Deciphering Rab32-associated antibacterial responses: Proteomics reveals the heterogeneity of macrophage defense against bacterial pathogen infection
April 2026
•Rab32, a Ras superfamily GTPase, exhibits broad-spectrum antimicrobial activity in macrophages against various bacterial pathogens.•Proteomic analysis reveals Rab32 deficiency alters host cell response...
Lipopolysaccharide activates platelet via the TLR4/MYD88 pathway to protect against bacterial lung injury
April 2026
•Platelet treatment protected against lung injury of S. pneumonia-infected mice.•Platelet treatment inhibited immune response, inflammation and oxidative stress in S. pneumonia-infected mice.•LPS induced...
In silico design and evaluation of a multi-epitope vaccine targeting SARS-CoV-2 structural proteins
April 2026
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to pose a serious global health threat....
Isolupalbigenin as a multi-target natural scaffold targeting HER2, EGFR, IGF-1R, and BCL-2 in breast cancer: An integrated docking, molecular dynamics, and DFT study
April 2026
This study aimed to identify potential multi-target natural compounds capable of interacting with key breast cancer–associated proteins using an integrated computational framework....
Curcumin inhibits Annexin A1 signaling to promote neuronal survival and functional recovery after ischemic stroke
April 2026
•Transcriptional profiling reveals age-, sex-, and cell type-specific upregulation of Annexin A1 (ANXA1) in ischemic stroke across mouse and human datasets.•A bioinformatics-guided drug screen identifies...
Leukemia stem cell differentiation in acute myeloid leukemia: Molecular mechanisms and multi-omics insights
April 2026
Acute myeloid leukemia (AML) is characterized by the accumulation of immature myeloid progenitors resulting from impaired differentiation. Increasing evidence supports a hierarchical organization sustained...
Design and synthesis of heterocyclic biphenyl-resultant novel pyrazole scaffolds: In-vitro and In-silico studies for potent antimicrobial agents
April 2026
•Novel biphenyl–heterocyclic pyrazole frameworks (4a–4 h) designed and synthesized.•Structures validated via FT-IR, NMR, and HRMS analyses.•Docking against Escherichia coli DNA gyrase B revealed strong...
Proteomic insights into myogenic progression in cultured muscle cells of Lates calcarifer (Bloch, 1790)
April 2026
Muscle cell lines serve as valuable models for investigating mechanisms underlying muscle proliferation and differentiation. This study aimed to characterize proteomic changes during passage progression...
Reframing cell death: Unveiling interactions and synergistic mechanisms in tumor immunity
February 2026
Cell death is a well-coordinated process that encompasses apoptosis as well as other mechanisms, including pyroptosis, autophagic cell death, ferroptosis and necroptosis. These modalities are hierarchically...
A research status and prospects of edible fungal-derived fibrinolytic enzymes: breakthroughs based on multi-omics and intelligent delivery technologies
February 2026
Thrombotic diseases represent a significant global health burden. Current clinical thrombolytic agents are plagued by limitations including short half-lives, high bleeding risks, and exorbitant costs....
Structure-based virtual screening and molecular dynamics simulation for the identification of novel potential inhibitors for the NDM-1 of Klebsiella Pneumoniae from the marine natural products
February 2026
The emergence of antibiotic-resistant bacteria, especially New Delhi Metallo-β-lactamase-1 (NDM-1) of Klebsiella pneumoniae, is a significant threat to serious public health. The aim of this study was...
Silencing of KLF9 alleviates palmitic acid-induced insulin resistance and inflammation in undifferentiated myoblasts by targeting GRB14, unveiling a pathogenic axis in Type 2 diabetic myopathy
February 2026
Skeletal muscle insulin resistance and inflammation are key drivers in the progression of skeletal muscle atrophy in Type 2 diabetes (T2D). This study aimed to identify novel molecular regulators underlying...
Etomidate alleviates PM2.5-induced cardiomyocyte injury by increasing the expression of HSCB based on transcriptome analysis
February 2026
Etomidate is a commonly used short-acting intravenous anesthetic and has become an important option for anesthesia induction in myocardial injury patients. However, the potential molecular mechanisms...
The mechanism of active components of Panax japonicus in mediating the HIF-VEGF signaling pathway to promote fracture healing: An investigation utilizing serum pharmacochemistry and network pharmacology approaches
February 2026
To establish a tibial fracture model in rats and preliminarily investigate the intervention mechanisms of Panax japonicus on the tibial fracture healing process based on the angiogenesis mechanisms...
Applications and challenges of tear proteomics in unveiling the molecular mechanisms and biomarkers of dry eye disease
February 2026
Dry Eye Disease (DED) stands as one of the most prevalent ocular surface disorders globally, with an increasing incidence that significantly impairs patients’ visual function and quality of life. Conventional...
METTL14 stabilizes KLF6 through m6A methylation modification, thereby exacerbating neuronal injury induced by ischemia-reperfusion
February 2026
Stroke is an acute cerebrovascular condition marked by high rates of disability and mortality. Kruppel-like factor 6 (KLF6), a pivotal transcription factor, is integral to cell proliferation and differentiation....
MCM2, AURKA and MCM6: potential diagnostic biomarkers for cervical cancer
February 2026
•MCM2, AURKA and MCM6 are highly expressed in CC tissues.•MCM2, AURKA and MCM6 can be used as diagnostic biomarkers for CC.•MCM2, AURKA and MCM6 are correlated with immune infiltration....
Identification of key fatty acid metabolism genes and lncRNAs in Tibial cortex transverse traction therapy for diabetic foot Ulcers
December 2025
To explore the potential molecular mechanisms of tibial cortex transverse traction (TTT) in diabetic foot ulcer (DFU) healing by identifying key fatty acid metabolism genes and long non-coding RNAs...
Proteome provides a full map on the physiology and mechanism of the gastrointestinal tract in humans and rodents
December 2025
GRHL3 promotes tumor growth and metastasis via the TGF-β signaling pathway in human epithelial ovarian cancer
December 2025
Grainyhead-like 3 (GRHL3) has been implicated in the biology of several epithelial malignancies, yet its function in epithelial ovarian cancer (EOC) remains insufficiently defined. Given the high mortality...
The progress and prospects of single-cell sequencing, multi-omics integration analysis, and immunotherapy targeting strategies in lung cancer research
December 2025
Lung cancer is a highly prevalent and lethal malignant tumor globally, imposing a heavy burden on public health. Traditional treatments such as surgery, chemotherapy, and radiotherapy have significant...
The expanding tool landscape of proteomics: From high-throughput quantification to intelligent data analysis
December 2025
Resveratrol regulates ferroptosis and endometrial cancer progression by inhibiting CEBPA-mediated FAM83B expression
December 2025
Endometrial cancer (EC) is one of the most common gynecologic malignancies. CCAAT enhancer binding protein α (CEBPA) and family with sequence similarity 83, member B (FAM83B) are related to development...
Compounds isolated from Rhabdophyllum arnoldianum: promising new molecules for cancer treatment through their inhibitory properties on tyrosine kinases and dihydrofolate reductase, revealed by molecular docking
October 2025
Resistance to current anticancer therapies drives the demand for novel, multitarget agents with improved safety. We screened flavonoid-derived phytochemicals isolated from Rhabdophyllum arnoldianum...