TRIM15 mediates ubiquitination and degradation of HOXD11 to promote IL-1β-induced chondrocyte injury
October 2026
•HOXD11 is lowly expressed in LPS-induced ATDC5 cells.•Overexpression of HOXD11 inhibits the apoptosis and inflammation in LPS-induced ATDC5 cells.•TRIM15 mediates the ubiquitination modification and...
Psoralen induces osteoblast differentiation by increasing ESR1 expression in human osteoblasts
August 2026
•Psoralen upregulated ESR1 expression in hFOB1.19 cells.•Psoralen treatment promoted ALP activity and contents and enhanced hFOB1.19 cell mineralization ability.•Psoralen treatment also increased the...
Dysregulation of circadian clock genes in hepatocellular carcinoma: Development of a four-gene prognostic signature
August 2026
Hepatocellular carcinoma (HCC) is one of the most lethal malignancies worldwide. Dysregulation of circadian clock genes (CCGs) plays a vital role in the progression of various cancers, including HCC....
In-Silico and Machine Learning-Based Evaluation of Dipeptide Inhibitors Targeting Isoleucyl-tRNA Synthetase in Dermatophytic Fungal Infection
August 2026
Dermatophytosis is one of the most widespread fungal infections caused by dermatophytes such as Trichophyton, Microsporum, and Epidermophyton. The increasing prevalence of antifungal resistance has...
NFIC transcriptionally activates DUSP1 to attenuate high glucose-induced mesangial cell injury in diabetic nephropathy: insights from integrative transcriptomics and functional studies
August 2026
•Integrative transcriptomic analysis identified 63 dysregulated genes in DN.•NFIC is downregulated in DN and directly promotes the transcription of DUSP1.•NFIC overexpression alleviates HG-induced ECM...
Advances in deciphering lung cancer immune microenvironment heterogeneity and immunotherapy response using single-cell and multi-omics technologies
August 2026
PD-1/PD-L1 immunotherapy has transformed lung cancer treatment, but resistance and variable responses persist due to tumor immune microenvironment (TIME) heterogeneity....
Investigation into the mechanisms of collagen deposition and extracellular matrix remodeling in keloid formation using multi-omics analysis, machine learning, and weighted gene co-expression network analysis
August 2026
•ASPN was identified as a hub gene exhibiting the most pronounced upregulation in keloid fibroblasts.•ASPN knockdown significantly inhibited collagen deposition, facilitated ECM remodeling, and suppressed...
Machine learning-driven plasma proteomics identifies MBP/PSMD10 panel for stratification of mild-to-moderate clinical Alzheimer's disease
August 2026
•Plasma proteomics identifies MBP/SOD2 as AD diagnostic biomarkers in a pilot cohort.•MBP/PSMD10 panel detects mild-to-moderate AD with AUC=0.996 in a pilot cohort.•Mitochondrial dysfunction links to...
NEDD4 and HDAC1 impair SMAD5-mediated osteogenic differentiation of human bone marrow mesenchymal stem cells via ubiquitination and deacetylation
August 2026
Osteoporosis is a bone disease characterized by reduced bone mass and microstructural deterioration, leading to increased fragility and fracture risk, which significantly impairs patient health and...
Ion channels as emerging drug targets: Pharmacological insights and therapeutic advances
August 2026
Ion channels are crucial regulators of cellular signaling and homeostasis, and their failure is associated with various clinical illnesses, including neurological disorders, cardiovascular diseases,...
Methylation-driven inactivation of TFPI2 functions as a tumor suppressor in esophageal squamous cell carcinoma: an exploratory study in Kazakh patients
August 2026
•5‑aza‑CdR alters Eca109 cell morphology and gene expression.•In non-tumor tissues and 5-aza-CdR-treated cells, TFPI2 expression increases while promoter methylation decreases.•TFPI2 overexpression...
Proteomics advances in screening early diagnostic biomarkers for non-alcoholic fatty liver disease
August 2026
Non-alcoholic fatty liver disease (NAFLD) has emerged as a global public health burden with an exponential rise in prevalence, encompassing a spectrum of pathological conditions from simple steatosis...
