PROM2 expression is associated with endometrial carcinoma progression-related features, PI3K/AKT pathway activation and immune infiltration estimates
October 2026
Prominin-2 (PROM2) is involved in the initiation and development of multiple cancers, but its role in endometrial carcinoma (EC) remains to be comprehensively characterized....
Silencing CREB3 activates the MAPK signaling pathway in acute myeloid leukemia and serves as a potent predictive gene for prognostic models
October 2026
Acute myeloid leukemia (AML) is a hematologic malignancy with a low survival rate and high mortality. Endoplasmic reticulum (ER) stress is strongly associated with apoptosis of human leukemia cells...
Psoralen induces osteoblast differentiation by increasing ESR1 expression in human osteoblasts
August 2026
•Psoralen upregulated ESR1 expression in hFOB1.19 cells.•Psoralen treatment promoted ALP activity and contents and enhanced hFOB1.19 cell mineralization ability.•Psoralen treatment also increased the...
Dysregulation of circadian clock genes in hepatocellular carcinoma: Development of a four-gene prognostic signature
August 2026
Hepatocellular carcinoma (HCC) is one of the most lethal malignancies worldwide. Dysregulation of circadian clock genes (CCGs) plays a vital role in the progression of various cancers, including HCC....
In-Silico and Machine Learning-Based Evaluation of Dipeptide Inhibitors Targeting Isoleucyl-tRNA Synthetase in Dermatophytic Fungal Infection
August 2026
Dermatophytosis is one of the most widespread fungal infections caused by dermatophytes such as Trichophyton, Microsporum, and Epidermophyton. The increasing prevalence of antifungal resistance has...
NFIC transcriptionally activates DUSP1 to attenuate high glucose-induced mesangial cell injury in diabetic nephropathy: insights from integrative transcriptomics and functional studies
August 2026
•Integrative transcriptomic analysis identified 63 dysregulated genes in DN.•NFIC is downregulated in DN and directly promotes the transcription of DUSP1.•NFIC overexpression alleviates HG-induced ECM...
Advances in deciphering lung cancer immune microenvironment heterogeneity and immunotherapy response using single-cell and multi-omics technologies
August 2026
PD-1/PD-L1 immunotherapy has transformed lung cancer treatment, but resistance and variable responses persist due to tumor immune microenvironment (TIME) heterogeneity....
Investigation into the mechanisms of collagen deposition and extracellular matrix remodeling in keloid formation using multi-omics analysis, machine learning, and weighted gene co-expression network analysis
August 2026
•ASPN was identified as a hub gene exhibiting the most pronounced upregulation in keloid fibroblasts.•ASPN knockdown significantly inhibited collagen deposition, facilitated ECM remodeling, and suppressed...
Machine learning-driven plasma proteomics identifies MBP/PSMD10 panel for stratification of mild-to-moderate clinical Alzheimer's disease
August 2026
•Plasma proteomics identifies MBP/SOD2 as AD diagnostic biomarkers in a pilot cohort.•MBP/PSMD10 panel detects mild-to-moderate AD with AUC=0.996 in a pilot cohort.•Mitochondrial dysfunction links to...
NEDD4 and HDAC1 impair SMAD5-mediated osteogenic differentiation of human bone marrow mesenchymal stem cells via ubiquitination and deacetylation
August 2026
Osteoporosis is a bone disease characterized by reduced bone mass and microstructural deterioration, leading to increased fragility and fracture risk, which significantly impairs patient health and...
Ion channels as emerging drug targets: Pharmacological insights and therapeutic advances
August 2026
Ion channels are crucial regulators of cellular signaling and homeostasis, and their failure is associated with various clinical illnesses, including neurological disorders, cardiovascular diseases,...
Methylation-driven inactivation of TFPI2 functions as a tumor suppressor in esophageal squamous cell carcinoma: an exploratory study in Kazakh patients
August 2026
•5‑aza‑CdR alters Eca109 cell morphology and gene expression.•In non-tumor tissues and 5-aza-CdR-treated cells, TFPI2 expression increases while promoter methylation decreases.•TFPI2 overexpression...
