SP1-mediated WTAP exacerbates the progression of colon adenocarcinoma by m6A methylation of KLK8
February 2025
•KLK8 knockdown repressed COAD cell progression and promotes CD8+ T cell cytotoxicity.•KLK8 silencing blocks tumorigenesis of COAD in vivo.•WTAP knockdown inhibits COAD progression by regulating KLK8...
Design, synthesis, and theoretical studies of sulfonylated purine derivatives as EGFR inhibitor
February 2025
Four novel 6-amino-9-sulfonyl-purine derivatives were synthesized and characterized by 1H-NMR, 13C NMR, IR, and Mass spectral analyses. Further DNA binding studies were performed with the synthesized...
An in-silico approach for structural and functional annotation of an uncharacterized protein of human papillomavirus (HPV)
February 2025
Human papillomavirus (HPV) is the predominant viral infection, which causes various new cancer cases globally each year, encompassing cervical and various other cancer types. HPVs have developed throughout...
Advances in bioinformatics techniques for ophthalmic diseases
February 2025
As the population ages and lifestyles evolve, the prevalence of ophthalmic diseases such as diabetic retinopathy, age-related macular degeneration, and glaucoma continues to rise, imposing a significant...