Silencing UHRF1 regulates TNBC cell ferroptosis and EMT via up-regulating SORBS1
August 2026
•UHRF1 is up-regulated in TNBC tissues and cells.•UHRF1 silencing promotes TNBC cell ferroptosis and suppresses EMT.•UHRF1 affects the ubiquitination level of SORBS1.•Down-regulated UHRF1 promotes ferroptosis...
FBP1 regulates epirubicin chemosensitivity in hepatocellular carcinoma through glycolysis modulation
August 2026
Hepatocellular carcinoma (HCC) is a common liver cancer subtype with a poor prognosis. Fructose-1,6-Bisphosphatase 1 (FBP1), one of the rate-limiting gluconeogenic enzymes, has been identified as a...
Protein network mechanisms by which gut microbial metabolites regulate neuroinflammation in Alzheimer’s disease: Recent advances in gut-brain axis research
August 2026
Image, graphical abstract...
Identification of ORM1 in acute myocardial infarction via proteomics plus machine learning and exploring its diagnostic value and function
June 2026
•ORM1 was identified as a biomarker for AMI via proteomics and machine learning.•ORM1 was upregulated in AMI and exhibited good diagnostic value for AMI.•ORM1 knockdown alleviated cell apoptosis, inflammatory...
Oral Lactobacillus rhamnosus Is associated with pancreatic tumor growth and reduced T-Cell infiltration in mice
June 2026
Lactobacillus species are widely used as probiotics and may influence host immunity, but their effects on tumor progression are context-dependent....
Synthesis, antimicrobial evaluation, and molecular docking of novel pyrene-functionalized pyrazole derivatives
June 2026
•Novel polynuclear pyrene-based pyrazoles were efficiently designed and synthesized.•Structures were confirmed by NMR and mass spectrometric analyses.•Pyrazoles showed broad-spectrum antibacterial and...
Integrating proteomics, metabolomics, and microbiome analysis: A comprehensive study on Hirschsprung's disease
June 2026
Hirschsprung's disease (HD) is a congenital disorder characterized by the absence or reduction of ganglion cells in the colonic wall, which leads to impaired intestinal motility and functional obstruction....
The anti-aging effect and mechanism of a compound peptide on sensitive skin
June 2026
•Complex peptides exhibit no toxic effects on primary keratinocytes and fibroblasts within a certain concentration range.•Complex peptides could suppress inflammatory responses and promote barrier repair...
Identification of ferroptosis-related biomarker in breast cancer and analysis of its role in breast cancer progression
June 2026
•The study identified BUB1B as a candidate hub gene.•Expression levels of BUB1B were significantly correlated with immune cell infiltration.•Silencing BUB1B significantly inhibited BC cell proliferation...
KLF4 drives aggressive RA-FLS phenotypes via HTR2A-mediated AKT/mTOR activation
June 2026
Rheumatoid arthritis (RA) represents a chronic autoimmune disorder that primarily impacts the joints through inflammatory processes. Despite therapeutic advances, a subset of patients remains difficult-to-treat,...
HERC5-mediated ubiquitination of IGFBP3 drives the inflammatory response and cell apoptosis in dry eye syndrome
June 2026
•Through the combined analysis of transcriptomics and WGCNA, the key ubiquitin ligase HERC5 for dry eye syndrome was screened out.•Reducing HERC5 effectively alleviated inflammation and cell damage...
The evolving landscape of immunotherapy in lung cancer: From mechanism to clinical translation
June 2026
Lung cancer is the leading cause of cancer-related mortality worldwide, accounting for 12.4% of all incident cancers and 18.7% of total cancer deaths globally. Most patients are diagnosed at advanced...
Integrated network pharmacology, behavior assessment, and bioinformatics to reveal the neuroprotective effect of Buzhong Yiqi Decoction combined with Fuzi Lizhong Decoction for diarrhea-predominant irritable bowel syndrome
June 2026
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a common functional gastrointestinal disease. Buzhong Yiqi Decoction combined with Fuzi Lizhong Decoction (BZFZ) has been clinically prescribed...