Proteomics advances in screening early diagnostic biomarkers for non-alcoholic fatty liver disease
August 2026
Non-alcoholic fatty liver disease (NAFLD) has emerged as a global public health burden with an exponential rise in prevalence, encompassing a spectrum of pathological conditions from simple steatosis...
Silencing UHRF1 regulates TNBC cell ferroptosis and EMT via up-regulating SORBS1
August 2026
•UHRF1 is up-regulated in TNBC tissues and cells.•UHRF1 silencing promotes TNBC cell ferroptosis and suppresses EMT.•UHRF1 affects the ubiquitination level of SORBS1.•Down-regulated UHRF1 promotes ferroptosis...
FBP1 regulates epirubicin chemosensitivity in hepatocellular carcinoma through glycolysis modulation
August 2026
Hepatocellular carcinoma (HCC) is a common liver cancer subtype with a poor prognosis. Fructose-1,6-Bisphosphatase 1 (FBP1), one of the rate-limiting gluconeogenic enzymes, has been identified as a...
Protein network mechanisms by which gut microbial metabolites regulate neuroinflammation in Alzheimer’s disease: Recent advances in gut-brain axis research
August 2026
Image, graphical abstract...
Emerging therapeutic approaches in amyotrophic lateral sclerosis: From gene therapy and stem cells to autophagy and nanotechnology
August 2026
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive motor neuron loss. This review summarizes recent advances in therapeutic strategies, with particular...
CREB1-driven SRPX upregulation is associated with CD8+ T cell apoptosis and malignant phenotypes in glioblastoma in vitro
August 2026
•SRPX promotes CD8+ T cell apoptosis in co-culture with GBM cells in vitro.•CREB1 activates SRPX transcription.•The CREB1/SRPX axis enhances GBM cell proliferation, migration, and invasion in vitro...
Machine learning-based prediction of protein–protein interactions in Escherichia coli bacteria using amino acid composition
August 2026
Protein–protein interactions are essential for understanding cellular processes and molecular mechanisms in living organisms. In Escherichia coli, accurate identification of PPIs is crucial for elucidating...
Streptococcus mutans induces NAT10 to cooperate with p300 and aggravate osteoclast–mediated inflammatory bone destruction
August 2026
•NAT10 is significantly upregulated during Streptococcus mutans (S. mutans)–induced osteoclastogenesis and inflammatory bone destruction.•Elevated NAT10 promotes osteoclast differentiation and bone...
Artificial intelligence-assisted computational identification of peptide candidates against various key targets for combating hyperpigmentation and skin aging
August 2026
Premature ageing of skin along with hyperpigmentation is a major dermatological concern worldwide. They often result from increased production of melanin, environmental factors, and the impact of reactive...
ETS1-driven transcriptional activation of ACSL4 mediates hypoxia-induced ferroptosis in anterior cruciate ligament fibroblasts
August 2026
•Hypoxia induces multifaceted injury in ACL fibroblasts.•Hypoxia triggers ferroptosis with ACSL4 upregulation in ACL fibroblasts.•ACSL4 silencing attenuates hypoxia-induced ferroptosis and cellular...
The anti-aging effect and mechanism of a compound peptide on sensitive skin
June 2026
•Complex peptides exhibit no toxic effects on primary keratinocytes and fibroblasts within a certain concentration range.•Complex peptides could suppress inflammatory responses and promote barrier repair...
The lactylation modification as a metabolic-epigenetic bridge: Research progress and prospects in renal fibrosis
June 2026
Chronic kidney disease (CKD) is a major global public health problem with a standardized global prevalence of 15–20%, and renal fibrosis serves as a common irreversible pathological feature of all progressive...
Regulation of macrophage efferocytosis and immune homeostasis by natural bioactive compounds: A novel therapeutic mechanism for rheumatic autoimmune diseases
June 2026
Rheumatic immune diseases (RID), mainly encompassing rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), systemic sclerosis (SSc) and Sjögren’s syndrome (SS), belong to a group of chronic...