Identification of ORM1 in acute myocardial infarction via proteomics plus machine learning and exploring its diagnostic value and function
June 2026
•ORM1 was identified as a biomarker for AMI via proteomics and machine learning.•ORM1 was upregulated in AMI and exhibited good diagnostic value for AMI.•ORM1 knockdown alleviated cell apoptosis, inflammatory...
Oral Lactobacillus rhamnosus Is associated with pancreatic tumor growth and reduced T-Cell infiltration in mice
June 2026
Lactobacillus species are widely used as probiotics and may influence host immunity, but their effects on tumor progression are context-dependent....
Synthesis, antimicrobial evaluation, and molecular docking of novel pyrene-functionalized pyrazole derivatives
June 2026
•Novel polynuclear pyrene-based pyrazoles were efficiently designed and synthesized.•Structures were confirmed by NMR and mass spectrometric analyses.•Pyrazoles showed broad-spectrum antibacterial and...
Integrating proteomics, metabolomics, and microbiome analysis: A comprehensive study on Hirschsprung's disease
June 2026
Hirschsprung's disease (HD) is a congenital disorder characterized by the absence or reduction of ganglion cells in the colonic wall, which leads to impaired intestinal motility and functional obstruction....
The anti-aging effect and mechanism of a compound peptide on sensitive skin
June 2026
•Complex peptides exhibit no toxic effects on primary keratinocytes and fibroblasts within a certain concentration range.•Complex peptides could suppress inflammatory responses and promote barrier repair...
Identification of ferroptosis-related biomarker in breast cancer and analysis of its role in breast cancer progression
June 2026
•The study identified BUB1B as a candidate hub gene.•Expression levels of BUB1B were significantly correlated with immune cell infiltration.•Silencing BUB1B significantly inhibited BC cell proliferation...
KLF4 drives aggressive RA-FLS phenotypes via HTR2A-mediated AKT/mTOR activation
June 2026
Rheumatoid arthritis (RA) represents a chronic autoimmune disorder that primarily impacts the joints through inflammatory processes. Despite therapeutic advances, a subset of patients remains difficult-to-treat,...
Deciphering Rab32-associated antibacterial responses: Proteomics reveals the heterogeneity of macrophage defense against bacterial pathogen infection
April 2026
•Rab32, a Ras superfamily GTPase, exhibits broad-spectrum antimicrobial activity in macrophages against various bacterial pathogens.•Proteomic analysis reveals Rab32 deficiency alters host cell response...
Lipopolysaccharide activates platelet via the TLR4/MYD88 pathway to protect against bacterial lung injury
April 2026
•Platelet treatment protected against lung injury of S. pneumonia-infected mice.•Platelet treatment inhibited immune response, inflammation and oxidative stress in S. pneumonia-infected mice.•LPS induced...
In silico design and evaluation of a multi-epitope vaccine targeting SARS-CoV-2 structural proteins
April 2026
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to pose a serious global health threat....
Isolupalbigenin as a multi-target natural scaffold targeting HER2, EGFR, IGF-1R, and BCL-2 in breast cancer: An integrated docking, molecular dynamics, and DFT study
April 2026
This study aimed to identify potential multi-target natural compounds capable of interacting with key breast cancer–associated proteins using an integrated computational framework....
Curcumin inhibits Annexin A1 signaling to promote neuronal survival and functional recovery after ischemic stroke
April 2026
•Transcriptional profiling reveals age-, sex-, and cell type-specific upregulation of Annexin A1 (ANXA1) in ischemic stroke across mouse and human datasets.•A bioinformatics-guided drug screen identifies...
Leukemia stem cell differentiation in acute myeloid leukemia: Molecular mechanisms and multi-omics insights
April 2026
Acute myeloid leukemia (AML) is characterized by the accumulation of immature myeloid progenitors resulting from impaired differentiation. Increasing evidence supports a hierarchical organization sustained...
