Psoralen induces osteoblast differentiation by increasing ESR1 expression in human osteoblasts
August 2026
•Psoralen upregulated ESR1 expression in hFOB1.19 cells.•Psoralen treatment promoted ALP activity and contents and enhanced hFOB1.19 cell mineralization ability.•Psoralen treatment also increased the...
Dysregulation of circadian clock genes in hepatocellular carcinoma: Development of a four-gene prognostic signature
August 2026
Hepatocellular carcinoma (HCC) is one of the most lethal malignancies worldwide. Dysregulation of circadian clock genes (CCGs) plays a vital role in the progression of various cancers, including HCC....
In-Silico and Machine Learning-Based Evaluation of Dipeptide Inhibitors Targeting Isoleucyl-tRNA Synthetase in Dermatophytic Fungal Infection
August 2026
Dermatophytosis is one of the most widespread fungal infections caused by dermatophytes such as Trichophyton, Microsporum, and Epidermophyton. The increasing prevalence of antifungal resistance has...
Identification of ORM1 in acute myocardial infarction via proteomics plus machine learning and exploring its diagnostic value and function
June 2026
•ORM1 was identified as a biomarker for AMI via proteomics and machine learning.•ORM1 was upregulated in AMI and exhibited good diagnostic value for AMI.•ORM1 knockdown alleviated cell apoptosis, inflammatory...
Oral Lactobacillus rhamnosus Is associated with pancreatic tumor growth and reduced T-Cell infiltration in mice
June 2026
Lactobacillus species are widely used as probiotics and may influence host immunity, but their effects on tumor progression are context-dependent....
Synthesis, antimicrobial evaluation, and molecular docking of novel pyrene-functionalized pyrazole derivatives
June 2026
•Novel polynuclear pyrene-based pyrazoles were efficiently designed and synthesized.•Structures were confirmed by NMR and mass spectrometric analyses.•Pyrazoles showed broad-spectrum antibacterial and...
Integrating proteomics, metabolomics, and microbiome analysis: A comprehensive study on Hirschsprung's disease
June 2026
Hirschsprung's disease (HD) is a congenital disorder characterized by the absence or reduction of ganglion cells in the colonic wall, which leads to impaired intestinal motility and functional obstruction....
The anti-aging effect and mechanism of a compound peptide on sensitive skin
June 2026
•Complex peptides exhibit no toxic effects on primary keratinocytes and fibroblasts within a certain concentration range.•Complex peptides could suppress inflammatory responses and promote barrier repair...
Identification of ferroptosis-related biomarker in breast cancer and analysis of its role in breast cancer progression
June 2026
•The study identified BUB1B as a candidate hub gene.•Expression levels of BUB1B were significantly correlated with immune cell infiltration.•Silencing BUB1B significantly inhibited BC cell proliferation...
KLF4 drives aggressive RA-FLS phenotypes via HTR2A-mediated AKT/mTOR activation
June 2026
Rheumatoid arthritis (RA) represents a chronic autoimmune disorder that primarily impacts the joints through inflammatory processes. Despite therapeutic advances, a subset of patients remains difficult-to-treat,...
HERC5-mediated ubiquitination of IGFBP3 drives the inflammatory response and cell apoptosis in dry eye syndrome
June 2026
•Through the combined analysis of transcriptomics and WGCNA, the key ubiquitin ligase HERC5 for dry eye syndrome was screened out.•Reducing HERC5 effectively alleviated inflammation and cell damage...
The evolving landscape of immunotherapy in lung cancer: From mechanism to clinical translation
June 2026
Lung cancer is the leading cause of cancer-related mortality worldwide, accounting for 12.4% of all incident cancers and 18.7% of total cancer deaths globally. Most patients are diagnosed at advanced...
Integrated network pharmacology, behavior assessment, and bioinformatics to reveal the neuroprotective effect of Buzhong Yiqi Decoction combined with Fuzi Lizhong Decoction for diarrhea-predominant irritable bowel syndrome
June 2026
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a common functional gastrointestinal disease. Buzhong Yiqi Decoction combined with Fuzi Lizhong Decoction (BZFZ) has been clinically prescribed...
