Tertiary lymphoid structures in squamous cell carcinoma: Moving beyond maturity grading toward a functional assessment
November 2026
Tertiary lymphoid structures (TLSs) are ectopic lymphoid aggregates that develop within chronically inflamed or tumor-associated microenvironments and have emerged as important prognostic and predictive...
Temporal and spatial patterns of head and neck cancer burden in China from 1990 to 2023: A subtype-specific analysis based on GBD 2023
November 2026
Head‑and‑neck cancers (HNCs) constitute a heterogeneous collection of malignancies characterized by diverse anatomical, etiological and epidemiological profiles. Comprehensive nationwide evidence regarding...
An inorganic biomaterials-containing composite hydrogel enables neuro-periodontal regenerative coupling
November 2026
Periodontal disease is a prevalent chronic inflammatory disorder that causes irreversible destruction of periodontal tissues and ultimately results in tooth loss. Owing to the structural complexity...
An Update and Perspective of Functional Tumor Fluorescence Imaging and Guided Surgery
Available online 4 November 2026
Optical imaging has become an increasingly important component of precision surgical oncology because it can provide real-time, radiation-free, and visually intuitive information during operative decision-making....
Ultrasound-Activated Wireless Piezoelectric Electrotherapy Platform for Osteosarcoma Treatment
Available online 27 October 2026
Maxillofacial osteosarcoma is a rare but highly aggressive bone malignancy. Effective local tumor control remains challenging because radical surgery and conventional adjuvant therapies are frequently...
Platelets are Key Players in the Oral-Cardiovascular-Cancer Interface: Emerging Roles in Thromboinflammation
Available online 27 October 2026
Oral disease, cardiovascular disease (CVD), and cancer represent an interconnected triad of pathologies for which platelets serve as important biological mediators. In chronic oral diseases such as...
Brain-computer interfaces: Transforming healthcare and navigating ethical boundaries
July 2026
Brain-computer interfaces (BCIs) enable direct communication between the brain and external devices. They hold promise for treating neurological disorders, restoring motor function, and enhancing human-computer...
OrthoAgent: A knowledge-enhanced multi-agent framework for multimodal orthodontic diagnosis and treatment planning
July 2026
Automated orthodontic diagnosis requires integration of multimodal geometric evidence with clinically grounded treatment reasoning. Existing multimodal models often lack the spatial precision required...
Expert consensus on the clinical application of artificial intelligence in the design of fixed dental restorations
July 2026
Prosthodontics is rapidly entering the digital era, with computer-aided design and manufacturing (CAD/CAM) soon becoming the mainstream method for fixed restoration design. Recent advances in image...
LIPUS-activated piezoelectric sutures exert antibacterial and pro-regenerative effects to promote wound healing
July 2026
Sutures are essential for preventing surgical site infections (SSIs) and promoting wound healing, yet current drug-based antibacterial strategies often fail to sustain long-term efficacy and may induce...
Pathology-adaptive sprayable hydrogel enables metal–metabolism–immune coordination for diabetic wound regeneration
July 2026
Diabetic wounds are characterized by infection, oxidative stress, persistent inflammation, and impaired angiogenesis. This study developed a pathology-adaptive sprayable hydrogel for diabetic wound...
PRMT5 promotes progression of oral potentially malignant disorders by epigenetically activating FOXM1 to rewire pyrimidine metabolism
July 2026
Oral potentially malignant disorders (OPMDs) carry a substantial risk of malignant transformation into oral squamous cell carcinoma (OSCC). Dysregulated nucleotide metabolism supports uncontrolled proliferation...
Generative AI for reference-free dentoalveolar aesthetic reconstruction: A multi-center study
July 2026
To develop and validate DAR-AI, a clinically applicable artificial intelligence system for reference-free dentoalveolar aesthetic reconstruction of alveolar bone defects....
Decellularized matrix hydrogel optimized MSC secretome alleviates radiation sialadenitis by apoptosis restoration to induce Senolysis
July 2026
Radiation sialadenitis is a debilitating complication of head and neck cancer radiotherapy for which no effective therapy exists. Conventional MSC-based strategies face translational barriers, and crude...
Necroptosis of stem cell aggregates suppresses bone regeneration via necroptosis-derived extracellular vesicles
April 2026
Despite the therapeutic promise of stem cell aggregates in bone regeneration, clinical outcomes remain unstable due to the complex and incompletely understood fate of transplanted cells. Here, we investigated...
Exosome-mediated lymphatic regeneration: Mechanisms, therapeutic strategies, and translational opportunities
April 2026
Lymphatic dysfunction, clinically presenting as secondary lymphedema and chronic inflammatory conditions, remains a significant clinical challenge following oncologic therapy and tissue trauma. Current...
Interfacial binding and mechanistic insights into enzyme-mediated homogeneous mineralization on TiO₂ nanotubes: A combined experimental and multi-scale computational study
April 2026
Enzyme-mediated mineralization offers a versatile strategy for developing advanced composite biomaterials, yet the precise mechanisms involving kinetic mineral-interface bonding and mineral growth remain...
Oral and systemic diseases under the framework of homeostatic medicine
April 2026
Homeostatic Medicine is an emerging integrative discipline that focuses on decoding the pivotal role of homeostasis in health and diseases and exploring strategies to restore inherent homeostasis for...
Excessive fibrin deposition disrupts immune-epithelial crosstalk and impairs resolution of diabetes-associated periodontitis
April 2026
Diabetic periodontitis is a refractory complication of diabetes with limited therapeutic options. Here, we identify excessive fibrin deposition as a key perpetuator of chronic inflammation in diabetic...
Notch signalling in alveolar bone development and regeneration: A critical regulator for osteoblasts to osteocytes transitioning
April 2026
Cell fate determination is controlled by a complex network of cell signalling pathways. The process of osteoblasts transforming into osteocytes can be described as several distinct stages: from osteoblasts...
Exosome-microneedle patches accelerate oral ulcer healing by remodeling macrophage-epithelial crosstalk via TSP‑1/CD47/NF‑κB signaling
April 2026
Oral ulcers are among the most common inflammatory lesions of the oral mucosa and often cause severe pain. However, current treatments are limited by short mucosal retention, suboptimal therapeutic...
Use of fluoride varnish with functionalized tricalcium phosphate for prevention of early childhood caries: A randomised clinical trial
April 2026
The aim of this study is to compare the caries-preventive effect of 5% sodium fluoride (NaF) varnish with and without functionalized tricalcium phosphate (fTCP) on young children with untreated active...
Inaugural editorial: Advancing the frontier of innovation in stomatology and interdisciplinary sciences
January 2026
Two-dimensional FeCu-metal-organic-framework boosts peroxidase activity for antibacterial application
January 2026
The overuse of antibiotics has led to the emergence of drug-resistant bacteria, posing a serious threat to human health and increasing the medical burden. Metal–organic frameworks (MOFs) have shown...
Effect of print parameters on the accuracy and fit of 3D-printed resin-based ceramic crowns
January 2026
This study evaluated the influence of print angle and layer thickness on the accuracy and fit of resin-based ceramic crowns fabricated using digital light processing (DLP). A mandibular first molar...