Design and synthesis of heterocyclic biphenyl-resultant novel pyrazole scaffolds: In-vitro and In-silico studies for potent antimicrobial agents
April 2026
•Novel biphenyl–heterocyclic pyrazole frameworks (4a–4 h) designed and synthesized.•Structures validated via FT-IR, NMR, and HRMS analyses.•Docking against Escherichia coli DNA gyrase B revealed strong...
Proteomic insights into myogenic progression in cultured muscle cells of Lates calcarifer (Bloch, 1790)
April 2026
Muscle cell lines serve as valuable models for investigating mechanisms underlying muscle proliferation and differentiation. This study aimed to characterize proteomic changes during passage progression...
The interplay of Drp1 post-translational modifications as a regulatory network driving mitochondrial fission in diabetic kidney disease
April 2026
Diabetic Kidney Disease (DKD) is the primary cause of end-stage renal disease (ESRD), with renal interstitial fibrosis being the core driver of its progression. Mitochondrial dynamics imbalance, particularly...
Tenascin C: a multifaceted interplayer in the rheumatoid arthritis pathogenesis and progression - insights and implications
April 2026
Tenascin-C (TNC) has emerged as an endogenous damage-associated molecular pattern (DAMP) molecule that sustains the inflammatory milieu in RA joints, because it acts not merely as a structural matrix...
Reframing cell death: Unveiling interactions and synergistic mechanisms in tumor immunity
February 2026
Cell death is a well-coordinated process that encompasses apoptosis as well as other mechanisms, including pyroptosis, autophagic cell death, ferroptosis and necroptosis. These modalities are hierarchically...
A research status and prospects of edible fungal-derived fibrinolytic enzymes: breakthroughs based on multi-omics and intelligent delivery technologies
February 2026
Thrombotic diseases represent a significant global health burden. Current clinical thrombolytic agents are plagued by limitations including short half-lives, high bleeding risks, and exorbitant costs....
Structure-based virtual screening and molecular dynamics simulation for the identification of novel potential inhibitors for the NDM-1 of Klebsiella Pneumoniae from the marine natural products
February 2026
The emergence of antibiotic-resistant bacteria, especially New Delhi Metallo-β-lactamase-1 (NDM-1) of Klebsiella pneumoniae, is a significant threat to serious public health. The aim of this study was...
Silencing of KLF9 alleviates palmitic acid-induced insulin resistance and inflammation in undifferentiated myoblasts by targeting GRB14, unveiling a pathogenic axis in Type 2 diabetic myopathy
February 2026
Skeletal muscle insulin resistance and inflammation are key drivers in the progression of skeletal muscle atrophy in Type 2 diabetes (T2D). This study aimed to identify novel molecular regulators underlying...
Etomidate alleviates PM2.5-induced cardiomyocyte injury by increasing the expression of HSCB based on transcriptome analysis
February 2026
Etomidate is a commonly used short-acting intravenous anesthetic and has become an important option for anesthesia induction in myocardial injury patients. However, the potential molecular mechanisms...
The mechanism of active components of Panax japonicus in mediating the HIF-VEGF signaling pathway to promote fracture healing: An investigation utilizing serum pharmacochemistry and network pharmacology approaches
February 2026
To establish a tibial fracture model in rats and preliminarily investigate the intervention mechanisms of Panax japonicus on the tibial fracture healing process based on the angiogenesis mechanisms...
Applications and challenges of tear proteomics in unveiling the molecular mechanisms and biomarkers of dry eye disease
February 2026
Dry Eye Disease (DED) stands as one of the most prevalent ocular surface disorders globally, with an increasing incidence that significantly impairs patients’ visual function and quality of life. Conventional...
METTL14 stabilizes KLF6 through m6A methylation modification, thereby exacerbating neuronal injury induced by ischemia-reperfusion
February 2026
Stroke is an acute cerebrovascular condition marked by high rates of disability and mortality. Kruppel-like factor 6 (KLF6), a pivotal transcription factor, is integral to cell proliferation and differentiation....