A robust gene model developed based on the features of ADME genes for predicting lung adenocarcinoma prognosis
June 2026
Lung adenocarcinoma (LUAD) is a common subtype of lung cancer with high morbidity and mortality. Absorption, Distribution, Metabolism, Excretion (ADME) genes play critical roles in drug pharmacokinetics...
The lactylation modification as a metabolic-epigenetic bridge: Research progress and prospects in renal fibrosis
June 2026
Chronic kidney disease (CKD) is a major global public health problem with a standardized global prevalence of 15–20%, and renal fibrosis serves as a common irreversible pathological feature of all progressive...
Procyanidin B2 attenuates hypoxia/reoxygenation injury in ovarian granulosa cells through suppression of ferroptosis via the SIRT1/Nrf2/GPX4 pathway
June 2026
Ovarian ischemia/reperfusion (I/R) injury is a critical clinical concern leading to follicular loss and infertility, yet effective therapeutic strategies remain limited....
Regulation of macrophage efferocytosis and immune homeostasis by natural bioactive compounds: A novel therapeutic mechanism for rheumatic autoimmune diseases
June 2026
Rheumatic immune diseases (RID), mainly encompassing rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), systemic sclerosis (SSc) and Sjögren’s syndrome (SS), belong to a group of chronic...
PDK4 as a potential therapeutic target for antineutrophil cytoplasmic antibody associated glomerulonephritis
June 2026
ANCA-associated glomerulonephritis (ANCA-GN) is a severe renal manifestation of ANCA-associated vasculitis, and additional molecular markers and therapeutic hypotheses are needed....
Deciphering Rab32-associated antibacterial responses: Proteomics reveals the heterogeneity of macrophage defense against bacterial pathogen infection
April 2026
•Rab32, a Ras superfamily GTPase, exhibits broad-spectrum antimicrobial activity in macrophages against various bacterial pathogens.•Proteomic analysis reveals Rab32 deficiency alters host cell response...
Platelet activationprotects againstbacterial lung injury via the TLR4/MYD88 pathway
April 2026
•Platelet treatment protected against lung injury of S. pneumonia-infected mice.•Platelet treatment inhibited immune response, inflammation and oxidative stress in S. pneumonia-infected mice.•LPS induced...
In silico design and evaluation of a multi-epitope vaccine targeting SARS-CoV-2 structural proteins
April 2026
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to pose a serious global health threat....
Isolupalbigenin as a multi-target natural scaffold targeting HER2, EGFR, IGF-1R, and BCL-2 in breast cancer: An integrated docking, molecular dynamics, and DFT study
April 2026
This study aimed to identify potential multi-target natural compounds capable of interacting with key breast cancer–associated proteins using an integrated computational framework....
Curcumin normalizes stress–associated Annexin A1 signaling to promote neuronal survival and functional recovery after ischemic stroke
April 2026
•Transcriptional profiling reveals age-, sex-, and cell type-specific upregulation of Annexin A1 (ANXA1) in ischemic stroke across mouse and human datasets.•A bioinformatics-guided drug screen identifies...
Leukemia stem cell differentiation in acute myeloid leukemia: Molecular mechanisms and multi-omics insights
April 2026
Acute myeloid leukemia (AML) arises from blocked myeloid differentiation and subsequent accumulation of immature myeloid progenitors. Leukemia stem cells (LSCs) sustain AML hierarchical architecture...
Design and synthesis of heterocyclic biphenyl-resultant novel pyrazole scaffolds: In-vitro and In-silico studies for potent antimicrobial agents
April 2026
•Novel biphenyl–heterocyclic pyrazole frameworks (4a–4 h) designed and synthesized.•Structures validated via FT-IR, NMR, and HRMS analyses.•Docking against Escherichia coli DNA gyrase B revealed strong...