TRIM15 mediates ubiquitination and degradation of HOXD11 to promote IL-1β-induced chondrocyte injury
October 2026
•HOXD11 is lowly expressed in LPS-induced ATDC5 cells.•Overexpression of HOXD11 inhibits the apoptosis and inflammation in LPS-induced ATDC5 cells.•TRIM15 mediates the ubiquitination modification and...
Research on prognostic markers and targeted therapy for oral squamous cell carcinoma based on immunogenic cell death
October 2026
•CTLA4, TNFRSF4, and CD5 are identified as the core prognostic markers for OSCC based on ICD.•The constructed ICD-related prognostic risk model can stratify OSCC patients into significantly distinct...
Pyrazole derivatives: A comprehensive review of synthesis, antimicrobial activity, structure-activity relationships, and therapeutic potential
October 2026
Pyrazole derivatives constitute a pharmacologically important category of nitrogenous heterocyclic chemicals with various therapeutic uses. Their structural complexity and diverse biological actions...
Impact of obstructive sleep apnea syndrome on serum and plasma S100B concentrations: a systematic review and meta-analysis of observational studies with experimental validation
October 2026
Obstructive sleep apnea–hypopnea syndrome (OSAHS) is the most prevalent type of sleep apnea. S100B, an astrocyte-derived calcium-binding protein, has been reported to be associated with OSAHS, but the...
Exploration of the immunogenomics connection between chronic obstructive pulmonary disease and lung cancer: The role of liquid biopsy in early diagnosis and precision prognosis
October 2026
Chronic obstructive pulmonary disease (COPD) and lung cancer (LC) are among the most prevalent and lethal respiratory disorders worldwide. COPD patients present a significantly higher risk of developing...
Cross-regulation of trophoblast function by DNA methylation, histone modification, and metabolism: Epigenetic–metabolic crosstalk in placental disorders and offspring metabolic programming
October 2026
Trophoblast cells are core components of the placental tissue. Abnormalities in their differentiation, invasion, and material exchange functions directly lead to placenta-originated pregnancy disorders,...
The bidirectional relationship between gut microbiota and the development of colorectal cancer
October 2026
As a core component of the human intestinal microecosystem, the gut microbiota has been increasingly recognized for its pivotal role in colorectal cancer (CRC), a globally prevalent malignancy with...
IREB2 overexpression inhibited the malignant progression of cervical cancer by inducing ferroptosis
Available online 22 September 2026
Ferroptosis is an iron-dependent form of regulated cell death driven by lipid peroxidation and has shown potential relevance in cancer therapy. Iron-responsive element-binding protein 2 (IREB2) is a...
Integrated transcriptomics, WGCNA and machine learning identify key biomarkers associated with tumor progression in diffuse large B-cell lymphoma
Available online 22 September 2026
Diffuse large B-cell lymphoma (DLBCL) is a highly heterogeneous and aggressive malignancy, yet its key biomarkers and underlying molecular mechanisms remain unclear....
Psoralen induces osteoblast differentiation by increasing ESR1 expression in human osteoblasts
August 2026
•Psoralen upregulated ESR1 expression in hFOB1.19 cells.•Psoralen treatment promoted ALP activity and contents and enhanced hFOB1.19 cell mineralization ability.•Psoralen treatment also increased the...
Dysregulation of circadian clock genes in hepatocellular carcinoma: Development of a four-gene prognostic signature
August 2026
Hepatocellular carcinoma (HCC) is one of the most lethal malignancies worldwide. Dysregulation of circadian clock genes (CCGs) plays a vital role in the progression of various cancers, including HCC....
In-Silico and Machine Learning-Based Evaluation of Dipeptide Inhibitors Targeting Isoleucyl-tRNA Synthetase in Dermatophytic Fungal Infection
August 2026
Dermatophytosis is one of the most widespread fungal infections caused by dermatophytes such as Trichophyton, Microsporum, and Epidermophyton. The increasing prevalence of antifungal resistance has...
