life-threatening syndrome characterized by a dysregulated host response to infection and marked clinical and biological heterogeneity, which complicates early diagnosis and risk stratification....