Reframing cell death: Unveiling interactions and synergistic mechanisms in tumor immunity
February 2026
Cell death is a well-coordinated process that encompasses apoptosis as well as other mechanisms, including pyroptosis, autophagic cell death, ferroptosis and necroptosis. These modalities are hierarchically...
Identification of key fatty acid metabolism genes and lncRNAs in Tibial cortex transverse traction therapy for diabetic foot Ulcers
December 2025
To explore the potential molecular mechanisms of tibial cortex transverse traction (TTT) in diabetic foot ulcer (DFU) healing by identifying key fatty acid metabolism genes and long non-coding RNAs...
Proteome provides a full map on the physiology and mechanism of the gastrointestinal tract in humans and rodents
December 2025
GRHL3 promotes tumor growth and metastasis via the TGF-β signaling pathway in human epithelial ovarian cancer
December 2025
Grainyhead-like 3 (GRHL3) has been implicated in the biology of several epithelial malignancies, yet its function in epithelial ovarian cancer (EOC) remains insufficiently defined. Given the high mortality...
Compounds isolated from Rhabdophyllum arnoldianum: promising new molecules for cancer treatment through their inhibitory properties on tyrosine kinases and dihydrofolate reductase, revealed by molecular docking
October 2025
Resistance to current anticancer therapies drives the demand for novel, multitarget agents with improved safety. We screened flavonoid-derived phytochemicals isolated from Rhabdophyllum arnoldianum...
Applications of artificial intelligence and large language models in cancer immunotherapy
October 2025
With the rapid advancement of artificial intelligence (AI) technologies, particularly the widespread adoption of large language models (LLMs), the field of cancer immunotherapy is experiencing unprecedented...
Proteomics and metabolomics analysis of Mongolian acupuncture therapy for type 2 diabetes mellitus with atherosclerosis
October 2025
Mongolian acupuncture therapy, a traditional modality involving stimulation of specific acupoints, has shown notable benefits in managing diabetes mellitus (DM) and its complications. However, its effects...
Advances in the combination of immunotherapy and radiotherapy for microsatellite-stable metastatic colorectal cancer
October 2025
Combining immunotherapy with radiotherapy has emerged as a novel and promising approach for treating microsatellite-stable metastatic colorectal cancer (MSS mCRC). This review offers an in-depth analysis...
A Multimodal artificial intelligence framework for mechanistic discovery and digital twin construction in cardiovascular medicine
October 2025
Multimodal artificial intelligence (AI) is reshaping contemporary cardiovascular medicine. Its contribution has moved far beyond early successes in image recognition, arrhythmia detection, and automated...
Immune biomarkers as key targets in managing tuberculosis: A systematic review
October 2025
Tuberculosis remains a major global health challenge and is one of the leading causes of mortality worldwide. In recent years, the resurgence of the disease has intensified research efforts aimed at...
Spatial omics: Deciphering heterogeneity in the tumor immune microenvironment and resistance to immunotherapy
October 2025
Drug resistance in tumor immunotherapy is a significant challenge, stemming from the high heterogeneity and intricate spatial architecture of the tumor immune microenvironment. Traditional omics technologies...
Emerging role of tumor associated macrophages in pan-tumor progression: Biological mechanisms to clinical application
October 2025
NSUN2/FOXM1 positive feedback pathway promotes the malignant development of non-small cell lung cancer
August 2025
•FOXM1 expression was upregulated in NSCLC tissues and cells.•FOXM1 silencing inhibited NSCLC cell proliferation, invasion, and M2 macrophage polarization and induced cell apoptosis and ferroptosis.•NSUN2...
Screening of immune-related secretory proteins linking primary Sjögren’s syndrome with pulmonary arterial hypertension based on comprehensive bioinformatics analysis and machine learning
August 2025
Pulmonary arterial hypertension (PAH) is a complication associated with primary Sjögren's syndrome (pSS). Nevertheless, the precise common mechanism linking pSS and PAH remains unclear. This study employs...
Multi-omics analysis reveals molecular characteristics and potential therapeutic targets of primary central nervous system lymphoma
August 2025
Primary central nervous system lymphoma (PCNSL) is a rare and aggressive extranodal lymphoma, which is distinct from nodal diffuse large B-cell lymphoma (DLBCL) in clinical presentation, molecular pathology,...
Proteomic analysis reveals the expression and impact of PRDX2 in ovarian cancer tissues
August 2025
The objective of this study is to elucidate the Peroxiredoxin 2(PRDX2) expression in ovarian cancer tissues and its effect on cancer progression using proteomic technology....
The characterization and immunoinformatic analysis of HN and F genes from the first reported XIII.2.1 Newcastle disease virus sub-genotype in Iran
August 2025
The global poultry industry faces considerable economic losses due to pathogenic strains of the Newcastle disease virus (NDV)....
Integrating the summary data-based mendelian randomization and transcriptomic analysis identifies candidate genes and repositioning targets for asthma
June 2025
Notwithstanding considerable progress in comprehending the molecular mechanisms and therapeutic approaches for asthma, it continues to be a widespread public health issue worldwide, resulting in considerable...
Comprehensive omics profiling in acute myeloid leukemia: From molecular landscape to clinical translation
June 2025
Acute Myeloid Leukemia (AML) is a molecularly heterogeneous hematologic malignancy driven by diverse genetic, epigenetic, and transcriptomic alterations. Recent advancements in high-throughput omics...
Targeting the unexplored 'dark proteome': Novel approaches in drug discovery
June 2025
The dark proteome, consisting of disordered, transient, and flexible regions of proteins, remains largely unexplored despite its potential for novel drug discovery. These regions, which lack stable...
Antioxidant defense gene expression associated with lung cancer pathology: implications for diagnostic and therapeutic targets
June 2025
Lung cancer is the leading cause of cancer-related mortality, and oxidative stress plays a central role in its pathogenesis. Antioxidant enzymes such as catalase (CAT) are crucial for maintaining redox...
Decoding disorder: Advances in predicting intrinsically disordered proteins
June 2025
Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) play critical roles in cellular signaling, transcriptional regulation, and dynamic protein-protein interactions....
Exploration of atractylenolide III targeting MDM2/p53 axis in breast cancer cell progression based on network pharmacology, molecular docking and ubiquitination analysis
April 2025
Atractylenolide III (AT III) is a promising drug used for cancer treatment. Herein, this study aimed to explore the anti-tumor mechanism of AT III in breast cancer (BC) associated with murine double...
Advances in machine learning for optimizing pharmaceutical drug discovery
April 2025
The integration of advanced machine learning methodologies has revolutionized the field of pharmaceutical drug discovery by addressing critical challenges in efficiency, scalability, and accuracy. This...