NFIC transcriptionally activates DUSP1 to attenuate high glucose-induced mesangial cell injury in diabetic nephropathy: insights from integrative transcriptomics and functional studies
August 2026
•Integrative transcriptomic analysis identified 63 dysregulated genes in DN.•NFIC is downregulated in DN and directly promotes the transcription of DUSP1.•NFIC overexpression alleviates HG-induced ECM...
Advances in deciphering lung cancer immune microenvironment heterogeneity and immunotherapy response using single-cell and multi-omics technologies
August 2026
PD-1/PD-L1 immunotherapy has transformed lung cancer treatment, but resistance and variable responses persist due to tumor immune microenvironment (TIME) heterogeneity....
Investigation into the mechanisms of collagen deposition and extracellular matrix remodeling in keloid formation using multi-omics analysis, machine learning, and weighted gene co-expression network analysis
August 2026
•ASPN was identified as a hub gene exhibiting the most pronounced upregulation in keloid fibroblasts.•ASPN knockdown significantly inhibited collagen deposition, facilitated ECM remodeling, and suppressed...
Machine learning-driven plasma proteomics identifies MBP/PSMD10 panel for stratification of mild-to-moderate clinical Alzheimer's disease
August 2026
•Plasma proteomics identifies MBP/SOD2 as AD diagnostic biomarkers in a pilot cohort.•MBP/PSMD10 panel detects mild-to-moderate AD with AUC=0.996 in a pilot cohort.•Mitochondrial dysfunction links to...
NEDD4 and HDAC1 impair SMAD5-mediated osteogenic differentiation of human bone marrow mesenchymal stem cells via ubiquitination and deacetylation
August 2026
Osteoporosis is a bone disease characterized by reduced bone mass and microstructural deterioration, leading to increased fragility and fracture risk, which significantly impairs patient health and...
Ion channels as emerging drug targets: Pharmacological insights and therapeutic advances
August 2026
Ion channels are crucial regulators of cellular signaling and homeostasis, and their failure is associated with various clinical illnesses, including neurological disorders, cardiovascular diseases,...
Methylation-driven inactivation of TFPI2 functions as a tumor suppressor in esophageal squamous cell carcinoma: an exploratory study in Kazakh patients
August 2026
•5‑aza‑CdR alters Eca109 cell morphology and gene expression.•In non-tumor tissues and 5-aza-CdR-treated cells, TFPI2 expression increases while promoter methylation decreases.•TFPI2 overexpression...
Proteomics advances in screening early diagnostic biomarkers for non-alcoholic fatty liver disease
August 2026
Non-alcoholic fatty liver disease (NAFLD) has emerged as a global public health burden with an exponential rise in prevalence, encompassing a spectrum of pathological conditions from simple steatosis...
Silencing UHRF1 regulates TNBC cell ferroptosis and EMT via up-regulating SORBS1
August 2026
•UHRF1 is up-regulated in TNBC tissues and cells.•UHRF1 silencing promotes TNBC cell ferroptosis and suppresses EMT.•UHRF1 affects the ubiquitination level of SORBS1.•Down-regulated UHRF1 promotes ferroptosis...
FBP1 regulates epirubicin chemosensitivity in hepatocellular carcinoma through glycolysis modulation
August 2026
Hepatocellular carcinoma (HCC) is a common liver cancer subtype with a poor prognosis. Fructose-1,6-Bisphosphatase 1 (FBP1), one of the rate-limiting gluconeogenic enzymes, has been identified as a...
Protein network mechanisms by which gut microbial metabolites regulate neuroinflammation in Alzheimer’s disease: Recent advances in gut-brain axis research
August 2026
Image, graphical abstract...
Emerging therapeutic approaches in amyotrophic lateral sclerosis: From gene therapy and stem cells to autophagy and nanotechnology
August 2026
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive motor neuron loss. This review summarizes recent advances in therapeutic strategies, with particular...
CREB1-driven SRPX upregulation is associated with CD8+ T cell apoptosis and malignant phenotypes in glioblastoma in vitro
August 2026
•SRPX promotes CD8+ T cell apoptosis in co-culture with GBM cells in vitro.•CREB1 activates SRPX transcription.•The CREB1/SRPX axis enhances GBM cell proliferation, migration, and invasion in vitro...